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At least 289 records · Page 16

Expanded Signal to Noise Ratio Estimates for Validating Next-Generation Satellite Sensors in Oceanic, Coastal, and Inland Waters

The launch of the NASA Plankton, Aerosol, Cloud, ocean Ecosystem (PACE) and the Surface Biology and Geology (SBG) satellite sensors will provide increased spectral resolution compared to existing platforms. These new sensors will require robust calibration and validation datasets, but existing field-based instrumentation is limited in its availability and potential for geographic coverage, particularly for coastal and inland waters, where optical complexity is substantially greater than in the open ocean. The minimum signal-to-noise ratio (SNR) is an important metric for assessing the reliability of derived biogeochemical products and their subsequent use as proxies, such as for biomass, in aquatic systems. The SNR can provide insight into whether legacy sensors can be used for algorithm development as well as calibration and validation activities for next-generation platforms. We extend our previous evaluation of SNR and associated uncertainties for representative coastal and inland targets to include the imaging sensors PRISM and AVIRIS-NG, the airborne-deployed C-AIR radiometers, and the shipboard HydroRad and HyperSAS radiometers, which were not included in the original analysis. Nearly all the assessed hyperspectral sensors fail to meet proposed criteria for SNR or uncertainty in remote sensing reflectance (R rs ) for some part of the spectrum, with the most common failures (>20% uncertainty) below 400 nm, but all the sensors were below the proposed 17.5% uncertainty for derived chlorophyll-a. Instrument suites for both in-water and airborne platforms that are capable of exceeding all the proposed thresholds for SNR and R rs uncertainty are commercially available. Thus, there is a straightforward path to obtaining calibration and validation data for current and next-generation sensors, but the availability of suitable high spectral resolution sensors is limited.

signal-to-noise ratio↗

Next Generation Exercise Device (NGED): Advancing Exercise Capabilities for Future Space Missions Through Biomechanical Modeling

BACKGROUND As space exploration extends to long-duration missions on the Moon and Mars, maintaining astronaut health and fitness becomes increasingly critical. The Next Generation Exercise Device (NGED), developed and tested by the HumanWorks Lab in NASA Johnson Space Center's (JSC) Software, Robotics, and Simulation Division, aims to address this challenge through innovative approaches. This study presents the development and evaluation of an NGED system, focusing on its adaptability to various mission scenarios, including prospective use in a Lunar Pressurized Rover (LPR). Central to this project is the application of biomechanical modeling to optimize exercise efficacy and safety in microgravity and partial gravity environments. The project is a collaborative effort with the Human Health and Performance group at Johnson Space Center, ensuring a comprehensive approach to astronaut well-being that integrates biomechanical principles with practical exercise solutions. The NGED represents the next generation of exercise capabilities for missions in space, on the Moon and Mars, with a specific focus on applications such as the LPR. METHODS AND RESULTS Data collection for NGED development was conducted with two motor-driven Beyond Power Voltra I [1] systems and a custom test structure to allow placement of the cable-based devices on the ground, at shoulder height, and overhead. The collection was performed in JSC’s Prototype Immersive Technology (PIT) Lab, utilizing an OptiTrack motion capture system and AMTI force platform, to enable detailed biomechanical analysis via OpenSim [2,3]. Motion capture data were collected for three subjects representing different body types and statures. The marker set used was an enhanced version of the full-body Plug-in Gait marker set [4], with additional markers strategically placed for the primary objective of informing exercise volume requirements. Subjects performed a series of 17 exercises, carefully selected to engage various muscle groups, including novel spaceflight exercises such as skiing (ergometer style), lateral pulldowns, wood chops, triceps extensions, and flies, with load variations ranging from 10 to 90 pounds to maintain kinematic form. This comprehensive approach allowed for a thorough evaluation of the NGED's performance across a wide range of motions and loads. The biomechanical modeling and analysis were conducted using a modified OpenSim Full Body Rajagopal Model [4,5] and also scaled to the maximum and minimum anthropometry provided in NASA-STD-3001 [6]. Volumetric convex hulls were generated based on model marker trajectories and aggregated into geometric assemblies. These can be placed in models of vehicle designs to assess fit to protect for exercise as well as to adapt NGED exercise to fit available space. Preliminary findings from the collection indicate that the NGED prototype demonstrates significant adaptability across varying user anthropometrics and exercise types. The device showed consistent performance in load-bearing exercises, with subjects able to perform exercises effectively while maintaining proper biomechanical form. CONCLUSION NGED represents a forward-looking advancement in exercise capabilities for future space missions. In the future, this system can be used to capture valuable metrics (e.g., isometric mid-thigh pull for force output measurements, assessments of postural muscle strength, overall isometric strength). Its versatility in accommodating various exercises and user physiques, coupled with the ability to provide targeted biomechanical loading, makes it a promising approach for maintaining astronaut health during long-duration missions to the Moon and Mars. Future work will focus on refining the NGED based on initial biomechanical findings, leveraging the detailed insights provided by motion capture and analysis techniques. Particular emphasis will be placed on optimizing its use within the confined spaces of a LPR and other space habitats. This work contributes significantly to NASA's goals of supporting human health and performance in deep space exploration, paving the way for sustainable long-term presence beyond Low Earth Orbit through advanced, biomechanically-informed exercise solutions.

C Wang↗

Development and demonstration of next generation technology for Nb_3Sn accelerator magnets with lower cost, improved performance uniformity, and higher operating point in the 12-14 T range

The scope of the proposal outlined in this white paper is the development and demonstration of the technology needed for next generation of Nb_3Sn accelerator magnets in the 12-14 T range. The main goal is to cut magnet cold-mass cost by a factor 2 or higher with respect to the Nb_3Sn magnets produced by the US Accelerator Upgrade Project (AUP) for the High-Luminosity Large Hadron Collider (HL-LHC). This goal will be achieved by significant reduction of labor hours, higher operating point, and improved performance uniformity. A key factor will be automation that will be achieved through industry involvement and benefitting from the experience gained in US national laboratories through the production of the AUP magnets. This partnership will enable the development of a technology that will be easily transferable to industry for mid- and large-scale production of Nb_3Sn accelerator magnets in the 12-14 T range. This step is essential to enable next generation of colliders such as the FNAL-proposed Muon Collider, FCC and other HEP hadron colliders. This is a Directed R&D where direction is given by the field range and industry involvement for high-automation and industry-ready technology. The plan includes ten milestones, to be achieved in 6-8 years at the cost of 5-7 $M/year.

43 PARTICLE ACCELERATORS↗

Novel Materials and Concepts for Next-Generation High Power Target Applications

Novel beam-intercepting materials and targetry concepts are essential to improve the performance, reliability and operation lifetimes of next generation multi-megawatt (multi-MW) accelerator target facilities. The beam-intercepting materials and components must sustain an order-of-magnitude increase in particle beam intensities and are beyond the current state-of-the-art. With conventional materials already limiting the scope of experiments, it is crucial to investigate novel target materials, technologies and concepts that will satisfy the requirements and maximize the physics benefits of future energy and intensity frontier experiments. This paper provides an overview of the related targetry R&D required over the next 10 years to support and enable future high-power accelerator target facilities.

43 PARTICLE ACCELERATORS↗

Gas-Phase Composition as a Predictive Metric for Calendar Life Behavior of Next-Generation Silicon Anodes

The expansion of renewable technologies and electrification of the transportation sector is driving increased demand for next-generation battery materials that provide higher power and energy density with superior cycling and calendar life stability. Silicon (Si) has a theoretical capacity nearly 10x that of graphite, and is therefore a promising anode material candidate to meet these rigorous performance demands. While leading Si anode battery demonstrations are approaching target metrics for cycle life, a series of complex and interrelated modes of reactivity lead to reduced calendar life and therefore challenge practical adoption of these materials. Deconvoluting the degradation processes that impact Si calendar life is critical to informing the rational and accelerated design of improved Si materials. In the present work, we employ novel sampling techniques and GC-MS-FID characterization to measure gas-phase composition during initial Si cycling, which we tie to selective mechanisms of Si passivation. We utilize a tiered analysis approach to identify and quantify the gas-phase reaction products associated with three advanced Si material candidates under practical operating conditions. Ex situ analysis of Si powders (pure chemical reactivity) is coupled with nondestructive in situ sampling of Si electrodes in a practical pouch-cell format (coupled chemical and electrochemical reactivity). We link the observed gas-phase species evolution to electrochemical behavior and measured calendar life of the three Si materials. Further, we evaluate the voltage-resolved evolution of gas-phase species for one such Si nanomaterial, where nonmonotonic gas generation implies competition between passivating reaction pathways. The measured gas-phase compositional data serves as a critical input for our advanced electrochemical SEI models to identify favorable vs unfavorable reaction pathways to stabilize Si. In addition to bolstering a fundamental understanding of Si reactivity, the present approach informs specific and quantifiable gas-phase metrics tied to calendar life improvements in Si, which can streamline and accelerate the process of next-generation material development.

DIRECT ENERGY CONVERSION,ENERGY STORAGE↗

Conventional and Next Generation Treatment Technologies for PFAS - 20067

In 2016, the United States Environmental Protection Agency (USEPA) established a Health Advisory Limit (HAL) for perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic acid (PFOS) (individually and the summation) of 70 nanograms per liter (ng/L) based on developing toxicological information. These two compounds are among several thousand per- and polyfluoroalkyl substances (PFAS). Due to a multitude of commercially beneficial physical and chemical properties, the availability of PFAS-relevant and practical water treatment technologies is limited. The use of conventional adsorbents, such as activated carbon (AC) and anion exchange (AIX) resins, have become a 'de facto' interim measure to immediately address drinking water above this criterion. However, these adsorbents can have marginal long-term efficiency and are relatively unproven against the diversity of polyfluorinated compounds. Additionally, geochemical and/or co-contaminant competition can significantly impede adsorption based PFAS removal. These challenges may be addressed using engineered filtration, such as reverse osmosis or nanofiltration (RO/NF); however, for larger flow systems RO/NF may have unacceptable reject ratios as high as 35% and the capital cost may preclude these technologies. Extending these technologies to natural waters, which have various degrees of geochemical and co-contaminant competition, often requires a treatment train, combining conventional adsorbents or engineered filtration with pretreatment and more innovative and emerging remediation solutions for PFAS. Conventional and Next Generation water treatment technologies for PFAS generally employ one of three mechanisms (adsorption, separation, or destruction). These mechanisms include many types of technologies for both municipal drinking water and extracted natural water applications. The previously mentioned AC, AIX, and RO/NF are commercially available technologies that are actively being deployed for PFAS treatment. Research and development around these technologies is focused on optimization, and ultimate destruction of PFAS is achieved through incineration. Next Generation water treatment technologies include PFAS-specific flocculants, foam fractionation, novel AIX resins, new engineered adsorptive media, electrochemical treatment, sonolysis, and photolysis, radiation, and plasma (forms of advanced reductive processes [ARP]). Research and development around these technologies is focused on proof of concept and assimilation to real world applications. As the PFAS-relevant destructive technologies (such as incineration, electrochemical treatment, sonolysis, and ARP) are energy intensive, the state of the practice for PFAS water treatment is to focus adsorption/separation based technologies on reducing and concentrating the volume of water requiring destructive treatment. This enables more flexibility with respect to circulation frequency, residence time, and more control over energy usage. Water treatment for PFAS presently requires multiple technologies (i.e. a treatment train) to protect human health in a cost-conscious manner. An investment in research and development to explore new technologies is part of a key initiative for efficient protection of human health. This presentation attempts to review PFAS-relevant water treatment technologies and provide perspective as to their status with respect to applicability and commercial relevance. (authors)

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEA↗

EVs@Scale Next-Gen Profiles - EV Profile Capture 2024

As part of the U.S. DOE EVs@Scale consortium Next-Gen Profiles (NGP) project, the profile capture and analysis of production electric vehicles undergoing high power charging (HPC) is conducted over a wide range of conditions to explore variance and performance. Charge session parameters are collected from both the electric vehicle (EV) and electric vehicle supply equipment (EVSE) at a rate of 10Hz and entered into a time-series database for analysis. These charge profiles are captured under nominal and off-nominal conditions, exploring the impact of battery state of charge (SOC), battery temperature, vehicle condition, smart charge management (SCM), and EVSE limitations. Nominal conditions are defined to be ideal conditions that should transfer the maximum allowable energy in the minimum possible amount of time. Nominal condition profiles are compared across EVs to characterize state-of-the-art EV charging performance against one another. Off-nominal condition profiles are compared against its nominal condition profile counterpart to highlight the variance across less desirable starting conditions within a single EV. This EV Profile Capture 2024 report stands as an update from the EV Profile Capture 2023 report to include the additional EV & EVSE assets tested and analyzed in 2024. The major updates within this report include the addition of three next-generation electric vehicles, added test cases, and further analysis. This expansion of analysis includes power profiles, power distribution, quantifying SOC, energy and range performance, EVSE limitation impacts, boost converter performance, etc. Additionally, NGP time-series data has been used as input towards three national laboratory-led grid modelling efforts: ANL’s IEEE-37 HIL model, INL’s Caldera model, and NREL’s EVI-X model. A summary of these platforms and how NGP has worked to improve their effectiveness has also been added to this years’ report.

Thurston, Sam↗

Optimizing flow condensation models for next-generation refrigerants in axial micro-fin aluminum tubes

To support the transition to next-generation refrigerants, accurate modelling of heat transfer and pressure drop is essential for designing efficient heat exchangers. Current models, largely based on traditional refrigerants and unexpanded micro-fin tubes, may not reliably predict performance for new refrigerants and expanded micro-fin geometries. This study evaluates four condensation models using experimental data for six A2L refrigerants: R-32, R-454B, R-454C, R-455A, R-1234yf, and R-1234ze(E). For heat transfer models, the Han and Lee (2005) model initially yields the best accuracy (mean absolute Deviation, MAD = 22.1%). To further improve predictions, a correction factor reduces the Cavallini et al. (2009) model’s MAD from 68.2% to 15.4%, while optimization of the Kedzierski and Goncalves (1997) model achieves a MAD of 13.1%. For pressure drop, the Cavallini et al. (1997) model proves most accurate (MAD = 6.4%), with the simpler Haraguchi et al. (1993) model also effective (MAD = 9.4%). Keywords: Flow condensation models, heat transfer coefficient, frictional pressure drop, next-generation refrigerants, aluminum micro-fin tubes

Hu, Yifeng [ORNL] (ORCID:0000000242875185)↗

Electroluminescence Yield Measurements in Xenon Gas with the NEXT-DEMO++ Detector

The NEXT-DEMO++ detector, a high-pressure xenon gas time projection chamber serving as a prototype for the NEXT-100 experiment, was used to measure the electroluminescence (EL) yield as a function of reduced electric field ($E/p$) across pressures from 2.0 to 9.4 bar, utilizing the 41.5 keV de-excitation peak of $^{83m}$Kr. These measurements were made to examine the pressure dependence of the slope of the reduced EL yield $Y/p$, which has shown inconsistencies in the literature. The reduced yield was fitted with a linear model, revealing a modest ($\sim$5%) change in slope, beginning around 5 bar and increasing with pressure up to 9.4 bar.

Renner, J. [Valencia U., IFIC]↗

Flow Boiling Pressure Drop Characteristics of Next-generation Refrigerants in a Micro‑fin Copper Tube

This paper presents experimental frictional pressure-drop data for flow boiling of R-410A, R-134a, and next-generation alternatives R-454C, R-455A, R-1234yf, and R-1234ze(E) in a horizontal micro-fin copper tube. Tests were conducted over a range of mass fluxes and evaporation temperatures to characterize refrigerant-dependent two-phase pressure-drop behavior. The results show that frictional pressure gradient increased with mass flux and vapor quality and generally increased as evaporation temperature decreased, with liquid viscosity strongly affecting the observed trends. Among the evaluated correlations, the Goto et al. (2001) model gave the best overall agreement with the measurements before optimization. Further optimization of the Kuo and Wang (1996) and Goto et al. (2001) models reduced the overall mean absolute deviation to below 15%, with the optimized Goto (2001) model providing the most consistent predictions across all six refrigerants. The results support improved pressure-drop prediction and evaporator design for next-generation refrigerants in micro-fin tubes.

Hu, Yifeng [ORNL] (ORCID:0000000242875185)↗

Evaluating the mutagenicity of N-nitrosodimethylamine in 2D and 3D HepaRG cell cultures using error-corrected next generation sequencing

Human liver-derived metabolically competent HepaRG cells have been successfully employed in both two-dimensional (2D) and 3D spheroid formats for performing the comet assay and micronucleus (MN) assay. In the present study, we have investigated expanding the genotoxicity endpoints evaluated in HepaRG cells by detecting mutagenesis using two error-corrected next generation sequencing (ecNGS) technologies, Duplex Sequencing (DS) and High-Fidelity (HiFi) Sequencing. Both HepaRG 2D cells and 3D spheroids were exposed for 72 h to N-nitrosodimethylamine (NDMA), followed by an additional incubation for the fixation of induced mutations. NDMA-induced DNA damage, chromosomal damage, and mutagenesis were determined using the comet assay, MN assay, and ecNGS, respectively. The 72-h treatment with NDMA resulted in concentration-dependent increases in cytotoxicity, DNA damage, MN formation, and mutation frequency in both 2D and 3D cultures, with greater responses observed in the 3D spheroids compared to 2D cells. The mutational spectrum analysis showed that NDMA induced predominantly A:T → G:C transitions, along with a lower frequency of G:C → A:T transitions, and exhibited a different trinucleotide signature relative to the negative control. These results demonstrate that the HepaRG 2D cells and 3D spheroid models can be used for mutagenesis assessment using both DS and HiFi Sequencing, with the caveat that severe cytotoxic concentrations should be avoided when conducting DS. With further validation, the HepaRG 2D/3D system may become a powerful human-based metabolically competent platform for genotoxicity testing.

3D spheroids↗

CUPID: The Next-Generation Neutrinoless Double Beta Decay Experiment

We report CUPID is a next-generation tonne-scale bolometric neutrinoless double beta decay experiment that will probe the Majorana nature of neutrinos and discover lepton number violation in case of observation of this singular process. CUPID will be built on experience, expertise and lessons learned in CUORE and will be installed in the current CUORE infra-structure in the Gran Sasso underground laboratory. The CUPID detector technology, successfully tested in the CUPID-Mo experiment, is based on scintillating bolometers of Li 2 MoO 4 enriched in the isotope of interest 100 Mo. In order to achieve its ambitious science goals, the CUPID collaboration aims to reduce the backgrounds in the region of interest by a factor 100 with respect to CUORE. This performance will be achieved by introducing the high efficient α/β discrimination demonstrated by the CUPID-0 and CUPID-Mo experiments, and using a high transition energy double beta decay nucleus such as 100 Mo to minimize the impact of the gamma background. CUPID will consist of about 1500 hybrid heat-light detectors for a total isotope mass of 250 kg. The CUPID scientific reach is supported by a detailed and safe background model based on CUORE, CUPID-Mo and CUPID-0 results. The required performances have already been demonstrated and will be presented.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

Effects of the next-nearest-neighbor hopping on the low-dimensional Hubbard model: ferromagnetism, antiferromagnetism, and superconductivity

The Hubbard model has attracted considerable interest due to its prototypical role in describing strongly interacting electronic systems, such as high-critical-temperature superconductors as well as many novel quantum materials. By introducing next-nearest-neighbor (NNN) hoppings to the Hubbard model, the phase diagram becomes richer, and fascinating phenomena arise in both, one-dimensional chains and square lattices, such as: antiferromagnetism, ferromagnetism, superconductivity (SC), as well as charge orders, among others. Moreover, NNN hoppings play a fundamental role in understanding effects of doping on magnetism and pairing orders in strongly interacting regimes. In this article, we review the recent progress in understanding the different competing phases of this model in one and two dimensions from a computational perspective. In conclusion, we comment on the pressing technical challenges, illustrate the controversial results concerning the emergence of the SC phase, and conclude with our perspectives on future explorations.

Hubbard model↗

Development and validation of a next-generation sequencing-based multigene assay to predict the prognosis of estrogen receptor-positive, HER2-negative breast cancer

Purpose: Multigene assays provide useful prognostic information regarding hormone receptor (HR)-positive breast cancer. Next-generation sequencing (NGS)-based platforms have numerous advantages including reproducibility and adaptability in local laboratories. Here we aimed to develop and validate an NGS-based multigene assay to predict the distant recurrence risk. Experimental Design: In total, 179 genes including 30 reference genes highly correlated with the 21-gene recurrence score (RS) algorithm were selected from public databases. Targeted RNA-sequencing was performed using 250 and 93 archived breast cancer samples with a known RS in the training and verification sets, respectively, to develop the algorithm and NGS–Prognostic Score (NGS-PS). The assay was validated in 413 independent samples with long-term follow-up data on distant metastasis. Results: In the verification set, the NGS-PS and 21-gene RS displayed 91.4% concurrence (85/93 samples). In the validation cohort of 413 samples, area under the receiver operating characteristic curve plotted using NGS-PS values classified for distant recurrence was 0.76. The best NGS-PS cut-off value predicting distant metastasis was 20. Furthermore, 269 and 144 patients were classified as low- and high-risk patients in accordance with the cut-off. Five- and 10-year estimates of distant metastasis–free survival (DMFS) for low- versus high-risk groups were 97.0% versus 77.8% and 93.2% versus 64.4%, respectively. The age-related HR for distant recurrence without chemotherapy was 9.73 (95% CI, 3.59–26.40) and 3.19 (95% CI, 1.40–7.29) for patients aged ≤50 and >50 years, respectively. Conclusions: The newly developed and validated NGS-based multigene assay can predict the distant recurrence risk in ER-positive, HER2-negative breast cancer.

60 APPLIED LIFE SCIENCES↗

Peña Station NEXT Energy District Master Plan (Cooperative Research and Development Final Report, CRADA Number CRD-17-681)

The objective of the project is to work in close collaboration with Panasonic, Xcel Energy (Public Service), and their partners L.C. Fulenwider, and Denver International Airport to examine different design and technology options in creating an energy master plan for the 400 acre Pena Station NEXT district in Denver, Colorado. To accomplish this, NREL will conduct a solar power/battery storage/grid integration study using the OpenDSS platform linked to UrbanOPT software.

25 ENERGY STORAGE↗

Next Generation Renewables and, Separately, Energy System Transformation, and Related Topics (CRADA CRD-14-557 Final Report)

The Joint Institute for Strategic Energy Analysis (JISEA, an institute within NREL) will support the design, development, delivery and dissemination of two (2) informational whitepapers, identified as Task 1 and Task 2, respectively: Next Generation Renewables and Energy Systems Integration. Note: multiple abstracts with each of 10 modifications.

29 ENERGY PLANNING, POLICY, AND ECONOMY↗

Neutron Next-Event Estimators Kinematics (Rev.2)

This paper reviews the kinematics of neutron elastic and inelastic scattering with moving and stationary targets for contributions to Neutron Next-Event Estimators (NEEs). NEEs are often used for simulating the response of detectors in locations that have few random walk particles. Contributions to NEEs from collisions differ from sampling the outgoing particle state in standard random walk collisions as the location of the estimator is fixed, thus fixing the scattering angle between the incoming and outgoing directions. To calculate contributions to NEEs, the outgoing energies and probabilities of scatter toward the estimator must be calculated. This paper presents the most general case that encompasses elastic and inelastic scattering with both moving and stationary targets. The moving target case is required for elastic scattering with thermal motion due to the free gas thermal treatment approximation. The stationary target equations are presented for comparison with equations presented in canonical Monte Carlo texts.

73 NUCLEAR PHYSICS AND RADIATION PHYSICS↗

Next Generation Feedstocks for the Emerging Bioeconomy

The Next Generation Feedstocks for the Emerging Bioeconomy project, led by the University of Illinois Urbana-Champaign, was designed to accelerate the development of sustainable, cost-competitive biomass feedstocks that can be grown on marginal lands, which are not suitable for row crop production. By focusing on advanced bioenergy-type switchgrass cultivars and related perennial grasses, the project directly supported the U.S. “Billion-Ton Vision,” which aims to expand biomass production to displace fossil fuels while providing environmental and economic benefits. The project improved understanding of perennial bioenergy crop performance at a large scale in marginal environments.

09 BIOMASS FUELS↗