SEARCH · Search NASA
Results for “methylation”
Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.
Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.
Bioconjugate Platform for Iterative Backbone N-Methylation of Peptides
Explore the source record for details and available documents.
Direct Brønsted Acid-Catalyzed Dehydration of Glucose to HMF in Methyl Isobutyl Ketone
Not provided.
Structural Basis for Control of Methylation Extent in Polyketide Synthase Metal-Dependent C-Methyltr
Explore the source record for details and available documents.
Serum-Stable and Selective Backbone-N-Methylated Cyclic Peptides That Inhibit Prokaryotic Glycolytic
Explore the source record for details and available documents.
Demethylation─The Other Side of the Mercury Methylation Coin: A Critical Review
Not Available
Alternating Methyl Methacrylate/ n -Butyl Acrylate Copolymer Prepared by Atom Transfer Radical Polymerization
Not provided.
Investigating the Role of Polymer Architecture in Poly(methyl methacrylate) Depolymerization
Advanced architectures in polymers have garnered traction within the last two decades due to their distinct and tunable properties compared to linear analogs. However, the effects of architecture on nascent polymethacrylate depolymerization strategies remain underexplored. Herein, we investigate the depolymerization behavior of poly(methacrylate)-based star copolymers synthesized via a core-first approach. By incorporating either labile chain-end or pendent-group triggers, we demonstrate the first direct comparison of bulk depolymerization behaviors in star versus linear methacrylate copolymers under matched conditions. While pendent-triggered systems required higher loadings of N-(methacryloxy)phthalimide methacrylate (PhthMA) to achieve similar mass loss compared to linear copolymers, chain-end-initiated depolymerization showed enhanced efficiency of monomer liberation in the star topology. Furthermore, these findings highlight the importance of considering macromolecular architecture in designing sustainable polymers and provide actionable guidelines for installing depolymerization triggers based on polymer topology.
Characterization of Methyl- and Acetyl-Ni Intermediates in Acetyl CoA Synthase Formed during Anaerobic CO 2 and CO Fixation
Not Available
Implementing a Doping Approach for Poly(methyl methacrylate) Recycling in a Circular Economy
Not Available
C S -Symmetric Pyridine(diimine) Iron Methyl Complexes for Catalytic [2+2] Cycloaddition and Hydrovinylation: Metallacycle Geometry Determines Selectivity
Not Available
DNMT1 reads heterochromatic H4K20me3 to reinforce LINE-1 DNA methylation
Explore the source record for details and available documents.
Conformational rearrangements enable iterative backbone N-methylation in RiPP biosynthesis
Explore the source record for details and available documents.
Mechanistic basis for maintenance of CHG DNA methylation in plants
Explore the source record for details and available documents.
Burkholderia cenocepacia epigenetic regulator M.BceJIV simultaneously engages two DNA recognition sequences for methylation
Not provided.
Factors governing $${\rm H}_{3}^{+}$$ formation from methyl halogens and pseudohalogens
Not Available
Symmetric adenine methylation is an essential DNA modification in the early-diverging fungus Rhizopus microsporus
The discovery of N6-methyladenine (6mA) in eukaryotic genomes, typically found in prokaryotic DNA, has revolutionized epigenetics. Here, we show that symmetric 6mA is essential in the early diverging fungus Rhizopus microsporus, as the absence of the MT-A70 complex (MTA1c) responsible for this modification results in a lethal phenotype. 6mA is present in 70% of the genes, correlating with the presence of H3K4me3 and H2A.Z in open euchromatic regions. This modification is found predominantly in nucleosome linker regions, influencing the nucleosome positioning around the transcription start sites of highly expressed genes. Controlled downregulation of MTA1c reduces symmetric 6mA sites affecting nucleosome positioning and histone modifications, leading to altered gene expression, which is likely the cause of the severe phenotypic changes observed. Our study highlights the indispensable role of the DNA 6mA in a multicellular organism and delineates the mechanisms through which this epigenetic mark regulates gene expression in a eukaryotic genome.