PDV Probe Designed with Stereo Imaging
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PDV, pyramid prism, optical metrology, stereo imag↗
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Atomic-scale EDS Mapping for Chemical Imaging and Quantification of Interdiffusion in Self-assembled Vertically Aligned Nanocomposite Thin Films.
Abstract not provided.
Romero, Eric David↗
The Residual Setup Errors of Different IGRT Alignment Procedures for Head and Neck IMRT and the Resulting Dosimetric Impact
Purpose: To assess residual setup errors during head and neck radiation therapy and the resulting consequences for the delivered dose for various patient alignment procedures. Methods and Materials: Megavoltage cone beam computed tomography (MVCBCT) scans from 11 head and neck patients who underwent intensity modulated radiation therapy were used to assess setup errors. Each MVCBCT scan was registered to its reference planning kVCT, with seven different alignment procedures: automatic alignment and manual registration to 6 separate bony landmarks (sphenoid, left/right maxillary sinuses, mandible, cervical 1 [C1]-C2, and C7-thoracic 1 [T1] vertebrae). Shifts in the different alignments were compared with each other to determine whether there were any statistically significant differences. Then, the dose distribution was recalculated on 3 MVCBCT images per patient for every alignment procedure. The resulting dose-volume histograms for targets and organs at risk (OARs) were compared to those from the planning kVCTs. Results: The registration procedures produced statistically significant global differences in patient alignment and actual dose distribution, calling for a need for standardization of patient positioning. Vertically, the automatic, sphenoid, and maxillary sinuses alignments mainly generated posterior shifts and resulted in mean increases in maximal dose to OARs of >3% of the planned dose. The suggested choice of C1-C2 as a reference landmark appears valid, combining both OAR sparing and target coverage. Assuming this choice, relevant margins to apply around volumes of interest at the time of planning to take into account for the relative mobility of other regions are discussed. Conclusions: Use of different alignment procedures for treating head and neck patients produced variations in patient setup and dose distribution. With concern for standardizing practice, C1-C2 reference alignment with relevant margins around planning volumes seems to be a valid option.
62 RADIOLOGY AND NUCLEAR MEDICINE↗
Definition and visualisation of regions of interest in post-prostatectomy image-guided intensity modulated radiotherapy
Standard post-prostatectomy radiotherapy (PPRT) image verification uses bony anatomy alignment. However, the prostate bed (PB) moves independently of bony anatomy. Cone beam computed tomography (CBCT) can be used to soft tissue match, so radiation therapists (RTs) must understand pelvic anatomy and PPRT clinical target volumes (CTV). The aims of this study are to define regions of interest (ROI) to be used in soft tissue matching image guidance and determine their visibility on planning CT (PCT) and CBCT. Published CTV guidelines were used to select ROIs. The PCT scans (n = 23) and CBCT scans (n = 105) of 23 post-prostatectomy patients were reviewed. Details on ROI identification were recorded. Eighteen patients had surgical clips. All ROIs were identified on PCTs at least 90% of the time apart from mesorectal fascia (MF) (87%) due to superior image quality. When surgical clips are present, the seminal vesicle bed (SVB) was only seen in 2.3% of CBCTs and MF was unidentifiable. Most other structures were well identified on CBCT. The anterior rectal wall (ARW) was identified in 81.4% of images and penile bulb (PB) in 68.6%. In the absence of surgical clips, the MF and SVB were always identified; the ARW was identified in 89.5% of CBCTs and PB in 73.7%. Surgical clips should be used as ROIs when present to define SVB and MF. In the absence of clips, SVB, MF and ARW can be used. RTs must have a strong knowledge of soft tissue anatomy and PPRT CTV to ensure coverage and enable soft tissue matching.
62 RADIOLOGY AND NUCLEAR MEDICINE↗
WE-AB-204-09: Respiratory Motion Correction in 4D-PET by Simultaneous Motion Estimation and Image Reconstruction (SMEIR)
Purpose: In conventional 4D-PET, images from different frames are reconstructed individually and aligned by registration methods. Two issues with these approaches are: 1) Reconstruction algorithms do not make full use of all projections statistics; and 2) Image registration between noisy images can Result in poor alignment. In this study we investigated the use of simultaneous motion estimation and image reconstruction (SMEIR) method for cone beam CT for motion estimation/correction in 4D-PET. Methods: Modified ordered-subset expectation maximization algorithm coupled with total variation minimization (OSEM- TV) is used to obtain a primary motion-compensated PET (pmc-PET) from all projection data using Demons derived deformation vector fields (DVFs) as initial. Motion model update is done to obtain an optimal set of DVFs between the pmc-PET and other phases by matching the forward projection of the deformed pmc-PET and measured projections of other phases. Using updated DVFs, OSEM- TV image reconstruction is repeated and new DVFs are estimated based on updated images. 4D XCAT phantom with typical FDG biodistribution and a 10mm diameter tumor was used to evaluate the performance of the SMEIR algorithm. Results: Image quality of 4D-PET is greatly improved by the SMEIR algorithm. When all projections are used to reconstruct a 3D-PET, motion blurring artifacts are present, leading to a more than 5 times overestimation of the tumor size and 54% tumor to lung contrast ratio underestimation. This error reduced to 37% and 20% for post reconstruction registration methods and SMEIR respectively. Conclusion: SMEIR method can be used for motion estimation/correction in 4D-PET. The statistics is greatly improved since all projection data are combined together to update the image. The performance of the SMEIR algorithm for 4D-PET is sensitive to smoothness control parameters in the DVF estimation step.
60 APPLIED LIFE SCIENCES↗
Alignment and focus of mirrored facets of a heliosat
Various technologies pertaining to aligning and focusing mirrored facets of a heliostat are described herein. Updating alignment and/or focus of mirrored facets is undertaken through generation of a theoretical image, wherein the theoretical image is indicative of a reflection of the target via the mirrored facets when the mirrored facets are properly aligned. This theoretical image includes reference points that are overlaid on an image of the target as reflected by the mirrored facets of the heliostat. A technician adjusts alignment/focus of a mirrored facet by causing reflected reference markings to become aligned with the reference points in the theoretical image.
47 OTHER INSTRUMENTATION↗
Laboratory calibration and characterization of video cameras
Some techniques for laboratory calibration and characterization of video cameras used with frame grabber boards are presented. A laser-illuminated displaced reticle technique (with camera lens removed) is used to determine the camera/grabber effective horizontal and vertical pixel spacing as well as the angle of nonperpendicularity of the axes. The principal point of autocollimation and point of symmetry are found by illuminating the camera with an unexpanded laser beam, either aligned with the sensor or lens. Lens distortion and the principal distance are determined from images of a calibration plate suitably aligned with the camera. Calibration and characterization results for several video cameras are presented. Differences between these laboratory techniques and test range and plumb line calibration are noted.
Burner, A. W.↗
Laboratory Calibration and Characterization of Video Cameras
Some techniques for laboratory calibration and characterization of video cameras used with frame grabber boards are presented. A laser-illuminated displaced reticle technique (with camera lens removed) is used to determine the camera/grabber effective horizontal and vertical pixel spacing as well as the angle of non-perpendicularity of the axes. The principal point of autocollimation and point of symmetry are found by illuminating the camera with an unexpanded laser beam, either aligned with the sensor or lens. Lens distortion and the principal distance are determined from images of a calibration plate suitable aligned with the camera. Calibration and characterization results for several video cameras are presented. Differences between these laboratory techniques and test range and plumb line calibration are noted.
Burner, A. W.↗
Broadband unidirectional visible imaging using wafer-scale nano-fabrication of multi-layer diffractive optical processors
We present a broadband and polarization-insensitive unidirectional imager that operates at the visible part of the spectrum, where image formation occurs in one direction, while in the opposite direction, it is blocked. This approach is enabled by deep learning-driven diffractive optical design with wafer-scale nano-fabrication using high-purity fused silica to ensure optical transparency and thermal stability. Our design achieves unidirectional imaging across three visible wavelengths (covering red, green, and blue parts of the spectrum), and we experimentally validated this broadband unidirectional imager by creating high-fidelity images in the forward direction and generating weak, distorted output patterns in the backward direction, in alignment with our numerical simulations. This work demonstrates wafer-scale production of diffractive optical processors, featuring 16 levels of nanoscale phase features distributed across two axially aligned diffractive layers for visible unidirectional imaging. This approach facilitates mass-scale production of ~0.5 billion nanoscale phase features per wafer, supporting high-throughput manufacturing of hundreds to thousands of multi-layer diffractive processors suitable for large apertures and parallel processing of multiple tasks. Beyond broadband unidirectional imaging in the visible spectrum, this study establishes a pathway for artificial-intelligence-enabled diffractive optics with versatile applications, signaling a new era in optical device functionality with industrial-level, massively scalable fabrication.
36 MATERIALS SCIENCE↗
SU-F-P-30: Clinical Assessment of Auto Beam-Hold Triggered by Fiducial Localization During Prostate RapidArc Delivery
Purpose: To assess the clinical efficacy of auto beam hold during prostate RapidArc delivery, triggered by fiducial localization on kV imaging with a Varian True Beam. Methods: Prostate patients with four gold fiducials were candidates in this study. Daily setup was accomplished by aligning to fiducials using orthogonal kV imaging. During RapidArc delivery, a kV image was automatically acquired with a momentary beam hold every 60 degrees of gantry rotation. The position of each fiducial was identified by a search algorithm and compared to a predetermined 1.4 cm diameter target area. Treatment continued if all the fiducials were within the target area. If any fiducial was outside the target area the beam hold was not released, and the operators determined if the patient needed re-alignment using the daily setup method. Results: Four patients were initially selected. For three patients, the auto beam hold performed seamlessly. In one instance, the system correctly identified misaligned fiducials, stopped treatment, and the patient was re-positioned. The fourth patient had a prosthetic hip which sometimes blocked the fiducials and caused the fiducial search algorithm to fail. The auto beam hold was disabled for this patient and the therapists manually monitored the fiducial positions during treatment. Average delivery time for a 2-arc fraction was increased by 59 seconds. Phantom studies indicated the dose discrepancy related to multiple beam holds is <0.1%. For a plan with 43 fractions, the additional imaging increased dose by an estimated 68 cGy. Conclusion: Automated intrafraction kV imaging can effectively perform auto beam holds due to patient movement, with the exception of prosthetic hip patients. The additional imaging dose and delivery time are clinically acceptable. It may be a cost-effective alternative to Calypso in RapidArc prostate patient delivery. Further study is warranted to explore its feasibility under various clinical conditions.
60 APPLIED LIFE SCIENCES↗
Fast imaging of filaments in the X-point region of Alcator C-Mod
A rich variety of field-aligned fluctuations has been revealed using fast imaging of D α emission from Alcator C-Mod's lower X-point region. Field-aligned filamentary fluctuations are observed along the inner divertor leg, within the Private-Flux-Zone (PFZ), in the Scrape-Off Layer (SOL) outside the outer divertor leg, and, under some conditions, at or above the X-point. The locations and dynamics of the filaments in these regions are strikingly complex in C-Mod. Changes in the filaments’ generation appear to be ordered by plasma density and magnetic configuration. Filaments are not observed for plasmas with n/n Greenwald ≲ 0.12 nor are they observed in Upper Single Null configurations. In a Lower Single Null with 0.12 ≲ n/n Greenwald ≲ 0.45 and Bx∇B directed down, filaments typically move up the inner divertor leg toward the X-point. Reversing the field direction results in the appearance of filaments outside of the outer divertor leg. With the divertor targets “detached”, filaments inside the LCFS are seen. Lastly, these studies were motivated by observations of filaments in the X-point and PFZ regions in MAST, and comparisons with those observations are made.
70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗
SU-G-JeP2-12: Quantification of 3D Geometric Distortion for 1.5T and 3T MRI Scanners Used for Radiation Therapy
Purpose: To quantify the magnitude of geometric distortion for MRI scanners and provide recommendations for MRI imaging for radiation therapy Methods: A novel phantom, QUASAR MRID3D [Modus Medical Devices Inc.], was scanned to evaluate the level of 3D geometric distortion present in five MRI scanners used for radiation therapy in our department. The phantom was scanned using the body coil with 1mm image slice thickness to acquire 3D images of the phantom body. The phantom was aligned to its geometric center for each scan, and the field of view was set to visualize the entire phantom. The dependence of distortion magnitude with distance from imaging isocenter and with magnetic field strength (1.5T and 3T) was investigated. Additionally, the characteristics of distortion for Siemens and GE machines were compared. The image distortion for each scanner was quantified in terms of mean, standard deviation (STD), maximum distortion, and skewness. Results: The 3T and 1.5T scans show a similar absolute distortion with a mean of 1.38mm (0.33mm STD) for 3T and 1.39mm (0.34mm STD) for 1.5T for a 100mm radius distance from isocenter. Some machines can have a distortion larger than 10mm at a distance of 200mm from the isocenter. The distortions are presented with plots of the x, y, and z directional components. Conclusion: The results indicate that quantification of MRI image distortion is crucial in radiation oncology for target and organ delineation and treatment planning. The magnitude of geometric distortion determines the margin needed for target contouring which is usually neglected in treatment planning process, especially for SRS/SBRT treatments. Understanding the 3D distribution of the MRI image distortion will improve the accuracy of target delineation and, hence, treatment efficacy. MRI imaging with proper patient alignment to the isocenter is vital to reducing the effects of MRI distortion in treatment planning.
60 APPLIED LIFE SCIENCES↗
Double Sided Aligned Si Grating for High Energy X-ray Phase Contrast Imaging.
Abstract not provided.
Hollowell, Andrew E↗
Active figure maintenance control using an optical truss laser metrology system for a space-based far-IR segmented telescope
A two-stage active control approach was developed addressing the figure control problem for a spaceborne FIR telescope, the Precision Segmented Reflectors Focus Moderate Mission Telescope (FMMT). The first active control stage aligns the optical segments based on images; attention is here given to the second stage, active figure maintenance control system, which maintains the alignment of the optical elements between initializations to hold the mirror figure steady while obtaining data and fixes translational and rotational changes of the optical segments induced by long-term thermal drifts of the support structure. Errors are expected to be 10-100 microns at the nodes of the primary backup structure over the course of an orbit. An rms performance of 0.8 microns of wavefront error can be expected during the maintenance function based on specified nominal sensor noises, actuator accuracies, and system environments. A performance of less than 0.3 microns rms can be expected, based on advanced components.
Lau, Kenneth↗
Initial On-Orbit Spatial Resolution Characterization of OrbView-3 Panchromatic Images
Characterization was conducted under the Memorandum of Understanding among Orbital Sciences Corp., ORBIMAGE, Inc., and NASA Applied Sciences Directorate. Acquired five OrbView-3 panchromatic images of the permanent Stennis Space Center edge targets painted on a concrete surface. Each image is available at two processing levels: Georaw and Basic. Georaw is an intermediate image in which individual pixels are aligned by a nominal shift in the along-scan direction to adjust for the staggered layout of the panchromatic detectors along the focal plane array. Georaw images are engineering data and are not delivered to customers. The Basic product includes a cubic interpolation to align the pixels better along the focal plane and to correct for sensor artifacts, such as smile and attitude smoothing. This product retains satellite geometry - no rectification is performed. Processing of the characterized images did not include image sharpening, which is applied by default to OrbView-3 image products delivered by ORBIMAGE to customers. Edge responses were extracted from images of tilted edges in two directions: along-scan and cross-scan. Each edge response was approximated with a superposition of three sigmoidal functions through a nonlinear least-squares curve-fitting. Line Spread Functions (LSF) were derived by differentiation of the analytical approximation. Modulation Transfer Functions (MTF) were obtained after applying the discrete Fourier transform to the LSF.
Blonski, Slawomir↗
SU-E-J-218: Novel Validation Paradigm of MRI to CT Deformation of Prostate
Purpose: Deformable registration algorithms are inherently difficult to characterize in the multi-modality setting due to a significant differences in the characteristics of the different modalities (CT and MRI) as well as tissue deformations. We present a unique paradigm where this is overcome by utilizing a planning-MRI acquired within an hour of the planning-CT serving as a surrogate for quantifying MRI to CT deformation by eliminating the issues of multi-modality comparisons. Methods: For nine subjects, T2 fast-spin-echo images were acquired at two different time points, the first several weeks prior to planning (diagnostic-MRI) and the second on the same day as the planning-CT (planning-MRI). Significant effort in patient positioning and bowel/bladder preparation was undertaken to minimize distortion of the prostate in all datasets. The diagnostic-MRI was rigidly and deformably aligned to the planning-CT utilizing a commercially available deformable registration algorithm synthesized from local registrations. Additionally, the quality of rigid alignment was ranked by an imaging physicist. The distances between corresponding anatomical landmarks on rigid and deformed registrations (diagnostic-MR to planning-CT) were evaluated. Results: It was discovered that in cases where the rigid registration was of acceptable quality the deformable registration didn’t improve the alignment, this was true of all metrics employed. If the analysis is separated into cases where the rigid alignment was ranked as unacceptable the deformable registration significantly improved the alignment, 4.62mm residual error in landmarks as compared to 5.72mm residual error in rigid alignments with a p-value of 0.0008. Conclusion: This paradigm provides an ideal testing ground for MR to CT deformable registration algorithms by allowing for inter-modality comparisons of multi-modality registrations. Consistent positioning, bowel and bladder preparation may Result in higher quality rigid registrations than typically achieved which limits the impact of deformable registrations. In this study cases where significant differences exist, deformable registrations provide significant value.
60 APPLIED LIFE SCIENCES↗
Ocular Screening System
Used to detect eye problems in children through analysis of retinal reflexes, the system incorporates image processing techniques. VISISCREEN's photorefractor is basically a 35 millimeter camera with a telephoto lens and an electronic flash. By making a color photograph, the system can test the human eye for refractive error and obstruction in the cornea or lens. Ocular alignment problems are detected by imaging both eyes simultaneously. Electronic flash sends light into the eyes and the light is reflected from the retina back to the camera lens. Photorefractor analyzes the retinal reflexes generated by the subject's response to the flash and produces an image of the subject's eyes in which the pupils are variously colored. The nature of a defect, where such exists, is identifiable by atrained observer's visual examination.
Source record↗
Self characterization of a coded aperture array for neutron source imaging
The neutron imaging system at the National Ignition Facility (NIF) is an important diagnostic tool for measuring the two-dimensional size and shape of the neutrons produced in the burning deuterium-tritium plasma during the stagnation stage of inertial confinement fusion implosions. Since the neutron source is small (∼100 μm) and neutrons are deeply penetrating (>3 cm) in all materials, the apertures used to achieve the desired 10-μm resolution are 20-cm long, triangular tapers machined in gold foils. These gold foils are stacked to form an array of 20 apertures for pinhole imaging and three apertures for penumbral imaging. These apertures must be precisely aligned to accurately place the field of view of each aperture at the design location, or the location of the field of view for each aperture must be measured. In this paper we present a new technique that has been developed for the measurement and characterization of the precise location of each aperture in the array. We present the detailed algorithms used for this characterization and the results of reconstructed sources from inertial confinement fusion implosion experiments at NIF.
46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗