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Space Biology and Medicine: Health, Performance, and Safety of Space Crews - Volume 4

Volume IV is devoted to examining the medical and associated organizational measures used to maintain the health of space crews and to support their performance before, during, and after space flight. These measures, collectively known as the medical flight support system, are important contributors to the safety and success of space flight. The contributions of space hardware and the spacecraft environment to flight safety and mission success are covered in previous volumes of the Space Biology and Medicine series. In Volume IV, we address means of improving the reliability of people who are required to function in the unfamiliar environment of space flight as well as the importance of those who support the crew. Please note that the extensive collaboration between Russian and American teams for this volume of work resulted in a timeframe of publication longer than originally anticipated. Therefore, new research or insights may have emerged since the authors composed their chapters and references. This volume includes a list of authors' names and addresses should readers seek specifics on new information. At least three groups of factors act to perturb human physiological homeostasis during space flight. All have significant influence on health, psychological, and emotional status, tolerance, and work capacity. The first and most important of these factors is weightlessness, the most specific and radical change in the ambient environment; it causes a variety of functional and structural changes in human physiology. The second group of factors precludes the constraints associated with living in the sealed, confined environment of spacecraft. Although these factors are not unique to space flight, the limitations they entail in terms of an uncomfortable environment can diminish the well-being and performance of crewmembers in space. The third group of factors includes the occupational and social factors associated with the difficult, critical nature of the crewmembers' work: the risks involved in space flight, changes in circadian rhythms, and intragroup interactions. The physical and emotional stress and fatigue that develop under these conditions also can disturb human health and performance. In addition to these factors, the risk also exists that crewmembers will develop various illnesses during flight. The risk of illness is no less during space flight than on Earth, and may actually be greater for some classes of diseases.

Dietlein, Lawrence F.↗

Life Sciences Data Archive (LSDA) in the Post-Shuttle Era

Now, more than ever before, NASA is realizing the value and importance of their intellectual assets. Principles of knowledge management, the systematic use and reuse of information/experience/expertise to achieve a specific goal, are being applied throughout the agency. LSDA is also applying these solutions, which rely on a combination of content and collaboration technologies, to enable research teams to create, capture, share, and harness knowledge to do the things they do well, even better. In the early days of spaceflight, space life sciences data were been collected and stored in numerous databases, formats, media-types and geographical locations. These data were largely unknown/unavailable to the research community. The Biomedical Informatics and Health Care Systems Branch of the Space Life Sciences Directorate at JSC and the Data Archive Project at ARC, with funding from the Human Research Program through the Exploration Medical Capability Element, are fulfilling these requirements through the systematic population of the Life Sciences Data Archive. This project constitutes a formal system for the acquisition, archival and distribution of data for HRP-related experiments and investigations. The general goal of the archive is to acquire, preserve, and distribute these data and be responsive to inquiries from the science communities.

Fitts, Mary A.↗

Life Sciences Data Archives (LSDA) in the Post-Shuttle Era

Now, more than ever before, NASA is realizing the value and importance of their intellectual assets. Principles of knowledge management-the systematic use and reuse of information, experience, and expertise to achieve a specific goal-are being applied throughout the agency. LSDA is also applying these solutions, which rely on a combination of content and collaboration technologies, to enable research teams to create, capture, share, and harness knowledge to do the things they do well, even better. In the early days of spaceflight, space life sciences data were collected and stored in numerous databases, formats, media-types and geographical locations. These data were largely unknown/unavailable to the research community. The Biomedical Informatics and Health Care Systems Branch of the Space Life Sciences Directorate at JSC and the Data Archive Project at ARC, with funding from the Human Research Program through the Exploration Medical Capability Element, are fulfilling these requirements through the systematic population of the Life Sciences Data Archive. This project constitutes a formal system for the acquisition, archival and distribution of data for HRP-related experiments and investigations. The general goal of the archive is to acquire, preserve, and distribute these data and be responsive to inquiries for the science communities. Information about experiments and data, as well as non-attributable human data and data from other species' are available on our public Web site http://lsda.jsc.nasa.gov. The Web site also includes a repository for biospecimens, and a utilization process. NASA has undertaken an initiative to develop a Shuttle Data Archive repository. The Shuttle program is nearing its end in 2010 and it is critical that the medical and research data related to the Shuttle program be captured, retained, and usable for research, lessons learned, and future mission planning. Communities of practice are groups of people who share a concern or a passion for something they do, and learn how to do it better as they interact regularly. LSDA works with the HRP community of practice to ensure that we are preserving the relevant research and data they need in the LSDA repository. An evidence-based approach to risk management is required in space life sciences. Evidence changes over time. LSDA has a pilot project with Collexis, a new type of Web-based search engine. Collexis differentiates itself from full-text search engines by making use of thesauri for information retrieval. The high-quality search is based on semantics that have been defined in a life sciences ontology. Additionally, Collexis' matching technology is unique, allowing discovery of partially matching dicuments. Users do not have to construct a complicated (Boolean) search query, but can simply enter a free text search without the risk of getting "no results". Collexis may address these issues by virtue of its retrieval and discovery capabilities across multiple repositories.

Fitts, Mary A.↗

A Tale of Two Chambers: Iterative Approaches and Lessons Learned from Life Support Systems Testing in Altitude Chambers

The drive for the journey to Mars is in a higher gear than ever before. We are developing new spacecraft and life support systems to take humans to the Red Planet. The journey that development hardware takes before its final incarnation in a fully integrated spacecraft can take years, as is the case for the Orion environmental control and life support system (ECLSS). Through the Pressure Integrated Suit Test (PIST) series, NASA personnel at Johnson Space Center have been characterizing the behavior of a closed loop ECLSS in the event of cabin depressurization. This kind of testing - one of the most hazardous activities performed at JSC - requires an iterative approach, increasing in complexity and hazards). The PIST series, conducted in the Crew and Thermal Systems Division (CTSD) 11-ft Chamber, started with unmanned test precursors before moving to a human-in-the-loop phase, and continues to evolve with the eventual goal of a qualification test for the final system that will be installed on Orion. Meanwhile, the Human Exploration Spacecraft Testbed for Integration and Advancement (HESTIA) program is an effort to research and develop technologies that will work in concert to support habitation on Mars. September 2015 marked the first unmanned HESTIA test, with the goal of characterizing how ECLSS technologies work together in a closed environment. HESTIA will culminate in crewed testing, but it can benefit from the lessons learned from another test that is farther ahead in its development and life cycle. Discussing PIST and HESTIA, this paper illustrates how we approach testing, the kind of information that facility teams need to ensure efficient collaborations and successful testing, and how we can apply what we learn to execute future tests.

Callini, Gianluca↗

Changes in Exercise Data Management

The suite of exercise hardware aboard the International Space Station (ISS) generates an immense amount of data. The data collected from the treadmill, cycle ergometer, and resistance strength training hardware are basic exercise parameters (time, heart rate, speed, load, etc.). The raw data are post processed in the laboratory and more detailed parameters are calculated from each exercise data file. Updates have recently been made to how this valuable data are stored, adding an additional level of data security, increasing data accessibility, and resulting in overall increased efficiency of medical report delivery. Questions regarding exercise performance or how exercise may influence other variables of crew health frequently arise within the crew health care community. Inquiries over the health of the exercise hardware often need quick analysis and response to ensure the exercise system is operable on a continuous basis. Consolidating all of the exercise system data in a single repository enables a quick response to both the medical and engineering communities. A SQL server database is currently in use, and provides a secure location for all of the exercise data starting at ISS Expedition 1 - current day. The database has been structured to update derived metrics automatically, making analysis and reporting available within minutes of dropping the inflight data it into the database. Commercial tools were evaluated to help aggregate and visualize data from the SQL database. The Tableau software provides manageable interface, which has improved the laboratory's output time of crew reports by 67%. Expansion of the SQL database to be inclusive of additional medical requirement metrics, addition of 'app-like' tools for mobile visualization, and collaborative use (e.g. operational support teams, research groups, and International Partners) of the data system is currently being explored.

Buxton, R. E.↗

Phase 1 Study for the Phobos L1 Operational Tether Experiment (PHLOTE)

NASA's Innovative Advanced Concepts (NIAC) program selected the PHLOTE mission proposal for a 2017 Phase 1 study. This PHLOTE study provides a credible example of an innovative mission architecture that can be used to enable many future missions throughout the solar system.One of the key Phase 1 deliverables identified in the PHLOTE proposal is this Study Report which is derived from the PHLOTE Concept of Operations (ConOps) Document developed during the study. The PHLOTE ConOps describes the PHLOTE mission and also provides a key systems engineering document to support future mission development.Since this report was produced as part of a NIAC feasibility study, it is intended to be publicly released at the completion of the NIAC study. Significant support was provided through the collaboration of NASA and PHLOTE team members from Space Technology And Research (STAR) Inc. and from the Clouds Architecture Office (Clouds AO). The NASA team was supported by summer and fall interns from five separate universities.

Kempton, Kevin↗

Changes in Exercise Data Management

The suite of exercise hardware aboard the International Space Station (ISS) generates an immense amount of data. The data collected, treadmill, cycle ergometer, and resistance strength training hardware, are basic exercise parameters (time, heart rate, speed, load, etc.). The raw data are processed in the laboratory and more detailed parameters are calculated from each exercise data file. Updates recently have been made to how these valuable data are stored, adding an additional level of security, increasing accessibility, and resulting in overall increased efficiency of medical report delivery. Questions regarding exercise performance or how exercise may influence other variables of crew health frequently arise within the crew health care community. Inquiries regarding the health of the exercise hardware often need quick analysis and response to ensure the exercise system is operable on a continuous basis. Consolidating all of the exercise system data in a single repository enables a quick response to both the medical and engineering communities. A SQL server database is currently in use, and provides a secure location for all of the exercise data starting at ISS Expedition 1 to current date. The database has been structured to update derived metrics automatically, making analysis and reporting available within minutes of dropping the in-flight data into the database. Commercial tools were evaluated to help aggregate and visualize data from the SQL database. The Tableau software provides manageable interface, which has improved the laboratory’s output time of crew reports by 67%. Expansion of the SQL database, to be inclusive of additional medical requirement metrics, addition of ‘app-like’ tools for mobile visualization, and collaborative use (e.g., operational support teams, research groups, and International Partners) of the data system, is currently being explored.

Buxton, R. E.↗

ISEP: A Joint SRAG/CCMC Collaboration to Improve Mitigation of Space Weather Effects on Crew Health in the Exo-LEO Era

The Space Radiation Analysis Group (SRAG) at Johnson Space Center (JSC) is tasked with monitoring changes to space weather and mitigating any resultant impacts to crew health and safety. As human spaceflight goals extend from Low-Earth Orbit (LEO) missions like the International Space Station (ISS) to the moon, Mars and beyond, SRAG will need to update their current approach for crew monitoring of and protection from radiation exposure due to energetic Solar Particle Events (ESPEs). Challenges faced in planning exo-LEO missions include the lack of protection from the Earth’s geomagnetic field employed by the ISS in addition to limited communication capability between the crew and the ground. In the event of an ESPE, the current ISS trajectory ensures that the vehicle is only traveling through fields of higher radiation exposure for a brief period of time; the Earth’s geomagnetic field prevents the penetration of the high-energy particles of concern throughout the majority of the orbit. Exo-LEO missions, on the other hand, require that the vehicle travel through free space, exposing vehicle and crew to the full impact of the ESPE. NASA has combined multiple approaches to resolve this radiation exposure issue. New vehicles are designed to take advantage of advances in particle transport modeling capabilities and shielding technology, allowing redistribution of mass throughout the vehicle to areas of thinner shielding when the energetic particle flux has increased to levels of concern. Although vehicle shielding is an important aspect of radiation exposure protection, there is a continued requirement to monitor and predict the space weather environment. To this end, SRAG maintains a console position in Mission Control with 24/7 mission support capability. In the event of increased solar activity, SRAG collaborates with the Flight Control Team (FCT) to determine if crew action (i.e., shelter) is required. During any increase in solar activity, the FCT needs three pieces of information to effectively decide the crew response in light of other required mission tasks: if an event (ESPE) will occur, how ‘intense’ an observed event will be, and how long will an observed event will last. An ideal alert system limits false alarms, therefore causing the crew to take action unnecessarily, without ignoring events that pose a hazard to the crew. SRAG’s current operational concept for ISS missions focuses on short-term forecasts, best described as ‘now-casting’. Console operators are in daily communication with the Space Weather Prediction Center (SWPC) for situational awareness purposes. When conditions exist that may lead to increased solar activity, operators receive notifications from SWPC. In the case of a well-connected ESPE, the console operator may only have on the order of minutes to several hours to notify the FCT of the event and provide a recommendation for crew action. As NASA shifts to exo-LEO missions, the increased time in free space as well as the reduced ability to communicate with the crew will force a transition in crew protection strategy that emphasizes improvments to both the accuracy and the lead time in forecasting capabilities.

Barzilla, Janet E.↗

Leveraging Partnerships, Science Content, Special Events, and NASA Assets to Help Girl Scouts Earn Space Science Badges

Throughout 2019, NASA celebrated historic anniversaries and announced bold new programs generating excitement about earth and space exploration. One of the most notable events was the celebration of the 50th anniversary of Apollo 11 historic first steps on the Moon. Complementing this anniversary event were the additional activities and events conducted across the agency that highlighted the many science achievements that were attained across all of NASA’s Science Mission Directorate (SMD) Divisions (earth, planetary, heliophysics, and astrophysics). Further excitement was generated through NASA’s Artemis program which plans to send the first woman and next man to the surface of the Moon. NASA continues to inspire the public including learners of all ages around the world. Building on this momentum, in October 2019, the Astromaterials Research and Exploration Science (ARES) Science Engagement team partnered with the Lunar and Planetary Institute (LPI) and the Girl Scouts of San Jacinto to host an event that enabled Girl Scouts to earn recently released space science badges developed by the Reach for the Stars: NASA Science for Girls Scouts Program. The event celebrated SMD science and highlighted Earth’s Moon and International Observe the Moon Night (InOMN) while facilitating the earning of the NASA inspired space science badges. This event was coordinated and led by the ARES Science Engagement team as part of their collaborative work and involvement in NASA’s SMD Science Activation Program.

Graff, P. V.↗

Variable Pressure - Scanning Electron Microscopy (VP-SEM)

Variable Pressure (or Environmental) Scanning Electron Microscopy (VP-SEM) combined with Energy Dispersive X-ray Spectroscopy (EDS) is one of the most powerful methods for characterizing the sub-micron topography and chemical composition of uncoated samples. Terrestrially, VP-SEM is extensively used to non-destructively study geologic and manufactured materials with high spatial resolution (tens of nanometers) and large depth-of-field. An SEM offers a geologist a first survey of microscopic mineral phases via secondary electron imaging (SEI), which provides a topographic look at a sample, as well as backscattered electron (BEI) imaging, which contrasts the phases present based on their geochemistry (atomic number). A VP-SEM utilizes a gas in the sample chamber as a charge dissipation and signal amplification method, allowing analysis of a sample without preparation in the form of a conductive coating. A miniaturized VP-SEM operating in-situ on a lander or rover would be able to use the CO2-rich Martian atmosphere (e.g., Nier et al., 1976; Williams 2016) as an imaging medium for this purpose. Adaptation of a VP-SEM for in-situ Mars surface studies will provide a new imaging capability (via SEI) that is at least an order of magnitude higher resolution than the Mars Hand Lens Imager (MAHLI) on the Mars Science Laboratory (Williams et al., 2015), and equal to or better than the achieved resolution of the Atomic Force Microscope on the Phoenix Mars lander (Pike et al., 2011). In addition, the MVP-SEM is capable of BSI and simultaneous chemical analysis of the imaged region. In this sense, the MVP-SEM can be regarded as an instrument suite that will provide a new set of information not achievable by any other instrument. The Miniaturized Variable Pressure Scanning Electron Microscope (MVP-SEM) was designed, built, and benchtop tested by a team at NASA’s Marshall Space Flight Center and Jet Propulsion Laboratory (JPL), Jacobs Space Exploration Group, Applied Physics Technologies, Inc. (AP-Tech), and Creare LLC, working with a team of technical and science collaborators. Benchtop testing was successful, proving concept feasibility. To date, the MVP-SEM has achieved an imaging resolution of <100 nm in the lab, and with continued optimization, even better performance (~50 nm resolution) is possible. Use in-situ on the lunar or other planetary surfaces would require some redesign to optimize instrument performance, but such an instrument would be equally useful.

Variable Pressure Scanning Electron Microscopy↗

Miniature Variable Pressure - Scanning Electron Microscopy (MVP-SEM)

Variable Pressure (or Environmental) Scanning Electron Microscopy (VP-SEM) combined with Energy Dispersive X-ray Spectroscopy (EDS) is one of the most powerful methods for characterizing the sub-micron topography and chemical composition of uncoated samples. Terrestrially, VP-SEM is extensively used to non-destructively study geologic and manufactured materials with high spatial resolution (tens of nanometers) and large depth-of-field. An SEM offers a geologist a first survey of microscopic mineral phases via secondary electron imaging (SEI), which provides a topographic look at a sample, as well as backscattered electron (BEI) imaging, which contrasts the phases present based on their geochemistry (atomic number). A VP-SEM utilizes a gas in the sample chamber as a charge dissipation and signal amplification method, allowing analysis of a sample without preparation in the form of a conductive coating. A miniaturized VP-SEM operating in-situ on a lander or rover would be able to use the CO2-rich Martian atmosphere (e.g., Nier et al., 1976; Williams 2016) as an imaging medium for this purpose. Adaptation of a VP-SEM for in-situ Mars surface studies will provide a new imaging capability (via SEI) that is at least an order of magnitude higher resolution than the Mars Hand Lens Imager (MAHLI) on the Mars Science Laboratory (Williams et al., 2015), and equal to or better than the achieved resolution of the Atomic Force Microscope on the Phoenix Mars lander (Pike et al., 2011). In addition, the MVP-SEM is capable of BSI and simultaneous chemical analysis of the imaged region. In this sense, the MVP-SEM can be regarded as an instrument suite that will provide a new set of information not achievable by any other instrument. The Miniaturized Variable Pressure Scanning Electron Microscope (MVP-SEM) was designed, built, and benchtop tested by a team at NASA’s Marshall Space Flight Center and Jet Propulsion Laboratory (JPL), Jacobs Space Exploration Group, Applied Physics Technologies, Inc. (AP-Tech), and Creare LLC, working with a team of technical and science collaborators. Benchtop testing was successful, proving concept feasibility. To date, the MVP-SEM has achieved an imaging resolution of <100 nm in the lab, and with continued optimization, even better performance (~50 nm resolution) is possible. Use in-situ on the lunar or other planetary surfaces would require some redesign to optimize instrument performance, but such an instrument would be equally useful.

Variable Pressure Scanning Electron Microscopy↗

BRAINSTACK – A Platform for Artificial Intelligence & Machine Learning Collaborative Experiments on a Nano-Satellite

As space missions continue to become more ambitious, complex, and distant to Earth, the need for advanced on-board intelligent decision making to guide everything from mission operations to fault detection and recovery has become a major front of space research. While the prevalence of research on such Artificial Intelligence / Machine Learning (AI/ML) modules has exploded, the capacity to experimentally validate such modules in space in a rapid and inexpensive format has not. To this end, the Nano Orbital Workshop (NOW) group at NASA Ames Research Center has been at the forefront of performing initial flight evaluation tests of ‘commercially’ available AI/ML computational platforms via the TechEdSat (TES-n) flight series as part of what is programmatically referred to as the BRAINSTACK. BRAINSTACK will provide an orbital AI/ML evaluation laboratory where computational experiments are pre-loaded into memory prior to launch, and then executed as desired during the mission, with results reported back and program tweaks or new data sets uploaded as needed. Processors selected as part of the BRAINSTACK are of ideal size, packaging, and power consumption for easy integration into a cube satellite structure. These experiments have included the evaluation of small, high-performance GPUs and more recently, neuromorphic processors in LEO operations. Neuromorphic processors are of particular interest due to their superior computational power efficiency over GPUs. The first TES-n flight test of an Intel first-generation Loihi neuromorphic processor launched on January 13, 2022 and continues to operate in orbit despite almost no space environment modifications. The Intel Loihi Gen-1 is characterized by a 14nm 128-core Spiking Neural Network (SNN) able to support on-chip training. This experiment utilized a Loihi packaged in the ‘Kapoho Bay’ USB module, providing a relatively straight-forward interface to the bus avionics system. The Kapoho Bay was in turn managed by a host Intel Pentium single-board computer to handle scheduling of the AI/ML application payloads, and communications with the satellite vehicle manager. The recently released Intel Loihi Gen-2, able to support integer-valued spike payloads and produced using 7nm process, will form part of the basis of the evolving BRAINSTACK in the upcoming three TES-n/NOW flights. Additionally, it is planned to measure the radiation environment these processors experience to understand any degradation or computational artifacts caused by long term space radiation exposure on these novel architectures. This evolving flexible and collaborative environment involving various research teams across NASA and other organizations is intended to be a convenient orbital test platform from which many anticipated future space AI/ML applications may be initially tested.

Artificial Intelligence↗

BRAINSTACK – A Platform for Artificial Intelligence & Machine Learning Collaborative Experiments on a Nano-Satellite

As space missions continue to become more ambitious, complex, and distant to Earth, the need for advanced on-board intelligent decision making to guide everything from mission operations to fault detection and recovery has become a major front of space research. While the prevalence of research on such Artificial Intelligence / Machine Learning (AI/ML) modules has exploded, the capacity to experimentally validate such modules in space in a rapid and inexpensive format has not. To this end, the Nano Orbital Workshop (NOW) group at NASA Ames Research Center has been at the forefront of performing initial flight evaluation tests of ‘commercially’ available AI/ML computational platforms via the TechEdSat (TES-n) flight series as part of what is programmatically referred to as the BRAINSTACK. BRAINSTACK will provide an orbital AI/ML evaluation laboratory where computational experiments are pre-loaded into memory prior to launch, and then executed as desired during the mission, with results reported back and program tweaks or new data sets uploaded as needed. Processors selected as part of the BRAINSTACK are of ideal size, packaging, and power consumption for easy integration into a cube satellite structure. These experiments have included the evaluation of small, high-performance GPUs and more recently, neuromorphic processors in LEO operations. Neuromorphic processors are of particular interest due to their superior computational power efficiency over GPUs. The first TES-n flight test of an Intel first-generation Loihi neuromorphic processor launched on January 13, 2022 and continues to operate in orbit despite almost no space environment modifications. The Intel Loihi Gen-1 is characterized by a 14nm 128-core Spiking Neural Network (SNN) able to support on-chip training. This experiment utilized a Loihi packaged in the ‘Kapoho Bay’ USB module, providing a relatively straight-forward interface to the bus avionics system. The Kapoho Bay was in turn managed by a host Intel Pentium single-board computer to handle scheduling of the AI/ML application payloads, and communications with the satellite vehicle manager. The recently released Intel Loihi Gen-2, able to support integer-valued spike payloads and produced using 7nm process, will form part of the basis of the evolving BRAINSTACK in the upcoming three TES-n/NOW flights. Additionally, it is planned to measure the radiation environment these processors experience to understand any degradation or computational artifacts caused by long term space radiation exposure on these novel architectures. This evolving flexible and collaborative environment involving various research teams across NASA and other organizations is intended to be a convenient orbital test platform from which many anticipated future space AI/ML applications may be initially tested.

Artificial Intelligence↗

BRAINSTACK – A Platform for Artificial Intelligence & Machine Learning Collaborative Experiments on a Nano-Satellite

As the space economy continues to expand through increasingly easy access to advanced and inexpensive technology, space missions themselves have become more ambitious with exploration targets growing ever distant while simultaneously requiring larger guidance and communication budgets. These conflicting desires of distance and control drive the need for advanced on-board intelligent decision making to reduce communication and control limitations by automating as many mission functions as possible in-situ. While the amount of research on such Artificial Intelligence and Machine Learning (AI/ML) software modules has grown exponentially, the capacity to experimentally validate such software modules in space in a rapid and inexpensive format has not. To this end, the Nano Orbital Workshop (NOW) group at NASA Ames Research Center has been at the forefront of performing initial flight evaluation tests of ‘commercially’ available bleeding-edge computational platforms via what is programmatically referred to as the BrainStack on the TechEdSat (TES-n) flight series. This on-orbit computational platform provides an evaluation laboratory where advanced software experiments are pre-loaded into memory prior to launch, then executed as payloads during mission operations with results reported back and program tweaks or new training sets uploaded as needed. Processors selected as part of the BrainStack are of ideal size, packaging, and power consumption for easy integration into a cube satellite structure. These experiments have included the evaluation of small, high-performance GPUs and, more recently, neuromorphic processors, in LEO operations. Neuromorphic processors are of particular interest due to their superior power efficiency over GPUs in intelligent automation applications. The first TES-n flight test of an Intel first-generation Loihi neuromorphic processor launched on TES-13, January 13, 2022, and continues to operate in orbit despite no significant modifications to harden the processor against the space environment. The Intel Loihi Gen-1 on TES-13 is characterized by a 14nm 128-core Spiking Neural Network (SNN) able to support on-chip training. The processor is packaged in the Kapoho Bay USB module, providing a relatively straight-forward interface to the bus avionics system. The Kapoho Bay was in turn managed by an Intel Pentium single-board computer to handle scheduling of the software application payloads and communications with the satellite’s primary computer. The recently released Intel Loihi Gen-2, able to support integer-valued spike payloads and produced using 7nm process, will form part of the continually evolving BrainStack in the upcoming three TES-n/NOW flights. The Kapoho Point unit will incorporate eight Loihi-2 processors, enabling neural networks of up to one million neurons and one billion synapsis. Additionally, it is planned to measure the radiation environment these processors experience to understand any degradation or computational artifacts caused by long term space radiation exposure on these novel architectures. This evolving flexible and collaborative environment involving various research teams across NASA and other organizations is intended to be a convenient orbital test platform from which many anticipated future space automation applications may be initially tested.

Artificial Intelligence↗

WIP: Collaborating to Introduce Second-Life Battery Technology Research in an Informal STEM Learning Environment

This work in progress, innovative practice, paper outlines an interdisciplinary collaborative model utilized by a team of educational researchers, and engineers to design a series of community-centered, place-based learning activities suitable for a middle or high school informal STEM learning environment. Based on the potential applications and benefits of Second-Life Electric Vehicle Batteries, the activities connect cutting-edge STEM research with multidimensional real-world challenges within their communities related to climate change, renewable energy integration and storage, intelligent transportation systems, and optimized energy management, that empowers students to think critically about the role they can play in shaping a more resilient, environmentally sustainable community.

Whiteside, Hope↗

Challenges of Operations in a Dynamic Environment: A Three-Year Perspective of SAGE III

The Stratospheric Aerosol and Gas Experiment~III on the International Space Station (SAGE III/ISS) was delivered to the International Space Station (ISS) on 23 February 2017. The SAGE III/ISS payload was robotically installed external to the ISS and began acquiring science measurements on 17 March 2017. The SAGE III/ISS instrument retrieves vertical profiles of atmospheric ozone, multi-wavelength aerosol extinctions, and other gaseous species. This paper will focus on the improvements made to the operations of the SAGE III/ISS payload. A key focus of the operations team following commissioning was to create robust tools that aide in the operations of the payload. A close collaboration with the SAGE III/ISS ground systems team allowed for the development of web-based tools to continuously monitor the health of the instrument. The mission operations team also worked with the SAGE III/ISS science team to gain a better sense of how the instrument works to maximize the quality and quantity of the science data collected. Another unique aspect of the SAGE III/ISS payload, that will be discussed, is the challenges of operating a hosted payload on the ISS; an active platform that has frequent attitude maneuvers, dockings, and EVA's. This active environment increases the need for the SAGE III/ISS operations team command the payload. Through coordination and teamwork, SAGE III/ISS mission has developed an operations team that has successfully managed the instrument around ISS activities and recovered from multiple instrument upsets. This has led the SAGE III/ISS payload to successfully surpass the acquisition metrics set forth prior to launch, allowing for the continued contribution to studying the atmospheric composition of the stratosphere and how it plays a role in earth’s climate.

SAGE III↗

Operations Challenges in a Dynamic Environment: A Three-Year Perspective of SAGE III

The Stratospheric Aerosol and Gas Experiment III on the International Space Station (SAGE III/ISS) was delivered to the International Space Station (ISS) on 23 February 2017. The SAGE III/ISS payload was robotically installed external to the ISS and began acquiring science measurements on 17 March 2017. The SAGE III/ISS instrument retrieves vertical profiles of atmospheric ozone, multi-wavelength aerosol extinctions, and other gaseous species. This paper will focus on the improvements made to the operations of the SAGE III/ISS payload. A key focus of the operations team following commissioning was to create robust tools that aid in the operations of the payload. A close collaboration with the SAGE III/ISS ground systems team allowed for the development of web-based tools to continuously monitor the health of the payload. The mission operations team also worked with the SAGE III/ISS science team to gain a better sense of how the instrument works to maximize the quality and quantity of the science data collected. Another unique aspect of the SAGE III/ISS payload, that will be discussed, is the challenges of operating a hosted payload on the ISS; an active platform that has frequent attitude maneuvers, dockings, and EVAs. This active environment increases the need for the SAGE III/ISS operations team command to the payload. Through coordination and teamwork, SAGE III/ISS mission has developed an operations team, tool, and procedures that have successfully managed the payload around ISS activities and recovered from multiple instrument upsets. This has led the SAGE III/ISS payload to successfully surpass the acquisition metrics set forth prior to launch, allowing for the continued contribution to studying the atmospheric composition of the stratosphere and how it plays a role in Earth’s climate.

SAGE III↗

A National Virtual Specimen Database for Early Cancer Detection

Access to biospecimens is essential for enabling cancer biomarker discovery. The National Cancer Institute's (NCI) Early Detection Research Network (EDRN) comprises and integrates a large number of laboratories into a network in order to establish a collaborative scientific environment to discover and validate disease markers. The diversity of both the institutions and the collaborative focus has created the need for establishing cross-disciplinary teams focused on integrating expertise in biomedical research, computational and biostatistics, and computer science. Given the collaborative design of the network, the EDRN needed an informatics infrastructure. The Fred Hutchinson Cancer Research Center, the National Cancer Institute,and NASA's Jet Propulsion Laboratory (JPL) teamed up to build an informatics infrastructure creating a collaborative, science-driven research environment despite the geographic and morphology differences of the information systems that existed within the diverse network. EDRN investigators identified the need to share biospecimen data captured across the country managed in disparate databases. As a result, the informatics team initiated an effort to create a virtual tissue database whereby scientists could search and locate details about specimens located at collaborating laboratories. Each database, however, was locally implemented and integrated into collection processes and methods unique to each institution. This meant that efforts to integrate databases needed to be done in a manner that did not require redesign or re-implementation of existing system

distributed↗