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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 307 records · Page 17
All sourcesNASA NTRSDOE OSTI
NASA NTRS1974

Prediction of femoral neck and spine bone mineral content from the BMC of the radius or ulna and the relationship between bone strength and BMC

The bone mineral content (BMC) is extensively used to provide information about the status of an entire skeleton. Changes in BMC are employed to evaluate the effect of various drugs, disease states, weightlessness, exercise, renal dialysis and others on the skeleton. Clinical and functional information is discussed that may be derived from the BMC of a limited region of the skeleton. In particular there is a fairly high degree of correlation between the BMC of the radius or ulna and that of the femoral neck, r about 0.85 and a somewhat lower relationship between the BMC of the radius or ulna and the thoracic vertebrae, r about 0.65. Also the BMC is highly related to the strength of bone at that scan site.

Wilson, C. R.↗
NASA NTRS1974

Automated analysis of oxidative metabolites

An automated system for the study of drug metabolism is described. The system monitors the oxidative metabolites of aromatic amines and of compounds which produce formaldehyde on oxidative dealkylation. It includes color developing compositions suitable for detecting hyroxylated aromatic amines and formaldehyde.

Furner, R. L.↗
NASA NTRS1974

Pathogenetic validation of the use of biological protective agents and early treatment in cases of radiation injury simulating radiation effects under space flight conditions

In considering a radiation safety system for space flights, the various measures to protect man against radiation include drug prophylaxis. At the present time a great deal of experimental material has been accumulated on the prevention and treatment of radiation injuries. Antiradiation effectiveness has been established for sulfur- and nitrogen-containing substances, auxins, cyanides, polynucleotides, mucopolysaccharides, lipopolysaccharides, aminosaccharides, synthetic polymers, vitamins, hormones, amino acids and other compounds which can be divided into two basic groups - biological and chemical protective agents.

Rogozkin, V. D.↗
NASA NTRS1974

The processing and transmission of EEG data

Interest in sleep research was stimulated by the discovery of a number of physiological changes that occur during sleep and by the observed effects of sleep on physical and mental performance and status. The use of the relatively new methods of EEG measurement, transmission, and automatic scoring makes sleep analysis and categorization feasible. Sleep research involving the use of the EEG as a fundamental input has the potential of answering many unanswered questions involving physical and mental behavior, drug effects, circadian rhythm, and anesthesia.

Schulze, A. E.↗
NASA NTRS1975

The role of brain biogenic amines in the control of pituitary-adrenocortical activity

It was found that pretreatment of animals with desmethyl imipramine antagonized the reserpine-induced sedation without preventing the decline in brain amines or the hypersecretion of adrenocorticotropic hormone (ACTH). The antagonism of reserpine-induced ACTH hypersecretion by the monoamine oxidose (MAO) inhibitor pargyline (MO 911, N-methyl-N-benzyl-2-propynylamine) was studied. Evidence is presented that this antagonism is related to the level of brain biogenic amines maintained during the course of action of the drug. Pretreatment with MAO inhibitors does not affect the ACTH hypersecretion evoked by exposure to cold or chlorpromazine, lending further support to the hypothesis that reserpine-induced ACTH hypersecretion is related to brain amine changes.

Maickel, R. P.↗
NASA NTRS1974

Susceptibility to motion sickness among Skylab astronauts

The mechanisms causing susceptibility to motion sickness in zero gravity are not well understood. Preflight and postflight motion sickness susceptibility tests conducted on the three Skylab crews are described. Under operational conditions, the first Skylab crew experienced no motion sickness, while the other two crews did. Susceptibility was greater in the Skylab workshop than in the command module. Weightlessness in itself is a unique motion environment. Changes occur in nonrigid body parts and in the response of macular receptors in the otolith organs. Tests in parabolic flight, where zero gravity is the only significant factor in motion sickness susceptibility, indicate that some people need to adapt to weightlessness and others do not. A comparison of all US and Soviet manned missions indicates that a headward shift of fluid on transition to zero gravity is not a predisposing factor in motion sickness. Under certain conditions after adaptation susceptibility was lower in the Skylab workshop than on the ground. The anti-motion sickness drugs used in Skylab are judged effective for prevention and treatment.

Graybiel, A.↗
NASA NTRS1975

Potential missions for advanced airships

The freight commodity transport and the intercity passenger travel markets in the U.S. for 1967 and 1972 are analyzed, along with 1985 estimates, in order to establish the size, speed and cost enabling use of the airship in these markets. Items examined include frozen meat, confectionary, drugs, electrical equipment, mechanical parts, clothing and plastic products. A 50 ton/500 passenger payload capacity, a cruise speed of 100 kt and a VTOL capability or at minimum short take-off and vertical landing capability are needed to make an LTA vehicle viable in the transport market if it had a direct operating cost of $500 to $800 per hour for freight carrying and $1100 to $2700 an hour in passenger service with utilizations between 2000 hours and 4000 hours a year.

Grant, D. T.↗
NASA NTRS1975

Optimal control of multiplicative control systems arising from cancer therapy

This study deals with ways of curtailing the rapid growth of cancer cell populations. The performance functional that measures the size of the population at the terminal time as well as the control effort is devised. With use of the discrete maximum principle, the Hamiltonian for this problem is determined and the condition for optimal solutions are developed. The optimal strategy is shown to be a bang-bang control. It is shown that the optimal control for this problem must be on the vertices of an N-dimensional cube contained in the N-dimensional Euclidean space. An algorithm for obtaining a local minimum of the performance function in an orderly fashion is developed. Application of the algorithm to the design of antitumor drug and X-irradiation schedule is discussed.

Bahrami, K.↗
NASA NTRS1976

Automated solvent concentrator

Designed for automated drug identification system (AUDRI), device increases concentration by 100. Sample is first filtered, removing particulate contaminants and reducing water content of sample. Sample is extracted from filtered residue by specific solvent. Concentrator provides input material to analysis subsystem.

Griffith, J. S.↗
NASA NTRS1976

Polyphosphazenes - New polymers with inorganic backbone atoms

Unique and useful properties of the class of nonhydrocarbon, nonhalocarbon, nonsilicone polymers known as polyphosphazenes are discussed at length. These polymers, with molecular weights to 4 million (degree of polymerization 15,000), can be fabricated as tubes, fibers, woven fabrics, flexible films, or plates, and many variants are stable to attack by water, bases, aqueous acids, jet fuels, oils, hydraulic fluids, gasoline, or other hydrocarbons. Rubbery polymers with these properties can be fashioned into flexible hose, fuel hose, gaskets, or O-rings. Since they do not provoke clotting reactions in blood, and reveal no carcinogenic effects to date, they are considered for internal prosthetic applications (replacement bone, temporary skin, heart valves), as biodegradable suturing material, as carriers for slow release of drugs, and as carriers for chemotherapeutic agents against cancers.

Allcock, H. R.↗
NASA NTRS1977

In-flight medical support system

The In-flight Medical Support System for Skylab was designed to provide the onboard Crew Physician or Scientist Pilot (or other crewmember if the Scientist Pilot was unable to act) with information adequate to make diagnostic assessment of those injuries or illnesses most likely to occur in the Skylab environment. The necessary diagnostic, therapeutic, and laboratory equipment needed to diagnose and to render first aid, resuscitative or supportive measures was stored in the Skylab Orbital Workshop. The resupply kit containing refrigerated laboratory and drug resupply items was stored in the Command Module.

Chassay, C.↗
NASA NTRS1976

Objective and automated measurement of dynamic vision functions

A phoria stimulus array and electro-oculographic (EOG) arrangements for measuring motor and sensory responses of subjects subjected to stress or drug conditions are described, along with experimental procedures. Heterophoria (as oculomotor function) and glare recovery time (time required for photochemical and neural recovery after exposure to a flash stimulus) are measured, in research aimed at developing automated objective measurement of dynamic vision functions. Onset of involuntary optokinetic nystagmus in subjects attempting to track moving stripes (while viewing through head-mounted binocular eyepieces) after exposure to glare serves as an objective measure of glare recovery time.

Flom, M. C.↗
NASA NTRS1977

Analysis of responses of cold pressor tests on pilots and executives

Statistical analyses were performed to study the relationship between cold pressor test responses and certain medical attributes of a group of 81 pilots and a group of 466 executives. The important results of this study were as follows: There was a significant relationship between a subject's cold pressor test response and his profession (that is, pilot or executive). The executives' diastolic cold pressor test responses were significantly related to their medical conditions, and their families' medical conditions. Significant relationships were observed between executives' diastolic and systolic cold pressor test responses and their history of tranquilizer and cardiac drug use.

Swaroop, R.↗
NASA NTRS1977

Biorhythms and space experiments with nonhuman primates

Man's response to exposure to spaceflight and weightlessness is expressed in physiological adjustments which involve his health and ability to function. The amplitude and periodicity of fluctuations in biological processes affect various functions and responses to provocative stimuli. Primates and other species are subjected to tests to determine the consequences of an altered biorhythm on work and performance, emotional stability, biomedical evaluation in space, the ability to cope with the unexpected, and susceptibility to infection, toxicity, radiation, drugs, and stress. Factors in the environment or operational setup which can change the physiological baseline must be determined and controlled.

Winget, C. M.↗
NASA NTRS1977

Cardiovascular studies using the chimpanzee (Pan troglodytes)

Despite the phylogenetic similarities between chimpanzees and man, there exists a paucity of reliable data on normal cardiovascular function and the physiological responses of the system to standard interventions. Totally implanted biotelemetry systems or hardwire analog techniques were used to examine the maximum number of cardiovascular variables which could be simultaneously monitored without significantly altering the system's performance. This was performed in order to acquire base-line data not previously obtained in this species, to determine cardiovascular response to specific forcing functions such as ventricular pacing, drug infusions, and lower body negative pressure. A cardiovascular function profile protocol was developed in order to adjust independently the three major factors which modify ventricular performance, namely, left ventricular performance, left ventricular preload, afterload, and contractility. Cardiac pacing at three levels above the ambient rate was used to adjust end diastolic volume (preload). Three concentrations of angiotensin were infused continuously to evaluate afterload in a stepwide fashion. A continuous infusion of dobutamine was administered to raise the manifest contractile state of the heart.

Hinds, J. E.↗
NASA NTRS1978

The control and prevention of seizures in children, a developmental and environmental approach

The clinical effectiveness of neurophysiological and developmental factors in controlling and preventing seizure mechanisms is detailed. It is shown that as cortical control advances with maturation, it requires increasingly severe environmental adversity to release this residual defensive reflex mechanism. Administration of anticonvulsant drugs is discouraged because of possible undesirable neuronal effects on the very young brain.

Lewinn, E. B.↗
NASA NTRS1979

Microbial transformation of nucleosides

A study involving the use of coulter counter in studying the effects of neomycin on E. coli, S. aureus and A. aerogenes was completed. The purpose of this was to establish proper technique for enumeration of cells per ml. It was found that inhibitory effects on growth of E. coli and A. aerogenes, both gram negative organisms, were directly related to the concentration of neomycin used. However, in case S. aureus, a gram positive organism, a decreased inhibition was noted at higher concentrations. A paper entitled, Use of Coulter Counter in Studying Effect of Drugs on Cells in Culture 1 - Effects of Neomycin on E. coli, S. aureus and A. aerogenes, is attached in the appendix. Laboratory procedures were also established to study the effects of nucleoside antibiotic cordycepin on He La cell grown in suspension cultures.

Lamba, S. S.↗
NASA NTRS1979

A tethering system for direct measurement of cardiovascular function in the caged baboon

A device suitable for the continuous measurement of physiological activity in large, conscious monkeys has permitted the direct recording of systemic arterial blood pressure and heart rate in caged baboons. The device comprises a lightweight fiberglass backpack, retained in place on the baboon by a thoracic elastic band and shoulder straps, and a flexible stainless steel tether connecting the pack to an electrocannular slip-ring in the top center of the baboon's cage. A chronically indwelling arterial catheter inserted retrograde into the abdominal aorta via the internal iliac artery and connected to a small pressure transducer on the pack provides direct measurement of blood pressure and heart rate. Body fluids can be sampled or drugs administered via an indwelling catheter in the inferior vena cava. Electrical and fluid connections between the fiberglass pack and recording and infusion equipment located outside the cage pass through the flexible tether and remain protected from the subject. The reliability of the tethering system has been demonstrated in physiological, pharmacological, and behavioral experiments with baboons.

Byrd, L. D.↗