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At least 343 records · Page 19

Changes of Gene Expression in the Apoptosis Pathway in Lncap and PC3 Cells Exposed to X-Rays or Protons

Radio-resistant or recurrent prostate cancer represents a serious health risk for approximately 20%-30% of patients treated with primary radiation therapy for clinically localized prostate cancer. In our current studies, we investigated the expressions of apoptosis related gene expression profile (84 genes) in two distinct prostate cell lines Lncap (P53+ and AR+) and PC3 (P53- and AR-) before and after exposure to X-rays or protons, using cDNA PCR arrays. In Lncap cells, 10Gy X-ray radiation significantly induced the expression of 19 out of 84 genes at 4h after irradiation. The changed genes were mostly in death and death receptor domain families, TNF ligand and receptor families, and apoptotic group of the BCL2 family, especially in P53 related genes, such as FAS, BAX, BAK1 and GADD45A. In PC3, X-rays only induced the expression of 3 genes, including an increased expression of BIRC3. There was no difference of the X-ray mediated cell killing in both cell lines using the cell cycle analysis. However, these X-ray-induced gene expression differences between PC3 and Lncap may explain the phenotype of PC3 cells that shows more tolerant not only to radiation, but also to other apoptosis inducing and sensitizing reagents. To compare the effectiveness of cell killing with X-rays, we also exposed PC3 cells to 10Gy protons at the Bragg peak region. Protons did not induce more apoptosis than X-rays for the same dose. In comparison to X-rays, protons significantly altered expressions of 13 genes in PC3, which included decreased expressions of anti-apoptosis genes (BCL2 and BCL2L2), and increased expressions of death and death receptor domain family genes, TNF ligand and receptor family and several kinases (FAS, DAPK1 and RIPK2). These data suggest that proton treatment is more effective in influencing the apoptosis pathways in PC3 cells than X-rays, thus protons may be more effective in the treatment of specific prostate tumor.

Zhang, Ye↗

Update on the Ares V to Support Heavy Lift for U.S. Space Exploration Policy

When NASA's Ares V cargo launch vehicle begins flying late next decade, its capabilities will significantly exceed the 1960s-era Saturn V. It will send more crew and cargo to more places on the lunar surface than Apollo and provide ongoing support to a permanent lunar outpost that will open the Moon to greater exploration, science and adventure than ever before. Moreover, it will restore the United States heavy-lift capability, which can support human and robotic exploration for decades to come. Ares V remains in a pre-design analysis cycle stage pending a planned Authority to Proceed (ATP) in late 2010. Ares V benefits from the decision to draw from heritage hardware and its commonality with the Ares I crew launch vehicle, which completed its preliminary design review (PDR) in September 2008. Most of the work on Ares V to date has been focused on refining the vehicle design through a variety of internal studies. This paper will provide background information on the Ares V evolution, emphasizing the vehicle configuration as it exists today.

Sumrall, John P.↗

A Comparison between One- and Two-Loop ATCS Architectures Proposed for CEV

In an effort to help future spacecraft thermal control analysts understand the characteristics of one- and two-loop Active Thermal Control Systems (ATCS), a comparison was made between the one- and two-loop ATCS architectures officially proposed for the Crew Exploration Vehicle (CEV) in Design Analysis Cycle 1 (DAC1) and DAC2, respectively. This report provides a description of each design, along with mass and power estimates derived from their respective Master Equipment List (MEL) and Power Equipment List (PEL). Since some of the components were sized independent of loop architecture (ex. coldplates and heat exchangers), the mass and power for these components were based on the MEL and PEL of the most mature design (i.e. two-loop architecture). The mass and power of the two architectures are then compared and the ability of each design to meet CEV requirements is discussed.

Ochoa, Dustin A.↗

TPF-C Performance Modeling

This slide presentation reviews the performance modeling of the Terrestrial Planet Finder Coronagraph (TPF-C). Included is a chart of the Error Budget Models, definitions of the static and dynamic terms, a chart showing the aberration sensitivity at 2 lambda/D, charts showing the thermal performance models and analysis, surface requirements, high-level requirements, and calculations for the beam walk model.Also included is a description of the control systems, and a flow for the iterative design and analysis cycle.

terrestrial planet finder↗

The Effect of Magnetohydrodynamic (MHD) Energy Bypass on Specific Thrust for a Supersonic Turbojet Engine

This paper describes the preliminary results of a thermodynamic cycle analysis of a supersonic turbojet engine with a magnetohydrodynamic (MHD) energy bypass system that explores a wide range of MHD enthalpy extraction parameters. Through the analysis described here, it is shown that applying a magnetic field to a flow path in the Mach 2.0 to 3.5 range can increase the specific thrust of the turbojet engine up to as much as 420 N/(kg/s) provided that the magnitude of the magnetic field is in the range of 1 to 5 Tesla. The MHD energy bypass can also increase the operating Mach number range for a supersonic turbojet engine into the hypersonic flight regime. In this case, the Mach number range is shown to be extended to Mach 7.0.

Benyo, Theresa L.↗

ARES I Aerodynamic Testing at the NASA Langley Unitary Plan Wind Tunnel

Small-scale force and moment and pressure models based on the outer mold lines of the Ares I design analysis cycle crew launch vehicle were tested in the NASA Langley Research Center Unitary Plan Wind Tunnel from May 2006 to September 2009. The test objectives were to establish supersonic ascent aerodynamic databases and to obtain force and moment, surface pressure, and longitudinal line-load distributions for comparison to computational predictions. Test data were obtained at low through high supersonic Mach numbers for ranges of the Reynolds number, angle of attack, and roll angle. This paper focuses on (1) the sensitivity of the supersonic aerodynamic characteristics to selected protuberances, outer mold line changes, and wind tunnel boundary layer transition techniques, (2) comparisons of experimental data to computational predictions, and (3) data reproducibility. The experimental data obtained in the Unitary Plan Wind Tunnel captured the effects of evolutionary changes to the Ares I crew launch vehicle, exhibited good agreement with predictions, and displayed satisfactory within-test and tunnel-to-tunnel data reproducibility.

Erickson, Gary E.↗

Aerodynamic Analyses and Database Development for Lift-Off/Transition and First Stage Ascent of the Ares I A106 Vehicle

NASA Langley Research Center, in partnership with NASA Marshall Space Flight Center and NASA Ames Research Center, was involved in the aerodynamic analyses, testing, and database development for the Ares I A106 crew launch vehicle in support of the Ares Design and Analysis Cycle. This paper discusses the development of lift-off/transition and ascent databases. The lift-off/transition database was developed using data from tests on a 1.75% scale model of the A106 configuration in the NASA Langley 14x22 Subsonic Wind Tunnel. The power-off ascent database was developed using test data on a 1% A106 scale model from two different facilities, the Boeing Polysonic Wind Tunnel and the NASA Langley Unitary Plan Wind Tunnel. The ascent database was adjusted for differences in wind tunnel and flight Reynolds numbers using USM3D CFD code. The aerodynamic jet interaction effects due to first stage roll control system were modeled using USM3D and OVERFLOW CFD codes.

Pamadi, Bandu N.↗

Ares I Aerodynamic Testing at the Boeing Polysonic Wind Tunnel

Throughout three full design analysis cycles, the Ares I project within the Constellation program has consistently relied on the Boeing Polysonic Wind Tunnel (PSWT) for aerodynamic testing of the subsonic, transonic and supersonic portions of the atmospheric flight envelope (Mach=0.5 to 4.5). Each design cycle required the development of aerodynamic databases for the 6 degree-of-freedom (DOF) forces and moments, as well as distributed line-loads databases covering the full range of Mach number, total angle-of-attack, and aerodynamic roll angle. The high fidelity data collected in this facility has been consistent with the data collected in NASA Langley s Unitary Plan Wind Tunnel (UPWT) at the overlapping condition ofMach=1.6. Much insight into the aerodynamic behavior of the launch vehicle during all phases of flight was gained through wind tunnel testing. Important knowledge pertaining to slender launch vehicle aerodynamics in particular was accumulated. In conducting these wind tunnel tests and developing experimental aerodynamic databases, some challenges were encountered and are reported as lessons learned in this paper for the benefit of future crew launch vehicle aerodynamic developments.

Pinier, Jeremy T.↗

Flow Matching Results of an MHD Energy Bypass System on a Supersonic Turbojet Engine Using the Numerical Propulsion System Simulation (NPSS) Environment

Flow matching has been successfully achieved for an MHD energy bypass system on a supersonic turbojet engine. The Numerical Propulsion System Simulation (NPSS) environment helped perform a thermodynamic cycle analysis to properly match the flows from an inlet employing a MHD energy bypass system (consisting of an MHD generator and MHD accelerator) on a supersonic turbojet engine. Working with various operating conditions (such as the applied magnetic field, MHD generator length and flow conductivity), interfacing studies were conducted between the MHD generator, the turbojet engine, and the MHD accelerator. This paper briefly describes the NPSS environment used in this analysis. This paper further describes the analysis of a supersonic turbojet engine with an MHD generator/accelerator energy bypass system. Results from this study have shown that using MHD energy bypass in the flow path of a supersonic turbojet engine increases the useful Mach number operating range from 0 to 3.0 Mach (not using MHD) to a range of 0 to 7.0 Mach with specific net thrust range of 740 N-s/kg (at ambient Mach = 3.25) to 70 N-s/kg (at ambient Mach = 7). These results were achieved with an applied magnetic field of 2.5 Tesla and conductivity levels in a range from 2 mhos/m (ambient Mach = 7) to 5.5 mhos/m (ambient Mach = 3.5) for an MHD generator length of 3 m.

Benyo, Theresa L.↗

Initial Flow Matching Results of MHD Energy Bypass on a Supersonic Turbojet Engine Using the Numerical Propulsion System Simulation (NPSS) Environment

Preliminary flow matching has been demonstrated for a MHD energy bypass system on a supersonic turbojet engine. The Numerical Propulsion System Simulation (NPSS) environment was used to perform a thermodynamic cycle analysis to properly match the flows from an inlet to a MHD generator and from the exit of a supersonic turbojet to a MHD accelerator. Working with various operating conditions such as the enthalpy extraction ratio and isentropic efficiency of the MHD generator and MHD accelerator, interfacing studies were conducted between the pre-ionizers, the MHD generator, the turbojet engine, and the MHD accelerator. This paper briefly describes the NPSS environment used in this analysis and describes the NPSS analysis of a supersonic turbojet engine with a MHD generator/accelerator energy bypass system. Results from this study have shown that using MHD energy bypass in the flow path of a supersonic turbojet engine increases the useful Mach number operating range from 0 to 3.0 Mach (not using MHD) to an explored and desired range of 0 to 7.0 Mach.

Benyo, Theresa L.↗

Annular MHD Physics for Turbojet Energy Bypass

The use of annular Hall type MHD generator/accelerator ducts for turbojet energy bypass is evaluated assuming weakly ionized flows obtained from pulsed nanosecond discharges. The equations for a 1-D, axisymmetric MHD generator/accelerator are derived and numerically integrated to determine the generator/accelerator performance characteristics. The concept offers a shockless means of interacting with high speed inlet flows and potentially offers variable inlet geometry performance without the complexity of moving parts simply by varying the generator loading parameter. The cycle analysis conducted iteratively with a spike inlet and turbojet flying at M = 7 at 30 km altitude is estimated to have a positive thrust per unit mass flow of 185 N-s/kg. The turbojet allowable combustor temperature is set at an aggressive 2200 deg K. The annular MHD Hall generator/accelerator is L = 3 m in length with a B(sub r) = 5 Tesla magnetic field and a conductivity of sigma = 5 mho/m for the generator and sigma= 1.0 mho/m for the accelerator. The calculated isentropic efficiency for the generator is eta(sub sg) = 84 percent at an enthalpy extraction ratio, eta(sub Ng) = 0.63. The calculated isentropic efficiency for the accelerator is eta(sub sa) = 81 percent at an enthalpy addition ratio, eta(sub Na) = 0.62. An assessment of the ionization fraction necessary to achieve a conductivity of sigma = 1.0 mho/m is n(sub e)/n = 1.90 X 10(exp -6), and for sigma = 5.0 mho/m is n(sub e)/n = 9.52 X 10(exp -6).

Schneider, Steven J.↗

Development of an Open Rotor Cycle Model in NPSS Using a Multi-Design Point Approach

NASA's Environmentally Responsible Aviation Project and Subsonic Fixed Wing Project are focused on developing concepts and technologies which may enable dramatic reductions to the environmental impact of future generation subsonic aircraft (Refs. 1 and 2). The open rotor concept (also referred to as the Unducted Fan or advanced turboprop) may allow the achievement of this objective by reducing engine emissions and fuel consumption. To evaluate its potential impact, an open rotor cycle modeling capability is needed. This paper presents the initial development of an open rotor cycle model in the Numerical Propulsion System Simulation (NPSS) computer program which can then be used to evaluate the potential benefit of this engine. The development of this open rotor model necessitated addressing two modeling needs within NPSS. First, a method for evaluating the performance of counter-rotating propellers was needed. Therefore, a new counter-rotating propeller NPSS component was created. This component uses propeller performance maps developed from historic counter-rotating propeller experiments to determine the thrust delivered and power required. Second, several methods for modeling a counter-rotating power turbine within NPSS were explored. These techniques used several combinations of turbine components within NPSS to provide the necessary power to the propellers. Ultimately, a single turbine component with a conventional turbine map was selected. Using these modeling enhancements, an open rotor cycle model was developed in NPSS using a multi-design point approach. The multi-design point (MDP) approach improves the engine cycle analysis process by making it easier to properly size the engine to meet a variety of thrust targets throughout the flight envelope. A number of design points are considered including an aerodynamic design point, sea-level static, takeoff and top of climb. The development of this MDP model was also enabled by the selection of a simple power management scheme which schedules propeller blade angles with the freestream Mach number. Finally, sample open rotor performance results and areas for further model improvements are presented.

Hendricks, Eric S.↗

Design and Parametric Sizing of Deep Space Habitats Supporting NASA'S Human Space Flight Architecture Team

NASA's Human Space Flight Architecture Team (HAT) is a multi-disciplinary, cross-agency study team that conducts strategic analysis of integrated development approaches for human and robotic space exploration architectures. During each analysis cycle, HAT iterates and refines the definition of design reference missions (DRMs), which inform the definition of a set of integrated capabilities required to explore multiple destinations. An important capability identified in this capability-driven approach is habitation, which is necessary for crewmembers to live and work effectively during long duration transits to and operations at exploration destinations beyond Low Earth Orbit (LEO). This capability is captured by an element referred to as the Deep Space Habitat (DSH), which provides all equipment and resources for the functions required to support crew safety, health, and work including: life support, food preparation, waste management, sleep quarters, and housekeeping.The purpose of this paper is to describe the design of the DSH capable of supporting crew during exploration missions. First, the paper describes the functionality required in a DSH to support the HAT defined exploration missions, the parameters affecting its design, and the assumptions used in the sizing of the habitat. Then, the process used for arriving at parametric sizing estimates to support additional HAT analyses is detailed. Finally, results from the HAT Cycle C DSH sizing are presented followed by a brief description of the remaining design trades and technological advancements necessary to enable the exploration habitation capability.

Toups, Larry↗

An Altair Overview: Designing a Lunar Lander for 21st Century Human Space Exploration

Altair, the lunar lander element of NASA's Constellation program, was conducted in a different design environment than many other NASA projects of similar scope. Because of this relatively unique approach, there are a number of significant success stories that should be considered during the development of any future lunar landers or human spacecraft. This paper is divided into two separate themes; the first is the approach used during the conceptual design studies, including the systematic analysis cycles and the decision making process associated with each: and the second is a summary of the resulting lessons learned that were compiled after looking back at the lifetime of the Project. Altair was terminated before entering Phase B of its design, and was often criticized for being a very heavy and very large vehicle. While there was specific rationale for all of the decisions that led up to that configuration, future design cycles were specifically planned to re-address the mass challenge. Had the project continued, the deliberate, stepwise design process would have converged on an optimized lander design that balanced mass, risk, cost and capabilities. Some of the specific items that will be addressed in this paper include project development strategy, organizational approach and team dynamics, risk-informed design process, mission architecture constraints, mission key driving requirements, model-based systems engineering process, configuration studies, contingency considerations, subsystem overviews and key trade studies. The paper will conclude with a summary of the lessons identified during the Altair project and make suggestions for application to future studies.

Brown, Kendall K.↗

Direct Radiative Effect of Mineral Dust on the Development of African Easterly Wave in Late Summer, 2003-2007

Episodic events of both Saharan dust outbreaks and African Easterly Waves (AEWs) are observed to move westward over the eastern tropical Atlantic Ocean. The relationship between the warm, dry, and dusty Saharan Air Layer (SAL) on the nearby storms has been the subject of considerable debate. In this study, the Weather Research and Forecasting (WRF) model is used to investigate the radiative effect of dust on the development of AEWs during August and September, the months of maximum tropical cyclone activity, in years 2003-2007. The simulations show that dust radiative forcing enhances the convective instability of the environment. As a result, most AEWs intensify in the presence of a dust layer. The Lorenz energy cycle analysis reveals that the dust radiative forcing enhances the condensational heating, which elevates the zonal and eddy available potential energy. In turn, available potential energy is effectively converted to eddy kinetic energy, in which local convective overturning plays the primary role. The magnitude of the intensification effect depends on the initial environmental conditions, including moisture, baroclinity, and the depth of the boundary layer. We conclude that dust radiative forcing, albeit small, serves as a catalyst to promote local convection that facilitates AEW development.

Ma, Po-Lun↗

Modified ACES Portable Life Support Integration, Design, and Testing for Exploration Missions

NASA's next generation of exploration missions provide a unique challenge to designers of EVA life support equipment, especially in a fiscally-constrained environment. In order to take the next steps of manned space exploration, NASA is currently evaluating the use of the Modified ACES (MACES) suit in conjunction with the Advanced Portable Life Support System (PLSS) currently under development. This paper will detail the analysis and integration of the PLSS thermal and ventilation subsystems into the MACES pressure garment, design of prototype hardware, and hardware-in-the-loop testing during the spring 2014 timeframe. Prototype hardware was designed with a minimal impact philosophy in order to mitigate design constraints becoming levied on either the advanced PLSS or MACES subsystems. Among challenges faced by engineers were incorporation of life support thermal water systems into the pressure garment cavity, operational concept definition between vehicle/portable life support system hardware, and structural attachment mechanisms while still enabling maximum EVA efficiency from a crew member's perspective. Analysis was completed in late summer 2013 to 'bound' hardware development, with iterative analysis cycles throughout the hardware development process. The design effort will cumulate in the first ever manned integration of NASA's advanced PLSS system with a pressure garment originally intended primarily for use in a contingency survival scenario.

Kelly, Cody↗

Definition ofthe Design Trajectory and Entry Flight Corridor for the NASA Orion Exploration Mission 1 Entry Trajectory Using an Integrated Approach and Optimization

One of the key design objectives of NASA's Orion Exploration Mission 1 (EM- 1) is to execute a guided entry trajectory demonstrating GN&C capability. The focus of this paper is defining the flyable entry corridor for EM-1 taking into account multiple subsystem constraints such as complex aerothermal heating constraints, aerothermal heating objectives, landing accuracy constraints, structural load limits, Human-System-Integration-Requirements, Service Module debris disposal limits and other flight test objectives. During the EM-1 Design Analysis Cycle 1 design challenges came up that made defining the flyable entry corridor for the EM-1 mission critical to mission success. This document details the optimization techniques that were explored to use with the 6-DOF ANTARES simulation to assist in defining the design entry interface state and entry corridor with respect to key flight test constraints and objectives.

McNamara, Luke W.↗

SLS Trade Study 0058: Day of Launch (DOL) Wind Biasing

SLS heritage hardware and legacy designs have shown load exceedances at several locations during Design Analysis Cycles (DAC): MPCV Z bending moments; ICPS Electro-Mechanical Actuator (EMA) loads; Core Stage loads just downstream of Booster forward interface. SLS Buffet Loads Mitigation Task Team (BLMTT) tasked to study issue. Identified low frequency buffet load responses are a function of the vehicle's total angle of attack (AlphaTotal). SLS DOL Wind Biasing Trade team to analyze DOL wind biasing methods to limit maximum AlphaTotal in the M0.8 - 2.0 altitude region for EM-1 and EM-2 missions through investigating: Trajectory design process; Wind wavelength filtering options; Launch availability; DOL process to achieve shorter processing/uplink timeline. Trade Team consisted of personnel supporting SLS, MPCV, GSDO programs.

Decker, Ryan K.↗