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At least 325 records · Page 18

Strong gravitational lensing as a tool to investigate the structure of jets at high energies

The components of blazar jets that emit radiation span a factor of 10{sup 10} in scale. The spatial structure of these emitting regions depends on the observed energy. Photons emitted at different sites cross the lens plane at different distances from the mass-weighted center of the lens. Thus there are differences in magnification ratios and time delays between the images of lensed blazars observed at different energies. When the lens structure and redshift are known from optical observations, these constraints can elucidate the structure of the source at high energies. At these energies, current technology is inadequate to resolve these sources, and the observed light curve is thus the sum of the images. Durations of γ-ray flares are short compared with typical time delays; thus both the magnification ratio and the time delay can be measured for the delayed counterparts. These measurements are a basis for localizing the emitting region along the jet. To demonstrate the power of strong gravitational lensing, we build a toy model based on the best studied and the nearest relativistic jet M87.

79 ASTRONOMY AND ASTROPHYSICS↗

Cataractogenesis from high-LET radiation and the Casarett model

The long-term effects on specific animal tissues of exposure to heavy ion irradiation are studied in experiments on cataractogenesis in mice and rabbits. Five groups of rabbits at ages from 8 weeks to 5.3 years were irradiated to a dose of 9.0 Gy of Bragg plateau Ne-20 ions, while mice were exposed to single and total fractionated doses of 4.17 Gy gamma rays or 0.40 to 1.20 Gy of C-12, Ne-20 or Ar-40 particles. Measurements of lens opacities over time show that in the year since irradiation, cataractogenesis is delayed and less severe in rabbits irradiated at age 6 months compared to younger animals, although it is possible that the late effects in adults will surpass those found in the young. The fractionation of the total dose of gamma rays in mice is observed to lead to a marked reduction in the extent of lens opacity after one year, while fractionated heavy ion doses caused a greater degree of posterior lens opacification. Evaluations of the effects of the LET of different ions on cataractogenesis are consistent with RBEs of about 5, 3 and 1-2 for Ar-40, Ne-20 and C-12 ions, respectively. Results thus support the Casarett model of radiation damaging stem cell populations that are not necessarily part of the vasculature.

Cox, A. B.↗

INTEGRAL burst alert service

The detection, accurate positioning, and spectral analysis of cosmic gamma ray bursts is an objective of the International Gamma Ray Astrophysics Laboratory (INTEGRAL) mission. Due to their unpredictable nature, gamma ray bursts can only be observed in serendipity mode. In order to allow and promote multiwavelength follow-up observations of such events, it is desirable to make the information available to the astrophysics community with a minimum delay through the use of Internet. Ideally, the data dissemination should occur within a few seconds of the start of the burst event so that follow up observations can proceed while gamma rays are still being emitted. The technical feasibility of building such a system to disseminate INTEGRAL burst alerts in real time is currently under consideration, the preliminary results of which are presented. It is concluded that such an alert service is technically feasible.

Pedersen, H.↗

HARD X-RAY EMISSION DURING FLARES AND PHOTOSPHERIC FIELD CHANGES

We study the correlation between abrupt permanent changes of magnetic field during X-class flares observed by the Global Oscillation Network Group and Helioseismic and Magnetic Imager instruments, and the hard X-ray (HXR) emission observed by RHESSI, to relate the photospheric field changes to the coronal restructuring and investigate the origin of the field changes. We find that spatially the early RHESSI emission corresponds well to locations of the strong field changes. The field changes occur predominantly in the regions of strong magnetic field near the polarity inversion line (PIL). The later RHESSI emission does not correspond to significant field changes as the flare footpoints are moving away from the PIL. Most of the field changes start before or around the start time of the detectable HXR signal, and they end at about the same time or later than the detectable HXR flare emission. Some of the field changes propagate with speed close to that of the HXR footpoint at a later phase of the flare. The propagation of the field changes often takes place after the strongest peak in the HXR signal when the footpoints start moving away from the PIL, i.e., the field changes follow the same trajectory as the HXR footpoint, but at an earlier time. Thus, the field changes and HXR emission are spatio-temporally related but not co-spatial nor simultaneous. We also find that in the strongest X-class flares the amplitudes of the field changes peak a few minutes earlier than the peak of the HXR signal. We briefly discuss this observed time delay in terms of the formation of current sheets during eruptions.

79 ASTRONOMY AND ASTROPHYSICS↗

Narrow lines from alpha-alpha reactions

Intensities and spectral shapes of the prompt gamma-ray lines of Li-7 at 0.431 MeV and Be-7 at 0.478 MeV and of the delayed 0.478-MeV line, all resulting from alpha-alpha reactions, are calculated using recent direct measurements of the cross sections for the alpha-alpha reactions. It is found that the intensities of these lines are comparable to that of the 4.44-MeV line of C-12, so that the investigated lines should be observable in large solar flares, provided their Doppler widths are not excessively large. An evaluation of the shapes of the prompt lines indicates that for an isotropic distribution of energetic alpha-particles, the two lines merge into a broad feature which essentially cannot be distinguished from the continuum. A situation in which the delayed 0.478-MeV line could be very narrow is considered.

Kozlovsky, B.↗

Delayed Complications in Patients Surviving at Least 3 Years After Stereotactic Radiosurgery for Brain Metastases

Purpose: Little is known about delayed complications after stereotactic radiosurgery in long-surviving patients with brain metastases. We studied the actual incidence and predictors of delayed complications. Patients and Methods: This was an institutional review board-approved, retrospective cohort study that used our database. Among our consecutive series of 2000 patients with brain metastases who underwent Gamma Knife radiosurgery (GKRS) from 1991-2008, 167 patients (8.4%, 89 women, 78 men, mean age 62 years [range, 19-88 years]) who survived at least 3 years after GKRS were studied. Results: Among the 167 patients, 17 (10.2%, 18 lesions) experienced delayed complications (mass lesions with or without cyst in 8, cyst alone in 8, edema in 2) occurring 24.0-121.0 months (median, 57.5 months) after GKRS. The actuarial incidences of delayed complications estimated by competing risk analysis were 4.2% and 21.2% at the 60th month and 120th month, respectively, after GKRS. Among various pre-GKRS clinical factors, univariate analysis demonstrated tumor volume-related factors: largest tumor volume (hazard ratio [HR], 1.091; 95% confidence interval [CI], 1.018-1.154; P=.0174) and tumor volume {<=}10 cc vs >10 cc (HR, 4.343; 95% CI, 1.444-12.14; P=.0108) to be the only significant predictors of delayed complications. Univariate analysis revealed no correlations between delayed complications and radiosurgical parameters (ie, radiosurgical doses, conformity and gradient indexes, and brain volumes receiving >5 Gy and >12 Gy). After GKRS, an area of prolonged enhancement at the irradiated lesion was shown to be a possible risk factor for the development of delayed complications (HR, 8.751; 95% CI, 1.785-157.9; P=.0037). Neurosurgical interventions were performed in 13 patients (14 lesions) and mass removal for 6 lesions and Ommaya reservoir placement for the other 8. The results were favorable. Conclusions: Long-term follow-up is crucial for patients with brain metastases treated with GKRS because the risk of complications long after treatment is not insignificant. However, even when delayed complications occur, favorable outcomes can be expected with timely neurosurgical intervention.

62 RADIOLOGY AND NUCLEAR MEDICINE↗

Methods of measurement for semiconductor materials, process control, and devices

Significant accomplishments include development of a procedure to correct for the substantial differences of transistor delay time as measured with different instruments or with the same instrument at different frequencies; association of infrared response spectra of poor quality germanium gamma ray detectors with spectra of detectors fabricated from portions of a good crystal that had been degraded in known ways; and confirmation of the excellent quality and cosmetic appearance of ultrasonic bonds made with aluminum ribbon wire. Work is continuing on measurement of resistivity of semiconductor crystals; study of gold-doped silicon, development of the infrared response technique; evaluation of wire bonds and die attachment; and measurement of thermal properties of semiconductor devices, delay time and related carrier transport properties in junction devices, and noise properties of microwave diodes.

Bullis, W. M.↗

BLAZAR FLARES FROM COMPTON DRAGGED SHELLS

We compute the dynamics and emission of dissipative shells that are subject to a strong Compton drag, under simplifying assumptions about the dissipation mechanism. We show that under conditions prevailing in blazars, substantial deceleration is anticipated on sub-parsec and parsec scales in cases of rapid dissipation. Such episodes may be the origin of some of the flaring activity occasionally observed in gamma-ray blazars. The shape of the light curves thereby produced reflects the geometry of the emitting surface if the deceleration is very rapid, or the dynamics of the shell if the deceleration is delayed, or initially more gradual, owing, e.g., to continuous injection of energy and momentum.

79 ASTRONOMY AND ASTROPHYSICS↗

OPTICAL MONITORING OF THE BROAD-LINE RADIO GALAXY 3C 390.3

We have undertaken a new ground-based monitoring campaign on the broad-line radio galaxy 3C 390.3 to improve the measurement of the size of the broad emission-line region and to estimate the black hole mass. Optical spectra and g-band images were observed in late 2005 for three months using the 2.4 m telescope at MDM Observatory. Integrated emission-line flux variations were measured for the hydrogen Balmer lines H{alpha}, H{beta}, H{gamma}, and for the helium line He II{lambda}4686, as well as g-band fluxes and the optical active galactic nucleus (AGN) continuum at {lambda} = 5100 A. The g-band fluxes and the optical AGN continuum vary simultaneously within the uncertainties, {tau}{sub cent} (0.2 {+-} 1.1) days. We find that the emission-line variations are delayed with respect to the variable g-band continuum by {tau}(H{alpha}) 56.3{sup +2.4}{sub -6.6} days, {tau}(H{beta}) = 44.3{sup +3.0}{sub -3.3} days, {tau}(H{gamma}) = 58.1{sup +4.3}{sub -6.1} days, and {tau}(He II 4686) = 22.3{sup +6.5}{sub -3.8} days. The blue and red peaks in the double-peaked line profiles, as well as the blue and red outer profile wings, vary simultaneously within {+-}3 days. This provides strong support for gravitationally bound orbital motion of the dominant part of the line-emitting gas. Combining the time delay of the strong Balmer emission lines of H{alpha} and H{beta} and the separation of the blue and red peaks in the broad double-peaked profiles in their rms spectra, we determine M {sup vir}{sub bh} = 1.77{sup +0.29}{sub -0.31} Multiplication-Sign 10{sup 8} M{sub Sun} and using {sigma}{sub line} of the rms spectra M {sup vir}{sub bh} 2.60{sup +0.23}{sub -0.31} Multiplication-Sign 10{sup 8} M{sub Sun} for the central black hole of 3C 390.3, respectively. Using the inclination angle of the line-emitting region which is measured from superluminal motion detected in the radio range, accretion disk models to fit the optical double-peaked emission-line profiles, and X-ray observations, the mass of the black hole amounts to M{sub bh} = 0.86{sup +0.19}{sub -0.18} Multiplication-Sign 10{sup 9} M{sub Sun} (peak separation) and M{sub bh} 1.26{sup +0.21}{sub -0.16} Multiplication-Sign 10{sup 9} M{sub Sun} ({sigma}{sub line}), respectively. This result is consistent with the black hole masses indicated by simple accretion disk models to describe the observed double-peaked profiles, derived from the stellar dynamics of 3C 390.3, and with the AGN radius-luminosity relation. Thus, 3C 390.3 as a radio-loud AGN with a low Eddington ratio, L{sub edd}/L{sub bol} = 0.02, follows the same AGN radius-luminosity relation as radio-quiet AGNs.

79 ASTRONOMY AND ASTROPHYSICS↗

Origin of the burst of TeV gamma-rays from SN 1987 A

An electromagnetic origin of the TeV gamma-ray burst from SN 1987 A is proposed. The TeV gamma-rays result from inverse Compton scattering in the extreme Klein-Nishina limit of nuclear Co-56 gamma-ray lines and soft X-rays by monoenergetic TeV electrons. The model accounts for the observed time delay between the TeV burst and the peak X-ray intensity of about 3 days, and the different burst duration at TeV and X-ray energies.

Schlickeiser, R.↗

Hard X-Ray Detection of the High Redshift Quasar 4C 71.07

BATSE/OSSE observations of the high redshift quasar 4C 71.07 indicate that this is the brightest and furthest AGN so far detected 20 keV. BATSE Earth occultation data have been used to search for emission from 4C 71.07 from nearly 3 years of observation. The mean source flux over the- whole period in the BATSE energy range 20-100 keV is (13.2 +/- 1.06) x 10(exp -11) erg/square cm/s corresponding to a luminosity of 2 x 10(exp 48 erg/s. The BATSE light curve over the 3 years of observations shows several flare-like events, one of which (in January 1996) is associated with an optical flare (R=16.1) but with a delay of 55 days. The OSSE/BATSE spectral analysis indicates that the source is characterized by a flat power spectrum (Gamma is approximately 1.1- 1.3) when in a low state: this spectral form is consistent within errors with the ASCA and ROSAT spectra. This means that the power law observed from 0.1 to 10 keV extends up to at least 1 MeV but steepens soon after to meet EGRET high energy data. BATSE data taken around the January 1996 flare suggests that the spectrum could be steeper when the source is in a bright state. The upsilon-F-upsilon representation of the source is typical of a low frequency peaked/ gamma- ray dominated blazar, with the synchrotron peak in the mm-FIR band and the Compton peak in the MeV band. The BATSE and OSSE spectral data seem to favour a model in which the high energy - flux is due to the sum of the synchrotron self-Compton and the external Compton contributions: this is also supported by the- variability behaviour of the source.

Malizia, A.↗

Upgrades to Monteburns, version 3.0

Monteburns, a Monte Carlo burnup code which has the flexibility to model time-dependent isotopic changes for a variety of nuclear systems by linking the neutron transport code MCNP/X to a production/depletion code, has undergone several performance upgrades recently that have increased the code's capabilities. Once limited to a specific number of regions, enhancements have been implemented that afford a much greater number of burn materials, such that users will be more limited by the physical constraints of their computing environment as opposed to inherent limits built into the coding of Monteburns. In conjunction with the increase in the number of burn materials, parallel execution of a production/depletion code of choice has been implemented, such that users have the option of using CINDER90, 0RIGEN2, or the newly released version of ORIGEN. Finally, the recoverable energy per fission calculation was upgraded to include capture gamma energy deposited in all specified materials as a function of irradiation time. The sum of the prompt and delayed recoverable energies from fission was obtained as before. These upgrades were first tested on a rigorous 1/8 core model of a Pressurized Water Reactor with fresh, once- and twice-burned fuel. We can now model several orders of magnitude more materials using Monte Carlo techniques, which is a significant advance in the reactor modeling world. (authors)

22 GENERAL STUDIES OF NUCLEAR REACTORS↗

High- and low-LET induced chromosome damage in human lymphocytes: a time-course of aberrations in metaphase and interphase

PURPOSE: To investigate how cell-cycle delays in human peripheral lymphocytes affect the expression of complex chromosome damage in metaphase following high- and low-LET radiation exposure. MATERIALS AND METHODS: Whole blood was irradiated in vitro with a low and a high dose of 1 GeV u(-1) iron particles, 400MeV u(-1) neon particles or y-rays. Lymphocytes were cultured and metaphase cells were collected at different time points after 48-84h in culture. Interphase chromosomes were prematurely condensed using calyculin-A, either 48 or 72 h after exposure to iron particles or gamma-rays. Cells in first division were analysed using a combination of FISH whole-chromosome painting and DAPI/ Hoechst 33258 harlequin staining. RESULTS: There was a delay in expression of chromosome damage in metaphase that was LET- and dose-dependant. This delay was mostly related to the late emergence of complex-type damage into metaphase. Yields of damage in PCC collected 48 h after irradiation with iron particles were similar to values obtained from cells undergoing mitosis after prolonged incubation. CONCLUSION: The yield of high-LET radiation-induced complex chromosome damage could be underestimated when analysing metaphase cells collected at one time point after irradiation. Chemically induced PCC is a more accurate technique since problems with complicated cell-cycle delays are avoided.

Non-NASA Center↗

Initial Radiation of Nuclear Power Plant Components (CRADA NFE-17-06892 Final Report)

As advanced reactor concepts are developed, instrumentation and control (I&C) cables and sensors will play a significant role in assuring their operation is well understood, and safety-related process information can be collected reliably over the course of their design life. As a first step to develop acceptance criteria and define the limits of currently available nuclear I&C cable and sensor technology, a collaboration between Oak Ridge National Laboratory and Analysis and Measurement Services (AMS) Corporation was initiated under the Gateway for Accelerated Innovation in Nuclear (GAIN) Program. This collaborative effort focused on providing technical information related to the combined thermal and radiation aging of nuclear power plant (NPP) cables, companion NPP cable insulation samples, and two prototype temperature and two pressure sensors. This work was carried out using the instrumented gamma irradiation system that is part of the High Flux Isotope Reactor Gamma Irradiation Facility (HFIR GIF). This system provided the opportunity for the condition of the prototype sensors to be tracked during the irradiation in order to determine their functional limits with greater granularity when compared to a simple irradiation insertion at the HFIRGIF. Experimental assemblies for sensor irradiation were successfully completed, and sensor irradiation to accumulated dose of 3000 kGy at a rate of approximately 6 kGy/hr was carried out. Two prototype temperature assemblies were continuously monitored during exposure to 3000 kGy and found to have no observable degradation from the irradiation. Two pressure sensors were first irradiated to 1000 kGy. At which point, one of the sensors was found to operate normally; however, a second sensor failed the operability test. The operable pressure sensor output was then continuously monitored from 1000 kGy to 3000 kGy. The sensor output exhibited steady trendable drift versus the accumulated radiation dose. At the conclusion of the irradiation, the four test sensors were released for laboratory calibration checks. The calibration check of the temperature sensors found no significant change after irradiation compared to baseline measurements before irradiation; however, both pressure sensors failed the post-test calibration checks and both sensors were not functioning properly. These results will help inform sensor manufacturers and I&C design engineers of potential limitations of these types of sensors for use in high radiation environments associated with the compact configuration of new Small Modular Reactors (SMRs) such as NuScale’s reactor power module. Irradiations on NPP cables and companion samples were not completed due to programmatic delays, however a path forward that was based on lessons learned from this project was defined to accommodate future, comparable instrumented gamma irradiations at the HFIR GIF.

22 GENERAL STUDIES OF NUCLEAR REACTORS↗

GRB 110205A: ANATOMY OF A LONG GAMMA-RAY BURST

The Swift burst GRB 110205A was a very bright burst visible in the Northern Hemisphere. GRB 110205A was intrinsically long and very energetic and it occurred in a low-density interstellar medium environment, leading to delayed afterglow emission and a clear temporal separation of the main emitting components: prompt emission, reverse shock, and forward shock. Our observations show several remarkable features of GRB 110205A: the detection of prompt optical emission strongly correlated with the Burst Alert Telescope light curve, with no temporal lag between the two; the absence of correlation of the X-ray emission compared to the optical and high-energy gamma-ray ones during the prompt phase; and a large optical re-brightening after the end of the prompt phase, that we interpret as a signature of the reverse shock. Beyond the pedagogical value offered by the excellent multi-wavelength coverage of a gamma-ray burst with temporally separated radiating components, we discuss several questions raised by our observations: the nature of the prompt optical emission and the spectral evolution of the prompt emission at high energies (from 0.5 keV to 150 keV); the origin of an X-ray flare at the beginning of the forward shock; and the modeling of the afterglow, including the reverse shock, in the framework of the classical fireball model.

79 ASTRONOMY AND ASTROPHYSICS↗

FERMI DETECTION OF {gamma}-RAY EMISSION FROM THE M2 SOFT X-RAY FLARE ON 2010 JUNE 12

The Geostationary Operational Environmental Satellite (GOES) M2-class solar flare, SOL2010-06-12T00:57, was modest in many respects yet exhibited remarkable acceleration of energetic particles. The flare produced an {approx}50 s impulsive burst of hard X- and {gamma}-ray emission up to at least 400 MeV observed by the Fermi Gamma-ray Burst Monitor and Large Area Telescope experiments. The remarkably similar hard X-ray and high-energy {gamma}-ray time profiles suggest that most of the particles were accelerated to energies {approx}>300 MeV with a delay of {approx}10 s from mildly relativistic electrons, but some reached these energies in as little as {approx}3 s. The {gamma}-ray line fluence from this flare was about 10 times higher than that typically observed from this modest GOES class of X-ray flare. There is no evidence for time-extended >100 MeV emission as has been found for other flares with high-energy {gamma}-rays.

79 ASTRONOMY AND ASTROPHYSICS↗

Induction of antigen-specific immunity by pH-sensitive carbonate apatite as a potent vaccine carrier

Highlights: Black-Right-Pointing-Pointer To develop effective vaccine, we examined the effects of CO{sub 3}Ap as an antigen carrier. Black-Right-Pointing-Pointer OVA contained in CO{sub 3}Ap was taken up by BMDCs more effectively than free OVA. Black-Right-Pointing-Pointer OVA-immunized splenocytes was activated by OVA contained in CO{sub 3}Ap effectively. Black-Right-Pointing-Pointer OVA contained in CO{sub 3}Ap induced strong OVA-specific immune responses to C57BL/6 mice. Black-Right-Pointing-Pointer CO{sub 3}Ap is promising antigen carrier for the achievement of effective vaccine. -- Abstract: The ability of carbonate apatite (CO{sub 3}Ap) to enhance antigen-specific immunity was examined in vitro and in vivo to investigate its utility as a vaccine carrier. Murine bone marrow-derived dendritic cells took up ovalbumin (OVA) containing CO{sub 3}Ap more effectively than free OVA. Interestingly, mice immunized with OVA-containing CO{sub 3}Ap produced OVA-specific antibodies more effectively than mice immunized with free OVA. Furthermore, immunization of C57BL/6 mice with OVA-containing CO{sub 3}Ap induced the proliferation and antigen-specific production of IFN-{gamma} by splenocytes more strongly than immunization with free OVA. Moreover, no significant differences were detected in the induction of delayed-type hypersensitivity responses, an immune reaction involving an antigen-specific, cell-mediated immune response between OVA-containing CO{sub 3}Ap and OVA-containing alumina salt (Alum), suggesting that CO{sub 3}Ap induced cell-mediated immune response to the same degree as Alum, which is commonly used for clinical applications. This study is the first to demonstrate the induction of antigen-specific immune responses in vivo by CO{sub 3}Ap.

60 APPLIED LIFE SCIENCES↗

Toward Distinguishing Recurrent Tumor From Radiation Necrosis: DWI and MTC in a Gamma Knife–Irradiated Mouse Glioma Model

Purpose: Accurate noninvasive diagnosis is vital for effective treatment planning. Presently, standard anatomical magnetic resonance imaging (MRI) is incapable of differentiating recurring tumor from delayed radiation injury, as both lesions are hyperintense in both postcontrast T1- and T2-weighted images. Further studies are therefore necessary to identify an MRI paradigm that can differentially diagnose these pathologies. Mouse glioma and radiation injury models provide a powerful platform for this purpose. Methods and Materials: Two MRI contrasts that are widely used in the clinic were chosen for application to a glioma/radiation-injury model: diffusion weighted imaging, from which the apparent diffusion coefficient (ADC) is obtained, and magnetization transfer contrast, from which the magnetization transfer ratio (MTR) is obtained. These metrics were evaluated longitudinally, first in each lesion type alone–glioma versus irradiation – and then in a combined irradiated glioma model. Results: MTR was found to be consistently decreased in all lesions compared to nonlesion brain tissue (contralateral hemisphere), with limited specificity between lesion types. In contrast, ADC, though less sensitive to the presence of pathology, was increased in radiation injury and decreased in tumors. In the irradiated glioma model, ADC also increased immediately after irradiation, but decreased as the tumor regrew. Conclusions: ADC is a better metric than MTR for differentiating glioma from radiation injury. However, MTR was more sensitive to both tumor and radiation injury than ADC, suggesting a possible role in detecting lesions that do not enhance strongly on T1-weighted images.

62 RADIOLOGY AND NUCLEAR MEDICINE↗