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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 307 records · Page 17
All sourcesNASA NTRSDOE OSTI
NASA NTRS1998

Spread Spectrum Receiver Electromagnetic Interference (EMI) Test Guide

This program consisted of: (1) a study to define appropriate EMI test guidelines and test methods for direct sequence (DS) spread spectrum receivers; and (2) preparation of a written test guide to document the recommended test methods. The scope of this test guide includes: (1) a discussion of generic DS receiver performance characteristics; (2) a summary of S-band TDRSS receiver operation; (3) a discussion of DS receiver EMI susceptibility mechanisms and characteristics; (4) a summary of military standard test guidelines; (5) recommended test approach and methods; and (6) general conclusions and recommendations for future studies in the area of spread spectrum receiver testing.

Wheeler, Mark L.↗
DOE OSTI2022

Pseudouridine synthase 7 is an opportunistic enzyme that binds and modifies substrates with diverse sequences and structures

Pseudouridine (Ψ) is a ubiquitous RNA modification incorporated by pseudouridine synthase (Pus) enzymes into hundreds of noncoding and protein-coding RNA substrates. Here, in this study, we determined the contributions of substrate structure and protein sequence to binding and catalysis by pseudouridine synthase 7 (Pus7), one of the principal messenger RNA (mRNA) modifying enzymes. Pus7 is distinct among the eukaryotic Pus proteins because it modifies a wider variety of substrates and shares limited homology with other Pus family members. We solved the crystal structure of Saccharomyces cerevisiae Pus7, detailing the architecture of the eukaryotic-specific insertions thought to be responsible for the expanded substrate scope of Pus7. Additionally, we identified an insertion domain in the protein that fine-tunes Pus7 activity both in vitro and in cells. These data demonstrate that Pus7 preferentially binds substrates possessing the previously identified UGUAR (R = purine) consensus sequence and that RNA secondary structure is not a strong requirement for Pus7-binding. In contrast, the rate constants and extent of Ψ incorporation are more influenced by RNA structure, with Pus7 modifying UGUAR sequences in less-structured contexts more efficiently both in vitro and in cells. Although less-structured substrates were preferred, Pus7 fully modified every transfer RNA, mRNA, and nonnatural RNA containing the consensus recognition sequence that we tested. Our findings suggest that Pus7 is a promiscuous enzyme and lead us to propose that factors beyond inherent enzyme properties (e.g., enzyme localization, RNA structure, and competition with other RNA-binding proteins) largely dictate Pus7 substrate selection.

59 BASIC BIOLOGICAL SCIENCES↗
DOE OSTI2021

Efficient flexible characterization of quantum processors with nested error models

We present a simple and powerful technique for finding a good error model for a quantum processor. The technique iteratively tests a nested sequence of models against data obtained from the processor, and keeps track of the best-fit model and its wildcard error (a metric of the amount of unmodeled error) at each step. Each best-fit model, along with a quantification of its unmodeled error, constitutes a characterization of the processor. We explain how quantum processor models can be compared with experimental data and to each other. We demonstrate the technique by using it to characterize a simulated noisy two-qubit processor.

71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSIC↗
DOE OSTI2023

Optimizing metaproteomics database construction: lessons from a study of the vaginal microbiome

Metaproteomics, a method for untargeted, high-throughput identification of proteins in complex samples, provides functional information about microbial communities and can tie functions to specific taxa. Metaproteomics often generates less data than other omics techniques, but analytical workflows can be improved to increase usable data in metaproteomic outputs. Identification of peptides in the metaproteomic analysis is performed by comparing mass spectra of sample peptides to a reference database of protein sequences. Although these protein databases are an integral part of the metaproteomic analysis, few studies have explored how database composition impacts peptide identification. Here, we used cervicovaginal lavage (CVL) samples from a study of bacterial vaginosis (BV) to compare the performance of databases built using six different strategies. We evaluated broad versus sample-matched databases, as well as databases populated with proteins translated from metagenomic sequencing of the same samples versus sequences from public repositories. Smaller sample-matched databases performed significantly better, driven by the statistical constraints on large databases. Additionally, large databases attributed up to 34% of significant bacterial hits to taxa absent from the sample, as determined orthogonally by 16S rRNA gene sequencing. We also tested a set of hybrid databases which included bacterial proteins from NCBI RefSeq and translated bacterial genes from the samples. These hybrid databases had the best overall performance, identifying 1,068 unique human and 1,418 unique bacterial proteins, ~30% more than a database populated with proteins from typical vaginal bacteria and fungi. Our findings can help guide the optimal identification of proteins while maintaining statistical power for reaching biological conclusions.

59 BASIC BIOLOGICAL SCIENCES↗
DOE OSTI2025

INFN LASA in-kind contribution to PIP-II

This paper reports the status and recent progress of INFN LASA’s in-kind contribution to the PIP-II project at Fermilab, with updates on key activities and major procurements. Production efforts for the 38 INFN LASA-designed, 5-cell cavities (β=0.61) for the LB650 section of the linac are underway and two pre-series prototypes are being realized as a first step to validate the manufacturing and treatment sequence. Concurrently, preliminary testing on existing prototypes is progressing to gain a deeper understanding of the surface preparation and qualification procedures, including cross-validation at different infrastructures. Series LB650 cavities will be industrially produced and surface-treated to achieve the stringent performance targets, qualified via vertical cold tests at DESY AMTF, and delivered installation-ready for string assembly.

Paparella, Rocco [INFN, Pisa; LASA, Segrate]↗
NASA NTRS1975

The Deep Space Network

The primary objectives during this portion of the extended mission were to assure survival of the spacecraft for a third Mercury encounter through conservation of attitude control gas and to conduct trajectory correction maneuvers (TCMs) as necessary to target the spacecraft for a solar occultation zone pass. Special support activities included TCMs 6 and 7 conducted on October 30, 1974 and on February 12-13, 1975, respectively. This period also saw the DSN interface organization involved in (1) the allocation of sufficient coverage to assure accurate orbit determination solutions, (2) monitoring of DSN implementation for Viking to assure maintenance of compatible interfaces and capabilities required for Mariner 10, and (3) the development of encounter coverage, sequences, and readiness test plans.

Source record↗
NASA NTRS1975

Pseudo-noise test set for communication system evaluation

A test set for communications systems is described which includes a pseudo noise sequence generator providing a test signal that is fed to a pair of signal channels. The first channel includes a spectrum shaping filter and a conditioning amplifier. The second channel includes a variable delay circuit, a spectrum shaping filter matched to the first filter, and an amplifier. The output of the first channel was applied to the system under test. The output of the system and the output of the second channel are compared to determine the degree of distortion suffered by the test signal due to the communications system.

Wallace, G. R.↗
NASA NTRS1978

Pollution Reduction Technology Program for Small Jet Aircraft Engines, Phase 2

A series of iterative combustor pressure rig tests were conducted on two combustor concepts applied to the AiResearch TFE731-2 turbofan engine combustion system for the purpose of optimizing combustor performance and operating characteristics consistant with low emissions. The two concepts were an axial air-assisted airblast fuel injection configuration with variable-geometry air swirlers and a staged premix/prevaporization configuration. The iterative rig testing and modification sequence on both concepts was intended to provide operational compatibility with the engine and determine one concept for further evaluation in a TFE731-2 engine.

Bruce, T. W.↗
NASA NTRS1978

The Array Automated Assembly Task for the Low Cost Solar Array Project, Phase 2

During the program a process sequence was proposed and tested for the fabrication of dendritic welb silicon into solar modules. This sequence was analyzed as to yield and cost and these data suggest that the price goals of 1986 are attainable. Specifically, it was shown that a low cost POCL3 is a suitable replacement for the semiconductor grade, and that a suitable CVD oxide can be deposited from a silane/air mixture using a Silox reactor. A dip coating method was developed for depositing an antireflection coating from a metalorganic precursor. Application of photoresist to define contact grids was made cost effective through use of a dip coating technique. Electroplating of both Ag and Cu was shown feasible and cost effective for producing the conductive metal grids on the solar cells. Laser scribing was used to separate the cells from the dendrites without degradation. Ultrasonic welding methods were shown to be feasible for interconnecting the cells. A study of suitable low cost materials for encapsulation suggest that soda lime glass and phenolic filled board are preferred.

Campbell, R. B.↗
NASA NTRS1984

Finding Open Faults In CMOS Circuits

Algorithm specifies sequence of input test signals and interpretation of resulting output signals for identifying stuck-open faults in complementary metal-oxide semiconductor (CMOS) integrated logic circuits. Incorporated in software for online production testing of CMOS circuits.

Chandramouli, R.↗
NASA NTRS1983

Wrap-rib antenna concept development overview

The wrap rib antenna design of a parabolic reflector large space antenna is discussed. Cost estimates, design/mission compatibility, deployment sequence, ground based tests, and fabrication are discussed.

Woods, A. A., Jr.↗
NASA NTRS1985

Numerical weather prediction in low latitudes

Based on the results of a number of numerical prediction experiments, the differential heating between land and ocean is an important and critical factor for investigation of phenomenon such as the onset of monsoons over the Indian subcontinent. The pre-onset period during the month of May shows a rather persistent flow field in the monsoon region. At low levels the circulation exhibits anticyclonic excursions over the Arabian Sea, flowing essentially parallel to the west coast of India from the north. Over the Indian subcontinent the major feature is a shallow heat low over northern India. As the heat sources commence a rapid northwestward movement toward the southern edge of the Tibetan Plateau, an interesting configuration of the large-scale divergent circulation occurs. A favorable configuration for a rapid exchange of energy from the divergent to the rotational kinetic energy develops. Strong low level monsoonal circulations evolve, attendant with that the onset of monsoon rains occurs. In order to test this observational sequence, a series of short-range numerical prediction experiments were initiated to define the initial heat sources.

Krishnamurti, T. N.↗
NASA NTRS1992

The structure of horizontal-branch models. I - The zero-age horizontal branch

A detailed study of the structure of zero-age horizontal-branch (ZAHB) models is studied in order to show how the hydrostatic structure of these models changes with the input parameters and determines the H-R diagram location of a given model. The properties of composite polytropes on the homology-invariant (U,V)-plane are demonstrated. A variety of test models and sequences were constructed to elucidate the underlying factors that give rise to the wide variation in HB model properties with composition. The roles of the CNO elements as nuclear catalysts and of the envelope sources, as well as the envelope helium abundance are reexamined. It is found that, for stars of a fixed range of mass arriving on the HB, the stellar distribution is determined mainly by CNO for low metallicities (Fe/H of less than about -1), but mainly by opacity sources for high metallicities. The value of Fe/H where CNO ceases to dominate depends significantly on the adopted opacity and will decrease if and when opacity estimates are revised upward.

Dorman, Ben↗
NASA NTRS1993

Adaptive adjustment of a precision truss structure - Experimental validation

Previous analytical studies have shown the feasibility of using a limited number of active members to adaptively alter the structural shape or behavior to other desired states. As a demonstration of this concept, this paper describes the results of a sequence of validation tests, their correlation with the analytical results, and the problems encountered. An existing full scale, space-erectable, high precision truss structure was used. For the most part, the results showed good agreement with the analysis. However, micron level nonlinearities in the structural behavior were discovered. The significance of the presence of these nonlinearities in precision structures and their impact on the basic premise of adaptivity are discussed.

Salama, M.↗
NASA NTRS1993

Design and application of electromechanical actuators for deep space missions

The annual report Design and Application of Electromechanical Actuators for Deep Space Missions is presented. The reporting period is 16 Aug. 1992 to 15 Aug. 1993. However, the primary focus will be work performed since submission of our semi-annual progress report in Feb. 1993. Substantial progress was made. We currently feel confident in providing guidelines for motor and control strategy selection in electromechanical actuators to be used in thrust vector control (TVC) applications. A small portion was presented in the semi-annual report. At this point, we have implemented highly detailed simulations of various motor/drive systems. The primary motor candidates were the brushless dc machine, permanent magnet synchronous machine, and the induction machine. The primary control implementations were pulse width modulation and hysteresis current control. Each of the two control strategies were applied to each of the three motor choices. With either pulse width modulation or hysteresis current control, the induction machine was always vector controlled. A standard test position command sequence for system performance evaluation is defined. Currently, we are gathering all of the necessary data for formal presentation of the results. Briefly stated for TVC application, we feel that the brushless dc machine operating under PWM current control is the best option. Substantial details on the topic, with supporting simulation results, will be provided later, in the form of a technical paper prepared for submission and also in the next progress report with more detail than allowed for paper publication.

Haskew, Tim A.↗
NASA NTRS1993

Multimission high speed spacecraft simulation for the Galileo and Cassini missions

A simulation system has been developed which is capable of bit level simulation of spacecraft data systems. Object oriented techniques and an embedded interpreted language have been employed to produce a highly configurable tool for control and viewing of spacecraft states. Parallel processing computers have been used for running simulations to achieve execution performance of up to ten times real time, which allows for effective utilization of the simulator in testing spacecraft command sequences before they are committed to operation. Elements of simulations can be reused as-is in the construction of new simulators.

Morrissett, Alan↗
NASA NTRS1998

Contrasting actions of pressor agents in severe autonomic failure

BACKGROUND: Orthostatic hypotension is the most disabling symptom of autonomic failure. The choice of a pressor agent is largely empiric, and it would be of great value to define predictors of a response. PATIENTS AND METHODS: In 35 patients with severe orthostatic hypotension due to multiple system atrophy or pure autonomic failure, we determined the effect on seated systolic blood pressure (SBP) of placebo, phenylpropanolamine (12.5 mg and 25 mg), yohimbine (5.4 mg), indomethacin (50 mg), ibuprofen (600 mg), caffeine (250 mg), and methylphenidate (5 mg). In a subgroup of patients, we compared the pressor effect of midodrine (5 mg) with the effect of phenylpropanolamine (12.5 mg). RESULTS: There were no significant differences in the pressor responses between patients with multiple system atrophy or pure autonomic failure. When compared with placebo, the pressor response was significant for phenylpropanolamine, yohimbine, and indomethacin. In a subgroup of patients, we confirmed that this pressor effect of phenylpropanolamine, yohimbine, and indomethacin corresponded to a significant increase in standing SBP. The pressor responses to ibuprofen, caffeine, and methylphenidate were not significantly different from placebo. Phenylpropanolamine and midodrine elicited similar pressor responses. There were no significant associations between drug response and autonomic function testing, postprandial hypotension, or plasma catecholamine levels. CONCLUSIONS: We conclude that significant increases in systolic blood pressure can be obtained in patients with orthostatic hypotension due to primary autonomic failure with phenylpropanolamine in low doses or yohimbine or indomethacin in moderate doses. The response to a pressor agent cannot be predicted by autonomic function testing or plasma catecholamines. Therefore, empiric testing with a sequence of medications, based on the risk of side effects in the individual patient and the probability of a response, is a useful approach.

Clinical Trial↗