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At least 325 records · Page 18

Influence of High Aspect Ratio Vessel Cell Culture on TNF-Alpha, Insulin Secretion and Glucose Homeostasis in Pancreatic Islets of Langerhans from Wistar Furth Rats

The present studies were carried out to determine the influence of a ground based microgravity paradigm, utilizing the High Aspect Ratio Vessel (HARV) cell culture upon lipopolysaccharide (LPS) stimulated tumor necrosis factor alpha (TNF-alpha) production of pancreatic islets of Langerhans. An additional aim was to elucidate alterations in insulin secretion and glucose utilization using the HARV low shear, gravity averaged vector, cell culture technique. Islets were isolated (1726 +/- 117, 150 micron islet equivalent units) from Wistar Furth rats and assigned to four treatment groups: 1) HARV, 2) HARV plus LPS, 3) static culture, 4) static culture plus LPS. Following 48 hours of culture, insulin concentration was increased in both HARV and static cultures (p<0.05). Islet medium from HARV and static cultures were assayed for TNF-alpha (L929 cytotoxicity assay) and was measured at selected time points for 48 hours. TNF-alpha was significantly increased in LPS-induced HARV and static cultures, yet the increase was more pronounced in the static culture group (p<0.05). This is a novel observation and indicates that TNF producing cells are present in islets and that LPS stimulates TNF secretion in isolated islets. A decrease in insulin concentration was demonstrated in the islet medium of the LPS stimulated HARV culture (p<0.05). That TNF-alpha is associated with a decreased insulin secretion is intriguing, both as it relates to in-flight investigations, and as it may provide insight into the pathophysiology of Type I and Type 11 diabetes. Glucose concentration in islet medium was lesser throughout the experiment in static cultures, suggesting a decreased reliance upon glucose as a metabolic substrate in the islets cultured in HARVS. In conclusion, the present studies demonstrate alterations in LPS induced TNF-alpha production of pancreatic islets of Langerhans, favoring a lesser TNF production in the microgravity HARV paradigm. Additionally, alterations in fuel homeostasis may be promulgated by HARV culture. The clinical and physiological significance of these observations remains to be determined.

Tobin, Brian W.a↗

Comparison of analytical and experimental subsonic steady and unsteady pressure distributions for a high-aspect-ratio-supercritical wing model with oscillating control surfaces

The results of a comparative study using the unsteady aerodynamic lifting surface theory, known as the Doublet Lattice method, and experimental subsonic steady- and unsteady-pressure measurements, are presented for a high-aspect-ratio supercritical wing model. Comparisons of pressure distributions due to wing angle of attack and control-surface deflections were made. In general, good correlation existed between experimental and theoretical data over most of the wing planform. The more significant deviations found between experimental and theoretical data were in the vicinity of control surfaces for both static and oscillatory control-surface deflections.

Mccain, W. E.↗

Investigation at Low Speeds of Deflectors and Spoilers as Gust Alleviators on a Model of the Bell X-5 Airplane with 35 Degree Swept Wings and on a High-aspect-ratio 35 Degree Swept-wing-fuselage Model

Results of an investigation at low speeds to determine the gust-alleviation capabilities (reduction in lift-curve slope) of spoilers and deflectors on a 35 degree swept-wing model of high aspect ratio and on a 1/4-scale model of the X-5 airplane with 35 degree swept wings indicate that deflector and spoiler-deflector types of controls can be designed to provide considerable gust alleviation for a swept-wing airplane while still maintaining stability and control.

CONTROLS, SPOILER - COMPLETE WINGS↗

Supersonic Aerodynamic Characteristics of a Low-Drag Aircraft Configuration having an Arrow Wing of Aspect Ratio 1.86 and a Body of Fineness Ratio 20

A free-flight rocket-propelled-model investigation was conducted at Mach numbers of 1.2 to 1.9 to determine the longitudinal and lateral aero-dynamic characteristics of a low-drag aircraft configuration. The model consisted of an aspect-ratio -1.86 arrow wing with 67.5 deg. leading-edge sweep and NACA 65A004 airfoil section and a triangular vertical tail with 60 deg. sweep and NACA 65A003 section in combination with a body of fineness ratio 20. Aerodynamic data in pitch, yaw, and roll were obtained from transient motions induced by small pulse rockets firing at intervals in the pitch and yaw directions. From the results of this brief aerodynamic investigation, it is observed that very slender body shapes can provide increased volumetric capacity with little or no increase in zero-lift drag and that body fineness ratios of the order of 20 should be considered in the design of long-range supersonic aircraft. The zero-lift drag and the drag-due-to-lift parameter of the test configuration varied linearly with Mach number. The maximum lift-drag ratio was 7.0 at a Mach number of 1.25 and decreased slightly to a value of 6.6 at a Mach number of 1.81. The optimum lift coefficient, normal-force-curve slope, lateral-force-curve slope, static stability in pitch and yaw, time to damp to one-half amplitude in pitch and yaw, the sum of the rotary damping derivatives in pitch and also in yaw, and the static rolling derivatives all decreased with an increase in Mach number. Values of certain rolling derivatives were obtained by application of the least-squares method to the differential equation of rolling motion. A comparison of the experimental and calculated total rolling-moment-coefficient variation during transient oscillations of the model indicated good agreement when the damping-in-roll contribution was included with the static rolling-moment terms.

Gillespie, Warren, Jr.↗

Low-Subsonic Static Stability and Damping Derivatives at Angles of Attack From 0 deg to 90 deg for a Model with a Low-Aspect-Ratio Unswept Wing and Two Different Fuselage Forebodies

An investigation has been made in the Langley free-flight tunnel at low-subsonic speed to determine the static stability, control effectiveness, and damping in roll and yaw of a model with a low-aspect-ratio unswept wing and two different fuselage forebodies at angles of attack from 0 deg to 90 deg. Results were obtained with a fuselage configuration having a long pointed nose and a shorter rounded nose. Although the wing stalled at an angle of attack of about 12 deg, maximum lift did not occur until an angle of attack of about 40 deg or 50 deg was obtained. The static longitudinal stability of the model having a short rounded nose was greater than that of the model having a longer pointed nose over the entire angle-of-attack range. The pointed-nose model had large out-of-trim yawing moments above an angle of attack of about 40 deg. Shortening and rounding the nose of the model delayed these out-of-trim yawing moments to slightly higher angles of attack. Both models were directionally unstable above an angle of attack of about 20 deg, but both had positive effective dihedral over virtually the entire angle-of-attack range. At the higher angles of attack the pointed-nose model had generally better damping in roll than that of the rounded-nose model. Both models had very high damping in yaw at an angle of attack of about 50 deg or 60 deg.

Boisseau, Peter C.↗

Transonic Aerodynamic Characteristics of a Wing-Body Combination having a 52.5 deg Sweptback Wing of Aspect Ratio 3 with Conical Camber and Designed for a Mach Number of the Square Root of 2

An investigation has been made of the effects of conical wing camber and supersonic body indentation on the aerodynamic characteristics of a wing-body configuration at transonic speeds. Wing aspect ratio was 3.0, taper ratio was 0.1, and quarter-chord line sweepback was 52.5 deg with airfoil sections of 0.03 thickness ratio. The tests were conducted in the Langley 16-foot transonic tunnel at various Mach numbers from 0.80 to 1.05 at angles of attack from -4 deg to 14 deg. The cambered-wing configuration achieved higher lift-drag ratios than a similar plane-wing configuration. The camber also reduced the effects of wing-tip flow separation on the aerodynamic characteristics. In general, no stability or trim changes below wing-tip flow separation resulted from the use of camber. The use of supersonic body indentation improved the lift-drag ratios at Mach numbers from 0.96 to 1.05.

Igoe, William B.↗

Low-speed wind-tunnel investigation of forward-located spoilers and trailing splines as trailing-vortex hazard-alleviation devices on an aspect-ratio-8 wing model

An investigation was made in the Langley V/STOL tunnel in order to determine, by the trailing-wing sensor technique, the effectiveness of either a forward-mounted spoiler or a tip-mounted spline as trailing-vortex attenuation devices on an unswept aspect-ratio-8 wing model. The trailing-wing rolling-moment data taken in the tunnel diffuser section show good agreement with the data taken in the tunnel test section. This agreement indicates that reasonable results may be obtained in the Langley V/STOL tunnel in experimental investigations of the trailing-vortex hazard at relatively great distances behind aircraft models.

Croom, D. R.↗

Large-Scale Wind-Tunnel Tests of an Airplane Model with an Unswept, Aspect-Ratio-10 Wing, Two Propellers, and Blowing Flaps

An investigation was made to determine the lifting effectiveness and flow requirements of blowing over the trailing-edge flaps and ailerons on a large-scale model of a twin-engine, propeller-driven airplane having a high-aspect-ratio, thick, straight wing. With sufficient blowing jet momentum to prevent flow separation on the flap, the lift increment increased for flap deflections up to 80 deg (the maximum tested). This lift increment also increased with increasing propeller thrust coefficient. The blowing jet momentum coefficient required for attached flow on the flaps was not significantly affected by thrust coefficient, angle of attack, or blowing nozzle height.

Griffin, Roy N., Jr.↗

Transonic Flutter Characteristics of an Aspect-Ratio-4, 45 deg. Sweptback, Taper-Ratio-0.2 Plan Form

The results of several flutter investigations to determine the effects of plan-form variations on the flutter characteristics of thin cantilevered wings at transonic Mach numbers have been reported previously. In the present investigation the data are extended to include a wing having an aspect ratio of 4, 45 of sweepback, and a taper ratio of 0.2. The data were obtained in the Langley transonic blowdown tunnel over a Mach number range from 0.6 to 1.4. The experimental results indicate an abrupt and rather large increase in both a flutter-speed parameter and a flutter-frequency parameter as the Mach number is increased from 1.05 to 1.10. The foregoing is interpreted as indicating a marked change in the flutter mode. Calculated flutter speeds, based on incompressible-flow aerodynamic coefficients, were too high by 20 percent or more throughout the subsonic Mach number range of the investigation. Calculated flutter frequencies were about 7 percent too high at a Mach number of 0.65 and were about 20 percent too high at a Mach number of 0.9. No significant independent effects of thickness were indicated for the plan form investigated as the thickness was changed from 3 to 4 percent chord.

Unangst, John R.↗

Circular-to-rectangular transition ducts for high-aspect ratio nonaxisymmetric nozzles

The next generation fighter aircraft will be equipped with nonaxisymmetric multifunction jet engine exhaust systems. The circular-to-rectangular transition duct employed in these systems has been made longer with the objective to maintain uniform flow. The weight of the exhaust system increases with increasing nozzle aspect ratio. The new design is to provide enhanced maneuvering and STOL performance. It is attempted to reduce the increase in weight as much as possible by new design strategies. The present paper has the objective to show through experimental data that the current design guidelines for transition ducts can be expanded so that shorter transitions are possible thereby reducing the nonaxisymmetric exhaust system weight penalty.

Burley, J. R., II↗

Static Footprint Local Forces, Areas, and Aspect Ratios for Three Type 7 Aircraft Tires

The National Tire Modeling Program (NTMP) is a joint NASA/industry effort to improve the understanding of tire mechanics and develop accurate analytical design tools. This effort includes fundamental analytical and experimental research on the structural mechanics of tires. Footprint local forces, areas, and aspect ratios were measured. Local footprint forces in the vertical, lateral, and drag directions were measured with a special footprint force transducer. Measurements of the local forces in the footprint were obtained by positioning the transducer at specified locations within the footprint and externally loading the tires. Three tires were tested: (1) one representative of those used on the main landing gear of B-737 and DC-9 commercial transport airplanes, (2) a nose landing gear tire for the Space Shuttle Orbiter, and (3) a main landing gear tire for the Space Shuttle Orbiter. Data obtained for various inflation pressures and vertical loads are presented for two aircraft tires. The results are presented in graphical and tabulated forms.

Howell, William E.↗

Low-speed aerodynamic performance of an aspect-ratio-10 supercritical-wing transport model equipped with a full-span slat and part-span and full-span double-slotted flaps

An investigation was conducted in the Langley 4 by 7 Meter Tunnel to determine the static longitudinal and lateral directional aerodynamic characteristics of an advanced aspect ratio 10 supercritical wing transport model equipped with a full span leading edge slat as well as part span and full span trailing edge flaps. This wide body transport model was also equipped with spoiler and aileron roll control surfaces, flow through nacelles, landing gear, and movable horizontal tails. Six basic wing configurations were tested: (1) cruise (slats and flaps nested), (2) climb (slats deflected and flaps nested), (3) part span flap, (4) full span flap, (5) full span flap with low speed ailerons, and (6) full span flap with high speed ailerons. Each of the four flapped wing configurations was tested with leading edge slat and trailing edge flaps deflected to settings representative of both take off and landing conditions. Tests were conducted at free stream conditions corresponding to Reynolds number of 0.97 to 1.63 x 10 to the 6th power and corresponding Mach numbers of 0.12 to 0.20, through an angle of attack range of 4 to 24, and a sideslip angle range of -10 deg to 5 deg. The part and full span wing configurations were also tested in ground proximity.

Morgan, H. L., Jr.↗

Boundary-layer measurements on a transonic low-aspect ratio wing

Tabulations and plots are presented of boundary-layer velocity and flow-direction surveys from wind-tunnel tests of a large-scale (0.90 m semi-span) model of the NASA/Lockheed Wing C. This wing is a generic, transonic, supercritical, highly three-dimensional, low-aspect-ratio configuration designed with the use of a three-dimensional, transonic full-potential-flow wing code (FLO22). Tests were conducted at the design angle of attack of 5 deg over a Mach number range from 0.25 to 0.96 and a Reynolds number range of 3.4x10 to the 6th power. Wing pressures were measured at five span stations, and boundary-layer surveys were measured at the midspan station. The data are presented without analysis.

Keener, Earl R.↗

Investigation of the Effects of Leading-edge Chord-extensions and Fences in Combination with Leading-edge Flaps on the Aerodynamic Characteristics at Mach Numbers from 0.40 to 0.93 of a 45 Degree Sweptback Wing of Aspect Ratio 4

This investigation was made to determine the effects of 6 degree full-spoan and 3 degree partial-span leading-edge flaps in combination with chord-extensions or fences on the aerodynamic characteristics of a wing-fuselage configuration with a 45 degree sweptback wing of aspect ratio 4, taper ratio 0.3, and NACA 65A006 airfoil sections. The investigation was made in the Langley high-speed 7- by 10-foot tunnel over a Mach number range of 0.40 to 0.93 and an angle-of-attack range of about -2 degrees to 24 degrees. Lift, drag, and pitching-moment data were obtained for all configurations. From overall considerations of stability and performance it appears that with the model of this investigation the 6 degree full-span leading-edge flaps in combination with the chord-extension over the outboard 35 percent of the span, with or without leading-edge camber, would be the most desirable configuration.

Spreeman, Kenneth P↗

Aerodynamic Characteristics of Missile Configurations with Wings of Low Aspect Ratio for Various Combinations of Forebodies, Afterbodies, and Nose Shapes for Combined Angles of Attack and Sideslip at a Mach Number of 2.01

An investigation has been made in the Langley 4-by-4-foot supersonic pressure tunnel to determine the aerodynamic characteristics of a series of missile configurations having low-aspect-ratio wings at a Mach number of 2.01. The effects of wing plan form and size, length-diameter ratio, forebody and afterbody length, boattailed and flared afterbodies, and component force and moment data are presented for combined angles of attack and sideslip to about 28 degrees. No analysis of the data was made in this report.

Robinson, Ross B↗

Simplified lifting-surface theory for flaps on wings of low and moderate aspect ratios

A modification of the simplified lifting-surface theory for wings with deflected flaps is presented and evaluated. The modification is simple and straightforward in application, and is shown to overcome the deficiency in the theory that results in an underestimation of flap lift effectiveness for wings that have low or moderate aspect ratios.

Wick, B. H.↗

Low-speed tests of a high-aspect-ratio, supercritical-wing transport model equipped with a high-lift flap system in the Langley 4- by 7-meter and Ames 12-foot pressure tunnels

The Ames 12-Foot Pressure Tunnel was used to determine the effects of Reynolds number on the static longitudinal aerodynamic characteristics of an advanced, high-aspect-ratio, supercritical wing transport model equipped with a full span, leading edge slat and part span, double slotted, trailing edge flaps. The model had a wing span of 7.5 ft and was tested through a free stream Reynolds number range from 1.3 to 6.0 x 10 to 6th power per foot at a Mach number of 0.20. Prior to the Ames tests, an investigation was also conducted in the Langley 4 by 7 Meter Tunnel at a Reynolds number of 1.3 x 10 to 6th power per foot with the model mounted on an Ames strut support system and on the Langley sting support system to determine strut interference corrections. The data obtained from the Langley tests were also used to compare the aerodynamic charactertistics of the rather stiff, 7.5-ft-span steel wing model tested during this investigation and the larger, and rather flexible, 12-ft-span aluminum-wing model tested during a previous investigation. During the tests in both the Langley and Ames tunnels, the model was tested with six basic wing configurations: (1) cruise; (2) climb (slats only extended); (3) 15 deg take-off flaps; (4) 30 deg take-off flaps; (5) 45 deg landing flaps; and (6) 60 deg landing flaps.

Morgan, H. L., Jr.↗

Computational study of a conical wing having unit aspect ratio at supersonic speeds

A study was conducted to identify and assess a computational method as a preliminary analysis and design tool for advanced military aircraft designs. The method of choice for this study was the Euler Marching Technique for Accurate Computation (EMTAC). Computational and experimental results were compared for a thick unit aspect ratio delta wing at Mach 2.8 and 4.0. This geometry along with the associated flow physics is representative of advanced aircraft designs. The comparisons of the lift and drag coefficients show that the computations agree with experimentally obtained data at Mach 2.8 and 4.0. Further, comparison between EMTAC and experiment shows that the computations accurately predict the overall shape and levels of the surface pressure distributions at Mach 2.8 and 4.0. Qualitative assessment of the computed flow-field properties shows that EMTAC captures the basic flow-field characteristics representative of advanced aircraft designs. The study further suggests that EMTAC can be successfully used in the preliminary analysis and design of advanced military aircraft.

Mcgrath, Brian E.↗