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At least 289 records · Page 16

Flg22‐induced Ca 2+ increases undergo desensitization and resensitization

The flagellin epitope flg22, a pathogen-associated molecular pattern (PAMP), binds to the receptor-like kinase FLAGELLIN SENSING2 (FLS2), and triggers Ca 2+ influx across the plasma membrane (PM). The flg22-induced increases in cytosolic Ca 2+ concentration ([Ca 2+ ]i) (FICA) play a crucial role in plant innate immunity. It's well established that the receptor FLS2 and reactive oxygen species (ROS) burst undergo sensitivity adaptation after flg22 stimulation, referred to as desensitization and resensitization, to prevent over responses to pathogens. However, whether FICA also mount adaptation mechanisms to ensure appropriate and efficient responses against pathogens remains poorly understood. Here, we analysed systematically [Ca 2+ ]i increases upon two successive flg22 treatments, recorded and characterized rapid desensitization but slow resensitization of FICA in Arabidopsis thaliana. Pharmacological analyses showed that the rapid desensitization might be synergistically regulated by ligand-induced FLS2 endocytosis as well as the PM depolarization. The resensitization of FICA might require de novo FLS2 protein synthesis. FICA resensitization appeared significantly slower than FLS2 protein recovery, suggesting additional regulatory mechanisms of other components, such as flg22-related Ca 2+ permeable channels. Taken together, we have carefully defined the FICA sensitivity adaptation, which will facilitate further molecular and genetic dissection of the Ca 2+ -mediated adaptive mechanisms in PAMP-triggered immunity.

59 BASIC BIOLOGICAL SCIENCES↗

Metal Oxide-Induced Instability and Its Mitigation in Halide Perovskite Solar Cells

Halide perovskite solar cells (PSCs) have emerged as a promising photovoltaic technology for sustainable energy solutions due to their impressive power conversion efficiency and a path to be manufactured by low-cost, high-throughput methods. To reach PSCs’ full potential for practical implementation, it is crucial to solving the issues related to its long-term operational stability. Furthermore, given that PSCs consist of many layers of dissimilar materials which form multiple internal interfaces, it is prudent to examine whether there exist interfacial interactions, most importantly between transport layers and perovskite absorbers, that can trigger device performance and instability. In this perspective, we bring to the attention of the PSC research community the lesser-known interfacial degradation of halide perovskites promoted by contact with metal oxide transport layers and highlight the deleterious effects on the PSCs’ performance and stability. We also discuss various mitigation strategies that have shown promises to achieve high-performing and stable PSCs.

14 SOLAR ENERGY↗

Circumventing UV Light Induced Nanomorphology Disorder to Achieve Long Lifetime PTB7‐Th:PCBM Based Solar Cells

Abstract Large area flexible electronics rely on organic or hybrid materials prone to degradation limiting the device lifetime. For many years, photo‐oxidation has been thought to be one of the major degradation pathways. However, intense illumination may lead to a burn‐in or a rapid decrease in performance for devices completely isolated from corrosive elements as oxygen or moisture. The experimental studies which are presented in here indicate that a plausible triggering for the burn‐in is a spin flip after a UV photon absorption leading to the accumulation of electrostatic potential energy that initiates a rapid destruction of the nanomorpholgy in the fullerene phase of a polymer cell. To circumvent this and achieve highly stable and efficient devices, a robust nanocrystalline ordering is induced in the PCBM phase prior to UV illumination. In that event, PTB7‐Th:PC 71 BM cells are shown to exhibit T 80 lifetimes larger than 1.6 years under a continuous UV‐filtered 1‐sun illumination, equivalent to 7 years for sunlight harvesting at optimal orientation and 10 years for vertical applications.

Liu, Quan↗

Size and Structural Control of Mechanoluminescent ZnS:Mn 2+ Nanocrystals for Optogenetic Neuromodulation

Mechanoluminescent materials hold immense potential for various transformative applications, from medical imaging and diagnostics to health monitoring and wearable displays. Conventionally produced as bulk powders or microparticles, they face significant size limitations for advanced applications, particularly in biological systems and microscale devices. Here, this work presents an approach to ZnS:Mn 2+ nanocrystal synthesis that involves self-assembly and subsequent calcination. In addition to effective size control within the nanoscale, this approach promotes the formation of abundant stacking faults, significantly enhancing piezoelectric and mechanoluminescent properties by increasing trap density and reducing trap depth. Unlike mechanoluminescent materials produced using conventional methods, these nanocrystals demonstrate strong mechanoluminescence without requiring UV pre-excitation, and the light emission persists even after mechanical stress is removed. These advantageous properties make them promising candidates for optogenetic neuromodulation, as they can effectively trigger electrical signals in neurons upon ultrasound stimulation both with and without UV pre-excitation. The persistent mechanoluminescence prolongs the duration of neuronal electrical activity, providing an extended temporal window for neuromodulation compared to conventional mechanoluminescent materials. This study provides a scalable method for producing efficient mechanoluminescent nanoparticles and reveals the crucial role of particle size and defect structures in determining their mechanoluminescent behavior.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗

Evaluating Modern GPU Interconnect: PCIe, NVLink, NV-SLI, NVSwitch and GPUDirect

High performance multi-GPU computing becomes an inevitable trend due to the ever-increasing demand on computation capability in emerging domains such as deep learning, big data and planet-scale simulations. However, the lack of deep understanding on how modern GPUs can be connected and the real impact of state-of-the-art interconnect technology on multi-GPU application performance become a hurdle. In this paper, we fill the gap by conducting a thorough evaluation on five latest types of modern GPU interconnects: PCIe, NVLink-V1, NVLink-V2, NVLink-SLI and NVSwitch, from six high-end servers and HPC platforms: NVIDIA P100-DGX-1, V100-DGX-1, DGX-2, OLCF’s SummitDev and Summit supercomputers, as well as an SLI-linked system with two NVIDIA Turing RTX-2080 GPUs. Based on the empirical evaluation, we have observed four new types of GPU communication network NUMA effects: three are triggered by NVLink’s topology, connectivity and routing, while one is caused by PCIe chipset design issue. These observations indicate that, for a multi-GPU application running in a multi-GPU node, choosing the right GPU combination can impose considerable impact on GPU communication efficiency, as well as an application’s overall performance. Our evaluation can be leveraged in building practical multi-GPU performance models, which are vital for GPU task allocation, scheduling and migration in a shared environment (e.g., AI cloud and HPC centers), as well as communication-oriented performance tuning.

Performance Evaluation, GPU, Interconnect, NUMA, P↗

Search for a low-energy excess of electron neutrinos in MicroBooNE

The Micro Booster Neutrino Experiment (MicroBooNE) is a Liquid Argon Time Projection Chamber (LArTPC) designed for short-baseline neutrino physics at the Fermi National Accelerator Laboratory. The main physics goal of MicroBooNE is to address the low-energy excess of electron-like events observed by the MiniBooNE experiment and, if confirmed, clarify its nature. The MiniBooNE experiment is a Cherenkov detector and this technology does not allow to distinguish between electrons and single photons in the final state. LArTPC detectors, instead, offer excellent granularity and powerful separation between electrons and photons. For this reason, they represent an ideal technology for the detection of electron neutrino interactions. This thesis presents the first fully-automated electron neutrino selection in a LArTPC. The selection looks for charged-current electron neutrino interactions with no pions and at least one proton in the final state. It is applied on a sub-sample of the data acquired by the detector in the Booster Neutrino Beam, corresponding to $4.34\times10^{19}$~protons-on-target. A validation of the analysis is performed on two orthogonal side-bands, enriched with neutral-current and charged-current muon neutrino interactions, respectively. The uncertainties on the neutrino cross sections, flux, and detector simulation are evaluated. The MicroBooNE detector is placed off-axis with the Neutrinos at the Main Injector (NuMI) beam. An independent dataset of events acquired by triggering on the NuMI beam is employed to measure the significance of the detection of electron neutrinos in the beam using the selection presented here. The sensitivity of the MicroBooNE experiment to the MiniBooNE low-energy excess of electron-like events is evaluated. The efficiency and background-rejection power necessary to achieve $5\sigma$ sensitivity are also quantified.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

In Situ Machine Learning for Intelligent Data Capture on Exascale Platforms. Final Report

In many dynamic systems, interesting events occur locally in time and space. Examples of such systems include ignition events in combustion simulations, material fractures in mechanics simulations, and extreme weather events in climate simulations. Due to memory constraints and data I/O costs, current simulation workflows save data at regularly spaced time-steps, at a fixed rate determined before the start of the simulation. Often this mode of operation results in missed events of interest, necessitating a simulation restart from before an event occurred with more frequent data saves. This data saving workflow is grossly inefficient and is already a bottleneck in the computing process. We propose to develop machine learning algorithms that can detect when interesting dynamical events are occurring, triggering data saves. These machine learning algorithms will perform in situ anomaly detection to flag regions with different dynamical properties than those previously recorded. The adaptive data saves would be local in time and space to match the event of interest, thereby enabling a much more efficient workflow that will reduce data I/O costs and data storage memory requirements. The algorithms will be tested on two applications: auto-ignition simulations and climate simulations. A critical component of this project will be developing machine learning algorithms that can be deployed efficiently in situ on HPC platforms with out-of-the-box functionality. The development of in situ machine learning methods to detect anomalous events would enable a more efficient and effective workflow, in which all the relevant data are saved in a single simulation run, without re-starts or scientist intervention.

42 ENGINEERING↗

Effect of calcium carbonate particle shape on phagocytosis and pro-inflammatory response in differentiated THP-1 macrophages

Phagocytosis is a physiological process used by immune cells such as macrophages to actively ingest and destroy foreign pathogens and particles. It is the cellular process that leads to the failure of drug delivery carriers because the drug carriers are cleared by immune cells before reaching their target. Therefore, clarifying the mechanism of particle phagocytosis would have a significant implication for both fundamental understanding and biomedical engineering. As far as we know, the effect of particle shape on biological response has not been fully investigated. In the present study, we investigated the particle shape-dependent cellular uptake and biological response of differentiated THP-1 macrophages by using calcium carbonate (CaCO{sub 3})-based particles as a model. Transmission electron microscopy analysis revealed that the high uptake of needle-shaped CaCO{sub 3} particles by THP-1 macrophages because of their high phagocytic activity. In addition, the THP-1 macrophages exposed to needle-shaped CaCO{sub 3} accumulated a large amount of calcium in the intracellular matrix. The enhanced release of interleukin-8 (IL-8) and tumor necrosis factor-alpha (TNF-α) by the THP-1 macrophages suggested that the needle-shaped CaCO{sub 3} particles trigger a pro-inflammatory response. In contrast, no pro-inflammatory response was induced in undifferentiated THP-1 monocytes exposed to either needle- or cuboidal-shaped CaCO{sub 3} particles, probably because of their low phagocytic activity. We also found that phosphate-coated particles efficiently repressed cellular uptake and the resulting pro-inflammatory response in both THP-1 macrophages and primary peritoneal macrophages. Our results indicate that the pro-inflammatory response of macrophages upon exposure to CaCO{sub 3} particles is shape- and surface property-dependent, and is mediated by the intracellular accumulation of calcium ions released from phagocytosed CaCO{sub 3} particles. - Highlights: • Needle-shaped CaCO{sub 3} particles are phagocytized by macrophages. • Needle-shaped CaCO{sub 3} particles induce intracellular accumulation of calcium ions. • Needle-shaped CaCO{sub 3} particles induce pro-inflammatory responses. • Surface-coating with phosphate decreases adverse effects on macrophages.

60 APPLIED LIFE SCIENCES↗

Manipulating the insulator–metal transition through tip-induced hydrogenation

Manipulating the insulator–metal transition in strongly correlated materials has attracted a broad range of research activity due to its promising applications in, for example, memories, electrochromic windows and optical modulators. Electric-field-controlled hydrogenation using ionic liquids and solid electrolytes is a useful strategy to obtain the insulator–metal transition with corresponding electron filling, but faces technical challenges for miniaturization due to the complicated device architecture. Here, in this work, we demonstrate reversible electric-field control of nanoscale hydrogenation into VO 2 with a tunable insulator–metal transition using a scanning probe. The Pt-coated probe serves as an efficient catalyst to split hydrogen molecules, while the positive-biased voltage accelerates hydrogen ions between the tip and sample surface to facilitate their incorporation, leading to non-volatile transformation from insulating VO 2 into conducting H x VO 2 . Remarkably, a negative-biased voltage triggers dehydrogenation to restore the insulating VO 2 . This work demonstrates a local and reversible electric-field-controlled insulator–metal transition through hydrogen evolution and presents a versatile pathway to exploit multiple functional devices at the nanoscale.

36 MATERIALS SCIENCE↗

Preparation for a Measurement of Charge Asymmetry in the Bethe-Heitler Process

We have prepared a measurement of the energy asymmetry in wide- and medium-angle electron/positron pair production off protons and heavy targets. This asymmetry is caused by the interference between the first- and second-order Born diagrams and the Compton scattering diagram. It directly probes aspects of QED, as well as providing a direct measurement of the real part of the Compton amplitude. It will be conducted at the HI??S facility at Duke University, using a 60 MeV photon beam. This dissertation serves as documentation of the preparation stage of the Bethe-Heitler experiment. The major was the recommissioning of the vertical drift chambers previously used in the Q-weak experiment at the Jefferson Lab. Cosmic test runs were conducted, drift time data were collected and efficiency plateaus were measured. We made modifications to the JLAB Hall A analyzer to suit the geometry and drift characteristics of these wire chambers. The analyzer was used for the reconstruction of the trajectories of cosmic ray test runs with the results confirmed by direct measurement of trigger geometry. Spatial and angular resolution is estimated to ~300?? and 0.17° respectively. Geant 4 simulations with generated Bethe-Heitler pairs satisfying theoretical differential cross sections. It was used to check detector acceptance, optimize apparatus layout, and estimate measurable energy asymmetry. The measurable asymmetries from electron/positron pairs with polar angles around between approximately 5° and 8°, azimuthal angles differing by 180°, and energy differing by approximately 9 MeV to 15 MeV are predicted to be above 10%. The kinematics of primary vertices are reconstructed using the data from wire chambers in the simulation. The energy resolution is determined to be better than 1MeV.

Chen, Haoyu↗

Spontaneous oscillation of the ciliary beat frequency regulated by release of Ca2+ from intracellular stores in mouse nasal epithelia

Highlights: • Spontaneous CBF oscillation was found in ciliated mouse nasal epithelial cells. • The CBF oscillation was caused by the [Ca{sup 2+}]i oscillation. • The [Ca{sup 2+}]i oscillations were generated by the periodic Ca{sup 2+} release from internal stores via interactions between IP{sub 3} and IP{sub 3} receptor. • The CBF oscillation may play a crucial role for maintaining an efficient mucociliary clearance in nasal epithelia. Ciliary beating frequency (CBF) was investigated in ciliated nasal epithelial cells (cMNECs) isolated from mice using video microscopy equipped with a high-speed camera. In cMNECs, a spontaneous CBF oscillation was observed. The CBF oscillation was abolished by BAPTA-AM but not by Ca{sup 2+}-free solution. The addition of thapsigargin, which depletes Ca{sup 2+} from internal stores, also abolished CBF oscillation. Moreover, the intracellular Ca{sup 2+} concentration [Ca{sup 2+}]{sub i}, spontaneously oscillated even with the Ca{sup 2+}-free solution. Moreover, 2APB (an inhibitor of the IP{sub 3} receptor) abolished CBF oscillation in cMNECs. Overall, these findings suggest that the CBF oscillation in cMNECs is triggered by the release of Ca{sup 2+} from the IP{sub 3}-sensitive internal stores. Moreover, IBMX, an inhibitor of phosphodiesterase, did not affect CBF oscillation in cMNECs, although it slightly increased CBF. These results suggest that CBF oscillations were induced by [Ca{sup 2+}]{sub i} oscillation controlled via the release of Ca{sup 2+} from IP{sub 3}-sensitive stores, rather than via cAMP accumulation. CBF oscillation possibly plays a crucial role in maintaining an efficient mucociliary clearance in the nasal epithelia.

60 APPLIED LIFE SCIENCES↗

Intramolecular Noncovalent Interactions Facilitate Thermally Activated Delayed Fluorescence (TADF)

In the conventional molecular design of thermally activated delayed fluorescence (TADF) organic emitters, simultaneously achieving a fast rate of reverse intersystem crossing (RISC) from the triplet to the singlet manifold and a fast rate of radiative decay is a challenging task. A number of recent experimental data, however, point to TADF emitters with intramolecular π-π interactions as a potential pathway to overcome the issue. Here, we report a comprehensive investigation of TADF emitters with intramolecular π…π or lone-pair…π non-covalent interactions. We uncover the impact of those intramolecular non-covalent interactions on the TADF properties. In particular, we find that folded geometries in TADF molecules can trigger lone-pair…π interactions, introduce a n → π* character of the relevant transitions, enhance the singlet-triplet spin-orbit coupling, and ultimately greatly facilitate the RISC process. Furthermore, this work provides a robust foundation for the molecular design of a novel class of highly efficient TADF emitters in which intramolecular non-covalent interactions play a critical function.

36 MATERIALS SCIENCE↗

DAQExpert the service to increase CMS data-taking efficiency

The Data Acquisition (DAQ) system of the Compact Muon Solenoid (CMS) experiment at the LHC is a complex system responsible for the data readout, event building and recording of accepted events. Its proper functioning plays a critical role in the data-taking efficiency of the CMS experiment. In order to ensure high availability and recover promptly in the event of hardware or software failure of the subsystems, an expert system, the DAQ Expert, has been developed. It aims at improving the data taking efficiency, reducing the human error in the operations and minimising the on-call expert demand. Introduced in the beginning of 2017, it assists the shift crew and the system experts in recovering from operational faults, streamlining the post mortem analysis and, at the end of Run 2, triggering fully automatic recovery without human intervention. DAQ Expert analyses the real-time monitoring data originating from the DAQ components and the high-level trigger updated every few seconds. It pinpoints data flow problems, and recovers them automatically or after given operator approval. We analyse the CMS downtime in the 2018 run focusing on what was improved with the introduction of automated recovery; present challenges and design of encoding the expert knowledge into automated recovery jobs. Furthermore, we demonstrate the web-based, ReactJS interfaces that ensure an effective cooperation between the human operators in the control room and the automated recovery system. We report on the operational experience with automated recovery.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

A neural-network-enhanced parameter-varying framework for multi-objective model predictive control applied to buildings

Management of the electrical grid is becoming more complex due to the increased penetration of alternative energy generation technologies and a broadening diversity of electric loads. This complexity creates challenges in balancing demand and generation that can increase the potential for grid instabilities. One effective way to address this issue is to leverage previously unexploited demand flexibility through advanced control strategies. In this work, we propose an advanced control method, called adaptive neural parameter-varying model predictive control (ANPV-MPC), to control the temperature and energy consumption of a building via its Heating, Ventilation, and Air Conditioning system. ANPV-MPC combines key ideas in parameter-varying control, adaptive control, and online learning strategies to bridge the gap between computationally efficient linear model predictive control and more accurate nonlinear model predictive control. The novelty in ANPV-MPC is the use of a physics-inspired Bayesian neural network to estimate the coefficients of the parameter-varying linear control model. The Bayesian neural network additionally provides uncertainty estimates, triggering online training to capture evolving building system conditions. We show that ANPV-MPC can approximate the building system dynamics with a 28.39% higher accuracy than traditional linear model predictive control, resulting in 36.23% better control performance without increasing complexity of the optimal control problem. ANPV-MPC also adapts in real time to previously unseen conditions using online learning, further improving its performance.

24 POWER TRANSMISSION AND DISTRIBUTION↗

High and Ultra-High Temperature Reaction Kinetics by Single Nanoparticle Mass Spectrometry

Methodology is presented for non-destructive, optically-detected single nanoparticle (NP) mass spectrometry, with the goal of extracting surface reaction kinetics for single NPs at high temperatures. Methods for determining the NP charge, mass, and temperature as a function of time are discussed, and the data are used to extract both the absolute kinetics for mass change, as well as the efficiencies of the surface processes that cause them. Factors that contribute to the uncertainties in absolute and relative mass determination, and in the resulting kinetic parameters, are discussed. The method allows the NP-to-NP variations in initial reactivity to be measured directly, along with the time evolution of reactivity resulting from NP structural/compositional changes that occur under reaction conditions. The strengths and limitations of single nanoparticle mass spectrometry as a high temperature surface kinetics tool are discussed in the context of sublimation and O2 oxidation kinetics experiments for single hafnium (Hf) NPs at temperatures ranging above 2400 K. The Hf oxidation kinetics are compared to analogous oxidation experiments for silicon, graphite, and carbon black NPs. In all four cases, the oxidation chemistry was dominated by processes that result in net mass loss, and the distinct mechanisms responsible are discussed. All four NPs also eventually passivated, i.e., the efficiencies for oxidative etching decreased by at least two orders of magnitude, relative to the initial efficiencies. Furthermore, the passivation mechanisms, which are quite different for carbon, compared to silicon or hafnium, are discussed. Carbon NP passivation is attributed to structural isomerization leading to fully coordinated, fullerene-like NP surfaces, while for silicon and hafnium, passivation results from delayed formation of an oxide layer, triggered by accumulation of oxygen in the NP sub-surface region.

36 MATERIALS SCIENCE↗

Single photon detection with the multi-anode CLAS12 RICH detector

Recently, the first module of the hybrid-optics large-area CLAS12 RICH at JLab has been put into operation using for the first time the well known Hamamatsu H8500 MAPMT and the new single-photon dedicated H12700, for a total of about 400 MAPMTs and 25000 pixels. The photon detector must efficiently detect single photons in the visible and near-UV light region, provide a fast response for background rejection and pattern recognition, and have a spatial resolution of less than 1 cm over an area of ≈1 m 2 . Each front-end readout unit is composed of three electronic boards with specific tasks directly connected to groups of 2 or 3 sensors. The core of the readout is composed of MAROC3 and FPGA chips. The MAROC3 chip is able to discriminate the 64 signals from one MAPMT and to produce 64 corresponding binary outputs with 100% efficiency starting at a small fraction of the single-photon signal, while the FPGA chip provides 1 ns TDC capability with 8 μs maximum latency and acts as a DAQ controller. The system is created to be almost dead-time free at the foreseen 20 kHz CLAS12 trigger rate. The best working conditions for single-photon detection have been studied at laser stands, test beams, and with the JLab electron beam data. A report of the photon detector preparation, commissioning and operation is here discussed.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

Dataset for "Bioaerosols are the dominant source of warm-temperature immersion-mode INPs and drive uncertainties in INP predictability

Ice nucleating particles (INPs) are a rare subset of atmospheric aerosol that can initiate primary ice formation and thus trigger cloud glaciation. The re is a significant gap between our ability to measure INPs and to predict their concentrations and variability in large-scale weather and climate models. Accurate simulation of I NPs requires simulation of their major particle sources, as well as representative parameterizations of IN efficiency. Thus, there is a need for measurements of INP concentrations , delineated by particle type, to validate and improve model prediction of INP concentrations. Here we present a novel method for speciating INP concentrations into the relative c ontributions from dust, sea spray aerosol (SSA), and bioaerosol using single particle measurements. In a field campaign at Bodega Bay (coastal California), we find that bioaerosol s were the primary source of INPs between -12 and -20 ?C, while dust was a relatively minor source and SSA did not contribute significantly. We show that recent INP parameterizati ons for dust and SSA accurately predict ambient INP concentrations for these particle types. Finally, we use the speciated INP concentrations to evaluate the simulation of INPs at Bodega Bay, using a Lagrangian approach to connect the locally-observed aerosol with regionally-widespread emissions parameterizations. We find that we can skillfully simulate du st and SSA INPs, but not bioaerosol INPs. This points to a need for additional research to identify the major factors controlling the emissions and INP efficiency of bioaerosol IN Ps in order to develop improved parameterizations and enable their improved representation in models.

54 ENVIRONMENTAL SCIENCES↗

Implementation of a Dose-based Compliance System for WCS - 19178

Waste Control Specialists LLC (WCS) operates a low-level radioactive waste (LLRW) disposal facility in Andrews, Texas. The site includes a compact waste facility (CWF) that began receiving waste in 2012, a federal waste facility (FWF) that started receiving waste in 2013, as well as a Resource Conservation and Recovery Act (RCRA) landfill and a byproduct facility. The current site license uses a complex system of concentration-based investigation levels and action levels (ILs and ALs) coupled with analytical decision levels (ADLs) that, when exceeded, require specific steps to be taken. These concentration-based ILs and ALs are media specific (i.e. air, soil, water), radionuclide specific, location specific, and disposal facility specific. This results in thousands of individual ILs, ALs, and ADLs that need to be managed and evaluated routinely in order to demonstrate compliance. Further, under the current system, each exceedance of an IL and AL can trigger comparisons to numerous additional isotopic ILs per sample, which is cumbersome, error prone, and costly. This paper describes implementation of a dose-based compliance system that has been developed to replace the existing system. The dose-based compliance system is implemented in RACER{sup C}, a cloud-based software developed by Risk Assessment Corporation (RAC). This system maintains all the analytical results related to the sampling and analysis conducted as part of the Radiological Environmental Monitoring Program (REMP) together with the geo-spatial data allowing instantaneous trending and analysis of the data. Further, the system contains the information needed to compare the analytical results to the new media-specific screening levels that have been developed, and the parameters and routines to compute doses using prescribed exposure scenarios and dose coefficients for compliance evaluation. Once measurement data are entered into RACER, the routines for continuous screening of air, soil, groundwater, and dosimeter data are triggered, and any sample result failing the screening step or exceeding the dose IL/AL is identified and flagged automatically for further review or action, as appropriate. Because RACER is cloud-based, the data, screening, and dose calculations can be accessed remotely at any time, providing a timely and efficient method for identifying any possible releases from the site to the environment as well as determining the potential dose consequences associated with a release. Furthermore, the system is accessible by the regulator providing transparency and ensuring they remain fully informed in an efficient manner. (authors)

12 MANAGEMENT OF RADIOACTIVE AND NON-RADIOACTIVE W↗