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All sourcesNASA NTRSDOE OSTI
NASA NTRS1986

M.I.T./Canadian vestibular experiments on the Spacelab-1 mission. I - Sensory adaptation to weightlessness and readaptation to one-g: An overview

Human sensory/motor adaptation to weightlessness and readaptation to earth's gravity are assessed. Preflight and postflight vestibular and visual responses for the crew on the Spacelab-1 mission are studied; the effect of the abnormal pattern of otolith afferent signals caused by weightlessness on the pitch and roll perception and postural adjustments of the subjects are examined. It is observed that body position and postural reactions change due to weightlessness in order to utilize the varied sensory inputs in a manner suited to microgravity conditions. The aspects of reinterpretation include: (1) tilt acceleration reinterpretation, (2) reduced postural response to z-axis linear acceleration, and (3) increased attention to visual cues.

Young, L. R.↗
NASA NTRS1986

M.I.T./Canadian vestibular experiments on the Spacelab-1 mission. II - Visual vestibular tilt interaction in weightlessness

Adaptation to weightlessness includes the substitution of other sensory signals for the no longer appropriate graviceptor information concerning static spatial orientation. Visual-vestibular interaction producing roll circularvection was studied in weightlessness to assess the influence of otolith cues on spatial orientation. Preliminary results from four subjects tested on Spacelab-1 indicate that visual orientation effects were stronger in weightlessness than pre-flight. The rod and frame test of visual field dependence showed a weak post-flight increase in visual influence. Localized tactile cues applied to the feet in space reduced subjective vection strength.

Young, L. R.↗
NASA NTRS1986

M.I.T./Canadian vestibular experiments on the Spacelab-1 mission. VI - Vestibular reactions to lateral acceleration following ten days of weightlessness

The effects of weightlessness on human orientation and balance are investigated. The responses of the Spacelab-1 crew to linear acceleration are measured using a perception of linear motion test, a closed-loop otolith assessment test (CLOAT), a dynamic ocular torsion test, and a lateral eye deviations test. The perception of linear motion tests measures a subject's ability to detect the presence and direction of small changes in linear acceleration; CLOAT assesses a person's ability to use linear acceleration cues to perform a manual control task; and the dynamic ocular torsion test examines the gravitoinertial contribution to dynamic ocular counterrolling. The threshold accelerations, velocity constants, regression coefficients, scalar performance measures, and torsion measurements for the subjects are analyzed and described. It is noted that the data support the tilt-translation reinterpretation hypothesis of Young et al. (1984, 1986).

Arrott, A. P.↗
NASA NTRS1987

Effects of proposed preflight adaptation training on eye movements, self-motion perception, and motion sickness - A progress report

The preflight adaptation trainer (PAT) was designed to produce rearranged relationships between visual and otolith signals analogous to those experienced in space. Investigations have been undertaken with three prototype trainers. The results indicated that exposure to the PAT sensory rearrangement altered self-motion perception, induced motion sickness, and changed the amplitude and phase of the horizontal eye movements evoked by roll stimulation. However, the changes were inconsistent.

Parker, D. E.↗
NASA NTRS1987

Effects of prolonged weightlessness on self-motion perception and eye movements evoked by roll and pitch

Seven astronauts reported translational self-motion during roll simulation 1-3 h after landing following 5-7 d of orbital flight. Two reported strong translational self-motion perception when they performed pitch head motions during entry and while the orbiter was stationary on the runway. One of two astronauts from whom adequate data were collected exhibited a 132-deg shift in the phase angle between roll stimulation and horizontal eye position 2 h after landing. Neither of two from whom adequate data were collected exhibited increased horizontal eye movement amplitude or disturbance of voluntary pitch or roll body motion immediately postflight. These results are generally consistent with an otolith tilt-translation reinterpretation model and are being applied to the development of apparatus and procedures intended to preadapt astronauts to the sensory rearrangement of weightlessness.

Reschke, Millard F.↗
NASA NTRS1988

Preadaptation to the stimulus rearrangement of weightlessness: Preliminary studies and concepts for trainer designs

An effort to develop preflight adaptation training (PAT) apparatus and procedures to adapt astronauts to the stimulus rearrangement of weightless spaceflight is being pursued. Based on the otolith tilt-translation reinterpretation model of sensory adaptation to weightlessness, two prototype preflight adaptation trainers (PAT) have been developed. These trainers couple pitch movement of the subject with translation of the visual surround. Subjects were exposed to this stimulus rearrangement for periods of 30 m. The hypothesis is that exposure to the rearrangement would attenuate vertical eye movements was supported by two experiments using the Miami University Seesaw (MUS) PAT prototype. The Dynamic Environment Simulator (DES) prototype failed to support this hypothesis; this result is attributed to a pecularity of the DES apparatus. A final experiment demonstrated that changes in vertical eye movements were not a consequence of fixation on an external target during exposure to a control condition. Together these experiments support the view that preflight adaptation training can alter eye movements in a manner consistent with adaptation to weightlessness. Following these initial studies, concepts for development of operational preflight trainers were proposed. The trainers are intended to: demonstrate the stimulus rearrangement of weightlessness; allow astronauts to train in altered sensory environment; modify sensory motor reflexes; and reduce/eliminate space motion sickness symptoms.

Parker, D. E.↗
NASA NTRS1990

Visual-vestibular interaction in humans during earth-horizontal axis rotation

Visual-vestibular interaction using 60 percent constant velocity earth horizontal axis yaw rotation, simulating both the horizontal semicircular canals and the otolith organs, was measured in seven human subjects. Subjects were tested with their eyes open in the dark (EOD) while fixating upon a target rotating with them (FIX), and while observing stationary optokinetic stripes (VVR). Resulting nystagmus slow component velocity (SCV) was analyzed for EOD, FIX, and VVR conditions. It is concluded that the visual-vestibular interactions during EHA differ significantly from those during rotation about the vertical; specifically, there is a nonlinear interaction between linear acceleration and optokinetic nystagmus.

Wall, Conrad, III↗
NASA NTRS1991

Gravitational Effects on Brain and Behavior

Visual, vestibular, tactile, proprioceptive, and perhaps auditory clues are combined with knowledge of commanded voluntary movement to produce a single, usually consistent, perception of spatial orientation. The recent Spacelab flights have provided especially valuable observations on the effects of weightlessness and space flight. The response of the otolith organs to weightlessness and readapting to Earth's gravitation is described. Reference frames for orientation are briefly discussed.

Young, Laurence R.↗
NASA NTRS1991

M.I.T./Canadian Vestibular Experiments on the Spacelab-1 Mission. Part 1: Sensory Adaptation to Weightlessness and Readaptation to One-G: An Overview

Experiments on human spatial orientation were conducted on four crewmembers of Space Shuttle Spacelab Mission 1. The conceptual background of the project, the relationship among the experiments, and their relevance to a 'sensory reinterpretation hypothesis' are presented. Detailed experiment procedures and results are presented in the accompanying papers in this series. The overall findings are discussed as they pertain to the following aspects of hypothesized sensory reinterpretation in weightlessness: (1) utricular otolith afferent signals are reinterpreted as indicating head translation rather than tilt, (2) sensitivity of reflex responses to footward acceleration is reduced, and (3) increased weighting is given to visual and tactile cues in orientation perception and posture control. Results suggest increased weighting of visual cues and reduced weighting of graviceptor signals in weightlessness.

Young, Laurence R.↗
NASA NTRS1990

International Union of Physiological Sciences Commission on Gravitational Physiology, Annual Meeting, 11th, Lyons, France, Sept. 25-27, 1989, Proceedings

Topics discussed include recent space flight results in gravitational physiology, cardiovascular changes, current concepts in gravitational physiology, musculoskeletal changes, gravity and the cardiovascular system, hypergravic conditions, and head-down tilt. Papers are presented on the effect of space flight on the ultrastructure of the rat cerebellar and hemisphere cortex, a comparative study of cardiovascular responses in primates exposed to tilt test and lower body positive pressure, catecholamines during short- and long-term head-down bedrest, and effects of a 40-day tail-suspension on rat weight-bearing bones. Attention is also given to otolith versus vertical semicircular canal input in the inhibition of horizontal postrotatory nystagmus, cardiovascular responses to sustained acceleration, effects of high sustained hypergravity on plasma catecholamines, and the carotid baroreceptor cardiac-vagal reflex responses during 10 days of head-down tilt.

Reynolds, Orr E.↗
NASA NTRS1992

Evaluation of tests for vestibular function

Vestibular testing methodologies are examined in terms of their clinical value and applicability to the assessment of astronaut candidates and human responses to microgravity. Classical and novel testing approaches are examined in terms of nine functions such as otolith organs, vestibular neural processing, and ocular motor systems. The tests reviewed include the basic vestibular-function test battery, postural stability testing, visual-vestibular interaction, reactions to off-axis rotation, and vestibular evoked responses. The basic test battery is shown to be essential for astronaut and inertial-environment baseline-data evaluations, whereas the newer and research tests are only recommended in special cases. Stimulus rearrangement and motion-sickness tests are indicated for testing adaptation to inertial environments. Postural stability and visual-vestibular interaction are recommended for evaluating one's suitability for being an astronaut.

Source record↗
NASA NTRS1992

Vestibuloocular reflex of rhesus monkeys after spaceflight

The vestibuloocular reflex (VOR) of two rhesus monkeys was recorded before and after 14 days of spaceflight. The gain (eye velocity/head velocity) of the horizontal VOR, tested 15 and 18 h after landing, was approximately equal to preflight values. The dominant time constant of the animal tested 15 h after landing was equivalent to that before flight. During nystagmus induced by off-vertical axis rotation (OVAR), the latency, rising time constant, steady-state eye velocity, and phase of modulation in eye velocity and eye position with respect to head position were similar in both monkeys before and after flight. There were changes in the amplitude of modulation of horizontal eye velocity during steady-state OVAR and in the ability to discharge stored activity rapidly by tilting during postrotatory nystagmus (tilt dumping) after flight: OVAR modulations were larger, and tilt dumping was lost in the one animal tested on the day of landing and for several days thereafter. If the gain and time constant of the horizontal VOR exchange in microgravity, they must revert to normal soon after landing. The changes that were observed suggest that adaptation to microgravity had caused alterations in way that the central nervous system processes otolith input.

Cohen, Bernard↗
NASA NTRS1992

Space flight and changes in spatial orientation

From a sensory point of view, space flight represents a form of stimulus rearrangement requiring modification of established terrestrial response patterns through central reinterpretation. Evidence of sensory reinterpretation is manifested as postflight modifications of eye/head coordination, locomotor patterns, postural control strategies, and illusory perceptions of self or surround motion in conjunction with head movements. Under normal preflight conditions, the head is stabilized during locomotion, but immediately postflight reduced head stability, coupled with inappropriate eye/head coordination, results in modifications of gait. Postflight postural control exhibits increased dependence on vision which compensates for inappropriate interpretation of otolith and proprioceptive inputs. Eye movements compensatory for perceived self motion, rather than actual head movements have been observed postflight. Overall, the in-flight adaptive modification of head stabilization strategies, changes in head/eye coordination, illusionary motion, and postural control are maladaptive for a return to the terrestrial environment. Appropriate countermeasures for long-duration flights will rely on preflight adaptation and in-flight training.

Reschke, Millard F.↗
NASA NTRS1990

Role of the vestibular end organs in experimental motion sickness - A primate model

Experimental studies of the role of vestibular end organs in motion sickness experienced by squirrel monkeys are reviewed. The first experiments in motion-sickness-susceptible squirrel monkeys were performed under a free-moving condition with horizontal rotation and vertical oscillation. In the following experiments, the vestibular-visual conflict in the pitch plane was given to the chair-restrained (upright position) squirrel monkeys. Results of this study showed that the existence of otolith afferents, which continually signal the directional change of gravity and linear acceleration vectors, was necessary for the elicitation of emesis by the sensory conflict in pitch.

Igarashi, Makoto↗
NASA NTRS1989

STS-28 Crew Presentation Clip

This Department of Defense space shuttle mission is shown during launch and landing. The video tape also includes scenes of the following: the crew working on the otolith Tilt Translation Reinterpretation Experiment, various views of the Earth, the crew during mealtime, and preparations for reentry.

Source record↗
NASA NTRS1993

Manual control in space research on perceptual-motor functions under zero gravity conditions (L-10)

Are human abilities to control vehicles and other machines the same in space as those on Earth? The L-10 Manual Control Experiment of the First Materials Processing Tests (FMPT) started from this question. Suppose a pilot has the task to align the head of a space vehicle toward a target. His actions are to look at the target, to determine the vehicle movement, and to operate the manipulator. If the activity of the nervous system were the same as on Earth, the movements, of the eye and hand would become excessive because the muscles do not have to oppose gravity. The timing and amount of movement must be arranged for appropriate actions. The sensation of motion would also be affected by the loss of gravity because the mechanism of the otolith, the major acceleration sensor, depends on gravity. The possible instability of the sensation of direction may cause mistakes in the direction of control of manipulator movement. Thus, the experimental data can be used for designing man-machine systems in space, as well as for investigation of physiological mechanisms. In this experiment, the direction of vehicle heading is expressed by a light spot on an array of light emitting diodes and the manipulator is of a finger stick type. As the light spot moves up and down, the Japanese Payload Specialist, and the subject, must move the manipulator forward and backward to keep the movement of the light spot within the neighborhood of the central point of the display. The position of the light spot is computed in such a manner that when the stick is kept at the neutral position, a motion whose acceleration is proportional to the angle of deflection is added to the movement of the light spot. The Operator Describing Function, which is an expression of human control characteristics, can be calculated from 2 minutes of raw data of the light spot position and stick deflection. The 2 minutes of operation is called a run, and 8 runs with resting periods composes a session. The on-orbit experiment will be conducted on the second, fourth, and seventh days. One session of experiment of each of these days is conducted following the L-4 experiment, which uses the same apparatus. The Payload Specialist, aided by a Mission Specialist, will take our apparatus from a rack container, set up the apparatus, attach electrodes for measurements of eye movement and muscle activity, conduct the L-4 Visual Stability Experiment, conduct one session of the manual control experiment, and then dissemble and stow the apparatus. In addition to the flight experiment, pre-flight and post-flight experiments will be conducted. The data of three sessions on orbit will reflect adaption of physiological systems to microgravity. The data of post-flight experiments, on the other hand, will reflect re-adaptation of physiological systems to the gravity condition on the ground. Control data collected with and without psychological tension will be scheduled just prior to and long before launch.

Tada, Akira↗
NASA NTRS1993

Amphibian fertilization and development in microgravity

During the year before launch, female frogs will be tested every 3 months for the quantity and quality of eggs produced. Two weeks or more prior to launch, male and female frogs will be transported to the John F. Kennedy Space Center (KSC). During the few weeks before launch, groups will be periodically tested for egg quality to assure that the frogs have adapted to the KSC laboratory environment. About 27 hours before launch, four females will be placed in a damp foam-lined box, called the Adult Frog Box (AFB), through which 100 cc/min of air wil be circulated. The AFB will be lowered into the Spacelab and loaded into the Frog Environmental Unit (FEU) during the final pre-launch preparations. A sperm suspension, for use in flight to fertilize the eggs, will also be prepared and loaded during the pre-launch period. The sperm suspension, together with a kit of syringes containing Human Chorionic Gonadotropin (HCG), will be stored in a refrigerator aboard the shuttle until needed in flight. On the first day of flight, the AFB will be transferred from the FEU to the General Purpose Work Station (GPWS), which is a type of glove box specially designed to allow the crew to use chemicals and biological materials during the flight without contaminating the shuttle/Spacelab environment. Inside the GPWS the four adult frogs will be injected with the HCG hormone and returned to the FEU. Approximately 16 hours after injection, ovulation should have taken place and 15 to 20 eggs from each frog will be placed on each of two egg baskets and covered with sperm for 10 minutes. The egg baskets are inserted into acrylic egg chambers and 50 ml of 'pond water' (20 percent strength Modified Ringers solution (is added. One of the chambers from each frog will be placed on a centrifuge within the FEU and rotated to simulate normal terrestrial gravity (1 g). The remaining chambers are incubated under microgravity conditions within the FEU. Forty minutes after fertilization, the four chambers exposed to 1 g will be removed and observed within the GPWS using a dissecting microscope and camera system. On the basis of egg rotation and egg appearance, the 'best' and 'second best' frogs will be selected to contribute additional eggs. Using the two best frogs, 22 egg chambers will be loaded with eggs and fertilized. Eleven chambers wil be incubated at microgravity and eleven will be incubated on the centrifuge. At various times during the flight, chambers will be removed from the FEU and transferred to the GPWS where a formaldehyde-based fixative will be injected in order to preserve important developmental stages for in depth study following the flight. Five of the 22 chambers plus the eight fertilization test chambers will be returned to Earth with live tadpoles. The swimming behavior of these free swimming tadpoles will be examined within several hours of landing and some will be fixed for a detailed analysis of their inner ear, the otolity, the animals 'balance system.' Lychakov and Vinikov reported an increase in otolith size in tadpoles that developed (but were not fertilized) in space. Live tadpoles from the SL-J flight will be raised through metamorphsis for studies of maturation including an analysis of the effects of space flight on their ability to produce normal progency. Following the flight, the fixed embryos will be serially sectioned and stained using procedures that were developed for this experiment. The embroys fixed at the 2-4 cell stage will be examined for the distribution of cytoplasmic contents, including the various classes of yolk platelets, and the location and shape of the cleavage furrows. The gastrulae will be assessed for the normality of the complex cellular rearrangements that constitute blastopore formation and involution, i.e., the differentiation of the embryo into its specialized body parts. Using a new procedure, the gastrulae will be bleached which will enable the initial sperm entry point (SEP) to be located. The correlation between the SEP and the dorsal lip of the blastopore will be determined. Under normal terrestrial conditions it was shown that the SEP typically is located on the side of the egg opposite the future dorsal side of the embryo. The neurulae will be examined for the normality and completeness of the neural plate and archenteron expansion. The tadpole stages will be used to study the allometry and morphology of the various organ systems.

Souza, Kenneth A.↗
NASA NTRS1992

Dynamics of the G-excess illusion

The G-excess illusion is increasingly recognized as a cause of aviation mishaps especially when pilots perform high-speed, steeply banked turns at low altitudes. Centrifuge studies of this illusion have examined the perception of subject orientation and/or target displacement during maintained hypergravity with the subject's head held stationary. The transient illusory perceptions produced by moving the head in hypergravity are difficult to study onboard centrifuges because the high angular velocity ensures the presence of strong Coriolis cross-coupled semicircular canal effects that mask immediate transient otolith-organ effects. The present study reports perceptions following head movements in hypergravity produced by high-speed aircraft maintaining a banked attitude with low angular velocity to minimize cross-coupled effects. Methods: Fourteen subjects flew on the NASA KC-135 and were exposed to resultant gravity forces of 1.3, 1.5, and 1.8 G for 3 minute periods. On command, seated subjects made controlled head movements in roll, pitch, and yaw at 30 second intervals both in the dark and with faint targets at a distance of 5 feet. Results: head movement produced transient perception of target displacement and velocity at levels as low as 1.3 G. Reports of target velocity without appropriate corresponding displacement were common. At 1.8 G when yaw head movements were made from a face down position, 4 subjects reported oscillatory rotational target displacement with fast and slow alternating components suggestive of torsional nystagmus. Head movements evoked symptoms of nausea in most subjects, with 2 subjects and 1 observer vomiting. Conclusions: The transient percepts present conflicting signals, which introduced confusion in target and subject orientation. Repeated head movements in hypergravity generate nausea by mechanisms distinct from cross-coupled Coriolis effects.

Baylor, K. A.↗