Goddard '63' a year in review at goddard spaceflight center
Review of 1963 at goddard space flight center - chronological index
CHRONOLOGY↗
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Goddard 1965 - A Year in Review at Goddard Space Flight Center National Aeronautics and Space Administration
Chronological data on satellite launchings and accomplishments of 1965
HISTORY↗
Successful cognitive aging is associated with thicker anterior cingulate cortex and lower tau deposition compared to typical aging
INTRODUCTION There is no consensus on either the definition of successful cognitive aging (SA) or the underlying neural mechanisms. METHODS We examined the agreement between new and existing definitions using: (1) a novel measure, the cognitive age gap (SA-CAG, cognitive-predicted age minus chronological age), (2) composite scores for episodic memory (SA-EM), (3) non-memory cognition (SA-NM), and (4) the California Verbal Learning Test (SA-CVLT). RESULTS Fair to moderate strength of agreement was found between the four definitions. Most SA groups showed greater cortical thickness compared to typical aging (TA), especially in the anterior cingulate and midcingulate cortices and medial temporal lobes. Greater hippocampal volume was found in all SA groups except SA-NM. Lower entorhinal 18 F-Flortaucipir (FTP) uptake was found in all SA groups. DISCUSSION These findings suggest that a feature of SA, regardless of its exact definition, is resistance to tau pathology and preserved cortical integrity, especially in the anterior cingulate and midcingulate cortices. Highlights: Different approaches have been used to define successful cognitive aging (SA). Regardless of definition, different SA groups have similar brain features. SA individuals have greater anterior cingulate thickness and hippocampal volume. Lower entorhinal tau deposition, but not amyloid beta is related to SA. A combination of cortical integrity and resistance to tau may be features of SA.
60 APPLIED LIFE SCIENCES↗
Cognitive aging outcomes are related to both tau pathology and maintenance of cingulate cortex structure
Abstract INTRODUCTION Successful cognitive aging is related to both maintaining brain structure and avoiding Alzheimer's disease (AD) pathology, but how these factors interplay is unclear. METHODS A total of 109 cognitively normal older adults (70+ years old) underwent amyloid beta (Aβ) and tau positron emission tomography (PET) imaging, structural magnetic resonance imaging (MRI), and cognitive testing. Cognitive aging was quantified using the cognitive age gap (CAG), subtracting chronological age from predicted cognitive age. RESULTS Lower CAG (younger cognitive age) was related to slower decline in episodic memory, multi‐domain cognition, and atrophy of the midcingulate cortex (MCC). Lower entorhinal cortical tau was linked to slower decline in episodic memory, multi‐domain cognition, and hippocampal atrophy. DISCUSSION These results suggest that aging outcomes may be influenced by two independent pathways: one associated with tau accumulation, affecting primarily memory and hippocampal atrophy, and another involving tau‐independent structural preservation of the MCC, benefiting multi‐domain cognition over time. Highlights Younger cognitive age (lower cognitive age gap [CAG]) is related to slower cognitive decline. Lower CAG is linked to slower midcingulate cortex (MCC) atrophy. Reduced tau in the entorhinal cortex is related to less hippocampal atrophy and cognitive decline. Structural preservation of the MCC benefits multi‐domain cognition over time. Two independent pathways influence cognitive aging: tau accumulation and MCC preservation.
Neurosciences & Neurology↗
Influence of weather on gobbling activity of male wild turkeys
Gobbling activity of Eastern wild turkeys (Meleagris gallopavo silvestris; hereafter, turkeys) has been widely studied, focusing on drivers of daily variation. Weather variables are widely believed to influence gobbling activity, but results across studies are contradictory and often equivocal, leading to uncertainty in the relative contribution of weather variables to daily fluctuations in gobbling activity. Previous works relied on road-based auditory surveys to collect gobbling data, which limits data consistency, duration, and quantity due to logistical difficulties associated with human observers and restricted sampling frames. Development of new methods using autonomous recording units (ARUs) allows researchers to collect continuous data in more locations for longer periods of time, providing the opportunity to delve into factors influencing daily gobbling activity. We used ARUs from 1 March to 31 May to detail gobbling activity across multiple study sites in the southeastern United States during 2014–2018. We used state-space modeling to investigate the effects of weather variables on daily gobbling activity. Our findings suggest rainfall, greater wind speeds, and greater temperatures negatively affected gobbling activity, whereas increasing barometric pressure positively affected gobbling activity. Therefore, when using daily gobbling activity to make inferences relative to gobbling chronology, reproductive phenology, and hunting season frameworks, stakeholders should recognize and consider the potential influences of extended periods of inclement weather.
60 APPLIED LIFE SCIENCES↗
Human–mouse comparison of the multistage nature of radiation carcinogenesis in a mathematical model
Abstract Mouse models are vital for assessing risk from environmental carcinogens, including ionizing radiation, yet the interspecies difference in the dose response precludes direct application of experimental evidence to humans. Herein, we take a mathematical approach to delineate the mechanism underlying the human–mouse difference in radiation‐related cancer risk. We used a multistage carcinogenesis model assuming a mutational action of radiation to analyze previous data on cancer mortality in the Japanese atomic bomb survivors and in lifespan mouse experiments. Theoretically, the model predicted that exposure will chronologically shift the age‐related increase in cancer risk forward by a period corresponding to the time in which the spontaneous mutational process generates the same mutational burden as that the exposure generates. This model appropriately fitted both human and mouse data and suggested a linear dose response for the time shift. The effect per dose decreased with increasing age at exposure similarly between humans and mice on a per‐lifespan basis (0.72‐ and 0.71‐fold, respectively, for every tenth lifetime). The time shift per dose was larger by two orders of magnitude in humans (7.8 and 0.046 years per Gy for humans and mice, respectively, when exposed at ~35% of their lifetime). The difference was mostly explained by the two orders of magnitude difference in spontaneous somatic mutation rates between the species plus the species‐independent radiation‐induced mutation rate. Thus, the findings delineate the mechanism underlying the interspecies difference in radiation‐associated cancer mortality and may lead to the use of experimental evidence for risk prediction in humans.
Oncology↗
Wrong signs are alright
It has been shown that some Lorentz-invariant quantum field theories, such as those with higher-dimensional operators with negative coefficients, lead to superluminality on some classical backgrounds. While superluminality by itself is not logically inconsistent, these theories also predict the formation of closed time-like curves at the classical level, starting from initial conditions without such curves. This leads to the formation of a Cauchy Horizon which prevents a complete description of the time evolution of such systems. Inspired by the chronology protection arguments of General Relativity, we show that quantum mechanical effects from low energy quanta strongly backreact on such configurations, exciting unknown short-distance degrees of freedom and invalidating the classical predictions. Thus, there is no obvious low-energy obstruction to the existence of these operators.
72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗
The age and potential causes of the giant Green Lake Landslide, Fiordland, New Zealand
Abstract Landslide deposits preserved in the geological record afford opportunities to better inform hillslope and seismic hazard and risk models, particularly in regions where observational records are short. In the Southern Alps of New Zealand, small coseismic landslides are frequent, but the geological record preserves several instances of more substantial (> 1 km 3 ) but infrequent mass failures. With an estimated volume of 27 km 3 , the giant Green Lake Landslide represents one of the largest subaerial landslides on Earth. Previous work has suggested this deep-seated mass movement was most likely triggered by high-intensity seismic shaking, but that local structural weakness and/or glacial debuttressing may help to explain the anomalously large failure volume. Resolving the potential contribution of the latter is important given predictions concerning alpine deglaciation in the coming decades to centuries. Key to resolution are secure chronologies of landslide emplacement and past glacier change. Here we present in situ cosmogenic 10 Be exposure ages from the Green Lake Landslide that suggest an emplacement age of 15.5 ± 0.7 ka. Recent work shows that glacial retreat in the region was underway by 19 ka, indicating that the Green Lake Landslide was emplaced 3–4 kyr after the onset of glacier retreat. Given the geometry of the former confining valley glacier, we expect that the deglaciation-landslide age gap is closer to the upper end of this estimate. If correct, this conclusion places greater weight on the roles of local geological structure and/or a great earthquake as factors contributing to the exceptionally large volume of this event.
58 GEOSCIENCES↗
Drought-induced decoupling between carbon uptake and tree growth impacts forest carbon turnover time
The ability of forests to withstand, and recover from, acute drought stress is a critical uncertainty regarding the impacts of climate change on the terrestrial carbon (C) cycle, but it is unclear how drought responses scale from individual trees to whole forests. Here, we assembled a dataset of tree-ring chronologies co-located within the footprint of eddy covariance towers across North America and Europe, with the aim of quantifying the sensitivity of tree radial growth versus gross primary productivity (GPP) during and following drought. We found that drought induced a large decoupling across C cycle processes, whereby GPP was relatively resistant to water stress despite large reductions in tree-ring widths. This decoupling also occurred in the year following drought (i.e., a ‘drought legacy effect’), and was similar in magnitude in response to both summer and winter droughts. By modeling whole-forest C turnover time, we show that a radial growth-GPP decoupling has important ramifications for the forest C cycle, especially if the C not used to support radial growth is instead allocated towards pools with short residence times. Furthermore, our results demonstrate that quantifications of drought impacts that rely solely on C uptake are missing this fundamental pathway through which drought alters the forest C cycle and the resulting feedbacks to the climate system.
54 ENVIRONMENTAL SCIENCES↗
Can Wholesale Electricity Markets Achieve Resource Adequacy and High Clean Energy Generation Targets in the Presence of Self-Interested Actors?
Wholesale electricity markets are intended to incentivize system generation investments and operations outcomes that meet evolving system needs. In this work, we evaluate the effectiveness of wholesale market structures, rules and policies in achieving system resource adequacy (RA) and clean energy targets in the presence of self-interested generation investors using the Electricity Markets and Investment Suite Agent-based Simulation (EMIS-AS) model. Results highlight that both capacity markets and operating reserve demand curves (ORDCs) can help achieve a reliable system but with different RA compliance timelines and distribution of generation technologies. Structures with capacity markets tend to favor more capital-intensive peaking technologies while reducing wind and solar build-outs due to suppressed energy and clean energy market prices, particularly in the absence of strong clean energy targets. Conversely, ORDCs improve the commitment of available generation units, but this comes at the expense of higher system costs and renewable generation curtailment. We also find that well-calibrated static capacity demand curves can yield similar reliability and total cost compared to capacity market demand curves informed dynamically by resource adequacy while also yielding stable annual capacity prices. Different approaches to formulating ORDC curves can also yield key trade-offs, namely that a more efficient treatment of storage chronology results in lower ORDC curves and prices, yielding less investment and cost but at the expense of reliability. Finally, the effectiveness of wholesale electricity markets in practically achieving very high clean energy generation targets highly depends on the cost-competitiveness of clean energy technologies that can support critical balancing needs across multiple timescales.
capacity expansion↗
The timing of lunar solidification and mantle overturn recorded in ferroan anorthosite 62237
Ferroan anorthosite suite (FAS) rocks are widely interpreted to represent primordial lunar crust. Despite their importance in pinpointing the timing of lunar crust formation, robust chronological investigations for this rock type are scarce. Here, we report the Ar-Ar, Rb-Sr, and Sm-Nd isotopic systematics for the FAS troctolitic anorthosite 62237. The Ar-Ar isotopic system has been reset by a thermal event at 3710 ± 48 Ma, and the Rb-Sr isotopic systematics has been disturbed such that a Rb-Sr isochron age cannot be determined. However, an internal isochron for the Sm-Nd isotopic system has yielded an age of 4350 ± 73 Ma (MSWD = 2.0) with an initial ε 143 Nd CHUR of -0.53 ± 0.26. The mineral and whole-rock fractions of 62237 plot on the same internal isochron as FAS sample 60025. The combined datasets define an age of 4372 ± 35 Ma (MSWD = 4.0) with an initial ε 143 Nd CHUR of -0.17 ± 0.22. Literature Sm-Nd data for FAS and Mg-suite whole-rocks also plot on the 60025-62237 isochron. The coherence of data from both FAS and Mg-suite rocks examined thus far suggests that both rock suites formed contemporaneously from identical, or nearly identical, sources. In addition, the concordance of FAS and Mg-suite ages suggests that primordial crust solidification either involved both magmatic suites, or that Mg-suite magmatism was contemporaneous with FAS magmatism within resolution of the Sm-Nd chronometer. The ages for FAS and Mg-suite also coincide with the formation ages of the mare basalt source regions and urKREEP. Ferroan anorthosite suite rocks and urKREEP are thought to represent primordial LMO solidification products, whereas Mg-suite and the mare basalt source regions are argued to represent mixtures of various LMO crystallization products that were formed during density-driven overturn of the LMO. The concordance of ages implies that the 4372 ± 35 Ma Sm-Nd isochron records the age of mantle overturn, and that overturn occurred during, or shortly after, solidification of the LMO.
58 GEOSCIENCES↗
Tungsten and molybdenum isotopic evidence for an impact origin of pallasites
The origin of pallasites—stony-iron meteorites mainly composed of olivine and Fe-Ni metal—is debated and proposed formation scenarios broadly range from models that explain pallasite formation by internal processes in the mantle of a differentiated planetesimal to those that involve impact–induced mixing of core and mantle materials. Here, the origin of pallasites is examined by studying the nebular source regions of their precursor material using Mo isotopes and their history of metal-silicate segregation using Hf-W chronometry. We report new Mo and W isotopic data for a large suite of pallasite metal samples, alongside Pt isotope data to quantify superimposed cosmic ray exposure effects. Most main-group pallasites exhibit uniform pre-exposure 182 W and Mo isotopic compositions that bear an excellent similarity to those of IIIAB iron meteorites. Four main-group pallasites and the IIIAB iron Thunda have more radiogenic pre-exposure 182 W compositions, but display the same Mo isotopic composition as other main-group pallasites and IIIAB irons. This strong chronological and genetic link strongly suggests that main-group pallasite metal originated in the IIIAB parent body core. This, combined with prior Pd-Ag chronometric evidence for an early collisional disruption of the IIIAB parent body, implies that main-group pallasites formed by impact–induced mixing of metal and silicates rather than by an internal process on the IIIAB parent body. This mixing led to elevated 182 W compositions in some pallasites, which are best accounted for by partial re-equilibration of IIIAB metal with radiogenic 182 W from the colliding body. Altogether, our results support models that explain main-group pallasite formation by injection of pallasite metal into the mantle of another differentiated body, implying that pallasite silicates did not primarily derive from the IIIAB mantle, but instead from that of the colliding body.
58 GEOSCIENCES↗
The importance of capturing power system operational details in resource adequacy assessments
Traditional methods for assessing the resource adequacy (RA) of a power system are becoming obsolete due to emerging trends such as the increasing deployment of variable renewable energy and storage. Consequently, analysts are recommending that RA be assessed using a Monte Carlo simulation approach that models chronological power system operations over many instances of possible operating conditions. However, this approach is necessarily more complex and computationally demanding, which is an obstacle to real-world implementation. Here, in this study, we investigate which operational details of power systems are important to capture in order to accurately evaluate a system's RA, versus details that add complexity but do not meaningfully affect RA results. To do so, we develop a probabilistic RA assessment framework by adapting an existing production cost model and apply it to a case study based on the IEEE Reliability Test System. Our results indicate that multi-year data, storage dispatch, and transmission limits are key details to incorporate. Accurate RA results can be obtained using non-economic dispatch strategies as long as they are coordinated with detailed operational strategies. We also demonstrate how popular expectation-based RA metrics can mask important differences in the characteristics of loss of load events.
29 ENERGY PLANNING, POLICY, AND ECONOMY↗
Glacial to periglacial transition at the end of the last ice age in the subtropical semiarid Andes
Atmospheric warming and circulation reorganization at the end of the last ice age represent the most important climate change of the last 100,000 years and provide an opportunity to uncover how the southern subtropics cryosphere responded to strong changes in the global climate system. Extensive mapping and chronologic records on cryogenic landforms to better understand the association and interactions between glaciers and viscous creep of ice-rich permafrost landforms (rock glaciers) are widely missing in the region. In this paper, we reconstruct the geomorphic imprint of the Last Glacial Maximum (LGM) and the Termination I in the high Andes of the Río Limarí Basin (30–31°S) in the subtropical semiarid Andes of Chile. 74 new 10 Be surface exposure dating ages constrain the timing of glaciation, deglaciation, and glacial to periglacial transition. Glacial advances occurred first by 41.2 ± 0.6 – 35.0 ± 0.5 ka during Marine Isotope Stage 3, but probably earlier also; then, a second advance occurred during the global LGM between 24.2 ± 0.4 and 18.6 ± 0.2 ka. Deglaciation by 17.6 ± 0.2 ka left extensive hummocky moraines on the main valleys. Characteristic patterns of furrows and ridges typical of rock glaciers and solifluction superimposed on the LGM hummocky moraine indicate ice-rich permafrost in glacial deposits likely between 15.5 ± 0.3 and 13.6 ± 0.3 ka. We propose that moraines deposited by LGM debris-covered glaciers served as a niche for strong seasonal frost and permafrost creep, which substantially modified the original landforms. Finally, our results contribute to a better understanding of major transformations in an ice-rich high mountain area of the southern hemisphere where the interplay of temperature and precipitation changes drove glacial to periglacial transitions.
10Be surface exposure dating↗
Characterization of mechanical discontinuities based on data-driven classification of compressional-wave travel times
Wave propagation and diffusive transport phenomena are influenced by the mechanical discontinuities in material. Here this study shows that certain bulk properties of the network of low-velocity mechanical discontinuities (e.g. air-filled cracks) in a material can be characterized by processing compressional-wave travel times using traditional data-driven classification techniques. To that end, we perform three tasks in chronological order: (1) use the discrete fracture network (DFN) method to create two-dimensional (2D) numerical models of crack-bearing material embedded with various types of low-velocity mechanical discontinuities, (2) use the fast marching method (FMM) to simulate the propagation of the wave/diffusion front from a single source through the 2D crack-bearing material to multiple receivers placed on the boundary of the material, and (3) train 9 data-driven classifiers to characterize the crack-bearing materials (i.e. bulk properties of the network of mechanical discontinuities in the crack-bearing material) by learning from the simulations of travel times detected by multiple receivers placed around the crack-bearing material. The classifiers identified the orientation, spatial distribution, and dispersion of the low-velocity mechanical discontinuities. Voting classifier performs the best among the 9 classifiers. For the characterization of bulk dispersion and distribution of discontinuities, the sensors located on the adjacent boundaries are more important; whereas for the characterization of bulk orientation of discontinuities, the sensors located on the opposite side are more important.
42 ENGINEERING↗
Deployment Pathways for Long Duration Energy Storage
We apply a least-cost generation expansion model of the continental United States to assess how optimal investments in long-duration energy storage (LDES) technologies are impacted by changes in system generation portfolios and technology costs, assessing 369 capacity expansion scenarios in total. The expansion model considers 8,760 h of chronological operations for the entire target year, 2040. We find that low-cost LDES technologies can reduce generation investments and system costs. Specifically, once the costs for 24- and 100-h storage reach $38/kWh and $14/kWh, respectively, substantial deployments are observed. The distribution of storage investments across durations is strongly influenced by the system generation portfolio. We also demonstrate that a high-fidelity temporal representation is required to capture the value of LDES in generation expansion. Finally, we conduct a regression analysis of our capacity expansion results and find that LDES deployments are positively correlated with the combined wind and solar capacity share and negatively correlated with peaking and baseload shares.
Levin, Todd↗
Highly efficient and simple SSPER and rrPCR approaches for the accurate site-directed mutagenesis of large and small plasmids
Advances are needed in the site-directed mutagenesis of large plasmids for protein structure-function studies, as current methods are often inefficient, complicated and time-consuming. Here two new methods are reported that overcome these difficulties, namely the single primer extension reaction (SSPER) strategy that reaches 100% efficiency and the reduce recycle PCR (rrPCR) method that is advantageous in generating single and pairwise combinations of mutations. Both methods are distinguished from current technologies by the addition of a step that easily removes the oligonucleotide primer(s) after the first reaction, thus allowing for the addition of a second reaction in chronological sequence to generate and isolate the appropriate DNA product with the site-directed mutation(s). High efficiency of the methods is demonstrated by generating single and paired combinations of the 11 site-directed mutations targeted on 5 different plasmid DNA templates ranging from 10 to 12 kb and 57–60% GC-content at a rate of 50–100%. Overall, the methods are demonstrated to be (i) highly accurate, allowing for screening of plasmids by DNA sequencing, (ii) streamlined to generate the mutations within a single day, (iii) cost-effective in requiring only two primers and two enzymes (DpnI and a proofreading DNA polymerase), (iv) straightforward in primer design, (v) applicable for both large and small plasmids, and (vi) easily implemented by entry level researchers.
59 BASIC BIOLOGICAL SCIENCES↗
Review and status of tool tip frequency response function prediction using receptance coupling
This paper provides a chronological review of publications that implement and advance the receptance coupling substructure analysis (RCSA) approach first applied to tool tip receptance (or frequency response function) prediction for milling applications in 2000. The review topics mimic the RCSA approach, where the tool, holder, and spindle-machine receptances are coupled analytically, and include: tool-holder receptance modeling; connection modeling; spindle-machine receptances; and applications. The review paper summarizes contributions from multiple, international authors (198 papers) to these topics. Additionally, it provides a comprehensive resource for those beginning an investigation into RCSA.
42 ENGINEERING↗