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Effects of prolonged bed rest on the total peripheral resistance baroreflex

Orthostatic intolerance following prolonged exposure to microgravity continues to be a primary concern of the human space program. Reduced autonomic tone has been demonstrated to contribute to this phenomenon, and the heart rate baroreflex, in particular, has been repeatedly shown to be impaired. However, only the works of Yelle et al. have attempted to address the role of the total peripheral resistance (TPR) baroreflex, a potentially more significant contributor to blood pressure regulation. We applied a previously developed method for estimating the static gains of both the arterial and cardiopulmonary TPR baroreflexes to data obtained before and after 16-day bed rest. Reductions in the estimated static gains of the arterial (statistically significant) and cardiopulmonary TPR baroreflexes were found after bed rest. This study supports the works of Yelle et al, which imply that the TPR baroreflex is reduced after spaceflight.

Non-NASA Center↗

Risk of Adverse Health Outcomes and Decrements in Performance Due to In-flight Medical Conditions

The drive to undertake long-duration space exploration missions at greater distances from Earth gives rise to many challenges concerning human performance under extreme conditions. At NASA, the Human Research Program (HRP) has been established to investigate the specific risks to astronaut health and performance presented by space exploration, in addition to developing necessary countermeasures and technology to reduce risk and facilitate safer, more productive missions in space (NASA Human Research Program 2009). The HRP is divided into five subsections, covering behavioral health, space radiation, habitability, and other areas of interest. Within this structure is the ExMC Element, whose research contributes to the overall development of new technologies to overcome the challenges of expanding human exploration and habitation of space. The risk statement provided by the HRP to the ExMC Element states: "Given that medical conditions/events will occur during human spaceflight missions, there is a possibility of adverse health outcomes and decrements in performance in mission and for long term health" (NASA Human Research Program 2016). Within this risk context, the Exploration Medical Capabilities (ExMC) Element is specifically concerned with establishing evidenced-based methods of monitoring and maintaining astronaut health. Essential to completing this task is the advancement in techniques that identify, prevent, and treat any health threats that may occur during space missions. The ultimate goal of the ExMC Element is to develop and demonstrate a pathway for medical system integration into vehicle and mission design to mitigate the risk of medical issues. Integral to this effort is inclusion of an evidence-based medical and data handling system appropriate for long-duration, exploration-class missions. This requires a clear Concept of Operations, quantitative risk metrics or other tools to address changing risk throughout a mission, and system scoping and system engineering. Because of the novel nature of the risks involved in exploration missions, new and complex ethical challenges are likely to be encountered. This document describes the relevant background and evidence that informs the development of an exploration medical system.

Antonsen,Erik↗

NASA Centers and Universities Collaborate in Annual Smallsat Technology Partnerships

The Small Spacecraft Technology program within the NASA Space Technology Mission Directorate sponsors the Smallsat Technology Partnerships (STP) initiative. The STP initiative awards cooperative agreements between NASA centers and university teams for technology development efforts that advance the capabilities of small spacecraft to achieve NASA mission objectives in unique and more affordable ways. NASA’s announcement to return humans to the Moon by 2024 raises new opportunities for Smallsats to contribute to missions in cislunar space, though technical challenges are to be overcome to establish their value in this environment. Precursor missions utilizing small spacecraft will blaze the trail for lunar exploration, establishing infrastructure such as communication and navigation networks, and performing assembly and repair services for larger structures and human habitats. To achieve these goals, certain novel Smallsat technologies will need to be developed and demonstrated. The 2020 STP solicitation sought proposals for specific technologies to enable these lunar missions. For the 2020 STP cycle, NASA selected nine university teams to mature new systems and capabilities in the laboratory, and in some cases, demonstrate in suborbital or orbital spaceflights. This paper describes the STP portfolio, past and present efforts, and the nine partnerships selected.

James J. Cockrell↗

Physical models reveal indirect reader protein interactions that facilitate epigenetic crosstalk

The spatial organization of chromatin is governed by epigenetic factors, including epigenetic marks and the reader proteins that bind them. By dictating the accessibility of genomic loci, epigenetic factors contribute to the physical regulation of gene expression, enabling diverse cellular phenotypes to be encoded by a shared genome in an individual. Epigenetic dysregulation can lead to aberrations in chromatin architecture, contributing to diseases such as neurological disorders and cancers. Despite the known importance of chromatin organization for human health, the physical mechanisms governing chromatin folding remain underspecified. In this work, we develop a physical model of chromatin organization based on contributions from multiple epigenetic factors. Using our model, we evaluate how conditions in the nuclear environment and crosstalk between epigenetic marks affect the compartmentalization of chromatin into dense heterochromatin and loose euchromatin. Our results emphasize the role of reader protein binding in chromatin compartmentalization. We show that reader proteins interact through an indirect mechanism facilitated by the shared chromatin “scaffold” to which they bind. Under a scenario where reader proteins compete for binding sites, we find that indirect interactions affect the program adopted by the chromatin fiber. By isolating indirect modes of epigenetic crosstalk, we demonstrate how the interplay between epigenetic patterning and environmental factors influences chromatin architecture.

59 BASIC BIOLOGICAL SCIENCES↗

Introduction to the Special Issue on Advanced Air Mobility Noise: Predictions, Measurements and Perception

This Special Issue focuses on noise associated with Advanced Air Mobility (AAM), an emerging class of predominantly electric distributed-propulsion aircraft designed for urban and regional transportation. As these vehicles move toward certification and deployment, noise has become a central challenge for regulatory approval and public acceptance, particularly due to operations in densely populated areas and at low altitudes. The 24 contributions in this issue address three key aspects of AAM noise: prediction, measurement, and human perception. Prediction studies span a wide range of modeling fidelities, from high-resolution simulations to improved semi-analytical approaches, and examine complex aeroacoustic mechanisms including rotor interactions, turbulence ingestion, and broadband noise generation. Measurement studies, largely at model scale, provide new insights into tonal and broadband noise characteristics across configurations and operating conditions, while supporting model validation. Perception-focused contributions investigate annoyance, sound quality metrics, and auralization, emphasizing the role of context and operational factors in shaping human response. Together, these works highlight the interdisciplinary nature of AAM noise research and the need for integrated approaches to enable quieter vehicle design.

Perception↗

Program for transfer research and impact studies

Research activities conducted under the Program for Transfer Research and Impact Studies (TRIS) during 1972 included: (1) preparation of 10,196 TSP requests for TRIS application analysis; (2) interviews with over 500 individuals concerning the technical, economic, and social impacts of NASA-generated technology; (3) preparation of 38 new technology transfer example files and 101 new transfer cases; and (4) maintenance of a technology transfer library containing more than 2,900 titles. Six different modes of technology utilization are used to illustrate the pervasiveness of the transfer and diffusion of aerospace innovations. These modes also provide a basis for distinguishing the unique characteristics of the NASA Technology Utilization Program. An examination is reported of the ways in which NASA-generated technology is contributing to beneficial social change in five major areas of human concern: health, environment, safety, transportation, and communication.

Rusnak, J. J.↗

Canadian medical experiments on Shuttle Flight 41-G

During the 41-G mission, two payload specialist astronauts took part in six Canadian medical experiments designed to measure how the human nervous system adapts to weightlessness, and how this might contribute to space motion sickness. Similar tests conducted pre-flight provided base-line data, and post-flight experiments examined re-adaptation to the ground. No changes were detected in the vestibulo-ocular reflex during this 8-day mission. Pronounced proprioceptive illusions were experienced, especially immediately post-flight. Tactile acuity was normal in the fingers and toes, but the ability to judge limb position was degraded. Estimates of the locations of familiar targets were grossly distorted in the absence of vision. There were no differences in taste thresholds or olfaction. Despite pre-flight tests showing unusual susceptibility to motion sickness, the Canadian payload specialist turned out to be less susceptible than normal on-orbit. Re-adaptation to the normal gravity environment occurred within the first day after landing.

Watt, D. G. D.↗

A Dynamic Earth: 50 Years of Observations from Space

Observations of the surface of the Earth began more than a half century ago with the earliest space missions. The global geopolitical environment at the beginning of the space age fueled advances in rocketry and human exploration, but also advances in remote sensing. At the same time that space-based Earth Observations were developing, global investments in infrastructure that were initiated after World War II accelerated large projects such as the construction of highways, the expansion of cities and suburbs, the damming of rivers, and the growth of big agriculture. These developments have transformed the Earth s surface at unprecedented rates. Today, we have a remarkable library of 50 years of observations of the Earth taken by satellite-based sensors and astronauts, and these images and observations provide insight into the workings of the Earth as a system. In addition, these observations record the footprints of human activities around the world, and illustrate how our activities contribute to the changing face of the Earth. Starting with the iconic "Blue Marble" image of the whole Earth taken by Apollo astronauts, we will review a timeline of observations of our planet as viewed from space.

Evans, Cynthia A.↗

International Space Station Earth Observations Working Group

The multilateral Earth Observations Working Group (EOWG) was chartered in May 2012 in order to improve coordination and collaboration of Earth observing payloads, research, and applications on the International Space Station (ISS). The EOWG derives its authority from the ISS Program Science Forum, and a NASA representative serves as a permanent co-chair. A rotating co-chair position can be occupied by any of the international partners, following concurrence by the other partners; a JAXA representative is the current co-chair. Primary functions of the EOWG include, 1) the exchange of information on plans for payloads, from science and application objectives to instrument development, data collection, distribution and research; 2) recognition and facilitation of opportunities for international collaboration in order to optimize benefits from different instruments; and 3) provide a formal ISS Program interface for collection and application of remotely sensed data collected in response to natural disasters through the International Charter, Space and Major Disasters. Recent examples of EOWG activities include coordination of bilateral data sharing protocols between NASA and TsNIIMash for use of crew time and instruments in support of ATV5 reentry imaging activities; discussion of continued use and support of the Nightpod camera mount system by NASA and ESA; and review and revision of international partner contributions on Earth observations to the ISS Program Benefits to Humanity publication.

Stefanov, William L.↗

The Role of Fire in Global Forest Loss Dynamics

Fires, among other forms of natural and anthropogenic disturbance, play a central role in regulating the location, composition and biomass of forests. Understanding the role of fire in global forest loss is crucial in constraining land-use change emissions and the global carbon cycle. We analysed the relationship between forest loss and fire at 500 m resolution based on satellite-derived data for the 2003–2018 period. Satellite fire data included burned area and active fire detections, to best account for large and small fires, respectively. We found that, on average, 38 ± 9% (± range) of global forest loss was associated with fire, and this fraction remained relatively stable throughout the study period. However, the fraction of fire-related forest loss varied substantially on a regional basis, and showed statistically significant trends in key tropical forest areas. Decreases in the fraction of fire-related forest loss were found where deforestation peaked early in our study period, including the Amazon and Indonesia while increases were found for tropical forests in Africa. The inclusion of active fire detections accounted for 41%, on average, of the total fire-related forest loss, with larger contributions in small clearings in interior tropical forests and human-dominated landscapes. Comparison to higher-resolution fire data with resolutions of 375 and 20 m indicated that commission errors due to coarse resolution fire data largely balanced out omission errors due to missed small fire detections for regional to continental-scale estimates of fire-related forest loss. Besides an improved understanding of forest dynamics, these findings may help to refine and separate fire-related and non-fire-related land-use change emissions in forested ecosystems.

Dan van Wees↗

Airspace Performance Observations of Scalable Autonomous Operations in a High Density Vertiplex Simulation

The National Aeronautics and Space Administration’s (NASA’s) High Density Vertiplex (HDV) subproject aims to develop and demonstrate progressive automation technologies that contribute to the Advanced Air Mobility (AAM) concept. Using Human-and-Hardware-In-TheLoop (HHITL) techniques, HDV demonstrates initial vertiport automation services at vertiports with increased air traffic volume in both simulated and live test environments. In 2023, the Scalable Autonomous Operations (SAO) simulation was conducted in which prototype vertiport, airspace, and ground control station technologies were assessed on technical performance. During the SAO simulation, an observational study captured an initial impression of the HDV airspace performance, potential disruptions to the airspace, and highlighted some capability and procedural gaps. Observations took place in two parts. In the first part, five scenario use cases (Nominal, Missed Approach, Speed Change, Divert, and MultiAircraft Divert) were conducted with three human operator roles (Vertiport Manager, Fleet Manager, and Ground Control Station Operator). Researchers collected metrics on throughput, closest point of approach, and airborne delay. In the second part of the study, the Missed Approach scenario was observed under three traffic density levels (20, 40, and 60 operations per hour) to challenge the automation to correctly identify slots in the vertiport arrival schedule. The results showed that the automation successfully found a slot for the Missed Approach vehicle in the 20 operations per hour condition, after some delay it found one in the 40 condition, and it did not find one in the 60 condition. The observations of technical and human performance throughout the five scenario use cases and the Missed Approach case study indicated that for HDV to increase traffic density and maintain or increase throughput, airspace monitoring services should be able to detect and resolve conflicts between aircraft. Furthermore, the roles and responsibilities of human operators need additional definition when it comes to responding to vehicle conflicts.

Advanced Air Mobility↗

Airspace Performance Observations of Scalable Autonomous Operations in a High Density Vertiplex Simulation

The National Aeronautics and Space Administration’s (NASA’s) High Density Vertiplex (HDV) sub- project aims to develop and demonstrate progressive automation technologies that contribute to the Advanced Air Mobility (AAM) concept. Using Human-and-Hardware-In-The- Loop (HHITL) techniques, HDV demonstrates initial vertiport automation services at vertiports with increased air traffic volume in both simulated and live test environments. In 2023, the Scalable Autonomous Operations (SAO) simulation was conducted in which prototype vertiport, airspace, and ground control station technologies were assessed on technical performance. During the SAO simulation, an observational study captured an initial impression of the HDV airspace performance, potential disruptions to the airspace, and highlighted some capability and procedural gaps. Observations took place in two parts. In the first part, five scenario use cases (Nominal, Missed Approach, Speed Change, Divert, and Multi- Aircraft Divert) were conducted with three human operator roles (Vertiport Manager, Fleet Manager, and Ground Control Station Operator). Researchers collected metrics on throughput, closest point of approach, and airborne delay. In the second part of the study, the Missed Approach scenario was observed under three traffic density levels (20, 40, and 60 operations per hour) to challenge the automation to correctly identify slots in the vertiport arrival schedule. The results showed that the automation successfully found a slot for the Missed Approach vehicle in the 20 operations per hour condition, after some delay it found one in the 40 condition, and it did not find one in the 60 condition. The observations of technical and human performance throughout the five scenario use cases and the Missed Approach case study indicated that for HDV to increase traffic density and maintain or increase throughput, airspace monitoring services should be able to detect and resolve conflicts between aircraft. Furthermore, the roles and responsibilities of human operators need additional definition when it comes to responding to vehicle conflicts.

advanced air mobility↗

Development of the Artemis Distributed Simulation FOMs

The National Aeronautics and Space Administration (NASA) is formulating and developing the Artemis Program, a collaboration with domestic commercial and international partners that will establish a long term human presence on the Moon and extend human exploration beyond the Earth-Moon system ahead of exploring Mars. These Artemis partners are developing a portfolio of space and surface systems to support human missions to the lunar surface and beyond. The Artemis systems will provide the mobility, habitation, and logistics infrastructure that will support human exploration and foster robust scientific investigations. Each partner will contribute one or more elements to the Artemis Program with NASA having the overarching responsibility for defining the Artemis architecture and guiding the integration of this complex system of space systems. To successfully accomplish this audacious task, NASA will rely on the development and execution of many complex models and simulations. Many of these simulations will be provided by the Artemis partners. While each of these simulations will provide important insight into the characteristics and performance of an associated system, individually they will not provide insight into the integrated performance of the architecture and the system of systems working in concert to execute a given Artemis mission. To address this need, NASA is developing a distributed simulation capability called the Artemis Distributed Simulation (ADS). ADS’s distributed nature supports the complex aggregation of constituent Artemis element simulations. Artemis partner simulations will be able to join into an ADS-based distributed simulation and interact with other Artemis element simulations while limiting the exposure of proprietary designs and data. ADS is defining a distributed simulation capability built on international simulation interoperability standards, specifically the High Level Architecture (HLA) and the Space Reference Federation Object Model (SpaceFOM). While HLA and SpaceFOM provide the substantive necessary technology basis for ADS, additional common datatypes, message definitions, and execution protocols are required. These extensions constitute the ADS Federation Object Model (FOM). This paper describes the fundamental architectural elements of ADS and the FOM extensions needed to support the complex nature of the Artemis Program. This includes the examination of the ADS FOM modules, ADS base datatypes, ADS SpaceFOM Object Class extensions, new ADS Object Classes, and new ADS Interaction Classes.

HLA↗

Development of the Artemis Distributed Simulation FOMs

The National Aeronautics and Space Administration (NASA) is formulating and developing the Artemis Program, a collaboration with domestic commercial and international partners that will establish a long term human presence on the Moon and extend human exploration beyond the Earth-Moon system ahead of exploring Mars. These Artemis partners are developing a portfolio of space and surface systems to support human missions to the lunar surface and beyond. The Artemis systems will provide the mobility, habitation, and logistics infrastructure that will support human exploration and foster robust scientific investigations. Each partner will contribute one or more elements to the Artemis Program with NASA having the overarching responsibility for defining the Artemis architecture and guiding the integration of this complex system of space systems. To successfully accomplish this audacious task, NASA will rely on the development and execution of many complex models and simulations. Many of these simulations will be provided by the Artemis partners. While each of these simulations will provide important insight into the characteristics and performance of an associated system, individually they will not provide insight into the integrated performance of the architecture and the system of systems working in concert to execute a given Artemis mission. To address this need, NASA is developing a distributed simulation capability called the Artemis Distributed Simulation (ADS). ADS’s distributed nature supports the complex aggregation of constituent Artemis element simulations. Artemis partner simulations will be able to join into an ADS-based distributed simulation and interact with other Artemis element simulations while limiting the exposure of proprietary designs and data. ADS is defining a distributed simulation capability built on international simulation interoperability standards, specifically the High Level Architecture (HLA) and the Space Reference Federation Object Model (SpaceFOM). While HLA and SpaceFOM provide the substantive necessary technology basis for ADS, additional common datatypes, message definitions, and execution protocols are required. These extensions constitute the ADS Federation Object Model (FOM). This paper describes the fundamental architectural elements of ADS and the FOM extensions needed to support the complex nature of the Artemis Program. This includes the examination of the ADS FOM modules, ADS base datatypes, ADS SpaceFOM Object Class extensions, new ADS Object Classes, and new ADS Interaction Classes.

HLA↗

Human-in-the-Loop Flight Simulation Experiment on Unmanned Aircraft Terminal Operations

A Detect and Avoid (DAA) System is a suite of sensors, tracker, and alerting and guidance algorithms that assist a remote pilot of an Unmanned Aircraft System in maintaining separation from airborne traffic by complying with current ‘see and avoid’ requirements. To date, work has focused on operations transiting to and from Class A or special use airspace. Current efforts are defining DAA system requirements for operations in and around terminal airspace. As a contribution to the current efforts, this paper presents results from a Human-in-the-Loop experiment comparing methods of changing from the transit-specific alerting and guidance criteria to the reduced terminal-specific alerting and guidance criteria.

Devin Patrick Jack↗

Recommendations Emerging from an Analysis of NASA's Deep Space Communications Capacity

During 2016-2017, NASA’s Space Communications and Navigation (SCaN) Office chartered a study of Deep Space Network (DSN) communications capacity relative to projected future-mission demand over the next 30 years. In this paper, we briefly describe the methodology used to analyze capacity vs. demand over such a broad timeframe, summarize key findings emerging from the analysis, and discuss the associated recommendations. Performing the analysis entailed: identifying key factors shaping the anticipated future mission set, identifying several alternative future mission set scenarios consistent with these factors, and then analyzing each mission set scenario in terms of required antenna capacity, downlink and uplink capabilities, and spectrum as a function of time. On the basis of these aggregate requirements, DSN loading simulations were then conducted that examined how well each of the postulated mission sets could load up onto the the DSN’s “in-plan” architecture. To the extent that capacity shortfalls emerged during these baseline simulations, architectural solutions to the shortfalls were then postulated and tested via additional simulations. In general, the trend analyses and baseline loading simulations indicated a significant progression in challenges over the next three decades. In the current decade, the DSN appeared to be operating very close to capacity. The first human exploration mission and its secondary payload launch opportunities for cubesats traveling beyond GEO contributed to this loading. As a consequence, the main challenge appeared to be managing peak assetcontention periods. In the next decade, the DSN continued to operate close to capacity but also began transitioning to more frequent human mission support. Upgrading for, and operating, a human-rated system while continuing to meet robotic mission customer requirements emerged as the key challenge. In the 2030’s and beyond, simulations suggested a need for fundamentally new capability and capacity. The high data rates and long link distances characteristic of human Mars exploration drove requirements far beyond what is currently “in plan.” The key challenge then became determining the most cost-effective combination of RF and optical assets for communicating with the postulated human Mars assets while still providing for the needs of all the other missions across the solar system. Various link budget, visibility, and loading analyses ultimately suggested that the human Mars exploration demands of the 2030’s could best be addressed with two cross-linked RF-optical areostationary relays (or an areostationary relay and deep space habitat) providing a dual “trunk link” to an array of 2-to-3 additional 34m beam waveguide antennas and an ~8.5m optical antenna at each DSN Complex. The dual “trunk link” would enable the same amount of total data return to Earth as a single trunk link at twice the data rate, but with only half the required array size on the ground, assuming use of Multiple Spacecraft Per Antenna (MSPA) techniques. MSPA techniques, including a Multiple Uplink Per Antenna (MUPA) technique currently under investigation, also showed promise for reducing asset contention in the decades prior to human Mars exploration.

Lee, Carlyn-Ann↗

The Importance of HRA in Human Space Flight: Understanding the Risks

Human performance is critical to crew safety during space missions. Humans interact with hardware and software during ground processing, normal flight, and in response to events. Human interactions with hardware and software can cause Loss of Crew and/or Vehicle (LOCV) through improper actions, or may prevent LOCV through recovery and control actions. Humans have the ability to deal with complex situations and system interactions beyond the capability of machines. Human Reliability Analysis (HRA) is a method used to qualitatively and quantitatively assess the occurrence of human failures that affect availability and reliability of complex systems. Modeling human actions with their corresponding failure probabilities in a Probabilistic Risk Assessment (PRA) provides a more complete picture of system risks and risk contributions. A high-quality HRA can provide valuable information on potential areas for improvement, including training, procedures, human interfaces design, and the need for automation. Modeling human error has always been a challenge in part because performance data is not always readily available. For spaceflight, the challenge is amplified not only because of the small number of participants and limited amount of performance data available, but also due to the lack of definition of the unique factors influencing human performance in space. These factors, called performance shaping factors in HRA terminology, are used in HRA techniques to modify basic human error probabilities in order to capture the context of an analyzed task. Many of the human error modeling techniques were developed within the context of nuclear power plants and therefore the methodologies do not address spaceflight factors such as the effects of microgravity and longer duration missions. This presentation will describe the types of human error risks which have shown up as risk drivers in the Shuttle PRA which may be applicable to commercial space flight. As with other large PRAs of complex machines, human error in the Shuttle PRA proved to be an important contributor (~12 percent) to LOCV. An existing HRA technique was adapted for use in the Shuttle PRA, but additional guidance and improvements are needed to make the HRA task in space-related PRAs easier and more accurate. Therefore, this presentation will also outline plans for expanding current HRA methodology to more explicitly cover spaceflight performance shaping factors.

Hamlin, Teri↗