A computer simulation study of preadaptation of the circulation by removal of different blood volumes to counteract central fluid shifts
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A finite element model of cardiac conduction was used to simulate two experimental protocols: 1) fibrillation threshold measurements and 2) clinical electrophysiologic (EP) testing procedures. The model consisted of a cylindrical lattice whose properties were determined by four parameters: element length, conduction velocity, mean refractory period, and standard deviation of refractory periods. Different stimulation patterns were applied to the lattice under a given set of lattice parameter values and the response of the model was observed through a simulated electrocardiogram. The studies confirm that the model can account for observations made in experimental fibrillation threshold measurements and in clinical EP testing protocols.
Equipment available in the primary training facility for the Space Transportation System (STS) flight crews includes the Fixed Base Simulator, the Motion Base Simulator, the Spacelab Simulator, and the Guidance and Navigation Simulator. The Shuttle Mission Simulator (SMS) consists of the Fixed Base Simulator and the Motion Base Simulator. The SMS utilizes four visual Computer Generated Image (CGI) systems. The Motion Base Simulator has a forward crew station with six-degrees of freedom motion simulation. Operation of the Spacelab Simulator is planned for the spring of 1983. The Guidance and Navigation Simulator went into operation in 1982. Aspects of orbital visual simulation are discussed, taking into account the earth scene, payload simulation, the generation and display of 1079 stars, the simulation of sun glare, and Reaction Control System jet firing plumes. Attention is also given to landing site visual simulation, and night launch and landing simulation.
The simulation of converter-controller combinations by means of a flexible digital computer program which produces output to a graphic display is discussed. The procedure is an alternative to mathematical analysis of converter systems. The types of computer programming involved in the simulation are described. Schematic diagrams, state equations, and output equations are displayed for four basic forms of inductor-energy-storage dc to dc converters. Mathematical models are developed to show the relationship of the parameters.
The transmembrane fragment of the influenza virus M(2) protein forms a homotetrameric channel that transports protons. In this paper, we use molecular dynamics simulations to help elucidate the mechanism of channel gating by four histidines that occlude the channel lumen in the closed state. We test two competing hypotheses. In the "shuttle" mechanism, the delta nitrogen atom on the extracellular side of one histidine is protonated by the incoming proton, and, subsequently, the proton on the epsilon nitrogen atom is released on the opposite side. In the "water-wire" mechanism, the gate opens because of electrostatic repulsion between four simultaneously biprotonated histidines. This allows for proton transport along the water wire that penetrates the gate. For each system, composed of the channel embedded in a hydrated phospholipid bilayer, a 1.3-ns trajectory was obtained. It is found that the states involved in the shuttle mechanism, which contain either single-protonated histidines or a mixture of single-protonated histidines plus one biprotonated residue, are stable during the simulations. Furthermore, the orientations and dynamics of water molecules near the gate are conducive to proton transfer. In contrast, the fully biprotonated state is not stable. Additional simulations show that if only two histidines are biprotonated, the channel deforms but the gate remains closed. These results support the shuttle mechanism but not the gate-opening mechanism of proton gating in M(2).
A time-dependent computer model is used to study a non-equilibrium structure of the heliosphere, resulting from the interaction between the solar wind and the interstellar plasma. An interaction of the heliospheric termination shock with various disturbances such as density or velocity jumps or interplanetary shocks in upstream solar wind as well as pressure jumps in local interstellar medium is investigated. Consequences of latitudinal variation in dynamic pressure are also discussed. The initial boundary conditions of unsteady calculations are given by the solar wind parameters as functions of time and/or latitude on an inner boundary, and/or by the local interstellar pressure as a function of time (roughly simulating the effect of the local interstellar medium) on an outer boundary.
The following FORTRAN language computer codes are presented: (1) efficient two- and three-dimensional central force potential solvers; (2) a three-dimensional simulator of an isolated galaxy which incorporates the potential solver; (3) a two-dimensional particle-in-cell simulator of the Jeans instability in an infinite self-gravitating compressible gas; and (4) a two-dimensional particle-in-cell simulator of a rotating self-gravitating compressible gaseous system of which rectangular coordinate and superior polar coordinate versions were written.
A computer program has been developed to solve the compressible flow equation for the velocity potential. The exterior of the airfoil is mapped onto the unit circle and the flow is computed on a grid in the circle plane. A relaxation method using backward differencing in the flow direction at supersonic points permits solutions for large supersonic areas. The pressure distribution resulting from the flow becomes the input to the von Karman momentum equation which when integrated gives the displacement thickness. This displacement thickness is smoothed and added to the airfoil to account for the turbulent boundary layer. The boundary layer correction is computed iteratively with the flow. Results from this program and test data agree well.
A computer program, SCAP2D (Solar Cell Analysis Program in 2-Dimensions), is used to evaluate the Etched Multiple Vertical Junction (EMVJ) and grating solar cells. The aim is to demonstrate how SCAP2D can be used to evaluate cell designs. The cell designs studied are by no means optimal designs. The SCAP2D program solves the three coupled, nonlinear partial differential equations, Poisson's Equation and the hole and electron continuity equations, simultaneously in two-dimensions using finite differences to discretize the equations and Newton's Method to linearize them. The variables solved for are the electrostatic potential and the hole and electron concentrations. Each linear system of equations is solved directly by Gaussian Elimination. Convergence of the Newton Iteration is assumed when the largest correction to the electrostatic potential or hole or electron quasi-potential is less than some predetermined error. A typical problem involves 2000 nodes with a Jacobi matrix of order 6000 and a bandwidth of 243.
A computational study has been conducted to gain a better understanding of the role of turbulence in the merger of corotating vortices and in the decay of a single vortex. The flow field is simulated by using an inviscid flow model and zero-, one-, and two-equation turbulent-flow models. An implicit finite-difference procedure is employed to integrate the unsteady, two-dimensional, incompressible flow equations in a cross-plane. In the zero- and one-equation models, a spatially varying mixing-length model that simulates the streamline curvature effect is used to define an eddy viscosity. The computational merging distance criterion is in good agreement with the experimental one. In the case of the two-equation model, the turbulent kinetic energy and a modified rate of dissipation equation incorporating a curvature correction term are solved. A comparative study of the computational results corresponding to the various flow models and the available experimental data is presented.
Far infrared collision induced absorption spectra of gaseous CO2 were computed using molecular dynamics simulations. The quadrupole and hexadecapole multipolar induction, through the trace, and the anisotropy of the molecular polarizability were found to be insufficient to represent properly the dipole induction mechanism. For a detailed analysis of the induction process the spectra obtained were decomposed into components resulting from different terms of the induced dipole. Based on this decomposition, all additional overlap contribution for each term was proposed. When spectra were recomputed including such overlap, good agreement between experiment and simulation was achieved over the temperature range at which measurements exist (233-400 K). The use of an anisotropic intermolecular potential was found to be of critical importance for obtaining the right shape of the far wings of the spectra.
The automation of a small, solid propellant mixer was studied. Temperature control is under investigation. A numerical simulation of the system is under development and will be tested using different control options. Control system hardware is currently being put into place. The construction of mathematical models and simulation techniques for understanding various engineering processes is also studied. Computer graphics packages were utilized for better visualization of the simulation results. The mechanical mixing of propellants is examined. Simulation of the mixing process is being done to study how one can control for chaotic behavior to meet specified mixing requirements. An experimental mixing chamber is also being built. It will allow visual tracking of particles under mixing. The experimental unit will be used to test ideas from chaos theory, as well as to verify simulation results. This project has applications to extraterrestrial propellant quality and reliability.
A study was performed to evaluate an experimental method to determine time lags in real-time computer systems as the one associated with the Vertical Motion Simulator at Ames Research Center. The approach was to use an ordinary frequency analyzer to measure the phase difference between inputs and outputs of the computer system. The various elements of the program and computational architecture were modeled. Various factors, such as computer frame time and input frequency, were varied so that they were representative of the operational use of the simulator facilities. Experimentally determined results were compared with predictions derived from the simulation models. The results indicate that the frequency analyzer can be readily used to evaluate time lags in systems of this type. Differences between predicted and measured phase values indicate that the hardware and software imparts a time lag of about 5 msec to this facility.
A computer program was developed to integrate avionics research in navigation, guidance, controls, and displays with a realistic aircraft model. A user oriented program is described that allows a flexible combination of user supplied models to perform research in any avionics area. A preprocessor technique for selecting various models without significantly changing the memory storage is included. Also included are mathematical models for several avionics error models and for the CH-47 helicopter used in this program.
A digital computer program is described which was developed to estimate Saturn 5 response to prelaunch wind conditions at Cape Kennedy. The program computes displacement and bending moment statistics as a function of parameters defining the atmospheric environment. A sample problem is provided to illustrate utilization of the program.
Any spiral structure in computer-generated galaxies is generally short lived and the final state is a rotating bar. The bar thus obtained rotates more slowly than the stars. It has been argued that core/halo components have a stabilizing effect on galaxies and result in longer lived spiral structure. However, numerical experiments with large fixed stellar components representing the core/halo component show that multiarmed spiral structure develops and persists for many rotations but only in an evolving manner. That is, the spiral structure is either wound up into a tight pattern or it is wound up and then reappears again. A recent study of the effect of fixed core/halo components does show that the bar instability is indeed inhibited by a sufficiently large fixed component. The present study determines the effect of a self-consistent (rather than fixed) core/halo component in order to show whether there are any instabilities (such as two-stream) or other important interactions present that may be suppressed with a fixed core. Also studied were the effects of finite thickness of the disk and of three-dimensional essentially spherical core/halo components.
The role of sophisticated numerical models and simulations in the field of plasma astrophysics is discussed. The need for an iteration between microphysics and macrophysics in order for astrophysical plasma physics to produce quantitative results that can be related to astronomical data is stressed. A discussion on computational requirements for simulations of astrophysical plasmas contrasts microscopic plasma simulations with macroscopic system models. An overview of particle-in-cell simulations (PICS) is given and two examples of PICS of astrophysical plasma are discussed including particle acceleration by collisionless shocks in relativistic plasmas and magnetic field reconnection in astrophysical plasmas.
A series of computer programs are presented with full documentation which simulate the transient behavior of a modern 4 cylinder Siemens arrangement Stirling engine with burner and air preheater. Cold start, cranking, idling, acceleration through 3 gear changes and steady speed operation are simulated. Sample results and complete operating instructions are given. A full source code listing of all programs are included.