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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 325 records · Page 18
All sourcesNASA NTRSDOE OSTI
NASA NTRS2024

Integrating Manned Aircraft and UAVs for the Prediction, Tracking, and Eradication of Desert Locust Swarms

Desert locusts (Schistocerca gregaria) present an acute threat to the agriculture of certain regions, capable of annihilating vast expanses of farmland and destabilizing food security. In this paper, an aviation-based framework concept is introduced that integrates both manned aircraft and Unmanned Aerial Vehicles (UAVs) to preemptively forecast, localize, and eliminate locust swarms efficiently. The framework begins by leveraging predictive modeling methods to refine search areas and pinpoint high-value Points of Interest (POIs) where locust swarms are most likely to materialize. From there, the proposed two-step model uses optical, infrared, and hyperspectral sensors onboard manned aircraft to conduct long-range surveying of probable swarm locations. Upon detection of a swarm, UAVs equipped with sophisticated sensors, including pheromone detectors, thermal and optical imaging systems, are deployed directly from the aircraft to carry out targeted biopesticide applications. This approach, which capitalizes on the combined strengths of both vehicles, provides the rapid response and large-scale intervention necessary to control locust outbreaks. By targeting locust swarms during their most destructive phase, this paper aims to disrupt the locust life cycle and mitigate their severe agricultural impact, offering a scalable and sustainable solution for food security in afflicted regions.

locust monitoring systems↗
DOE OSTI2022

Extension of Interferometric Synthetic Aperture Radar to Multiple Phase-Centers (Midyear LDRD Final Report – second edition)

This document contains the final report for the midyear LDRD titled "Extension of Interferometric Synthetic Aperture Radar to Multiple Phase-Centers." This report presents an overview of several methods for approaching the two-target in layover problem that exists in interferometric synthetic aperture radar systems. Simulation results for one of the methods are presented. In addition, a new direct approach is introduced.

42 ENGINEERING↗
DOE OSTI2023

Autonomous and dynamic precursor selection for solid-state materials synthesis

Abstract Solid-state synthesis plays an important role in the development of new materials and technologies. While in situ characterization and ab-initio computations have advanced our understanding of materials synthesis, experiments targeting new compounds often still require many different precursors and conditions to be tested. Here we introduce an algorithm (ARROWS 3 ) designed to automate the selection of optimal precursors for solid-state materials synthesis. This algorithm actively learns from experimental outcomes to determine which precursors lead to unfavorable reactions that form highly stable intermediates, preventing the target material’s formation. Based on this information, ARROWS 3 proposes new experiments using precursors it predicts to avoid such intermediates, thereby retaining a larger thermodynamic driving force to form the target. We validate this approach on three experimental datasets, containing results from over 200 synthesis procedures. In comparison to black-box optimization, ARROWS 3 identifies effective precursor sets for each target while requiring substantially fewer experimental iterations. These findings highlight the importance of domain knowledge in optimization algorithms for materials synthesis, which are critical for the development of fully autonomous research platforms.

36 MATERIALS SCIENCE↗
NASA NTRS2017

NASA's Near Earth Asteroid Scout Mission

NASA is developing solar sail propulsion for a near-term Near Earth Asteroid (NEA) reconnaissance mission and laying the groundwork for their future use in deep space science and exploration missions. The NEA Scout mission, funded by NASA's Advanced Exploration Systems Program and managed by NASA MSFC, will use the sail as primary propulsion allowing it to survey and image one or more NEA's of interest for possible future human exploration. NEA Scout uses a 6U cubesat (to be provided by NASA's Jet Propulsion Laboratory), an 86 m2 solar sail and will weigh less than 14 kilograms. The solar sail for NEA Scout will be based on the technology developed and flown by the NASA NanoSail-D and The Planetary Society's Lightsail-A. Four ~7 m stainless steel booms wrapped on two spools (two overlapping booms per spool) will be motor deployed and pull the sail from its stowed volume. The sail material is an aluminized polyimide approximately 3 microns thick. NEA Scout will launch on the Space Launch System (SLS) first mission in 2018 and deploy from the SLS after the Orion spacecraft is separated from the SLS upper stage. The NEA Scout spacecraft will stabilize its orientation after ejection using an onboard cold-gas thruster system. The same system provides the vehicle Delta-V sufficient for a lunar flyby. After its first encounter with the moon, the 86 m2 sail will deploy, and the sail characterization phase will begin. A mechanical Active Mass Translation (AMT) system, combined with the remaining ACS propellant, will be used for sail momentum management. Once the system is checked out, the spacecraft will perform a series of lunar flybys until it achieves optimum departure trajectory to the target asteroid. The spacecraft will then begin its two year-long cruise. About one month before the asteroid flyby, NEA Scout will pause to search for the target and start its approach phase using a combination of radio tracking and optical navigation. The solar sail will provide continuous low thrust to enable a relatively slow flyby of the target asteroid under lighting conditions favorable to geological imaging. Once complete, NASA will have demonstrated the capability to fly low-cost, high Delta-V cubesats to perform interplanetary missions.

Johnson, Les↗
NASA NTRS2019

OSIRIS-REx Orbit Determination Performance During the Navigation Campaign

The OSIRIS-REx mission Navigation Campaign consists of three sub-phases: Approach,Preliminary Survey, and Orbital A. Approach was designed for initial characterization ofBennu while matching Bennu's heliocentric velocity. Preliminary Survey provided the firstspacecraft-based estimate of Bennu's mass. This phase consisted of five target flybys witha close approach distance of about 7 km. Orbital A was a two-month phase devoted to theNavigation Team learning the close proximity operations dynamics and environment aroundBennu and transitioning from center-finding optical navigation to landmark feature-basednavigation. This paper provides a detailed summary of the orbit determination performancethroughout the Navigation Campaign.

Leonard, Jason M.↗
NASA NTRS2019

Near Earth Asteroid Scout: Exploring Asteroid 1991VG Using A Smallsat

After its deployment from NASA’s Space Launch System (SLS) in 2020, the Near Earth Asteroid (NEA) Scout mission will image an asteroid on a close flyby using an 86m2 solar sail as its primary propulsion. NEA Scout, with a 6U CubeSat form factor, is one of several secondary CubeSat payloads to be deployed from the SLS on its maiden flight. The NEA Scout will be ejected from the SLS on a trajectory toward the moon and will use its onboard cold gas propulsion system to attain an elliptical lunar orbit. Once the spacecraft is in orbit, the solar sail will deploy and spacecraft checkout will begin. The NEA Scout will remain in the lunar vicinity until the low-thrust trajectory to the destination asteroid, 1991VG, or another NEA of interest, can be attained. The spacecraft will then begin its 2.0 – 2.5 year journey to the asteroid. About one month before the asteroid flyby, NEA Scout will search for the target and start its Approach Phase, using a combination of radio tracking and optical navigation. The solar sail will provide continuous low thrust to enable a relatively slow flyby (10-20 m/s) of the target asteroid under lighting conditions favorable to geological imaging (<50 degree phase angle). Once the flyby is complete, and if the system is still fully functioning, an extended mission will be considered – the reconnaissance of another asteroid or a re-flyby of the first asteroid several months later are both options. NEA Scout is funded by the NASA Human Exploration and Operations Mission Directorate.

In-Space Propulsion↗
NASA NTRS2004

Autonomous target tracking of small bodies during flybys

Spacecraft flybys of small solar system bodies provide important science return in the form of images of the target body taken around closest approach. In order to maximize the number of images taken of the target, an autonomous closed-loop tracking system has been developed to maintain lock on the target during the flyby. The system uses images to estimate the spacecrafts target-relative position and attitude, which is then used to point the camera. The system has been successfully used twice: the Deep Space 1 flyby of comet Borrelly and the Stardust flyby of asteroid Annefrank. This paper describes in detail the tracking algorithms and flight results.

Synnott, Stephen P.↗
DOE OSTI2024

Multiomic Network Analysis Identifies Dysregulated Neurobiological Pathways in Opioid Addiction

BACKGROUND: Opioid addiction is a worldwide public health crisis. In the United States, for example, opioids cause more drug overdose deaths than any other substance. However, opioid addiction treatments have limited efficacy, meaning that additional treatments are needed. METHODS: To help address this problem, we used network-based machine learning techniques to integrate results from genome-wide association studies of opioid use disorder and problematic prescription opioid misuse with transcriptomic, proteomic, and epigenetic data from the dorsolateral prefrontal cortex of people who died of opioid overdose and control individuals. RESULTS: Here we identified 211 highly interrelated genes identified by genome-wide association studies or dysregulation in the dorsolateral prefrontal cortex of people who died of opioid overdose that implicated the Akt, BDNF (brain-derived neurotrophic factor), and ERK (extracellular signal-regulated kinase) pathways, identifying 414 drugs targeting 48 of these opioid addiction–associated genes. Some of the identified drugs are approved to treat other substance use disorders or depression. CONCLUSIONS: Our synthesis of multiomics using a systems biology approach revealed key gene targets that could contribute to drug repurposing, genetics-informed addiction treatment, and future discovery.

60 APPLIED LIFE SCIENCES↗
NASA NTRS2020

Computational Investigation of Powered Descent for Human-Scale Mars Landers

NASA human-scale Mars entry, descent, and landing vehicles currently under consideration have system requirements beyond the current state of the art. Specifically, heritage approaches for deceleration using parachutes and initiating engines at subsonic speeds are not adequate to land these large vehicles (50-60 metric ton entry mass) precisely (within 50 meters of a surface target). Therefore, the present approach for landing humans on Mars utilizes entry vehicles with large aerodynamic surface areas that transition to the descent and landing phase by initiating retropropulsion at supersonic speeds. Vehicle performance, including stability and control, depends on accurate characterization of the aerodynamic-propulsive interference effects, especially at engine initiation, when the vehicles are transitioning from an entry attitude to that suitable for descent and landing. This paper summarizes the human Mars entry vehicle configurations, retropropulsion integration, performance assumptions, and expected flight environment at engine initiation. Cases spanning supersonic, transonic, and subsonic conditions during powered descent are analyzed using four computational fluid dynamics codes, all of which have been previously applied to supersonic retropropulsion at varying scales and conditions. The results of the analysis are used to develop an aerodynamic-propulsive interference model that has since been applied in trajectory simulations to augment the fidelity of human-scale Mars entry vehicle performance.

Ashley M Korzun↗
DOE OSTI2023

A New Drug Discovery Platform: Application to DNA Polymerase Eta and Apurinic/Apyrimidinic Endonuclease 1

The ability to quickly discover reliable hits from screening and rapidly convert them into lead compounds, which can be verified in functional assays, is central to drug discovery. The expedited validation of novel targets and the identification of modulators to advance to preclinical studies can significantly increase drug development success. Our SaXPyTM (“SAR by X-ray Poses Quickly”) platform, which is applicable to any X-ray crystallography-enabled drug target, couples the established methods of protein X-ray crystallography and fragment-based drug discovery (FBDD) with advanced computational and medicinal chemistry to deliver small molecule modulators or targeted protein degradation ligands in a short timeframe. Our approach, especially for elusive or “undruggable” targets, allows for (i) hit generation; (ii) the mapping of protein–ligand interactions; (iii) the assessment of target ligandability; (iv) the discovery of novel and potential allosteric binding sites; and (v) hit-to-lead execution. These advances inform chemical tractability and downstream biology and generate novel intellectual property. We describe here the application of SaXPy in the discovery and development of DNA damage response inhibitors against DNA polymerase eta (Pol η or POLH) and apurinic/apyrimidinic endonuclease 1 (APE1 or APEX1). Notably, our SaXPy platform allowed us to solve the first crystal structures of these proteins bound to small molecules and to discover novel binding sites for each target.

59 BASIC BIOLOGICAL SCIENCES↗
NASA NTRS1978

Perpetual factors involved in performance of air traffic controllers using a microwave landing system

The task involved the control of two simulated aircraft targets per trial, in a 37.0 -km radius terminal area, by means of conventional radar vectoring and/or speed control. The goal was to insure that the two targets crossed the Missed Approach Point (MAP) at the runway threshold exactly 60 sec apart. The effects on controller performance of the MLS configuration under wind and no-wind conditions were examined. The data for mean separation time between targets at the MAP and the range about that mean were analyzed by appropriate analyses of variance. Significant effects were found for mean separation times as a result of the configuration of the MLS and for interaction between the configuration and wind conditions. The analysis of variance for range indicated significantly poorer performance under the wind condition. These findings are believed to be a result of certain perceptual factors involved in radar air traffic control (ATC) using the MLS with separation of targets in time.

Gershzohn, G.↗
DOE OSTI2026

A Data-Driven Method for Synthetic Extreme Weather Generation and Solar Impact Assessment: Preprint

High-resolution, high-fidelity weather datasets are essential for testing and evaluating the resilience of power systems, particularly under extreme weather conditions. However, existing extreme weather datasets are typically derived from historical events that are localized and may lack the spatial and temporal resolution or scenario diversity needed to test largescale power systems. In this work, we propose a synthetic extreme weather simulation approach capable of generating targeted extreme events, such as hurricanes, using publicly available data sources. Preliminary results demonstrate the impact of a simulated Category 1 hurricane on renewable generation and critical infrastructure in California. The work aims to provide a flexible approach for creating multiple types of extreme weather scenarios across different regions, enabling comprehensive system stress testing, training, and resilience assessment.

24 POWER TRANSMISSION AND DISTRIBUTION↗
NASA NTRS1992

Spacecraft-spacecraft very long baseline interferometry. Part 1: Error modeling and observable accuracy

In Part 1 of this two-part article, an error budget is presented for Earth-based delta differential one-way range (delta DOR) measurements between two spacecraft. Such observations, made between a planetary orbiter (or lander) and another spacecraft approaching that planet, would provide a powerful target-relative angular tracking data type for approach navigation. Accuracies of better than 5 nrad should be possible for a pair of spacecraft with 8.4-GHz downlinks, incorporating 40-MHz DOR tone spacings, while accuracies approaching 1 nrad will be possible if the spacecraft incorporate 32-GHz downlinks with DOR tone spacing on the order of 250 MHz; these accuracies will be available for the last few weeks or months of planetary approach for typical Earth-Mars trajectories. Operational advantages of this data type are discussed, and ground system requirements needed to enable spacecraft-spacecraft delta DOR observations are outlined. This tracking technique could be demonstrated during the final approach phase of the Mars '94 mission, using Mars Observer as the in-orbit reference spacecraft, if the Russian spacecraft includes an 8.4-GHz downlink incorporating DOR tones. Part 2 of this article will present an analysis of predicted targeting accuracy for this scenario.

Edwards, C. D., Jr.↗
NASA NTRS1991

Spacecraft-spacecraft very long baseline interferometry for planetary approach navigation

The study presents an error budget for Delta differential one-way range (Delta-DOR) measurements between two spacecraft. Such observations, made between a planetary orbiter (or lander) and another spacecraft approaching that planet, would provide a powerful target-relative angular tracking data type for approach navigation. Accuracies of about 5 nrad should be possible for a pair of X-band spacecraft incorporating 40-MHz DOR tone spacings, while accuracies approaching 1 nrad will be possible if the spacecraft incorporate Ka-band downlinks with DOR tone spacings of order 250 MHz. Operational advantages of this data type are discussed, and ground system requirements needed to enable S/C-S/C Delta-DOR observations are outlined. A covariance analysis is presented to examine the potential navigation improvement for this scenario. The results show factors of 2-3 improvement in spacecraft targeting over conventional Doppler, range, and quasar-relative VLBI, along with reduced sensitivity to ephemeris uncertainty and other systematic errors.

Edwards, Charles D., Jr.↗
NASA NTRS2019

Validation and Uncertainty Analysis of Stereo Time-Resolved PIV Measurements for Boundary-Layer Transition Research

An uncertainty analysis was performed on the stereo time-resolved particle image velocimetry measurements that were obtained in the boundary-layer of a swept wing model. Several different approaches were undertaken to estimate the uncertainty of the PIV measurements and to understand how that uncertainty propagates through to the results of interest. It was found that the stereo registration error, which is often neglected in stereo- PIV uncertainty analysis, can cause significant errors in the measured amplitude of the stationary cross ow instability due to the large spanwise velocity gradients that occur in the ow. The self-calibrations do not always adequately correct for the stereo-registration error. A simple approach is demonstrated for estimating the error due to a misalignment of the calibration target and laser plane. This approach was found to be very successful at predicting the error in stationary cross ow amplitude caused by the misalignment. The time-resolved PIV results are also compared to previously-acquired hotwire data. The TRPIV technique is successful at measuring the same types of unsteady instabilities as the hotwire, and thus does not appear to have any adverse e ect on the transition process due to the introduction of particles into the ow. It was also found that a larger interrogation window size is beneficial for reducing the noise of the TRPIV results.

Eppink, Jenna L.↗
NASA NTRS2012

Challenges of Sustaining the International Space Station through 2020 and Beyond: Including Epistemic Uncertainty in Reassessing Confidence Targets

This paper introduces an analytical approach, Probability and Confidence Trade-space (PACT), which can be used to assess uncertainty in International Space Station (ISS) hardware sparing necessary to extend the life of the vehicle. There are several key areas under consideration in this research. We investigate what sparing confidence targets may be reasonable to ensure vehicle survivability and for completion of science on the ISS. The results of the analysis will provide a methodological basis for reassessing vehicle subsystem confidence targets. An ongoing annual analysis currently compares the probability of existing spares exceeding the total expected unit demand of the Orbital Replacement Unit (ORU) in functional hierarchies approximating the vehicle subsystems. In cases where the functional hierarchies availability does not meet subsystem confidence targets, the current sparing analysis further identifies which ORUs may require additional spares to extend the life of the ISS. The resulting probability is dependent upon hardware reliability estimates. However, the ISS hardware fleet carries considerable epistemic uncertainty (uncertainty in the knowledge of the true hardware failure rate), which does not currently factor into the annual sparing analysis. The existing confidence targets may be conservative. This paper will also discuss how confidence targets may be relaxed based on the inclusion of epistemic uncertainty for each ORU. The paper will conclude with strengths and limitations for implementing the analytical approach in sustaining the ISS through end of life, 2020 and beyond.

Anderson, Leif↗
DOE OSTI2021

Discovery of amivantamab (JNJ-61186372), a bispecific antibody targeting EGFR and MET

A bispecific antibody (BsAb) targeting the epidermal growth factor receptor (EGFR) and mesenchymal–epithelial transition factor (MET) pathways represents a novel approach to overcome resistance to targeted therapies in patients with non–small cell lung cancer. In this study, we sequentially screened a panel of BsAbs in a combinatorial approach to select the optimal bispecific molecule. The BsAbs were derived from different EGFR and MET parental monoclonal antibodies. Initially, molecules were screened for EGFR and MET binding on tumor cell lines and lack of agonistic activity toward MET. Hits were identified and further screened based on their potential to induce untoward cell proliferation and cross-phosphorylation of EGFR by MET via receptor colocalization in the absence of ligand. After the final step, we selected the EGFR and MET arms for the lead BsAb and added low fucose Fc engineering to generate amivantamab (JNJ-61186372). The crystal structure of the anti-MET Fab of amivantamab bound to MET was solved, and the interaction between the two molecules in atomic details was elucidated. Amivantamab antagonized the hepatocyte growth factor (HGF)-induced signaling by binding to MET Sema domain and thereby blocking HGF β-chain—Sema engagement. The amivantamab EGFR epitope was mapped to EGFR domain III and residues K443, K465, I467, and S468. Furthermore, amivantamab showed superior antitumor activity over small molecule EGFR and MET inhibitors in the HCC827-HGF in vivo model. Based on its unique mode of action, amivantamab may provide benefit to patients with malignancies associated with aberrant EGFR and MET signaling.

59 BASIC BIOLOGICAL SCIENCES↗