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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 343 records · Page 19

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NASA NTRS1977

A review of animal flight experiments

Extensive experience with biologic systems was obtained with a variety of vertebrate species over the past 18 years. Subhuman primates were precursors to man in the American space flight program; dogs and mice were animals of choice for the Soviet program. Recent attempts to use heavily instrumented animals for observations of long-term physiological effects indicate problems which must be corrected in future experiments for monitoring the effects of environmental stresses over the longer periods required for accomplishing meaningful habitation in near-Earth orbit or for travel to nearby planets.

Sandler, H.↗

NASA NTRS1977

Some effects of acceleration in man and chimpanzees

Early physiologic experiments using dogs and humans in centrifuges are reviewed. Because of the close similarity between the shape and dimensions of the thoraces of chimpanzees and humans, the former were used to obtain roentgenograms and photokymographic recordings of multiple physiologic variables before and during exposure to +5.8 Gy to study the effects of changes in the gravitational-inertial force environment on the cardiovascular and pulmonary systems during long duration space flight. A computer-controlled sciscanning system was used to obtain a two dimensional map of the amount of radiation emanating from the dorsal and ventricle surfaces after insertion of radioactive microspheres in the right ventricle. By using four different batches of microspheres tagged with isotopes of different energies, the spatial distribution of pulmonary blood flow under four conditions was determined.

Wood, E. H.↗

NASA NTRS1978

NASA satellite to track North Pole expedition

The proposed expedition of a lone explorer and the use of Nimbus 6 (NASA meteorological research satellite) to track his journey is reported. The journey is scheduled to start March 4, 1978, and will cover a distance of 6.000 Km (3,728 miles) from northern Canada to the North Pole and return, traveling the length of Greenland's isolated interior. The mode of transportation for the explorer will be by dog sled. Instrumentation and tracking techniques are discussed.

Source record↗

NASA NTRS1978

The effect of seawater on thermoregulator centers

Experiments were done on dogs to determine the mechanism of thermoregulation. Results show that natural seawater, injected intravenously (150, 200, and 300 cc ), causes narcosis of the thermic centers and increases temperature. Diluted seawater injection causes an excitation of the thermic centers and an antipyretic effect.

Dontas, S.↗

NASA NTRS1978

Effect of gravitational and inertial forces on vertical distribution of pulmonary blood flow

Vertical distribution of pulmonary blood flow (VDPBF) was studied, using radioactive microsphere emboli, in dogs without thoracotomy in the right decubitus position during exposure to lateral accelerations of 1, 2, 4, and 6 G. At all levels of force environment studied, an inverse linear relationship was observed between vertical height in the thorax and pulmonary blood flow (ml/min/ml lung tissue) with a decrease in flow to the most dependent region of the lung despite large increases in intravascular pressures at this site. Changes in blood flow were smallest at the mid-lung level, the hydrostatic 'balance point' for vascular and pleural pressures. These force environment-dependent changes in VDPBF are not readily explainable by the Starling resistor analog. Gravity-dependent regional differences in pleural and associated interstitial pressures, plus possible changes in vascular tone resulting from inadequate aeration of blood in the most dependent regions of the lung, probably also affect VDPBF.

Chevalier, P. A.↗

NASA NTRS1977

A subcutaneous channeling probe for implanting long leads

The channeling probe described in the present paper was designed to overcome surgical problems of the type that were encountered when a multichannel radio transmitter had to be implanted in a cow. The probe was made of a flexible but sufficiently stiff 9.5-mm-diam nylon rod, consisting of 46-cm sections for convenience in sterilization and surgical handling. Stainless steel sleaves reinforced the threaded connecting joints. At one end, arrowhead-shaped channeling heads could be attached to produce wide channels for large sensors. The other end was tapered for narrow channels. Postoperative problems were not encountered in the use of this probe in cows, sheep, and dogs.

Lund, G. F.↗

NASA NTRS1978

Kinetic measurements of bone mineral metabolism: The use of Na-22 as a tracer for long-term bone mineral turnover studies

Sodium-22 was studied as a tracer for bone mineral metabolism in rats and dogs. When incorporated into bone during growth from birth to adulthood, the bone becomes uniformly tagged with (22)Na which is released through the metabolic turnover of the bone. The (22)Na which is not incorporated in the bone matrix is rapidly excreted within a few days when animals are fed high but nontoxic levels of NaCl. The (22)Na tracer can be used to measure bone mineral loss in animals during space flight and in research on bone disease.

Palmer, H. E.↗

NASA NTRS1978

Studies on the erythron and the ferrokinetic responses in beagles adapted to hypergravity

Red cell survival, ferrokinetics, and hematologic parameters were investigated in beagle dogs exposed to chronic hypergravity (2.6 Gx). Ineffective erythropoiesis, red cell mass, plasma volume, and Cr-51-elution were significantly increased; maximum Fe-59 incorporation was decreased; and there was no change in the mean erythrocyte life span following autologous injection of Cr-51-labeled red cells and Fe-59-labeled transferrin. Red cell count, F(cells), total body hemoglobin (Hb), susceptability to osmotic lysis, and differential reticulocyte count were increased. White blood cell count, venous blood %Hb, mean cell volume, mean cell Hb, mean cell Hb concentration, and serum iron were decreased. No changes were observed for body mass, mg Fe per g Hb, iron binding capacity, percent saturation of iron carrying capacity, or the electrophoretic mobility of purified Hb. This study indicated that chronic exposure to hypergravity induced changes in red cell size, volume, total mass, and membrane permeability.

Beckman, D. A.↗

NASA NTRS1979

The use of Na-22 as a tracer for long-term bone mineral turnover studies.

Sodium-22 has been studied as a tracer for bone mineral metabolism in rats and dogs. When incorporated into bone during growth from birth to adulthood, the bone becomes uniformly tagged with Na-22, which is released through the metabolic turnover of the bone. The Na-22 not incorporated in the bone matrix is rapidly excreted within a few days when animals are fed high, but nontoxic levels of NaCl. The Na-22 tracer can be used to measure bone mineral loss in animals during space flight and in research on bone disease.

Palmer, H. E.↗

NASA NTRS1980

Metabolism during hypodynamia

Physical immobilization, inaction due to space travel, a sedentary occupation, or bed confinement due to a chronic illness elicit similar alternations in the metabolism of man and animals (rat, rabbit, dog, mouse). After a preliminary period of weight loss, there is eventually weight gain due to increased lipid storage. Protein catabolism is enhanced and anabolism depressed, with elevated urinary excretion of amino acids, creatine, and ammonia. Glycogen stores are depleted and glyconeogenesis is accelerated. Polyuria develops with subsequent redistribution of body fluids in which the blood volume of the systemic circulation is decreased and that of pulmonary circulation increased. This results in depressed production of vasopressin by the posterior pituitary which further enhances urinary water and salt loss.

Federov, I. V.↗

NASA NTRS1980

Initial dynamics of the EKG during an electrical defibrillation of the heart

In tests on 11 mature dogs, immobilized by means of an automatic blocking and synchronization system, artefact free EKG were obtained, beginning 0.04-0.06 sec after passage of a defibrillating current. Different versions of the start of fibrillation were noted, in application of the defibrillating stimulus in the early phase of the cardiac cycle. A swinging phenomenon, increasing amplitude, of fibrillation was noted for 0.4-1.5 sec after delivery of a subthreshold stimulus. Conditions for a positive outcome of repeated defibrillation were found, and a relationship was noted between the configuration of the exciting process with respect to the lines of force of the defibrillating current and the defibrillation threshold. It was shown that the initial EKG dynamics after defibrillation is based on a gradual shift of the pacemaker from the myocardium of the ventricles to the sinus node, through phases of atrioventricular and atrial automatism.

Bikov, I. I.↗

NASA NTRS1982

Safety Bolt Doubles as a Bushing-Removal Tool

Bushings fitted to close tolerances and limited access can be removed without damage to housing by using bolt with integrated locking dog. Such self-retaining positive - locking bolts are normally used as fasteners in critical joints where accidentally loosened bolt could cause damage or injuries.

Haverkamp, C. E.↗

NASA NTRS1980

Landing in the future: Biological experiments on Earth and in space orbit

The development of an Earth biosatellite to duplicate the parameters of pressure, temperature, humidity and others in a space environment onboard Cosmos-1129 is discussed. Effects of a space environment on fruit flies, dogs, laboratory rats in procreation, behavior, stress, biorhythm, body composition, gravitation preference, and cell cultures are examined. The space environment for agricultural products is also studied. The effects of heavy nuclei of galactic space radiation on biological objects inside and outside the satellite is studied, and methods of electrostatic protection are developed.

Pokrovskiy, A.↗

NASA NTRS1980

Heart rate, multiple body temperature, long-range and long-life telemetry system for free-ranging animals

The design details and rationale for a versatile, long-range, long-life telemetry data acquisition system for heart rates and body temperatures at multiple locations from free-ranging animals are presented. The design comprises an implantable transmitter for short to medium range transmission, a receiver retransmitter collar to be worn for long-range transmission, and a signal conditioner interface circuit to assist in signal discrimination and demodulation of receiver or tape-recorded audio outputs. Implanted electrodes are used to obtain an ECG, from which R-wave characteristics are selected to trigger a short RF pulse. Pulses carrying heart rate information are interrupted periodically by a series of pulse interval modulated RF pulses conveying temperature information sensed at desired locations by thermistors. Pulse duration and pulse sequencing are used to discriminate between heart rate and temperature pulses as well as radio frequency interference. The implanted transmitter may be used alone for medium and short-range tracking, or with a receiver-transmitter collar that employs commercial tracking equipment for transmissions of up to 12 km. A system prototype has been tested on a dog.

Lund, G. F.↗

NASA NTRS1982

Implantable telemetry for small animals

A series of totally implantable telemetry devices for use in measuring deep body parameters in small animals were developed. Under a collaborative agreement with NASA, several of these systems; the continuous wave Doppler ultrasonic flowmeter, the multichannel telemetry system, and the inductively-powered dual channel cardiac pacer were evaluated in a series of ten mongrel dogs (15 to 20 kg.). These systems were used to measure ascending aortic and coronary blood flow, aortic pressure, and subcutaneous EKG.

Source record↗

NASA NTRS1982

A specific radioimmunoassay for osteocalcin with advantageous species crossreactivity

The specificities of immunoassays to rat and bovine osteocalcin are examined. Extracts of noncalcified tissues and tissue fractions are unreactive to the antibody, with the exception of the kidney, in which the reactive component appears to be identical with osteocalcin by gel filtration and dose dilution analysis. The assays, developed against protein isolated from bone, are also demonstrated to be reactive to the native protein (bone in situ) and to osteocalcin in serum. The assays are sensitive to less than 50 pg osteocalcin. Intra- and interassay coefficients of variation are less than 6.8%. The bovine antibody crossreacts with human, horse, monkey, baboon, and cat osteocalcin, while the rat antibody crossreacts with dog and mouse.

Patterson-Allen, P.↗

NASA NTRS1985

Bone and muscle atrophy with suspension of the rat

In order to identify a suitable model for the study of muscle atrophy due to suspension in space, a modified version of the Morey tail suspension model was used to measure the atrophic responses of rat bone and muscle to 14-30 days of unloading of the hindlimbs. The progress of atrophy was measured by increases in methylene diphosphonate (MDP) uptake. It is found that bone uptake of methylene diphosphonate followed a phasic pattern similar to changes in the bone formation rate of immobilized dogs and cats. Increased MDP uptake after a period of 60 days indicated an accelerated bone metabolism. Maximum muscle atrophy in the suspended rats was distinctly different from immobilization atrophy. On the basis of the experimental results, it is concluded that the tail suspension model is an adequate simulation of bone atrophy due to suspension.

Leblanc, A.↗

NASA NTRS1985

Transpulmonary passage of venous air emboli

Twenty-seven paralyzed anesthetized dogs were embolized with venous air to determine the effectiveness of the pulmonary vasculature for bubble filtration or trapping. Air doses ranged from 0.05 to 0.40 ml/kg min in 0.05-ml increments with ultrasonic Doppler monitors placed over arterial vessels to detect any microbubbles that crossed the lungs. Pulmonary vascular filtration of the venous air infusions was complete for the lower air doses ranging from 0.05 to 0.30 ml/kg min. When the air doses were increased to 0.35 ml/kg min, the filtration threshold was exceeded with arterial spillover of bubbles occurring in 50 percent of the animals and reaching 71 percent for 0.40 ml/kg min. Significant elevations were observed in pulmonary arterial pressure and pulmonary vascular resistance. Systemic blood pressure and cardiac output decreased, whereas left ventricular end-diastolic pressure remained unchanged. The results indicate that the filtration of venous bubbles by the pulmonary vasculature was complete when the air infusion rates were kept below a threshold value of 0.30 ml/kg min.

Butler, B. D.↗