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NASA NTRS2011

Defining the Relationship Between Biomarkers of Oxidative and Inflammatory Stress and the Risk for Atherosclerosis in Astronauts During and After Long-Duration Spaceflight

Future human space travel will primarily consist of long-duration missions aboard the International Space Station (ISS) or exploration class missions to Mars, its moons, or nearby asteroids. These missions will expose astronauts to increased risk of oxidative and inflammatory damage primarily from radiation, but also from psychological stress, reduced physical activity, diminished nutritional status, and, in the case of extravehicular activity, hyperoxic exposure. There is evidence that increased oxidative damage and inflammation can accelerate the development of atherosclerosis. PURPOSE The purpose of this proposal is to identify biomarkers of oxidative and inflammatory stress and to correlate them to indices of atherosclerosis risk before, during, and after long-duration spaceflight. METHODS To meet the objectives of the study, we will study astronauts before, during, and up to 5 years after long-duration missions aboard ISS. Biomarkers of oxidative and inflammatory stress, some of which we have previously shown to be elevated with spaceflight, will be measured before, during, and after spaceflight. Arterial structure will be monitored using ultrasound to measure carotid intima-medial thickness before, during, and after weightlessness. Carotid intima-medial thickness has been shown to be a better indicator than Framingham Risk scores for prediction of atherosclerosis. Arterial function will be monitored using brachial flow-mediated dilation before flight and after landing. Brachial flow-mediated dilation is a good index of endothelium-dependent vasodilation, which is a sensitive predictor of atherosclerotic risk. This is the first study to propose assessing atherosclerotic risk using biochemical, structural, and functional measures before, during, and immediately after spaceflight and structural functional measures for up to 5 years after landing. EXPECTED RESULTS We hypothesize that these biomarkers of oxidative and inflammatory stress will be increased with spaceflight and will correlate with increased carotid intima-medial thickness in- and postflight and with decreased flow-mediated dilation after the mission. Furthermore, we hypothesize that measures of oxidative stress will return to baseline after flight, but that biomarkers of inflammatory stress and vascular indices of atherosclerosis risk will remain elevated.

Lee, Stuart M. C.↗

NASA NTRS2014

Defining the Relationship between Biomarkers of Oxidative and Inflammatory Stress and the Risk for Atherosclerosis in Astronauts during and after Long-duration Spaceflight

Future human space travel will consist primarily of long-duration missions onboard the International Space Station (ISS) or exploration-class missions to Mars, its moons, or nearby asteroids. These missions will expose astronauts to increased risk of oxidative and inflammatory damage from a variety of sources, including radiation, psychological stress, reduced physical activity, diminished nutritional status, and hyperoxic exposure during extravehicular activity. Evidence exists that increased oxidative damage and inflammation can accelerate the development of atherosclerosis. PURPOSE The purpose of this investigation is to determine whether biomarkers of oxidative and inflammatory stress are elevated during and after long-duration spaceflight and investigate if a relation exists between levels of these biomarkers and structural and functional indices of atherosclerotic risk measured in the carotid and brachial arteries. This is the first study to propose assessing atherosclerotic risk using biochemical, structural, and functional measures before, during, and immediately after spaceflight, and structural and functional measures for up to 5 years after landing. METHODS We will study 12 astronauts before, during, and up to 5 years after long-duration ISS missions. A panel of biomarkers of oxidative and inflammatory stress will be measured twice before flight, early (flight days 15 and 60) and late (2 weeks before landing) during the mission, and early in the postflight recovery phase (approx 3 days after landing). Arterial structure and vascular compliance will be measured at the same times and also at 1, 3, and 5 years after landing (surveillance). Arterial function will be measured using the same preflight, postflight, and surveillance schedule as arterial structure and vascular compliance measures, but will not be measured inflight. Biomarkers, some of which we have previously shown to be elevated with spaceflight, will be measured in venous blood samples and 24-h (in-flight) and 48-h (pre- and post-flight) urine pools. Arterial structure will be assessed from measures of carotid intima-media thickness, which have been shown to be better indicators of atherosclerotic than the Framingham Risk Score. Arterial function will be assessed using brachial flow-mediated dilation, a well-validated measure used to assess endothelium-dependent vasodilation and is a sensitive predictor of atherosclerotic risk. Arterial pulse pressure measured in the brachial artery and stroke volume measured from cardiac ultrasound will be used to assess hemodynamic status, cardiac function, and systemic vascular compliance. Three astronauts are actively participating in the preflight data collection and training activities. One astronaut has completed all preflight activities and will participate in the first in-flight data collection sessions by the end of 2013. The first post-flight data collection sessions will occur in the spring of 2014. EXPECTED RESULTS We hypothesize that biomarkers of oxidative and inflammatory stress will increased with spaceflight and will correlate with increased carotid intima-media thickness during and after flight and with decreased flow-mediated dilation after the mission. Furthermore, we hypothesize that measures of oxidative stress will return to baseline after flight, but biomarkers of inflammatory stress and vascular indices of atherosclerotic risk will remain elevated.

Lee, Stuart M. C.↗

NASA NTRS2015

Advanced Curation: Solving Current and Future Sample Return Problems

Advanced Curation is a wide-ranging and comprehensive research and development effort at NASA Johnson Space Center that identifies and remediates sample related issues. For current collections, Advanced Curation investigates new cleaning, verification, and analytical techniques to assess their suitability for improving curation processes. Specific needs are also assessed for future sample return missions. For each need, a written plan is drawn up to achieve the requirement. The plan draws while upon current Curation practices, input from Curators, the analytical expertise of the Astromaterials Research and Exploration Science (ARES) team, and suitable standards maintained by ISO, IEST, NIST and other institutions. Additionally, new technologies are adopted on the bases of need and availability. Implementation plans are tested using customized trial programs with statistically robust courses of measurement, and are iterated if necessary until an implementable protocol is established. Upcoming and potential NASA missions such as OSIRIS-REx, the Asteroid Retrieval Mission (ARM), sample return missions in the New Frontiers program, and Mars sample return (MSR) all feature new difficulties and specialized sample handling requirements. The Mars 2020 mission in particular poses a suite of challenges since the mission will cache martian samples for possible return to Earth. In anticipation of future MSR, the following problems are among those under investigation: What is the most efficient means to achieve the less than 1.0 ng/sq cm total organic carbon (TOC) cleanliness required for all sample handling hardware? How do we maintain and verify cleanliness at this level? The Mars 2020 Organic Contamination Panel (OCP) predicts that organic carbon, if present, will be present at the "one to tens" of ppb level in martian near-surface samples. The same samples will likely contain wt% perchlorate salts, or approximately 1,000,000x as much perchlorate oxidizer as organic carbon. The chemical kinetics of this reaction are poorly understood at present under the conditions of cached or curated martian samples. Among other parameters, what is the maximum temperature allowed during storage in order to preserve native martian organic compounds for analysis? What is the best means to collect headspace gases from cached martian (and other) samples? This gas will contain not only martian atmosphere but also off-gassed volatiles from the cached solids.

Fries, M.↗

NASA NTRS2015

Asteroid and Lava Tube In Situ Resource Utilization (ISRU) Prospecting Free Flyer Project

This project seeks to develop a small free flyer that can be used to safely and effectively prospect on an Asteroid while being controlled by the crew. This will enable the characterization of the Asteroid for the In Situ Resource Utilization (ISRU). Lava tubes can be explored remotely from the outside Asteroids can contain vast amounts of resources such as water for propellants and metals for feed stocks. Lava Tubes on Mars and the Moon may contain frozen volatile resources. Before the resources can be used, they must be found with a prospecting method. The NASA Agency Asteroid Grand Challenge seeks new ideas for Asteroid retrieval mission technologies for exploration and utilization of asteroids in a Distant Retrograde Orbit (DRO). This project will develop a small free flying platform that can be used to safely and effectively prospect on an Asteroid with limited autonomy while being controlled by the crew. This will enable the characterization of the Asteroid for ISRU. Lava tubes can be explored remotely from the outside as well using this same technology.

Technology Portfolio System↗

NASA NTRS2016

Defining the Relationship Between Biomarkers of Oxidation and Inflammatory Stress and the Risk for Atherosclerosis in Astronauts During and After Long-Duration Spaceflight

Lee, Stuart M. C.↗

NASA NTRS2014

Asteroid, Lunar and Planetary Regolith Management A Layered Engineering Defense

During missions on asteroid and lunar and planetary surfaces, space systems and crew health may be degraded by exposure to dust and dirt. Furthermore, for missions outside the Earth‐Moon system, planetary protection must be considered in efforts to minimize forward and backward contamination. This paper presents an end‐to‐end approach to ensure system reliability, crew health, and planetary protection in regolith environments. It also recommends technology investments that would be required to implement this layered engineering defense.

Wagner, Sandra↗

NASA NTRS2019

Near Earth Asteroid Scout: Exploring Asteroid 1991VG Using A Smallsat

After its deployment from NASA’s Space Launch System (SLS) in 2020, the Near Earth Asteroid (NEA) Scout mission will image an asteroid on a close flyby using an 86m2 solar sail as its primary propulsion. NEA Scout, with a 6U CubeSat form factor, is one of several secondary CubeSat payloads to be deployed from the SLS on its maiden flight. The NEA Scout will be ejected from the SLS on a trajectory toward the moon and will use its onboard cold gas propulsion system to attain an elliptical lunar orbit. Once the spacecraft is in orbit, the solar sail will deploy and spacecraft checkout will begin. The NEA Scout will remain in the lunar vicinity until the low-thrust trajectory to the destination asteroid, 1991VG, or another NEA of interest, can be attained. The spacecraft will then begin its 2.0 – 2.5 year journey to the asteroid. About one month before the asteroid flyby, NEA Scout will search for the target and start its Approach Phase, using a combination of radio tracking and optical navigation. The solar sail will provide continuous low thrust to enable a relatively slow flyby (10-20 m/s) of the target asteroid under lighting conditions favorable to geological imaging (<50 degree phase angle). Once the flyby is complete, and if the system is still fully functioning, an extended mission will be considered – the reconnaissance of another asteroid or a re-flyby of the first asteroid several months later are both options. NEA Scout is funded by the NASA Human Exploration and Operations Mission Directorate.

In-Space Propulsion↗

NASA NTRS2004

Lunar and Planetary Science XXXV: Asteroids, Meteors, Comets

Reports included:Long Term Stability of Mars Trojans; Horseshoe Asteroids and Quasi-satellites in Earth-like Orbits; Effect of Roughness on Visible Reflectance Spectra of Planetary Surface; SUBARU Spectroscopy of Asteroid (832) Karin; Determining Time Scale of Space Weathering; Change of Asteroid Reflectance Spectra by Space Weathering: Pulse Laser Irradiation on Meteorite Samples; Reflectance Spectra of CM2 Chondrite Mighei Irradiated with Pulsed Laser and Implications for Low-Albedo Asteroids and Martian Moons; Meteorite Porosities and Densities: A Review of Trends in the Data; Small Craters in the Inner Solar System: Primaries or Secondaries or Both?; Generation of an Ordinary-Chondrite Regolith by Repetitive Impact; Asteroid Modal Mineralogy Using Hapke Mixing Models: Validation with HED Meteorites; Particle Size Effect in X-Ray Fluorescence at a Large Phase Angle: Importance on Elemental Analysis of Asteroid Eros (433); An Investigation into Solar Wind Depletion of Sulfur in Troilite; Photometric Behaviour Dependent on Solar Phase Angle and Physical Characteristics of Binary Near-Earth-Asteroid (65803) 1996 GT; Spectroscopic Observations of Asteroid 4 Vesta from 1.9 to 3.5 micron: Evidence of Hydrated and/or Hydroxylated Minerals; Multi-Wavelength Observations of Asteroid 2100 Ra-Shalom: Visible, Infrared, and Thermal Spectroscopy Results; New Peculiarities of Cometary Outburst Activity; Preliminary Shape Modeling for the Asteroid (25143) Itokawa, AMICA of Hayabusa Mission; Scientific Capability of MINERVA Rover in Hayabusa Asteroid Mission; Characteristics and Current Status of Near Infrared Spectrometer for Hayabusa Mission; Sampling Strategy and Curation Plan of Hayabusa Asteroid Sample Return Mission; Visible/Near-Infrared Spectral Properties of MUSES C Target Asteroid 25143 Itokawa; Calibration of the NEAR XRS Solar Monitor; Modeling Mosaic Degradation of X-Ray Measurements of 433 Eros by NEAR-Shoemaker; Scattered Light Remediation and Recalibration of near Sheomaker s NIS Global Dataaset at 433 Eros; Evaluation of Preparation and Measuring Techniques for Interplanetary Dust Particles for the MIDAS Experiment on Rosetta; Chiron: a Proposed Remote Sensing Prompt Gamma Ray Activation Analysis Instrument for a Nuclear Powered Prometheus Mission;From Present Surveying to Future Prospecting of the Asteroid Belt; Asteroid Physical Properties Probe Microgravity Testing of a Surface Sampling System for Sample Return from Small Solar System Bodies;and Penetrator Coring Apparatus for Cometary Surfaces.

Source record↗

NASA NTRS2016

Concept of Operations for a Prospective "Proving Ground" in the Lunar Vicinity

NASA is studying conceptual architectures for a "Proving Ground" near the Moon or in high lunar orbit to conduct human space exploration missions that bridge the gap between today's operations with the International Space Station (ISS) and future human exploration of Mars beginning in the 2030s. This paper describes the framework of a concept of operations ("Conops") for candidate activities in the Proving Ground. The Conops discusses broad goals that the Proving Ground might address, such as participation from commercial entities, support for human landings on the Moon, use of mature technologies, and growth of capability through a steady cadence of increasingly ambitious piloted missions. Additional Proving Ground objectives are outlined in a companion paper. Key elements in the Conops include the Orion spacecraft (with mission kits for docking and other specialized operations) and the Space Launch System (SLS) heavy-lift rocket. Potential additions include a new space suit, commercial launch vehicles and logistics carriers, Solar Electric Propulsion (SEP) stages to move elements between different orbits and eventually take them on excursions to deep space, a core module with multiple docking ports, a habitation block, and robotic and piloted lunar landers. The landers might include reusable ascent modules which could remain docked to in-space elements between lunar sorties. A module providing advanced regenerative life support functions could launch to the ISS, and later move to the Proving Ground. The architecture will include infrastructure for launch preparation, communication, mission control, and range safety. The Conops describes notional missions chosen to guide the design of the architecture and its elements. One such mission might be the delivery of a approximately 10-t Transit Habitat element, comanifested with Orion on a Block 1B SLS launcher, to the Proving Ground. In another mission, the architecture might participate in direct human exploration of an asteroidal boulder brought to high lunar orbit by the Asteroid Redirect Mission. The Proving Ground stack could serve as a staging point and tele-operation center for robotic and piloted Moon landings. With the addition of a SEP stage, the architecture could support months-long excursions within and beyond the Earth's sphere of influence, possibly culminating in a year-long mission to land humans on a near-Earth asteroid. In the last case, after returning to near-lunar space, two of the asteroid explorers could join two crewmembers freshly arrived from Earth for a Moon landing, helping to quantify the risk of landing deconditioned crews on Mars. In a conceptual mission particularly stressing to system design, Proving Ground elements could transit to Mars orbit. Other possible design-driving operations include relocation of the stack with no crew on board, the unpiloted journey of the advanced life support module from ISS to the lunar vicinity, excursions to other destinations in near-Earth space, and additional support for Mars exploration in conjunction with the Evolvable Mars Campaign. The Proving Ground Conops concludes with a discussion of aborts and contingency operations

Love, Stanley G.↗

NASA NTRS2014

Habitat Concepts for Deep Space Exploration

Future missions under consideration requiring human habitation beyond the International Space Station (ISS) include deep space habitats in the lunar vicinity to support asteroid retrieval missions, human and robotic lunar missions, satellite servicing, and Mars vehicle servicing missions. Habitat designs are also under consideration for missions beyond the Earth-Moon system, including transfers to near-Earth asteroids and Mars orbital destinations. A variety of habitat layouts have been considered, including those derived from the existing ISS designs and those that could be fabricated from the Space Launch System (SLS) propellant tanks. This paper presents a comparison showing several options for asteroid, lunar, and Mars mission habitats using ISS derived and SLS derived modules and identifies some of the advantages and disadvantages inherent in each. Key findings indicate that the larger SLS diameter modules offer built-in compatibility with the launch vehicle, single launch capability without on-orbit assembly, improved radiation protection, lighter structures per unit volume, and sufficient volume to accommodate consumables for long duration missions without resupply. The information provided with the findings includes mass and volume comparison data that should be helpful to future exploration mission planning efforts.

Smitherman, David↗

NASA NTRS2015

Impact of Utilizing Photos and Deimos as Waypoints for Mars Human Surface Missions

Phobos and Deimos, the moons of Mars, are interesting exploration destinations that offer extensibility of the Asteroid Redirect Mission (ARM) technologies. Solar Electric Propulsion (SEP), asteroid rendezvous and docking, and surface operations can be used to land on and explore the moons of Mars. The close Mars vicinity of Phobos and Deimos warrant examining them as waypoints, or intermediate staging orbits, for Mars surface missions. This paper outlines the analysis performed to determine the mass impact of using the moons of Mars both as an intermediate staging point for exploration as well as for in-situ recourse utilization, namely propellant, to determine if the moons are viable options to include in the broader Mars surface exploration architecture.

Cianciolo, Alicia D.↗

NASA NTRS1987

Application of solar electric propulsion to future planetary missions

Application of solar electric propulsion (SEP) to several near term planetary missions has been investigated and is described in this paper. The missions under consideration include a comet rendezvous-asteroid flyby mission (CRAF), an orbiter mission to Saturn (CASSINI) and a comet nucleus sample return mission (CNSR). Advances in both thruster and solar array technology indicate that these missions could benefit by use of a moderate size solar electric propulsion system. The trajectory scenarios considered in this paper include a solar electric earth gravity assist (SEEGA) mode for all three missions and a SEP rendezvous mode for both the CRAF and CNSR missions. In addition an all SEP propulsion mode and a hybrid SEP-chemical propulsion mode is described for the CNSR mission.

Sauer, Carl G., Jr.↗

NASA NTRS1989

Spectral mineralogy of terrestrial planets - Scanning their surfaces remotely

Information on the surface mineralogy, chemical composition, and lithology of terrestrial planets, as well as on their atmospheres, that can be obtained by earth-based from visible and NIR spectra of light reflected from planetary surfaces is discussed. Such reflectance spectra may have absorption bands in the 1- and 2-micron wavelength regions which originate from crystal field transitions within Fe(2+) ions. Since pyroxenes with Fe(2+) in M2 positions usually dominate the spectra, the resulting 1-micron vs 2-micron spectral determinative curves can be used to identify compositions and structural types of pyroxenes on the surface of a planet or an asteroid. Future spececraft missions to solar system objects will concentrate on remote-sensing experiments using visible and NIR reflectance spectra. These include the Galileo mission to Jupiter; the Mars Orbiter mission to Phoebus; the Comet Rendezvous Asteroid Flyby mission; the Cassini mission to Saturn; the Lunar Geoscience Observer; and the Mars Rover/Sample Return mission.

Burns, Roger G.↗

NASA NTRS2001

Geophysical Exploration of Asteroids: The Deep Interior Mission Concept

We describe a possible international multiple-rendezvous mission to probe the interiors representative near-Earth objects. Features include SEP, autonomous navigation, stereo imaging, radio tomography, anchored seismology stations and explosive signal sources. Additional information is contained in the original extended abstract.

Asphaug, E.↗

NASA NTRS2001