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HRP Overview - Increments 51/52 and 53/54
NASA's Human Research Program (HRP) on ISS. Conducting research for safe, productive human space travel and for astronauts to remain healthy during and after extended space travel.
NASA's Human Exploration Research Analog (HERA) for Studying Behavioral Effects of Exploration Missions
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The Effects of CDKN1a/p21 on Oxidative Stress and Mitochondrial Function During Long Duration Spaceflight
Spaceflight factors, such as microgravity and space radiation, are known to put astronauts at risk for negative effects to their tissue regeneration and degenerative conditions. On our previous spaceflight research, we found that long duration spaceflight produced increased oxidative stress and activation of the inflammatory response as a major contributor to physiological changes, including alterations to the cardiovascular and musculoskeletal systems, metabolism, and the liver. Proliferation, apoptosis, and ion-channel remodeling of vascular smooth muscle cells, as well as endothelial inflammation, and nitric oxide synthase-nitric oxide system regulation have been shown by spaceflight and simulated spaceflight projects. CDKN1ap21 is a regulatory gene for tissue regeneration and also plays an important role in upregulating oxidative stress caused by radiation. In further research, we have also determined CDKN1ap21 to be overexpressed during spaceflight. When knocked out in mice, however, it protects against unloading-induced changes to the morphology and physiology of carotid arteries. In this proposal, we seek to test a potential dietary countermeasure to down-regulate CDKN1ap21 in the mice and protect against oxidative stress in the rodents. Specifically, we will expose both Wildtype and CDKN1ap21-null mice to hydrogen peroxide to induce oxidative stress and observe the molecular mechanisms in which a dietary supplement protects vascular smooth muscle cells against the consequences of the apoptotic environment within Wildtype mice versus the, hypothetically, sound physiology of CDKN1ap21-null mice. The successful completion of this experiment will conclusively determine accuracy of a dietary supplement as a CDKN1ap21 suppressor. This will provide a new perspective on the problem of increased oxidative stress developing into cardiovascular disease as a result of long-term space flight. This research will address the Human Research Plan Roadmaps Risk of Cardiac Rhythm Problems including CV-8, the Risk of Cardiovascular Disease and Other Degenerative Tissue Effects from Radiation Exposure including Degen-6 and Degen-7, and the Risk of Adverse Health Event from Radiation Exposure including IM-8. Additionally, this research will address Space Biology Research Plans questions SBP CMB-1, SBP CMB-3, and SB AN-2.
Future of Human Spaceflight Research from an HRP Perspective
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Imaging-Based Human Physiology Research and Innovation in Early Spaceflight: Polaris Dawn Mission
Objectives - Physiological data - Early inflight period historically unobtainable - Spacefaring population becoming more diverse - Many spaceflight changes still poorly understood, risks unmitigated - Private spaceflight offers more rapid access to higher n - Autonomous procedures - Communication delays and outages - Transition to new training paradigms - Terrestrial application (remote medicine, DOD) - Leverage new hardware and software - Concepts extend beyond medical realm (medical ultrasound as a use case)
Human Factors and Behavioral Performance Exploration Measures in Human Exploration Research Analog (HERA) Campaign 6
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Results for the Subjective Habitability Acceptability Questionnaire From HERA C5 and C6
BACKGROUND The impact of habitability on psychological and performance outcomes is recognized as an important factor in habitat and vehicle design—especially as missions increase in length. Formal evaluation of habitability’s impact is possible using the Spaceflight Habitability Acceptability Questionnaire (SHAQ), which was psychometrically validated by Roma et al. in 2022 [1]. The SHAQ survey systematically quantifies the relationships between habitat areas (e.g., bedroom, kitchen, hygiene area, office, etc.) and behavioral health and performance (BHP) outcomes (i.e., individual and team performance, mood, stress, sleep, social interaction), and considers the moderating effects of key habitability aspects (i.e., privacy, control, convenience, efficiency, comfort, social density) on that relationship. METHOD Respondents were HERA participants from Campaign 5 and 6 (n = 32). Data from three environments were used in our SHAQ analyses: SHAQ in HERA (in-mission), SHAQ at Home (pre-mission), and SHAQ in Hotel (pre- and post-mission for C6, just pre-mission for C5). For each habitat area, respondents are asked how that area layout impacts six BHP outcomes on a 201-point visual analog scale with the anchors: impairs, has no effect, and facilitates. They also had the option to respond “Not Applicable”. Follow up questions asked why six key habitability aspects (e.g., privacy) influenced the way the habitat area affected a given outcome. Participants indicated whether a habitat area’s habitability aspects were inadequate (low score) to adequate (midpoint) to ideal (high score), using a 201-point visual analog scale as well but were binned to a 7-point scale for analyses. RESULTS AND CONCLUSION When comparing across environments, ratings of BHP outcomes were worse in HERA compared to home and pre-mission hotel, but rebounded for the post-mission hotel such that post-mission hotel rating were often higher than all previous ratings. Within HERA, ratings of how a habitat area impacted an outcome skewed towards facilitation with communal areas (i.e., galley and office) rated most facilitating. The follow up questions about why six key aspects related to habitability moderated outcomes indicated that most habitat areas were rated as having “adequate” habitability characteristics. Privacy was the only moderator with average scores below adequate for all habitat areas. The office had the most moderators scoring above adequate for all habitat areas. Ratings indicated small to moderate effects of layouts on BHP outcomes: with facilitating layouts averaging between 4 and 5, and impairing layouts averaging between 2 and 4. The sleeping module layout facilitated sleep, with ratings indicating adequate comfort but inadequate privacy. The galley layout facilitated social interaction and mood, with ratings indicating adequate efficiency and convenience. The office layout facilitated social interaction, team and individual performance, with ratings similarly indicating adequate efficiency and convenience. The hygiene module worsened individual performance, mood and stress, with ratings indicating less than adequate privacy and social density. Our findings suggest there is value in having dedicated team and individual spaces. REFERENCES [1] Roma, P. G., Landon, L.B., Spencer, C. A., Whitmire, A. M., & Williams, T. J. (2022). SHAQ: Development and Validation. Human Factors: Special Issue on Spaceflight, 65(6), 1074-1104. ACKNOWLEDGEMENTS This project was funded by the NASA Human Research Program directed task Human Factors and Behavioral Performance in HERA (PI = S. Bell) to the BHP Lab. KBR Inc. and JES Tech authors were supported by KBR’s Human Health and Performance Contract NNJ15HK11B with NASA.
Microbes in Deep Space: How Microbiology Research Facilitates Human Space Exploration
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Human Factors and Behavioral Performance Exploration Measures in Human Exploration Research Analog (HERA) Campaign 6
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Integrating Spaceflight Human System Risk Research
NASA is working to increase the likelihoods of human health and performance success during exploration missions, and subsequent crew long-term health. To manage the risks in achieving these goals, a system modeled after a Continuous Risk Management framework is in place. "Human System Risks" (Risks) have been identified, and approximately 30 are being actively addressed by NASA's Human Research Program (HRP). Research plans for each of HRP's Risks have been developed and are being executed. Ties between the research efforts supporting each Risk have been identified, however, this has been in an ad hoc fashion. There is growing recognition that solutions developed to address the full set of Risks covering medical, physiological, behavioral, vehicle, and organizational aspects of the exploration missions must be integrated across Risks and disciplines. We will discuss how a framework of factors influencing human health and performance in space is being applied as the backbone for bringing together sometimes disparate information relevant to the individual Risks. The resulting interrelated information is allowing us to identify and visualize connections between Risks and research efforts in a systematic and standardized way. We will discuss the applications of the visualizations and insights to research planning, solicitation, and decision-making processes.
Integrating Spaceflight Human System Risk Research
NASA is working to increase the likelihood of human health and performance success during exploration missions as well as to maintain the subsequent long-term health of the crew. To manage the risks in achieving these goals, a system modelled after a Continuous Risk Management framework is in place. "Human System Risks" (Risks) have been identified, and approximately 30 are being actively addressed by NASA's Human Research Program (HRP). Research plans for each of HRP's Risks have been developed and are being executed. Inter-disciplinary ties between the research efforts supporting each Risk have been identified; however, efforts to identify and benefit from these connections have been mostly ad hoc. There is growing recognition that solutions developed to address the full set of Risks covering medical, physiological, behavioural, vehicle, and organizational aspects of exploration missions must be integrated across Risks and disciplines. This paper discusses how a framework of factors influencing human health and performance in space is being applied as the backbone for bringing together sometimes disparate information relevant to the individual Risks. The resulting interrelated information enables identification and visualization of connections between Risks and research efforts in a systematic and standardized manner. This paper also discusses the applications of the visualizations and insights into research planning, solicitation, and decision-making processes.
Acquisition of and Access to Research Omics Data
Omics data are essential for understanding the myriad and complex effects of space environments on humans. To assure maximum benefit from these kinds of data, the NASA Human Research Program Data Management Plan stipulates that human omics data should be archived within and accessed through the NASA Life Sciences Portal (NLSP). The NLSP has the capability to acquire and provision access to omics (and other kinds of) research results for individual and ad-hoc groups of subjects at the direction of institutional review boards, or other authorizing bodies or individuals, per institutional, program and investigation-specific policies and procedures. However, because some single-subject omics data, like CT scans and other kinds of large, complex biomedical data, could be used to identify heretofore unknown risks to the subject’s health, or, in certain cases, be used to identify a subject, NASA Policy Directive 7170.1 describes various policies regarding the management of and access to “research genetic testing” data, which includes many kinds of omics data. For example, NPD 7170.1 prohibits access to human research genetic data by NASA personnel who make employment decisions for the subjects from whom the data were obtained. To meet the objective of acquiring research omics data for NLSP in compliance with the policies in NPD 7170.1 and other applicable NASA policies, we designed NOMADS (the NLSP Omics Multimodal Acquisition of Data System), a new component that supports the transfer of large research data files, including research genetic testing data, using one of several different transfer mechanisms. The choice of mechanism is made by the submitter of the data, with guiding information from the system, and is likely to often be determined in large part by the nature and source location of the data. For example, for small files where the source data files are not already stored in a cloud storage system, users are likely to prefer to transfer their data to the NLSP via a web browser. Conversely, for large sets of files already organized and stored in a cloud storage system, users may opt for NOMAD’s cloud-to-cloud transfer method. All omics datasets targeted for the NASA Life Sciences Data Archive must pass a variety of quality checks to ensure data integrity and adherence to the standards defined by the LSDA Data Submission Guidelines (DSG) (see https://nlsp.nasa.gov/explore/lsdahome/datasubmit). These include requirements that data are consistent with open standards established by the omics community. Non-compliant data will not be accepted however archivists are available to advise submitters on how to revise data submissions and re-submit until compliance is achieved. Following compliance with the LSDA DSG, omics data next undergo a variety of additional quality checks to ensure the data meet omics community standards. Domain specific Omics data quality control tools and techniques are continually evolving and linked to the advancements in omics assays utilized and thus, the tools and techniques utilized by the LSDA for data quality control and validation will need to be sustained accordingly. All human omics data will be access controlled according to the policies described above, and requiring IRB approval for any additional access grants once the data are acquired (including access for analysis using the NLSP workspace tools).
Acquisition of and Access to Research Omics Data
Omics data are essential for understanding the myriad and complex effects of space environments on humans. To assure maximum benefit from these kinds of data, the NASA Human Research Program Data Management Plan stipulates that human omics data should be archived within and accessed through the NASA Life Sciences Portal (NLSP). The NLSP has the capability to acquire and provision access to omics (and other kinds of) research results for individual and ad-hoc groups of subjects at the direction of institutional review boards, or other authorizing bodies or individuals, per institutional, program and investigation-specific policies and procedures. However, because some single-subject omics data, like CT scans and other kinds of large, complex biomedical data, could be used to identify heretofore unknown risks to the subject’s health, or, in certain cases, be used to identify a subject, NASA Policy Directive 7170.1 describes various policies regarding the management of and access to “research genetic testing” data, which includes many kinds of omics data. For example, NPD 7170.1 prohibits access to human research genetic data by NASA personnel who make employment decisions for the subjects from whom the data were obtained. To meet the objective of acquiring research omics data for NLSP in compliance with the policies in NPD 7170.1 and other applicable NASA policies, we designed NOMADS (the NLSP Omics Multimodal Acquisition of Data System), a new component that supports the transfer of large research data files, including research genetic testing data, using one of several different transfer mechanisms. The choice of mechanism is made by the submitter of the data, with guiding information from the system, and is likely to often be determined in large part by the nature and source location of the data. For example, for small files where the source data files are not already stored in a cloud storage system, users are likely to prefer to transfer their data to the NLSP via a web browser. Conversely, for large sets of files already organized and stored in a cloud storage system, users may opt for NOMAD’s cloud-to-cloud transfer method. All omics datasets targeted for the NASA Life Sciences Data Archive must pass a variety of quality checks to ensure data integrity and adherence to the standards defined by the LSDA Data Submission Guidelines (DSG) (see https://nlsp.nasa.gov/explore/lsdahome/datasubmit). These include requirements that data are consistent with open standards established by the omics community. Non-compliant data will not be accepted however archivists are available to advise submitters on how to revise data submissions and re-submit until compliance is achieved. Following compliance with the LSDA DSG, omics data next undergo a variety of additional quality checks to ensure the data meet omics community standards. Domain specific Omics data quality control tools and techniques are continually evolving and linked to the advancements in omics assays utilized and thus, the tools and techniques utilized by the LSDA for data quality control and validation will need to be sustained accordingly. All human omics data will be access controlled according to the policies described above, and requiring IRB approval for any additional access grants once the data are acquired (including access for analysis using the NLSP workspace tools).
OP3 NASA JAXA Rodent Research Collaboration Opportunities
Space Biology and Human Research Projects Integrated Proposal to use the JAXA MARS facility to be presented to JAXA and JAXA investigator audience at JAXA Kibo Utilization Symposium and OP3 negotiation for 2019 ISS rodent mission. Slides present a pictorial overview of the proposed science and analysis techniques desired from the US investigator team. Prior published data form a recent collaboration with JAXA is also mentioned.
Medical Database Accomplishments and Lessons Learned - 2021
The Medical Database (MD) is a virtual repository consisting of two software components: the Medical Item Database (MedID) and the Evidence Library (EL). MedID consists of engineering data and associated information for specific medical resource items (e.g., pharmaceutical, medical devices, and supporting components), while the EL is a tool which provides all of the medical evidence necessary. The Medical Database will serve as the single “source of truth” for the Informing Mission Planning via Analysis of Complex Tradespaces (IMPACT) tool suite for both medical evidence and medical resource engineering data. It will be used in conjunction with the IMPACT tool suite to inform research prioritizations and perform systematic trade study evaluations using probabilistic risk assessment and simulated human spaceflight missions to aid stakeholders in making informed decisions during Pre-Phase-A planning of human spaceflight missions. The IMPACT project is conducted under the Exploration Medical Capability (ExMC) element of the Human Research Program (HRP), within NASA’s Human Exploration and Operations Mission Directorate. Over the past year, the MedID software has been successfully merged with the Evidence Library into one cohesive Medical Database with two independent user interface experiences for modifying either clinical evidence or resource engineering data. As MD has evolved substantially over the past year, a number of challenges have been encountered and overcome along the way. A number of ‘lessons learned’ and practical/logistical realizations have emerged which will be detailed in the forthcoming Medical Database presentation.
Always Sweat the Small Stuff: Hrp-Research Operations and Integration Mission Science
Human Research Program (HRP) Research Operations and Integration (ROI) ISS facilities overview.
Advancing Translational Space Research Through Biospecimen Sharing: Amplified Impact of Studies Utilizing Analogue Space Platforms
Biospecimen Sharing Programs (BSPs) have been organized by NASA Ames Research Center since the 1960s with the goal of maximizing utilization and scientific return from rare, complex and costly spaceflight experiments. BSPs involve acquiring otherwise unused biological specimens from primary space research experiments for distribution to secondary experiments. Here we describe a collaboration leveraging Ames expertise in biospecimen sharing to magnify the scientific impact of research informing astronaut health funded by the NASA Human Research Program (HRP) Human Health Countermeasures (HHC) Element. The concept expands biospecimen sharing to one-off ground-based studies utilizing analogue space platforms (e.g., Hindlimb Unloading (HLU), Artificial Gravity) for rodent experiments, thereby significantly broadening the range of research opportunities with translational relevance for protecting human health in space and on Earth.