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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 325 records · Page 18
All sourcesNASA NTRSDOE OSTI
DOE OSTI2019

Fluorescent Amplification of Next Generation Sequencing Libraries Tools (FA-NGS tools) v1

This is a software utility for calculating pooling volumes and graphing quality control data of next generation sequencing libraries amplified with fluorescent intercalating agents and monitored by real-time quantitative PCR (qPCR). The tool is used to calculate pooling volumes of individual next generation sequencing libraries based on experimentally determined fluorescence values. To do this, fluorescent values are used as a proxy for relative concentration to determine the ratio of transfer volumes. The output is a "transfer file" that specifies the transfer volume and destination well of a given library. The tool can also be used to assess the quality of individual next generation sequencing libraries by melting curve analysis. The output are small-multiples graphs of the melting curves of individual sequencing libraries according to the specified plate layout.

Garber, Megan↗
DOE OSTI2019

Injection laser system for Advanced Radiographic Capability using chirped pulse amplification on the National Ignition Facility

We report on the design, performance, and qualification of the injection laser system designed to deliver joule-level chirped pulse beamlets arranged in dual rectangular beam formats into two main laser amplifier beamlines of the National Ignition Facility. The system is designed to meet the requirements of the Advanced Radiographic Capability upgrade with features that deliver performance, adjustability, and long-term reliability.

47 OTHER INSTRUMENTATION↗
DOE OSTI2019

Methodology for designing grism stretchers for idler-based optical parametric chirped-pulse-amplification systems

Powerful ultrafast lasers with wavelengths above 1 mm are in demand to create attosecond pulses and ultra-intense laser sources. A promising technology to achieve these laser sources uses the by-product from an optical parametric chirped-pulse amplifier, known as the idler. Compression of the idler to high peak powers requires a grism stretcher and a grating compressor. Grism stretchers have many more design parameters than conventional stretchers, complicating the design process. This paper presents a method for designing a grism stretcher and grating compressor that logically navigates the design process. This method was applied to design a grism stretcher for the optical parametric amplifier line that is under construction at the Laboratory for Laser Energetics to produce a 50-mJ, 115-fs pulse at 1170 nm.

47 OTHER INSTRUMENTATION↗
DOE OSTI2025

Amplification of 10 μm picosecond pulses in a compact optically pumped multiatmosphere CO 2 laser

Picosecond pulses, generated by a commercial mid-IR optical parametric source (∼0.5 ps, 1-5 μJ), have been regeneratively amplified to an energy of ≤2 mJ in a palm-size high-pressure CO 2 amplifier optically pumped by a Q-switched 2.8 μm Cr:Er:YSGG laser. The characteristics of the amplified pulses have been studied as a function of seed wavelength centered around 10.3 or 10.6 μm, and the pressure in the gain medium. The measured amplified pulse length is ∼5 ps. Numerical modeling suggests that pulses as short as ∼0.5 ps with multi-GW peak power can be generated in a mixture of CO 2 isotopes. Robustness of the output of a compact CO 2 regenerative amplifier to the seed and pump fluctuations measured at 3 Hz and a perfect Gaussian beam profile indicates the potential of such laser technology for producing high-power ultrashort long-wave infrared pulses at high repetition rates.

43 PARTICLE ACCELERATORS↗
DOE OSTI2025

Yb:Lu 2 O 3 single-crystal fiber: spectroscopy, amplification, and lasing

For the first time, to our knowledge, a lutetium oxide (Lu 2 O 3 ) single-crystal fiber (SCF) laser is demonstrated. The laser heated pedestal growth (LHPG) technique was used to pull Yb-doped Lu 2 O 3 SCFs between 10 and 50 mm long and with diameters between 150 and 225 μm. Spectroscopic properties are first reported in detail, as the two-site nature of the host demands careful attention. Short 10 mm long, unclad fibers were used as amplifier media in a single pass copropagating configuration. Then, a 50 mm long 0.1%Yb:Lu 2 O 3 SCF with a 180 μm diameter was configured to lase by butt-coupling mirrors on the ends and pumping at 976 nm. Lasing occurred at the 1033 nm peak of Yb, and a maximum output of around 300 mW is reported. Finally, the results indicate there is no, at least obvious, fundamental reason that should deter future interest in Lu 2 O 3 as a SCF platform, which has been considered to have high potential for power scaling based on its beneficial intrinsic properties.

47 OTHER INSTRUMENTATION↗