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At least 325 records · Page 18

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NASA NTRS1974

Evaluation of exercise-respiratory system modifications and integration schemes for physiological systems

Exercise subroutine modifications are implemented in an exercise-respiratory system model yielding improvement of system response to exercise forcings. A more physiologically desirable respiratory ventilation rate in addition to an improved regulation of arterial gas tensions and cerebral blood flow is observed. A respiratory frequency expression is proposed which would be appropriate as an interfacing element of the respiratory-pulsatile cardiovascular system. Presentation of a circulatory-respiratory system integration scheme along with its computer program listing is given. The integrated system responds to exercise stimulation for both nonstressed and stressed physiological states. Other integration possibilities are discussed with respect to the respiratory, pulsatile cardiovascular, thermoregulatory, and the long-term circulatory systems.

Gallagher, R. R.↗

NASA NTRS1979

Limb blood flow - Rest and heavy exercise in sitting and supine positions in man

The objectives of the study were twofold: (1) to determine the effect of body position (hydrostatic pressure) on total blood flow in active and passive limbs at rest and after severe exercise; and (2) to further evaluate the impedance technique for measurement of blood flow. To this end, the effect of body position on the redistribution of total blood flow in active (leg) and passive (forearm) limbs during exercise was determined by measuring total limb impedance (blood flow) in five male and one female subjects in sitting and supine positions with a modified Beckman BR-100 rheograph. The results show that, at rest and after exercise, the supine position induces significantly greater flows in the leg but not in the forearm. With severe exercise, blood flows are increased in both passive and active limbs, so that there is probably no net transfer of blood volume from passive to active muscles. The advantages of the impedance technique over other methods are stressed.

Greenleaf, J. E.↗

NASA NTRS1982

Effect of orthostatic stress on exercise performance after bedrest

The cardiorespiratory responses to supine against upright exercise were compared to determine the orthostatic effects of gravity on exercise performance following bedrest. Five healthy male subjects underwent seven days of continuous bedrest. A deconditioning effect was manifested by significant increases in ventilation volume, carbon dioxide production, respiratory exchange ratio, heart rate, heart rate-pressure product, and diastolic blood pressure during submaximal exercise following bedrest. The major finding from this study was that bedrest resulted in a general decrease in exercise tolerance, which was more stressful in the upright posture compared to the supine position, judging from specific submaximal cardiorespiratory responses to cycle ergometry. The data support the hypothesis that there is an orthostatic factor to the reduction in work tolerance following bedrest deconditioning, in addition to the effects caused by increased physical activity.

Convertino, V. A.↗

NASA NTRS1983

Discordance of exercise thallium testing with coronary arteriography in patients with atypical presentations

Eighty-one patients with diagnostically difficult clinical presentations suggesting coronary artery disease underwent symptom-limited maximal-exercise treadmill testing (ETT) and exercise radionuclide scanning with thallium-201 followed by coronary angiography. Results showed that in nearly half of the patients (47%) these tests were in agreement, while either exercise thallium or ETT was positive in 94% of patients with coronary artery disease. It was found that agreement between exercise thallium and ETT tests predicted disease in 92% of the instances or excluded disease in 82% of the instances. It is concluded that despite frequent discord between these two tests in 53% of the cases, a significant gain in exclusive diagnostic capability is realized when applied to a patient population anticipated to have a disease prevalence equal to the 67% encountered in this study.

Bungo, M. W.↗

NASA NTRS1983

Drinking and water balance during exercise and heat acclimation

The interactions between fluid intake and balance, and plasma ion, osmotic, and endocrine responses during dehydration produced by exercise in cool and warm environments during acclimation are explored. Two groups of five male subjects performed 8 days of ergometer exercise in hot and thermoneutral conditions, respectively. The exercise trials lasted 2 hr each. Monitoring was carried out on the PV, osmotic, sodium, and endocrine concentrations, voluntary fluid intake, fluid balances, and fluid deficits. A negative correlation was observed between the plasma sodium and osmolality during acclimation. The presence of hypervolemia during acclimation is suggested as a cause of drinking, while the vasopressin concentration was not found to be a significant factor stimulating drinking. Finally, the predominant mechanism in fluid intake during exercise and heat exposure is concluded to be the renin-angiotensin II system in the presence of reductions in total body water and extracellular plasma volumes.

Greenleaf, J. E.↗

NASA NTRS1983

Cardiovascular responses to exercise as functions of absolute and relative work load

The roles of absolute and relative oxygen uptake (VO2 and percent of muscle group specific VO2-max) as determinants of the cardiovascular and ventilatory responses to exercise over a wide range of active muscle mass are investigated. Experiments were conducted using four types of dynamic exercise: one-arm curl, one-arm cranking, and one and two-leg cycling at four different relative work loads (25, 50, 75, and 100 percent of VO2-max) for the corresponding muscle group. Results show that VO2 during maximal one-arm curl, one-arm cranking, and one-leg cycling averaged 20, 50, and 75 percent, respectively, of that for maximal two-leg cycling. Cardiac output was determined to be linearly related to VO2 with a similar slope and intercept for each type of exercise, and the heart rate at a given percent VO2-max was higher with larger active muscle mass. It is concluded that the cardiovascular responses to exercise was determined to a large extent by the active muscle mass and the absolute oxygen uptake, with the principal feature appearing to be the tight linkage between systematic oxygen transport and utilization.

Lewis, S. F.↗

NASA NTRS1984

Oxygen uptake kinetics of constant-load work - Upright vs. supine exercise

Supine and upright positions were used in a comparitive study of the effects of constant load exercise on oxygen uptake (VO2), O2 deficit, steady-state VO2 and VO2 following recovery from constant load work. Ten male subjects (36-40 yr.) performed one submaximal exercise test in the supine and one test in the upright position consisting of 5 min rest and 5 min cycle ergometer exercise at 700 kg/min followed by ten minutes of recovery. It is found that the significant difference in VO2 kinetics during exercise in the upright compared to supine position resulted from changes in oxygen transport and utilization mechanisms rather than changes in mechanical efficiency. To the extent that data measured in the supine position can be used to estimate physiological responses to zero gravity, it is suggested that limitation of systemic O2 consumption may be the result of slow rates of oxygen uptake during transient periods of muscular work. Significant reductions in the rate of steady-state VO2 attainment at submaximal work intensities may produce an onset of muscle fatigue and exhaustion.

Convertino, V. A.↗

NASA NTRS1984

VO2 kinetics of constant-load exercise following bed-rest-induced deconditioning

Previous studies have shown that the oxygen uptake kinetics during exercise and recovery may be changed by alterations in work intensity, prior exercise, muscle group involvement, ambient conditions, posture, disease state, and level of physical conditioning. However, the effects of detraining on oxygen uptake kinetics have not been determined. The present investigation has the objective to determine the effects of deconditioning following seven days of continuous head-down bed rest on changes in steady-state oxygen uptake, O2 deficit, and recovery oxygen uptake during the performance of constant-load exercise. The obtained results may provide support for previous proposals that submaximal oxygen uptake was significantly reduced following bed rest. The major finding was that bed-rest deconditioning resulted in a reduction of total O2 transport/utilization capacity during the transient phase of upright but not supine exercise.

Convertino, V. A.↗

NASA NTRS1987

Potential benefits of maximal exercise just prior to return from weightlessness

The purpose of this study was to determine whether performance of a single maximal bout of exercise during weightlessness within hours of return to earth would enhance recovery of aerobic fitness and physical work capacities under a 1G environment. Ten healthy men were subjected to a 10-d bedrest period in the 6-deg headdown position. A graded maximal supine cycle ergometer test was performed before and at the end of bedrest to simulate exercise during weightlessness. Following 3 h of resumption of the upright posture, a second maximal exercise test was performed on a treadmill to measure work capacity under conditions of 1G. Compared to before bedrest, peak oxygen consumption, V(O2), decreased by 8.7 percent and peak heart rate (HR) increased by 5.6 percent in the supine cycle test at the end of bedrest. However, there were no significant changes in peak V(O2) and peak HR in the upright treadmill test following bedrest. These data suggest that one bout of maximal leg exercise prior to return from 10 d of weightlessness may be adequate to restore preflight aerobic fitness and physical work capacity.

Convertino, Victor A.↗

NASA NTRS1989

Effect of low air velocities on thermal homeostasis and comfort during exercise at space station operational temperature and humidity

The effectiveness of different low air velocities in maintaining thermal comfort and homeostasis during exercise at space station operational temperature and humidity was investigated. Five male subjects exercised on a treadmill for successive ten minute periods at 60, 71, and 83 percent of maximum oxygen consumption at each of four air velocities, 30, 50, 80, and 120 ft/min, at 22 C and 62 percent relative humidity. No consistent trends or statistically significant differences between air velocities were found in body weight loss, sweat accumulation, or changes in rectal, skin, and body temperatures. Occurrence of the smallest body weight loss at 120 ft/min, the largest sweat accumulation at 30 ft/min, and the smallest rise in rectal temperature and the greatest drop in skin temperature at 120 ft/min all suggested more efficient evaporative cooling at the highest velocity. Heat storage at all velocities was evidenced by increased rectal and body temperatures; skin temperatures declined or increased only slightly. Body and rectal temperature increases corresponded with increased perception of warmth and slight thermal discomfort as exercise progressed. At all air velocities, mean thermal perception never exceeded warm and mean discomfort, greatest at 30 ft/min, was categorized at worst as uncomfortable; sensation of thermal neutrality and comfort returned rapidly after cessation of exercise. Suggestions for further elucidation of the effects of low air velocities on thermal comfort and homeostasis include larger numbers of subjects, more extensive skin temperature measurements and more rigorous analysis of the data from this study.

Beumer, Ronald J.↗

NASA NTRS1992

Effect of leg exercise training on vascular volumes during 30 days of 6 deg head-down bed rest

In order to investigate the effects of leg exercise training on vascular volumes during 30 d of 6-deg head-down bed rest, plasma and red cell volumes, body density, and water balance were measured in 19 men confined to bed rest (BR). One group had no exercise training (NOE), another near-maximal variable-intensity isotonic exercise (ITE) for 60 min/d, and the third near-maximal intermittent isokinetic exercise (IKE) for 60 min/d. Mean energy costs for the NOE, IKE, and ITE regimens were determined. Body densities within groups and mean urine volumes between groups were unchanged during BR. Changes in red cell volume followed changes in plasma volume. There was close coupling between resting plasma volume and plasma protein and osmotic content. It is argued that the ITE training protocol is better than the IKE protocol for maintaining plasma volume during prolonged exposure to BR.

Greenleaf, J. E.↗

NASA NTRS1991

Interaction of the carotid baroreflex, the muscle chemoreflex and the cardiopulmonary baroreflex in man during exercise

The interaction of the muscle chemoreflex and the cardiopulmonary baroreflex with the carotid baroreflex in humans performing exercise was investigated in healthy subjects using specially designed exercise regimen and apparatus. Stimulation of the muscle chemoreflex was achieved by restricting blood flow in the exercising muscles by means of applying a pressure of 50 mm Hg, whereas cardiopulmonary baroreceptors were unloaded by employing LBNP of -20 mm Hg. The carotid baroreceptors were unloaded and stimulated by neck-pressure maneuvers (Sprenkle et al., 1986). Results showed that the cardiodecelerating capacity of the carotid baroreflex remains active during exercise, and may even be sensitized by the chemoreflex-induced increase in arterial pressure; but it is not affected by the cardiopulmonary baroreceptor activity.

Eiken, O.↗

NASA NTRS1992

Exercise performance, core temperature, and metabolism after prolonged restricted activity and retraining in dogs

Physiological effects of restricted activity (RA) and subsequent retraining have been studied. Ten male mongrel dogs performed a submaximal exercise endurance test on a treadmill during kennel control, after 8 weeks of cage confinement and after eight weeks of retraining using the same treadmill protocol 1 h/d for 6 d/week. Data obtained show that RA reduces exercise endurance, the effectiveness of exercise thermoregulation, muscle glycogen stores, and the lipolytic response to exercise and to noradrenaline stimulation.

Nazar, K.↗

NASA NTRS1993

Isotonic And Isokinetic Exercise During Bed Rest

Brief, intense activity prevents deterioration of peak oxygen uptake, a measure of work capacity. Study intended to explore effectiveness of exercise in maintaining fitness during long missions in microgravity so crewmembers able to keep up arduous work of building and expanding Space Station. Showed that intermittent, intense exercise of short duration more effective than similar exercise at lower intensity for longer times measured in previous studies. Intense short-term exercise seems to maintain volumes of plasma and red blood cells at normal levels.

Greenleaf, J. E.↗

NASA NTRS1990

Daily exercise routines

Viewgraphs on daily exercise routines are presented. Topics covered include: daily exercise and periodic stress testings; exercise equipment; physiological monitors; exercise protocols; physiological levels; equipment control; control systems; and fuzzy logic control.

Anderson, Patrick L.↗

NASA NTRS1993

Intramuscular pressure and electromyography as indexes of force during isokinetic exercise

A direct method for measuring force production of specific muscles during dynamic exercise is presently unavailable. Previous studies indicate that both intramuscular pressure (IMP) and electromyography (EMG) correlate linearly with muscle contraction force during isometric exercise. The objective of this study was to compare IMP and EMG as linear assessors of muscle contraction force during dynamic exercise. IMP and surface EMG activity were recorded during concentric and eccentric isokinetic plantarflexion and dorsiflexion of the ankle joint from the tibialis anterior (TA) and soleus (SOL) muscles of nine male volunteers. Ankle torque was measured using a dynamometer, and IMP was measured via catheterization. IMP exhibited better linear correlation than EMG with ankle joint torque during concentric contractions of the SOL and the TA, as well as during eccentric contractions. IMP provides a better index of muscle contraction force than EMG during concentric and eccentric exercise through the entire range of torque. IMP reflects intrinsic mechanical properties of individual muscles, such as length-tension relationships, which EMG is unable to assess.

Aratow, M.↗

NASA NTRS1994

Plasma volume shifts and exercise thermoregulation with water immersion and six-degree head-down tilt

The hypothesized fluid shifts and resultant responses that occur during spaceflight are simulated by six-degree head down tilt (HDT) and water immersion (WI). The purpose of this study was to compare exercise thermoregulation before and after physiologic mechanisms reduce plasma volume (PV) in response to 24-hr HDT (HDT24). A secondary study utilized WI to reproduce the PV reduction of HDT24. Seven males were studied in two conditions: during 70 minutes of supine cycling ergometry at 58 percent of peak oxygen consumption following 1-hr HDT (HDT1) and HDT24; and up to 6 hr WI at 34.5 C. Plasma volume was reduced by 10.4 percent in HDT24 when compared to HDT1. Pre-exercise rectal temperature, T(sub re), was an average 0.22 C higher after HDT24. Rectal temperature increased during exercise with no interaction between time and treatment. The reduced PV and elevated pre-exercise T(sub re) had offsetting effects on thermoregulatory mechanisms, suggesting no alteration in the response at a given T(sub re). Plasma volume was reduced by 4.3 +/- 2.3 percent and 1.1 +/- 1.8 percent following HDT24 and WI, respectively, compared to upright chair rest. Although the reductions in PV were not significantly different, great intra-individual variability was evident. The ability to reproduce PV changes consistently with HDT and WI is limited by this variability.

Ertl, Andrew Carl↗

NASA NTRS1994

Thermoregulatory effects of caffeine ingestion during rest and exercise in men

Body temperatures and thermoregulatory responses were measured at rest and during submaximal exercise under normal ambient conditions in 11 aerobically-conditioned men (age = 29.2 +/- 6.2 yr, VO2(max) = 3.73 +/- 0.46 min(sup -1), relative body fat = 12.3 +/- 3.7 percent, mean +/- SD) with (CT) and without (NCT) the ingestion of 10 mg of caffeine per kg of body weight. Oxygen uptake (VO2), heart rate (HR), and rectal (T(sub re)) and mean skin (T-bar(sub sk)) temperatures were recorded for 100 minutes starting one minute after ingestion of caffeine or a placebo. Data were collected throughout 30 minutes of rest (sitting) and the following 70 minutes of sitting leg ergometer exercise using the same constant load (1,088 +/- 153 kgm/min) in both NCT and CT. The load resulted in a mean relative exercise intensity equal to approximately 68 percent of VO2(sub max). Skin heat conductance (H(sub sk)) and sweat rate were calculated. Two-way analysis of covariance revealed no significant (P greater than 0.05) differences between NCT and CT in VO2, HR, T(sub re), T-bar(sub sk), or H(sub sk). A dependent t-test indicated no significant difference between NCT and CT in sweat rate. Thus, a high level of caffeine ingestion has no detrimental effects on body temperatures and thermoregulatory responses during moderately heavy exercise in normal ambient conditions.

Dunagan, Nancy↗