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At least 307 records · Page 17

Combinations of Earth Orientation Measurements: COMB94 and POLE94

A Kalman filter has been used to combine Earth orientation measurements taken by optical astrometry with SPACE94, a previously determined combination of Earth orientation measurements taken by space-geodetic techniques. This created two series of combined, smoothed, and interpolated polar motion: COMB94 covering 1962-1995 at 5-day intervals, and POLE94 covering 1900 to 1995 at 30.4375-day intervals.

Earth↗

A W-Band Spatial Power-Combining Amplifier using GaN MMICs

In this paper, we describe a miniature powercombiner for monolithic millimetre-wave integrated circuit (MMIC) chips using spatial power-combining with cavity modes. We have designed GaN MMIC power amplifier chips for 94 GHz, and illustrate the concept of the W-Band Spatial Power Combining Amplifier (WSPCA). Using 1 Watt, 94 GHz MMIC chips in a two-way cavity mode combiner, we were able to achieve 2 Watts of output power with 9 dB gain and 15 % PAE. This technique could be extended to high power MMICs and larger numbers of chips to achieve higher output power in a compact size. The applications include earth science radar, but may be extended to other applications requiring wider bandwidth.

Gawande, Rohit↗

Atacama Cosmology Telescope: Combined kinematic and thermal Sunyaev-Zel’dovich measurements from BOSS CMASS and LOWZ halos

The scattering of cosmic microwave background (CMB) photons off the free-electron gas in galaxies and clusters leaves detectable imprints on high resolution CMB maps: the thermal and kinematic Sunyaev-Zel’dovich effects (tSZ and kSZ respectively). We use combined microwave maps from the Atacama Cosmology Telescope DR5 and Planck in combination with the CMASS (mean redshifthzi¼0.55and host halo masshMviri¼3×1013M⊙) and LOWZ (hzi¼0.31,hMviri¼5×1013M⊙) galaxy catalogs from the Baryon Oscillation Spectroscopic Survey (BOSS DR10 and DR12), to study the gas associated with these galaxy groups. Using individual reconstructed velocities, we perform a stacking analysis and reject the no-kSZ hypothes is at 6.5σ, the highest significance to date. This directly translates into a measurement of the electron number density profile, and thus of the gas density profile. Despite the limited signal to noise, the measurement shows at high significance that the gas density profile is more extended than the dark matter density profile, for any reasonable baryon abundance (formally>90σfor the cosmic baryon abundance). We simultaneously measure the tSZ signal, i.e., the electron thermal pressure profile of the same CMASS objects, and reject theno-tSZ hypothesis at10σ. We combine tSZ and kSZ measurements to estimate the electron temperature to20% precision in several aperture bins, and find it comparable to the virial temperature. In a companion paper, we analyze these measurements to constrain the gas thermodynamics and the properties of feedback inside galaxy groups. We present the corresponding LOWZ measurements in this paper, ruling out a null kSZ (tSZ)signal at 2.9ð13.9Þσ, and leave their interpretation to future work. This paper and the companion paper demonstrate that current CMB experiments can detect and resolve gas profiles in low mass halos and at high redshifts, which are the most sensitive to feedback in galaxy formation and the most difficult to measure any other way. They will be a crucial input to cosmological hydrodynamical simulations, thus improving our understanding of galaxy formation. These precise gas profiles are already sufficient to reduce the main limiting theoretical systematic in galaxy-galaxy lensing: baryonic uncertainties. Future such measurements will thus unleash the statistical power of weak lensing from the Rubin, Euclid and Roman observatories. Our stacking software Thumb Stack is publicly available and directly applicable to future Simons Observatory andCMB-S4 data.

Emmanuel Schaan↗

Measurements of Rainfall Rate, Drop Size Distribution, and Variability at Middle and Higher Latitudes: Application to the Combined DPR-GMI Algorithm

The Global Precipitation Measurement mission is a major U.S.–Japan joint mission to understand the physics of the Earth’s global precipitation as a key component of its weather, climate, and hydrological systems. The core satellite carries a dual-precipitation radar and an advanced microwave imager which provide measurements to retrieve the drop size distribution (DSD) and rain rates using a Combined Radar-Radiometer Algorithm (CORRA). Our objective is to validate key assumptions and parameterizations in CORRA and enable improved estimation of precipitation products, especially in the middle-to-higher latitudes in both hemispheres. The DSD parameters and statistical relationships between DSD parameters and radar measurements are a central part of the rainfall retrieval algorithm, which is complicated by regimes where DSD measurements are abysmally sparse (over the open ocean). In view of this, we have assembled optical disdrometer datasets gathered by research vessels, ground stations, and aircrafts to simulate radar observables and validate the scattering lookup tables used in CORRA. The joint use of all DSD datasets spans a large range of drop concentrations and characteristic drop diameters. The scaling normalization of DSDs defines an intercept parameter N(W), which normalizes the concentrations, and a scaling diameter D(m), which compresses or stretches the diameter coordinate axis. A major finding of this study is that a single relationship between N(W) and D(m), on average, unifies all datasets included, from stratocumulus to heavier rainfall regimes. A comparison with the N(W)–D(m) relation used as a constraint in versions 6 and 7 of CORRA highlights the scope for improvement of rainfall retrievals for small drops (D(m) < 1 mm) and large drops (D(m) > 2 mm). The normalized specific attenuation–reflectivity relationships used in the combined algorithm are also found to match well the equivalent relationships derived using DSDs from the three datasets, suggesting that the currently assumed lookup tables are not a major source of uncertainty in the combined algorithm rainfall estimates.

Viswanathan Bringi↗

Leveraging the Multiplatform Precipitation Feature Database of Combined Ground Radar and Satellite Lightning Observations for Convective Studies

The Multiplatform Precipitation Feature (MPF) database combines coincident observations of lightning from space with satellite- and ground-based radar data in a storm-based, feature-defined framework. The concept for the MPF database stems from the motivation to extend the scale and scope of investigations into the complex connections between ice precipitation, updrafts, and lightning in thunderstorms. The earliest iteration of the MPF database incorporates NASA International Space Station Lightning Imaging Sensor (ISS LIS) observations alongside the NASA Global Precipitation Measurement (GPM) Mission Dual-frequency Precipitation Radar (DPR) and Validation Network (VN). Because of the specific role of the GPM VN in forming the first MPFs, this subset is referred to as the VNMPF database. The synthesis of these multi-scale and multi-resolution observations leveraged each platform’s unique insights into convective properties and processes, offering a more complete view of deep convection over the large viewing area afforded by satellite coverage. The VNMPF database established the feasibility and infrastructure to combine microphysical, kinematic, and lightning observations from multiple satellite- and ground-based platforms. Following this successful proof-of-concept, recent progress has expanded the MPF database to make use of coincident ISS LIS lightning observations and data from the operational Weather Surveillance Radar - 1988 Doppler (WSR-88D) network, where individual WSR-88D proximity facilitates vertical wind retrievals via dual-Doppler analysis. These database changes have expanded the scope of the dataset by removing the requirement for coincident GPM and ISS LIS overpasses. This increases the sample size dramatically and facilitates analysis of higher-resolution radar-derived properties. These advancements allow both storm-scale and unprecedented broad statistical analyses of deep convection from electrical, kinematic, and microphysical perspectives over the contiguous United States. This presentation outlines the construction of the new MPF database and introduces some preliminary analyses of the convection captured within it. Early results summarize relationships based on updraft characteristics ascertained from WSR-88D dual-Doppler three-dimensional wind retrievals, properties of ice microphysics gleaned from dual-polarization analyses, and electrical characteristics observed by the ISS LIS. The expanded scale and scope offered by more than five years of ISS LIS observations enable new insights into regional and seasonal variations in the microphysical, kinematic, and electrical relationships of convection. Analysis of the database highlights the potential for advancements in lightning meteorology made possible by combining large-scale spaceborne lightning detection and proven storm interrogation tools such as operational polarimetric Doppler radar.

Lightning↗

Moss Tolerance of Deep Space-Like Ionizing Radiation, Singular or Combined With Spaceflight Microgravity-Preparation for the BRIC-27 Experiment to the ISS

Understanding how terrestrial life perceives and tolerates deep space environments is essential to advancing human space exploration missions and searching for life beyond our solar system. Throughout evolution moss adapted to living in extreme environments from the edge of habitability. Moss inhabits areas with high UVB/UVC photon levels such as polar regions subject to ozone holes, high elevation mountain environments, and sites with elevated ionizing particle levels such as those found at nuclear plant accident sites, atomic bomb test sites or radioactive element-rich regions. We investigate if moss tolerance of ionizing radiation encounter terrestrially extends to resistance to deep space ionizing radiation. We exposed moss to high energy ion beams simulating Galactic Cosmic Ray (GCRSim) and Solar Particle Event (SPESim) (NSRL, BNL) that permeate deep space, and moss was unharmed. We also exposed moss to high doses of gamma rays as released in astrophysical events, and moss survived absorption of extremely high doses. Next, we ask if moss tolerance of deep space-like ionizing radiation observed terrestrially differs from that in other deep space environments. In the upcoming BRIC-27 spaceflight experiment we will sequentially expose Antarctic moss C.purpureus to GCRSim and SPESim followed by exposure to spaceflight microgravity and compare gene expression profiles in deep space-like ionizing radiation, singular or combined with spaceflight microgravity. Additionally, we will compare gene expression profiles in spaceflight microgravity, singular or combined with deep space-like ionizing radiation. Hence, BRIC-27 will advance our understanding of the combined effects of both deep space ionizing radiation and microgravity, which may have different and more profound effects on plant physiology and performance than each condition separately.

Agata Klaudia Zupanska↗

Solar Array System Combined Environmental Effects Tests: Gateway Power and Propulsion Element

The NASA Lunar Orbital Platform-Gateway (LOP-G), a vital component of NASA’s Artemis program, will serve as a multi-purpose outpost orbiting the Moon. A foundational component of LOP-G is the Power and Propulsion Element (PPE). The PPE is a high-power, +60-kilowatt solar electric propulsion spacecraft that will provide power, high-rate communications, attitude control, and orbital transfer capabilities for the Gateway. The solar array system will utilize 4-junction photovoltaic cell technology on a flexible substrate (roll-out solar array or ROSA) in combination with multiple diode assemblies to combine the power of the solar array strings. NASA’s Marshall Space Flight Center, together with the PPE developer, Maxar, are in the midst of completing a rigorous combined environments test campaign of 3 solar array coupons and 1 array blocking diode board coupon. The campaign includes Ultra-Violet Radiation, Charged Particle Radiation, Ion Erosion, Thermal Cycles, and Electrostatic Discharge tests. The environments are applied in 3 separate incremental stages reflecting the various mission phases: 460 days of Earth-to-Lunar Transit, with much of that time through the Van Allen Belts, 5-years in Lunar Near-Rectilinear Halo Orbit (NRHO) at the Moon, and finally 15-years in Lunar NRHO, which represents the end of the design life. This paper will report on the state of the testing for each coupon, and brief look at the array performance, including some unexpected sensitivities of array blocking diodes.

Gateway↗

Development of a Combined Cohesive and Virtual Crack-Closure Technique Approach to Represent R-Curves

Resistance curve (R-curve) effects due to fiber bridging, crack migration, and other blunting mechanisms are common in composite laminates. These mechanisms can dramatically increase the resistance to crack propagation but can be challenging to simulate. Delamination with R-curves can be analyzed using cohesive zone modeling (CZM) or the virtual crack closure technique (VCCT). Large fracture process zones can be simulated with CZM, but they require highly refined meshes. Coarser meshes can be used with VCCT, but this method is only applicable to small fracture process zones with R-curves defined as functions of position. Therefore, a technique with the computational efficiency of VCCT and the natural ability of cohesive elements to represent large fracture process zones is desirable. An approach is proposed that starts as a CZM in which the cohesive traction separation law (TSL) is separated into high-strength (HS) and low-strength (LS) components. The HS part, which is responsible for the mesh requirements of the CZM analysis, is replaced by VCCT. The combined method is evaluated by analyzing the response of double cantilevered beam specimens. Two specimen layup configurations, [0/90/90/0] 3s and [0/90/90/0] 9s , are evaluated. The R-curve response from each configuration is determined and applied to the constitutive properties of models built with CZM and with VCCT. The results and computational efficiency of the CZM, VCCT, and combined approaches are compared. The results are indicative that a combined cohesive/VCCT approach can enable progressive failure analyses to retain the computational efficiency of VCCT with the ability of the cohesive elements to capture R-curve effects.

Virtual Crack-Closure Technique↗

A Combined Computational, Experimental, and Technology Development Approach to In-Space Laser Manufacturing Maturation at NASA Marshall Space Flight Center

In-space manufacturing (ISM) is emerging as a field vital to continued access and capabilities in the space environment. NASA Marshall Space Flight Center (MSFC) is advancing the frontier of in-space laser manufacturing (ISLM) techniques through work initially focused on maturing laser beam welding (LBW) and laser forming (LF) for use in space. Such techniques proffer the ability to assemble and join structures in space from sheet metal or other stock – extant satellites, in situ resource utilization of Lunar regolith, etc. – by forming to desired shapes and then joining via in-space welding (ISW). ISLM processes are useful for assembly, joining, modification, and repair of structures in free space and on the Lunar surface such as large observatories, antennas, trusses, blast/thermal/radiation shields, pressure vessels, and more. However, these techniques are not yet qualified & certified (Q&C) for regular application in space. It would be prohibitively expensive, laborious, and time-consuming to perform Q&C via traditional experimental approaches as data collection & experimentation in space is resource-intensive. As such, benchmark experiments and focused, properly instrumented technology demonstration efforts in space can collect sufficient data that – when combined with verified computational models in an integrated computational materials engineering (ICME) approach – can validate ICME tools capable of translating more readily obtained ground data to in-space, in situ, computationally informed Q&C of ISLM techniques. Several ISLM projects at MSFC are obtaining the data required to validate ICME tools through both ground and flight experiments. A parabolic flight experiment of LBW under vacuum is manifested for August 2024, including both microgravity and Lunar gravity profiles. This collaboration with the Ohio State University is investigating common aerospace alloys such as 316L stainless steel, 2219 aluminum alloy, and Ti64 titanium alloy. In situ data collection includes videography, thermography, and reference thermocouples to build a thermal model of the welds. This will elucidate the relevant physics when combined with post-flight microstructural examination and mechanical testing. MSFC is also progressing towards a suborbital flight experiment of LBW under vacuum, which could provide reams of data on ISW during sustained, high-quality reduced gravity. The effect of combined thermal (cryogenic and high-temperature) and vacuum exposure on both LBW (NASA-funded) and LF (DARPA-funded) is being investigated through ground experiments. In addition to the copious data collected during these ground experiments, ruggedization of LBW hardware will also be pursued. The datasets from these experiments will be used to validate computational models which will inform future ISLM efforts in an ICME framework. A variety of techniques across lengths scales, from CALPHAD-driven thermodynamics & kinetics to phase field modeling of solidification to kinetic Monte Carlo simulations of grain evolution at the mesoscale, will be employed to accelerate the infusion and eventual Q&C of LBW and LF for use in space. The development of data-driven surrogate models to bridge ground to flight experiments and thereby reduce the need for resource-intensive experiments in space will also be investigated. These ICME techniques, surrogate models, and datasets from ground testing can also be employed to advance manufacturing in terrestrial environments.

in-space welding↗

Pion Nucleon Scattering in BCHPT Combined with 1/Nc Expansion

Pion nucleon scattering has played a crucial role in advancing our understanding of the low-energy regime of strong interactions. This dissertation presents the development of a new theoretical framework that combines Baryon Chiral Perturbation Theory (BChPT) with the 1/Nc Expansion to analyze pion nucleon scattering. The resulting effective Lagrangian incorporates both chiral and spin-flavor symmetries. Scattering amplitudes are calculated up to the one-loop level (NNLO), which includes four tree-level Feynman diagrams and 45 non-zero loop diagrams. The effective Lagrangian is renormalized at the one-loop level. With spin-3/2 baryons naturally included, the framework demonstrates strong convergence at higher energies. The NNLO pion nucleon scattering amplitude shows good agreement with experimental data from the SAID database. This novel approach, BChPT combined with 1/Nc Expansion, demonstrates substantial predictive power at higher energies where other low-energy theories fall short, achieving the goals of this combined framework. The contribution from loop diagrams is essential for achieving good agreement with the data, highlighting the importance of conducting the calculation up to NNLO. Extracted values for physically measurable quantities agree reasonably well with independently extracted values, underscoring the robustness of the theory.

Jayakodige, Dulitha [Hampton Univ., Hampton, VA (U↗

Longitudinal Stability Characteristics of a 42 Degree Sweptback Wing and Tail Combination at a Reynolds Number of 6.8 x 10(exp 6)

Results are given of a wind-tunnel investigation at a Reynolds number of 6.8 x 10(exp 6) to determine the static longitudinal stability characteristics of a 42 degree sweptback wing and fuselage combination with a sweptback horizontal tail. Included are the effects of vertical position of fuselage and tail with respect to wing for several combinations of high-lift and staff-control devices. Also included is the effect of a simulated ground.

FLAPS - COMPLETE WINGS↗

Poromechanical cohesive interface element with combined Mode I-II cohesive zone elastoplasticity for simulating fracture in fluid-saturated porous media

A combined Mode I-II cohesive zone (CZ) elasto-plastic constitutive model, and a two-dimensional (2D) cohesive interface element (CIE) are formulated and implemented at small strain within an ABAQUS User Element (UEL) for simulating 2D crack nucleation and propagation in fluid-saturated porous media. Here, the CZ model mitigates problems of convergence for the global Newton-Raphson solver within ABAQUS, which when combined with a viscous stabilization procedure allows for simulation of post-peak response under load control for coupled poromechanical finite element analysis, such as concrete gravity dam stability analysis. Verification examples are presented, along with a more complex ambient limestone-concrete wedge fracture experiment, water-pressurized concrete wedge experiment, and concrete gravity dam stability analyses. A calibration procedure for estimating the CZ parameters is demonstrated with the limestone-concrete wedge fracture process. For the water-pressurized concrete wedge fracture experiment it is shown that the inherent time-dependence of the poromechanical CIE analysis provides a good match with experimental force versus displacement results at various crack mouth opening rates, yet misses the pore water pressure evolution ahead of the crack tip propagation. This is likely a result of the concrete being partially-saturated in the experiment, whereas the finite element analysis assumes fully water saturated concrete. For the concrete gravity dam analysis, it is shown that base crack opening and associated water uplift pressure leads to a reduced Factor of Safety, which is confirmed by separate analytical calculations.

97 MATHEMATICS AND COMPUTING↗

Nuclear—thermal energy storage configurations for industrial combined heat and power supply—conceptual and thermodynamic study with high temperature gas-cooled reactor

Nuclear systems are promising candidates for delivering resilient heat and power for future energy security and independence. Traditionally, nuclear plants have been used for baseload electricity production and cogeneration of heat has seen relatively limited application utilizing typically only small portion of a reactor's thermal output. This paradigm may shift due to the increasing penetration of intermittent renewables and need for resource flexibility, various decarbonization efforts aimed at both electricity and heat demands, along with the perspective of small modular nuclear reactor applications, which can be sized based on local industrial needs. Here, this study provides a comprehensive guide for the nuclear and industrial sectors, emphasizing controllability in the combined heat and power configuration options for high temperature gas-cooled reactor and process steam supply. It investigates the integration of thermal energy storage to improve nuclear energy's responsiveness to varying industrial demands. The study emphasizes placing thermal energy storage between the nuclear primary loop and steam cycle to achieve greater efficiency and flexibility in power and heat output, surpassing traditional combined heat and power systems and avoiding efficiency losses seen in other thermal energy storage integration approaches.

combined heat and power (CHP)↗

Combined measurements and interpretations of Higgs boson production and decay in proton–proton collisions at $\sqrt{s}$ = 13 TeV

Combined measurements of Higgs boson production and decay rates are reported, representing the most comprehensive study performed by the CMS Collaboration to date. The included analyses use proton–proton collision data recorded by the CMS experiment at $\sqrt{s}$ = 13 TeV from 2016 to 2018, corresponding to an integrated luminosity of 138 fb –1 . The statistical combination is based on analyses that measure the following decay channels: H → γγ, H → ZZ, H → WW, H → ππ, H → bb, H → μμ, and H → Zγ. Information in the events from each decay channel is used to target multiple Higgs boson production processes. Searches for invisible Higgs boson decays are also considered, as well as an analysis that measures off-shell Higgs boson production in the H → ZZ → 4$\ell$ ($\ell$ = e, μ) decay channel. The best fit inclusive signal yield is measured to be 1.014$^{+0.055}_{–0.053}$ times the standard model (SM) expectation, for a Higgs boson mass of 125.38 GeV. Measurements in kinematic regions defined by the simplified template cross section framework are also provided, as well as interpretations in the coupling modifier and SM effective field theory frameworks. The coupling modifier interpretation is further used to place constraints on various two-Higgs-doublet models. The results show good compatibility with the SM predictions for the majority of the measured parameters.

CMS↗

Northwest Combined Heat and Power Technical Assistance Partnership: Final Scientific/Technical Report

During the years of 2018 through 2023, The Washington State University Energy Program (WSU EP) operated the Northwest Combined Heat and Power Technical Assistance Partnership under contract to the US Department of Energy’s Advanced Manufacturing Office (AMO), a part of DOE’s larger Office of Energy Efficiency and Renewable Energy. This contract provided direction and funding for providing technical outreach, information and technical/economic analysis services in support of expanding development of Combined Heat and Power (CHP) over a four state region in the Pacific Northwest. The states served included Alaska, Idaho, Oregon and Washington. During the duration of this contract, the WSU EP delivered performed specific assigned tasks and provided services of various generally prescribed types, with the overall goal of increasing adoption of CHP as an efficient heat and power supply in the region. Indications – though not formally evaluated to our knowledge – are that this goal was achieved. Over many years, the WSU team has provided support for CHP developments in these states under similar previous Department of Energy contracts, and many such projects have been built. While the early-phase outreach, education and techno-economic assessments that the NW CHP TAP provides rarely immediately result in project construction, there is no doubt that the WSU EP team has had substantial influence in the construction of a number of important CHP projects in the region. Examples of projects implemented directly under the current team’s guidance and services during this contract cycle include an 875 kilowatt biomass fueled CHP system installed at the University of Idaho, and 5 megawatt natural gas fueled CHP system at the University of Montana ( UM Breaks Ground on New Power Facility, Slashes Emissions 30% (umt.edu) ). Many other CHP systems recently installed are also either directly or at least partially the result of information and technical services provided by the team. Finally, though much more difficult to quantify and less glamorous, the team has helped countless organizations to understand CHP and determine whether and how CHP may be a fit for them, before they consider paying for engineering services. Whether the ultimate outcome has been to include CHP or not, the expert skills provided by the NW CHP TAP team have provided real value to these organizations considering this relatively complex technology. Over the duration of the contract our team provided 71 Initial Technical Assessments and 17 Advanced Technical Assessments; 53 End-User Engagements and 33 Stakeholder Engagements of various types; 42 Technical Profiles (Project Profiles, Program Profiles and Policy Profiles), and produced 14 technical articles for the Department of Energy. Unfortunately, these quantities provide no measure of the value that the team has provided. Only our clients can judge that, and we are confident that they are pleased with the benefits we have offered them.

29 ENERGY PLANNING, POLICY, AND ECONOMY↗

The inward bulge type buckling of monocoque cylinders II : experimental investigation of the buckling in combined bending and compression

This paper is the second part of a series of reports on the inward bulge type buckling of monocoque cylinders. It presents the results of an experimental investigation of buckling in combined bending and compression. In the investigation it was found that the theory developed in part I of the present series predicts the buckling load in combined bending and compression with the same degree of accuracy as the older theory does in pure bending. In the realm covered by the experiments no systematic variation of the parameter N was observed. The analysis of the test results afforded a check on the theories of buckling of a curved panel. The agreement between experiment and theory was reasonably good. In addition, the effect of the end conditions upon the stress distribution under loads and upon initial stresses was investigated.

LOADS-CYLINDERS, MONOCOQUE-STRESS DISTRIBUTION↗

The Effect of Boundary-layer Control by Suction and Several High-lift Devices on the Longitudinal Aerodynamic Characteristics of a 47.5 Degree Sweptback Wing-fuselage Combination

An investigation has been made in the Langley full-scale tunnel of a 47.5 degree sweptback wing-fuselage combination equipped for boundary-layer control by suction. The wing aspect ratio was 3.5, the taper ratio was 0.5, and the airfoil sections normal to the quarter-chord line were NACA 64(sub 1)-A112. The wing configurations tested included the wing with various combinations of extensible leading-edge and split flaps. The effect of Reynolds number, suction-slot location and suction flow coefficient on the aerodynamic characteristics was determined for the model at zero yaw over a range of angle of attack.

WING-FUSELAGE COMBINATIONS - AIRPLANES↗

Evaluation of radiation effects against C6 glioma in combination with vaccinia virus-p53 gene therapy

The primary objective of this study was to evaluate the antitumor effects of recombinant vaccinia virus-p53 (rVV-p53) in combination with radiation therapy against the C6 rat glioma, a p53 deficient tumor that is relatively radioresistant. VV-LIVP, the parental virus (Lister strain), was used as a control. Localized treatment of subcutaneous C6 tumors in athymic mice with either rVV-p53 or VV-LIVP together with tumor irradiation resulted in low tumor incidence and significantly slower tumor progression compared to the agents given as single modalities. Assays of blood and spleen indicated that immune system activation may account, at least partly, for the enhance tumor inhibition seen with combined treatment. No overt signs of treatment-related toxicity were noted.

NASA Discipline Radiation Health↗