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At least 343 records · Page 19

Measuring the spectrum of mutation induced by nitrogen ions and protons in the human-hamster hybrid cell line A(L)C

Astronauts can be exposed to charged particles, including protons, alpha particles and heavier ions, during space flights. Therefore, studying the biological effectiveness of these sparsely and densely ionizing radiations is important to understanding the potential health effects for astronauts. We evaluated the mutagenic effectiveness of sparsely ionizing 55 MeV protons and densely ionizing 32 MeV/nucleon nitrogen ions using cells of two human-hamster cell lines, A(L) and A(L)C. We have previously characterized a spectrum of mutations, including megabase deletions, in human chromosome 11, the sole human chromosome in the human-hamster hybrid cell lines A(L)C and A(L). CD59(-) mutants have lost expression of a human cell surface antigen encoded by the CD59 gene located at 11p13. Deletion of genes located on the tip of the short arm of 11 (11p15.5) is lethal to the A(L) hybrid, so that CD59 mutants that lose the entire chromosome 11 die and escape detection. In contrast, deletion of the 11p15.5 region is not lethal in the hybrid A(L)C, allowing for the detection of chromosome loss or other chromosomal mutations involving 11p15.5. The 55 MeV protons and 32 MeV/nucleon nitrogen ions were each about 10 times more mutagenic per unit dose at the CD59 locus in A(L)C cells than in A(L) cells. In the case of nitrogen ions, the mutations observed in A(L)C cells were predominantly due to chromosome loss events or 11p deletions, often containing a breakpoint in the pericentromeric region. The increase in the CD59(-) mutant fraction for A(L)C cells exposed to protons was associated with either translocation of portions of 11q onto a hamster chromosome, or discontinuous or "skipping" mutations. We demonstrate here that A(L)C cells are a powerful tool that will aid in the understanding of the mutagenic effects of different types of ionizing radiation.

Non-NASA Center↗

Stability of {sup 248–254}Cf isotopes against alpha and cluster radioactivity

Stability of {sup 248–254}Cf nuclei against alpha and cluster emissions is studied within our Coulomb and proximity potential model (CPPM). It is found that these nuclei are stable against light clusters (except alpha particles) and unstable against heavy cluster (A{sub 2}≥40) emissions. For heavy cluster emissions the daughter nuclei lead to doubly magic {sup 208}Pb or the neighbouring one. The effects of quadrupole and hexadecapole deformations of parent nuclei, daughter nuclei and emitted cluster on half lives are also studied. The computed alpha decay half life values (including quadrupole deformation β{sub 2}) are in close agreement with experimental data. Inclusion of quadrupole deformation reduces the height and width of the barrier (increases the barrier penetrability) and hence half life decreases. -- Highlights: •{sup 248–254}Cf parents are stable against light clusters (except alpha particles) and are unstable against heavy clusters ({sup 46}Ar, {sup 48,50}Ca etc.). •For the case of heavy cluster emissions the daughter nuclei are doubly magic {sup 208}Pb or neighbouring one. •The alpha decay half lives are in agreement with experimental data. •The cluster decay half lives decrease with the inclusion of quadrupole deformation.

73 NUCLEAR PHYSICS AND RADIATION PHYSICS↗

A review of solar wind ion and electron plasma distribution functions: Present understanding and Ulysses results

Our present understanding of the distribution functions of the solar wind ion and electron thermal/suprathermal populations will be reviewed covering selected theoretical and observational topics. Roughly half the review will be devoted to recent discoveries (since Solar Wind 7). Among recent results are those of the Ulysses mission. The SWICS experiment observed pick-up protons and alpha particles, and acceleration of these particles at interplanetary shocks. Positive ion phenomena observed by SWOOPS include enhanced proton-alpha particle differential streaming both: (1) at high latitudes; and (2) in the ecliptic beyond 1 AU in the vicinity of shocks. The SWOOPS positive ion observations also demonstrate relative constancy of the entropy per proton at high latitudes beyond about 2.5 AU. Double beaming in both protons and alphas is observed by SWOOPS on either side of the current sheet, but not within; a possible explanation is reconnection at the edge of the current sheet. SWOOPS observed bi-directional streaming of electrons beyond 2 AU not only within Coronal Mass Ejections, but also upstream of corotating interplanetary shocks. Latitudinal and radial gradients of Ulysses electron core and halo temperatures will be discussed, as will work in progress on the three dimensional (in velocity space) properties of ion distributions.

Goldstein, B. E.↗

SU-F-T-140: Assessment of the Proton Boron Fusion Reaction for Practical Radiation Therapy Applications Using MCNP6

Purpose: The proton boron fusion reaction is a reaction that describes the creation of three alpha particles as the result of the interaction of a proton incident upon a 11B target. Theoretically, the proton boron fusion reaction is a desirable reaction for radiation therapy applications in that, with the appropriate boron delivery agent, it could potentially combine the localized dose delivery protons exhibit (Bragg peak) and the local deposition of high LET alpha particles in cancerous sites. Previous efforts have shown significant dose enhancement using the proton boron fusion reaction; the overarching purpose of this work is an attempt to validate previous Monte Carlo results of the proton boron fusion reaction. Methods: The proton boron fusion reaction, 11B(p, 3α), is investigated using MCNP6 to assess the viability for potential use in radiation therapy. Simple simulations of a proton pencil beam incident upon both a water phantom and a water phantom with an axial region containing 100ppm boron were modeled using MCNP6 in order to determine the extent of the impact boron had upon the calculated energy deposition. Results: The maximum dose increase calculated was 0.026% for the incident 250 MeV proton beam scenario. The MCNP simulations performed demonstrated that the proton boron fusion reaction rate at clinically relevant boron concentrations was too small in order to have any measurable impact on the absorbed dose. Conclusion: For all MCNP6 simulations conducted, the increase of absorbed dose of a simple water phantom due to the 11B(p, 3α) reaction was found to be inconsequential. In addition, it was determined that there are no good evaluations of the 11B(p, 3α) reaction for use in MCNPX/6 and further work should be conducted in cross section evaluations in order to definitively evaluate the feasibility of the proton boron fusion reaction for use in radiation therapy applications.

60 APPLIED LIFE SCIENCES↗

Production of Astatine-211 at the Duke University Medical Center for its regional distribution

Systemic targeted radiation therapy and radioimmunotherapy continue to be important tools in the treatment of certain cancers. Because of their high energy and short path length, alpha particle emitters such as 211 At are more effective than either external beam x- ray or in vivo beta radiation in delivering potentially curative doses of radiation. The limited clinical trials that have been conducted to date have yielded encouraging responses in some patients, e.g., malignant brain tumors. In order to escalate the additional necessary research and development in radiochemistry, radiobiology and efficacy evaluation of alpha particle radiotherapeutics, it is universally agreed that access to an affordable, reliable supply of 211 At is warranted. In conjunction with the Department of Energy's intent to enhance stable and radioactive isotope availability for research applications, it is the primary objective of this project to improve 211 At production and purification capabilities at Duke so that this radionuclide can be supplied to researchers at other institutions throughout the US.The most widely used 211 At production method involves the α,2n reaction on Bismuth using a cyclotron with beams ≤ 28 MeV. Yields can be enhanced with use of an internal target that allows for a higher alpha fluence plus efficient heat dissipation in the target. Both of these items are in place at Duke; however, in order to support production for multi-institutional use, irradiation campaigns in excess of 50 µAp and four hours duration will be needed. Further, post-irradiation processing equipment is lacking that will enable the distribution process. Financial support is sought for i) a shielded, ventilated processing/containment hood; ii) development of a post-irradiation target retrieval system; iii) fabrication of a 211 At distillation and recovery module and iv) a performance review and, where needed, an enhancement of seven major subsystems that comprise the CS-30 Cyclotron. With these modifications in place, routine production of ≥200 mCi of At-211 should be readily achievable, given our methodological development of At-211 target preparation, internal target irradiation and dry distillation to recover the radionuclide.

62 RADIOLOGY AND NUCLEAR MEDICINE↗

ITER diagnostic systems in development in Ioffe Institute

Three diagnostic systems are being developed in Ioffe Institute for ITER. Those are Neutral Particle Analysis (NPA), Thomson Scattering in Divertor (TSD) and Gamma Spectroscopy (GS). The main objective of NPA in ITER is to measure D/T fuel ration in plasma on the basis of measurement of neutralized fluxes of D and T ions [1]. Fuel ratio is one of the key parameters needed by ITER control system to provide the optimal conditions in plasma and the most effective plasma burning. Another objective is to measure the distribution function of fast ions (including alpha particles) generated as a result of the additional heating and nuclear fusion reactions. Thomson Scattering in Divertor (TSD) [2] will be used to measure electron temperature and density in the scrape-off layer in outer leg of ITER divertor. The main task of TSD is to protect the machine from divertor overloading. Gamma Spectroscopy (GS) [3] is based on the measurement of spectral lines of MeV range gammas generated in nuclear reactions in plasma. 2-D gamma-ray emission measurements give valuable information on the confined alpha particles in DT plasma. They also provide important information on the location of MeV range runaway electron beams in ITER plasma. For all three cases the physical basis and instrumentation are presented. The simple NPA version for measurements of D/T ratio in DEMO is also briefly described.

73 NUCLEAR PHYSICS AND RADIATION PHYSICS↗

Thoron detection with an active Radon exposure meter—First results

For state-of-the-art discrimination of Radon and Thoron several measurement techniques can be used, such as active sampling, electrostatic collection, delayed coincidence method, and alpha-particle-spectroscopy. However, most of the devices available are bulky and show high power consumption, rendering them unfeasible for personal exposition monitoring. Based on a Radon exposure meter previously realized at the Helmholtz Center Munich (HMGU), a new electronic prototype for Radon/Thoron monitoring is currently being developed, which features small size and weight. Operating with pin-diode detectors, the low-power passive-sampling device can be used for continuous concentration measurements, employing alpha-particle-spectroscopy and coincidence event registration to distinguish decays originating either from Radon or Thoron isotopes and their decay products. In open geometry, preliminary calibration measurements suggest that one count per hour is produced by a 11 Bq m{sup −3} Radon atmosphere or by a 15 Bq m{sup −3} Thoron atmosphere. Future efforts will concentrate on measurements in mixed Radon/Thoron atmospheres.

54 ENVIRONMENTAL SCIENCES↗

Transport and deceleration of fusion products in microturbulence

The velocity-space distribution of alpha particles born in fusion devices is subject to modification at moderate energies due to turbulent transport. Therefore, one must calculate the evolution of an equilibrium distribution whose functional form is not known a priori. Using a novel technique, applicable to any trace impurity, we have made this calculation for fully nonlinear gyrokinetic simulations not only possible but also particularly efficient. We demonstrate a microturbulence-induced departure from the local slowing-down distribution, an inversion of the energy distribution, and associated modifications to the alpha heating and pressure profiles in an ITER-like scenario.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗

Leakage of magnetospheric ions into the magnetosheath along reconnected field lines at the dayside magnetopause

Strong evidence is presented for escape of magnetospheric particles along reconnected field lines into the magnetosheath, using observations of approximately 30 to approximately 120-keV/charge protons and alpha particles made by the Max-Planck-Institut/University of Maryland instrument on Isee 1. During three magnetopause crossings, which have been identified from tangential stress balance analysis as reconnection events, the magnetospheric particle distribution extends well into the magnetosheath, and the particles in the magnetosheath show a strong anisotropy along the magnetic field. The proton to alpha particle ratio in this layer as well as in distinct bursts within the magnetosheath is the same as this ratio within the magnetosphere (at equal energy per charge). It is concluded that the most likely explanation for these observations is that magnetospheric particles are escaping along reconnected field lines into the magnetosheath. It is argued that magnetospheric particles are seen in the magnetosheath up to the reconnection separatrix, and the magnetosheath bursts are interpreted as multiple encounters of this magnetosheath layer by the satellite due to boundary motions.

Scholer, M.↗

DUSEL R&D: BetaCage: A Screener of Ultra-Low-Level Radioactive Surface Contamination (Final Report)

The eventual full-size, radiopure BetaCage will be a low-background, atmospheric-pressure neon drift chamber with unprecedented sensitivity to emitters of low-energy electrons and alpha particles. We expect that the prototype BetaCage already developed will be an excellent screener of alpha particles. Both the prototype and final BetaCage will provide new infrastructure for rare-event science.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

Roles of core-shell and {delta}-ray kinetics in layered BN {alpha}-voltaic efficiency

{alpha}-voltaics harvest electron-hole pairs created as energetic {alpha} particles collide with and ionize electrons in a semiconductor, creating {delta}-rays. After ionization, charged pair production continues through {delta}-ray impact ionization events and the Auger relaxation of core-shell holes created through K-shell ionization events. Secondary ionization events are quantified using the TPP-2M model, the fraction of K-shell ionization events is determined using the energy-loss Coulomb-repulsion perturbed-stationary-state relativistic theory, and the relaxation of the resulting holes is treated with a fully ab initio approach using multiple Fermi golden rule calculations for ranges of carrier concentrations and temperatures. The limiting rate is 15 ns{sup -1} for small carrier concentrations and high temperatures, as compared to the radiative core-shell relaxation rate estimated here at 20 ns{sup -1}, indicating that Auger modes contribute significantly. Moreover, the K-shell ionization events are shown to dominate for low energy {alpha} particles and vanish for high energy ones. Thus, the efficiency loss due to energy dissipation in the fuel layer is mitigated, which is demonstrated by the analysis of a layered fuel-voltaic device with an efficiency from 20% to 14% for fuel layers between 5 and 10 {mu}m thick. The design of a {alpha}-voltaic integrated with a thermoelectric generator is suggested for improved efficiency and the system-level mitigation of radiation damage and geometric inefficiency.

75 CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND↗

Comparing Measured (a,n) Thick Target Yields to MCNP6 using TENDL 2012 Libraries - Paper 31

MCNP6, due to the heritage of MCNPX, has always possessed the capability to transport the light ions, such as alpha particles. Two types of competing physics take place during the particle transport: atomic and nuclear physics. Charged particles lose energy to media due to Coulombic interactions. MCNP6 models Coulombic interactions through the use of the continuous slowing down approximation. Stopping powers are calculated at a variety of energies using the Bethe-Bloch formula with Sternheimer and Peierls density effect correction. For energies less than 1.31 MeV/AMU, a low-energy SPAR model is used. When the energy of the particle is high enough, there is a transition from nuclear interactions to nucleon interactions. MCNP6 possess various physics models to account for these types of intra-nuclear cascades. These models are less accurate at low energies. Even though MCNP6 will transport these light ions to low energies (i.e. less than 20 MeV), most of the available model physics in MCNP6, for nuclear interactions, has a suggested minimum energy of ∼20-200 MeV. The result of the poorer prediction at low energies causes important light ion events, such as F-19(a,n)Na-22 from U-234 decay in UF{sub 6}, to produce orders of magnitude fewer neutrons in MCNP6 than should be emitted. As with neutrons, ACE (A Compact ENDF) formatted light ion libraries have been developed from several different evaluations. These libraries possess better physics at low energies where the physics models break down. The TENDL 2012 evaluations possess alpha transport libraries, in ACE format, such that they can easily be used with codes like MCNP6 that read ACE formatted cross sections. As a result, a capability was developed for MCNP6 to read and implement these library cross sections when the light ion reached energies below the library upper energy cutoff. Perfectly modelling an experiment for benchmark comparisons to a code calculation can be tricky. For complex setups, systematic error is always possible; and usually a hefty uncertainty analysis is required to quantify just the geometry setup and material combination choices. For an (a,n) interaction, a thick target yield is defined as the amount of neutrons emitted given that the alpha ranges out in the material. For alpha transport at low energy <10 MeV, in reasonably dense materials (>1-2 g/cc), with a material dimension length larger than a few hundred microns, alpha particles will tend to completely stop and range out in the material. For Li, Be, B, C, N, O, F, Na, Mg and Al thick target yields exist in 200 keV intervals from 1 to 9.8 MeV (most of the elements do have (a,n) thresholds above 1 MeV). Because modelling a thick target yield in MCNP6 is much easier than attempting to account for the complexity of systematic error from a full out experiment, we present here comparisons of (a,n) thick target yields to those calculated in MCNP6 using the TENDL 2012 alpha library evaluations.

61 RADIATION PROTECTION AND DOSIMETRY↗

Effect of Space Radiation on TES Detectors Performance

The Athena mission and its X-IFU instrument (X-ray Integral Field Unit) will be positioned at the Sun-Earth Lagrangian point L1, where it will be subject to solar wind (low flux plasma of 95% protons and 5% alpha particles) with energy below 0.1 MeV, and to galactic cosmic rays and solar flares (energetic protons, alpha particles, and electrons) with energies up to hundreds of MeV for protons and the GeV for heavier ions. Some of these particles will go through the satellite and hit the focal plane assembly and hence the detectors. These detectors will be TES (Transition-edge sensor) microcalorimeters, flown for the first time in such an environment. In order to ensure the performance of this type of detectors throughout the duration of such mission, it is critical to study the impact of the radiation on their behavior. Indeed, although a lot of reference material exist for semiconductor detectors such as CCDs, little is currently known about the impact of radiation on TES detectors. These energetic events could cause local heating or damage to the detectors and affect their performance. In this work, we describe how we designed a test campaign to assess the impact of L1 radiation on TES detectors for Athena/X-IFU-like missions and present the results of the tests. Analyses includes assessing changes in the pulse shapes and energy resolution of the detectors measured at 55 mK after several radiation dose steps performed at 4 K.

Sophie Beaumont↗

The high-foot implosion campaign on the National Ignition Facility

The “High-Foot” platform manipulates the laser pulse-shape coming from the National Ignition Facility laser to create an indirect drive 3-shock implosion that is significantly more robust against instability growth involving the ablator and also modestly reduces implosion convergence ratio. This strategy gives up on theoretical high-gain in an inertial confinement fusion implosion in order to obtain better control of the implosion and bring experimental performance in-line with calculated performance, yet keeps the absolute capsule performance relatively high. In this paper, we will cover the various experimental and theoretical motivations for the high-foot drive as well as cover the experimental results that have come out of the high-foot experimental campaign. At the time of this writing, the high-foot implosion has demonstrated record total deuterium-tritium yields (9.3×1015) with low levels of inferred mix, excellent agreement with implosion simulations, fuel energy gains exceeding unity, and evidence for the “bootstrapping” associated with alpha-particle self-heating.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗

The ion-ion hybrid Alfvén resonator in a fusion environment

An investigation is made of a shear Alfvén wave resonator for burning plasma conditions expected in the ITER device. For small perpendicular scale-lengths the shear mode, which propagates predominantly along the magnetic field direction, experiences a parallel reflection where the wave frequency matches the local ion-ion hybrid frequency. In a tokamak device operating with a deuterium–tritium fuel, this effect can form a natural resonator because of the variation in local field strength along a field line. The relevant kinetic dispersion relation is examined to determine the relative importance of Landau and cyclotron damping over the possible resonator parameter space. A WKB model based on the kinetic dispersion relation is used to determine the eigenfrequencies and the quality factors of modes trapped in the resonator. The lowest frequency found has a value slightly larger than the ion-ion hybrid frequency at the outboard side of a given flux surface. The possibility that the resonator modes can be driven unstable by energetic alpha particles is considered. It is found that within a bandwidth of roughly 600 kHz above the ion-ion hybrid frequency on the outboard side of the flux surface, the shear modes can experience significant spatial amplification. An assessment is made of the form of an approximate global eigenmode that possesses the features of a resonator. It is identified that magnetic field shear combined with large ion temperature can cause coupling to an ion-Bernstein wave, which can limit the instability.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗

Understanding Temporal and Spatial Variability of the Lunar Helium Atmosphere Using Simultaneous Observations from LRO, LADEE, and ARTEMIS

Simultaneous measurements of helium in the exosphere of the Moon are made from the Lunar Reconnaissance Orbiter (LRO) Lyman Alpha Mapping Project (LAMP) and the Lunar Atmosphere and Dust Environment Explorer (LADEE) Neutral Mass Spectrometer (NMS) through the entire 5-month span of the LADEE mission. In addition, the ARTEMIS mission monitored the solar wind alpha particle flux to the Moon. Modeling the lunar helium exosphere, we relate the LAMP polar observations to the LADEE equatorial observations. Further, using the ARTEMIS alpha flux in the Monte Carlo model reproduces the temporal variations in helium density. Comparing the LAMP data to the LADEE data shows excellent agreement. Comparing those with the ARTEMIS data reveals that the solar wind alpha flux is the primary driver to variability in the helium exosphere throughout the LADEE mission. Using a decay time for exospheric helium of 5 days, we determine that the solar wind contributes 64 +/- 5% of the helium to the lunar exosphere. The remaining 36 +/- 5% is presumed to come from outgassing of radiogenic helium from the interior of the Moon. Furthermore, the model reproduces the measurements if 63 +/- 6% of the incident alpha particles are converted to thermalized helium atoms through the interaction between the alphas and the lunar surface. However, these values are dependent on both inferred source rates from LAMP and LADEE observations and on the assumed time constant of the exospheric decay rate.

Moon↗

Laser-initiated p – 11 B fusion reactions in petawatt high-repetition-rate laser facilities

Driving of the nuclear fusion reaction p + 11 B → 3α + 8.7 MeV under laboratory conditions by interaction between high-power laser pulses and matter has become a popular field of research, owing to its numerous potential applications: as an alternative to deuterium–tritium for fusion energy production, astrophysics studies, and alpha-particle generation for medical treatment. One possible scheme for laser-driven p– 11 B reactions is to direct a beam of laser-accelerated protons onto a boron (B) sample (the so-called “pitcher-catcher” scheme). This technique has been successfully implemented on large high-energy lasers, yielding hundreds of joules per shot at low repetition. We present here a complementary approach, exploiting the high repetition rate of the VEGA III petawatt laser at CLPU (Spain), aiming at accumulating results from many interactions at much lower energy, to provide better control of the parameters and the statistics of the measurements. Despite a moderate energy per pulse, our experiment allowed exploration of the laser-driven fusion process with tens (up to hundreds) of laser shots. The experiment provided a clear signature of the reactions involved and of the fusion products, accumulated over many shots, leading to an improved optimization of the diagnostics for experimental campaigns of this type. In this paper, we discuss the effectiveness of laser-driven p– 11 B fusion in the pitcher–catcher scheme, at a high repetition rate, addressing the challenges of this experimental scheme and highlighting its critical aspects. Our proposed methodology allows evaluation of the performance of this scheme for laser-driven alpha particle production and can be adapted to high-repetition-rate laser facilities with higher energy and intensity.

Alpha particles↗

Coupling of the coronal helium abundance to the solar wind

Models of the transition region-corona-solar wind system are investigated in order to find the coronal helium abundance and to study the role played by coronal helium in controlling the solar wind proton flux. The thermal force on alpha-particles in the transition region sets the flow of helium into the corona. The frictional coupling between alpha-particles and protons and/or the electric polarization field determines the proton flux in the solar wind as well as the fate of the coronal helium content. The models are constructed by solving the time-dependent population and momentum equations for all species of hydrogen and helium in an atmosphere with a given temperature profile. Several temperature profiles are considered in order to very the roles of frictional coupling and electric polarization field in the solar wind, and the thermal force in the transition region. Steady-state solutions are found for coronae with a hydrogen flux at 1 AU of 1.0 x 10(exp 9)/cm(exp 2)/sec or larger. For coronae with lower hydrogen fluxes, the helium flux into the corona is larger than the flux 'pulled out' by the solar wind protons, and solutions with increasing coronal helium content are found. The timescale for forming a helium-filled corona, that may allow for a steady outflow, is long compared to the mixing time for the corona.

Hansteen, Viggo H.↗