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At least 343 records · Page 19

NASA Lewis Launch Collision Probability Model Developed and Analyzed

There are nearly 10,000 tracked objects orbiting the earth. These objects encompass manned objects, active and decommissioned satellites, spent rocket bodies, and debris. They range from a few centimeters across to the size of the MIR space station. Anytime a new satellite is launched, the launch vehicle with its payload attached passes through an area of space in which these objects orbit. Although the population density of these objects is low, there always is a small but finite probability of collision between the launch vehicle and one or more of these space objects. Even though the probability of collision is very low, for some payloads even this small risk is unacceptable. To mitigate the small risk of collision associated with launching at an arbitrary time within the daily launch window, NASA performs a prelaunch mission assurance Collision Avoidance Analysis (or COLA). For the COLA of the Cassini spacecraft, the NASA Lewis Research Center conducted an in-house development and analysis of a model for launch collision probability. The model allows a minimum clearance criteria to be used with the COLA analysis to ensure an acceptably low probability of collision. If, for any given liftoff time, the nominal launch vehicle trajectory would pass a space object with less than the minimum required clearance, launch would not be attempted at that time. The model assumes that the nominal positions of the orbiting objects and of the launch vehicle can be predicted as a function of time, and therefore, that any tracked object that comes within close proximity of the launch vehicle can be identified. For any such pair, these nominal positions can be used to calculate a nominal miss distance. The actual miss distances may differ substantially from the nominal miss distance, due, in part, to the statistical uncertainty of the knowledge of the objects positions. The model further assumes that these position uncertainties can be described with position covariance matrices. With these, and some additional simplifying assumptions, a closed-form solution for the probability of collision is obtained. This solution provides clear insights into how each of the independent parameters affects the probability of collision. It shows that for a given maximum probability of collision and prior knowledge of the objects position uncertainties and sizes, only knowledge of the nominal closest approach distance is required to make the launch/no launch decision. The model was completed and used for the mission assurance COLA analysis for the Cassini spacecraft, which was launched on a Titan IV/Centaur rocket on October 15, 1997. Although the model was specifically developed for the Cassini mission, it is clearly applicable for other launches as well. The effect of COLA closures on the launch window is shown. The bar represents the entire 140-min launch window on October 15, 1997; the blackened areas represent the loss of launch opportunities due to the potential for a collision with an orbiting object.

Bollenbacher, Gary↗

STS-114 Flight Day 1 Highlights

Video coverage of NASA's Return to Flight begins with the pre-flight meal and suit-up of the STS-114 crew (Commander Eileen Collins, Pilot James Kelly, Mission Specialists Soichi Noguchi, Stephen Robinson, Andrew Thomas, Wendy Lawrence, and Charles Camarda), and its departure for the launch pad on the Astrovan. The astronauts board Space Shuttle Discovery and are seated. Arms on the launch pad's Fixed Service Structure pull away, and Discovery is shown from liftoff through booster separation. Video of the ascent from a new camera onboard the External Tank (ET) is included, which features views of the ET's bipod and the tank's separation from the orbiter, with Earth in the background. During a change of shift at Mission Control Center, staff members congratulate the Shuttle crew, and Commander Collins thanks them.

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STS-114: Discovery Shuttle Processing Overview Briefing

This video of a briefing to representatives from the national media took the form of a slide show presentation by Jon Cowart, Manager of the Resident Office at Johnson Space Center. The presentation was an overview of ground maintainance facilities and procedures at Kennedy Space Center used to support Space Shuttle operations. The photographs in the slide show: Shuttle ground transport, maintenance, computers, and payloads, the Vehicle Assembly Building, ground operations, launch operations, crew boarding, liftoff, Pad A and Pad B, Solid Rocket Motor retrieval, crew procedures on-orbit, and landing. After the presentation is a brief question and answer session, in which reporters ask Cowart about Shuttle readiness, changes in Shuttle operations made for the Return to Flight, and how weather affects Shuttle operations.

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Instrumentation and Control Needs for Reliable Operation of Lunar Base Surface Nuclear Power Systems

As one of the near-term goals of the President's Vision for Space Exploration, establishment of a multi-person lunar base will require high-endurance power systems which are independent of the sun, and can operate without replenishment for several years. These requirements may be obtained using nuclear power systems specifically designed for use on the lunar surface. While it is envisioned that such a system will generally be supervised by humans, some of the evolutions required maybe semi or fully autonomous. The entire base complement for near-term missions may be less than 10 individuals, most or all of which may not be qualified nuclear plant operators and may be off-base for extended periods thus, the need for power system autonomous operation. Startup, shutdown, and load following operations will require the application of advanced control and health management strategies with an emphasis on robust, supervisory, coordinated control of, for example, the nuclear heat source, energy conversion plant (e.g., Brayton Energy Conversion units), and power management system. Autonomous operation implies that, in addition to being capable of automatic response to disturbance input or load changes, the system is also capable of assessing the status of the integrated plant, determining the risk associated with the possible actions, and making a decision as to the action that optimizes system performance while minimizing risk to the mission. Adapting the control to deviations from design conditions and degradation due to component failures will be essential to ensure base inhabitant safety and mission success. Intelligent decisions will have to be made to choose the right set of sensors to provide the data needed to do condition monitoring and fault detection and isolation because of liftoff weight and space limitations, it will not be possible to have an extensive set of instruments as used for earth-based systems. Advanced instrumentation and control technologies will be needed to enable this critical functionality of autonomous operation. It will be imperative to consider instrumentation and control requirements in parallel to system configuration development so as to identify control-related, as well as integrated system-related, problem areas early to avoid potentially expensive work-arounds . This paper presents an overview of the enabling technologies necessary for the development of reliable, autonomous lunar base nuclear power systems with an emphasis on system architectures and off-the-shelf algorithms rather than hardware. Autonomy needs are presented in the context of a hypothetical lunar base nuclear power system. The scenarios and applications presented are hypothetical in nature, based on information from open-literature sources, and only intended to provoke thought and provide motivation for the use of autonomous, intelligent control and diagnostics.

Turso, James↗

Launch Vehicle Propulsion Design with Multiple Selection Criteria

The approach and techniques described herein define an optimization and evaluation approach for a liquid hydrogen/liquid oxygen single-stage-to-orbit system. The method uses Monte Carlo simulations, genetic algorithm solvers, a propulsion thermo-chemical code, power series regression curves for historical data, and statistical models in order to optimize a vehicle system. The system, including parameters for engine chamber pressure, area ratio, and oxidizer/fuel ratio, was modeled and optimized to determine the best design for seven separate design weight and cost cases by varying design and technology parameters. Significant model results show that a 53% increase in Design, Development, Test and Evaluation cost results in a 67% reduction in Gross Liftoff Weight. Other key findings show the sensitivity of propulsion parameters, technology factors, and cost factors and how these parameters differ when cost and weight are optimized separately. Each of the three key propulsion parameters; chamber pressure, area ratio, and oxidizer/fuel ratio, are optimized in the seven design cases and results are plotted to show impacts to engine mass and overall vehicle mass.

Shelton, Joey D.↗

Understanding of the Dynamics of the Stirling Convertor Advanced by Structural Testing

The NASA Glenn Research Center, the U.S. Department of Energy, and the Stirling Technology Company (STC) are developing a highly efficient, long-life, free-piston Stirling convertor for use as an advanced spacecraft power system for future NASA missions, including deep-space and Mars surface applications. As part of this development, four structural dynamic test programs were recently performed on Stirling Technology Demonstration Convertors (TDC's) that were designed and built by STC under contract to the Department of Energy. This testing was performed in Glenn's Structural Dynamics Laboratory and Microgravity Emissions Laboratory. The first test program, in November and December 1999, demonstrated that the Stirling TDC could withstand the harsh random vibration experienced during a typical spacecraft launch and survive with no structural damage or functional power performance degradation. This was a critical step in enabling the use of Stirling convertors for future spacecraft power systems. The most severe test was a 12.3grms random vibration test, with test durations of 3 min per axis. The random vibration test levels were chosen to simulate, with margin, the maximum anticipated launch vibration conditions. The Microgravity Emissions Laboratory is typically used to measure the dynamics produced by operating space experiments and the resulting impact to the International Space Station's microgravity environment. For the second Stirling dynamic test program, performed in January 2001, the Microgravity Emissions Laboratory was used to characterize the structure-borne disturbances produced by the normal operation of a pair of Stirling convertors. The forces and moments produced by the normal operation of a Stirling system must be recognized and controlled, if necessary, so that other nearby spacecraft components, such as cameras, are not adversely affected. The Stirling convertor pair emitted relatively benign tonal forces at its operational frequency and associated harmonics. Therefore, Stirling power systems will not disturb spacecraft science experiments if minimal appropriate mounting efforts are made. The third test program, performed in February and May 2001, resulted in a modal characterization of a Stirling convertor. Since the deflection of the TDC piston rod, under vibration excitation, was of particular interest, the outer pressure shell was removed to allow access to the rod. Through this testing, the Stirling TDC's natural frequencies and modes were identified. This knowledge advanced our understanding of the successful 1999 vibration test and may be utilized to optimize the output power of future Stirling designs. The fourth test program, in April 2001, was conducted to characterize the structural response of a pair of Stirling convertors, as a function of their mounting interface stiffness. The test results provide guidance for the Stirling power package interface design. Properly designed, the interface may lead to increased structural capability and power performance beyond what was demonstrated in the successful 1999 vibration test. Dynamic testing performed to date at Glenn has shown that the Stirling convertors can withstand liftoff random vibration environments and meet "good neighbor" vibratory emission requirements. Furthermore, the future utilization of the information obtained during the tests will allow the corporation selected to be the Stirling system integrator to optimize their convertor and system interfaces designs. Glenn's Thermo-Mechanical Systems Branch provides Stirling technology expertise under a Space Act Agreement with the Department of Energy. Additional vibration testing by Glenn's Structural Systems Dynamics Branch is planned to continue to demonstrate the Stirling power system's vibration capability as its technology and flight system designs progress.

Hughes, William O.↗

Integrated Propulsion/Vehicle System Structurally Optimized

Ongoing research and testing are essential in the development of air-breathing hypersonic propulsion technology, and this year some positive advancement was made at the NASA Glenn Research Center. Recent work performed for GTX, a rocket-based combined-cycle, single-stage-to-orbit concept, included structural assessments of both the engine and flight vehicle. In the development of air-breathing engine technology, it is impractical to design and optimize components apart from the fully integrated system because tradeoffs must be made between performance and structural capability. Efforts were made to control the flight trajectory, for example, to minimize the aerodynamic heating effects. Structural optimization was applied to evaluate concept feasibility and was instrumental in the determination of the gross liftoff weight of the integrated system. Achieving low Earth orbit with even a small payload requires an aggressive approach to weight minimization through the use of lightweight, oxidation-resistant composite materials. Assessing the integrated system involved investigating the flight trajectory to determine where the critical load events occur in flight and then generating the corresponding environment at each of these events. Structural evaluation requires the mapping of the critical flight loads to finite element models, including the combined effects of aerodynamic, inertial, combustion, and other loads. NASA s APAS code was used to generate aerodynamic pressure and temperature profiles at each critical event. The radiation equilibrium surface temperatures from APAS were used to predict temperatures through the thickness. Heat transfer solutions using NASA's MINIVER code and the SINDA code (Cullimore & Ring Technologies, Littleton, CO) were calculated at selective points external to the integrated vehicle system and then extrapolated over the entire exposed surface. FORTRAN codes were written to expedite the finite element mapping of the aerodynamic heating effects for the internal structure.

Hunter, James E.↗

GPS World, Innovation: Autonomous Navigation at High Earth Orbits

Calculating a spacecraft's precise location at high orbital altitudes-22,000 miles (35,800 km) and beyond-is an important and challenging problem. New and exciting opportunities become possible if satellites are able to autonomously determine their own orbits. First, the repetitive task of periodically collecting range measurements from terrestrial antennas to high altitude spacecraft becomes less important-this lessens competition for control facilities and saves money by reducing operational costs. Also, autonomous navigation at high orbital altitudes introduces the possibility of autonomous station keeping. For example, if a geostationary satellite begins to drift outside of its designated slot it can make orbit adjustments without requiring commands from the ground. Finally, precise onboard orbit determination opens the door to satellites flying in formation-an emerging concept for many scientific space applications. The realization of these benefits is not a trivial task. While the navigation signals broadcast by GPS satellites are well suited for orbit and attitude determination at lower altitudes, acquiring and using these signals at geostationary (GEO) and highly elliptical orbits is much more difficult. The light blue trace describes the GPS orbit at approximately 12,550 miles (20,200 km) altitude. GPS satellites were designed to provide navigation signals to terrestrial users-consequently the antenna array points directly toward the earth. GEO and HE0 orbits, however, are well above the operational GPS constellation, making signal reception at these altitudes more challenging. The nominal beamwidth of a Block II/IIA GPS satellite antenna array is approximately 42.6 degrees. At GEO and HE0 altitudes, most of these primary beam transmissions are blocked by the Earth, leaving only a narrow region of nominal signal visibility near opposing limbs of the earth. This region is highlighted in gray. If GPS receivers at GEO and HE0 orbits were designed to use these higher power signals only, precise orbit determination would not be practical. Fortunately, the GPS satellite antenna array also produces side lobe signals at much lower power levels. NASA has designed and tested the Navigator, a new GPS receiver that can acquire and track these weaker signals, thereby dramatically increasing the signal visibility at these altitudes. While using much weaker signals is a fundamental requirement for a high orbital altitude GPS receiver, it is certainly not the only challenge. There are other unique characteristics of this application that must also be considered. For example, Position Dilution of Precision (PDOP) figures are much higher at GEO and HE0 altitudes because visible GPS satellites are concentrated in a much smaller area with respect to the spacecraft antenna. These poor PDOP values contribute considerable error to the point solutions calculated by the spacecraft GPS receiver. Finally, spacecraft GPS receivers must be designed to withstand a variety of extreme environmental conditions. Variations in acceleration between launch and booster separation are extreme. Temperature gradients in the space environment are also severe. Furthermore, radiation effects are a major concern-spacecraft-borne GPS receivers must be designed with radiation-hardened electronics to guard against this phenomenon, otherwise they simply will not work. Perhaps most importantly, there are no opportunities to repair or modify any space-borne GPS receiver after it has been launched. Great care must be taken to ensure all performance characteristics have been analyzed prior to liftoff.

Bamford, William↗

Common Cause Case Study: An Estimated Probability of Four Solid Rocket Booster Hold-down Post Stud Hang-ups

Until Solid Rocket Motor ignition, the Space Shuttle is mated to the Mobil Launch Platform in part via eight (8) Solid Rocket Booster (SRB) hold-down bolts. The bolts are fractured using redundant pyrotechnics, and are designed to drop through a hold-down post on the Mobile Launch Platform before the Space Shuttle begins movement. The Space Shuttle program has experienced numerous failures where a bolt has "hung-up." That is, it did not clear the hold-down post before liftoff and was caught by the SRBs. This places an additional structural load on the vehicle that was not included in the original certification requirements. The Space Shuttle is currently being certified to withstand the loads induced by up to three (3) of eight (8) SRB hold-down post studs experiencing a "hang-up." The results af loads analyses performed for four (4) stud-hang ups indicate that the internal vehicle loads exceed current structural certification limits at several locations. To determine the risk to the vehicle from four (4) stud hang-ups, the likelihood of the scenario occurring must first be evaluated. Prior to the analysis discussed in this paper, the likelihood of occurrence had been estimated assuming that the stud hang-ups were completely independent events. That is, it was assumed that no common causes or factors existed between the individual stud hang-up events. A review of the data associated with the hang-up events, showed that a common factor (timing skew) was present. This paper summarizes a revised likelihood evaluation performed for the four (4) stud hang-ups case considering that there are common factors associated with the stud hang-ups. The results show that explicitly (i.e. not using standard common cause methodologies such as beta factor or Multiple Greek Letter modeling) taking into account the common factor of timing skew results in an increase in the estimated likelihood of four (4) stud hang-ups of an order of magnitude over the independent failure case.

Cross, Robert↗

Numerical Evaluation of Mode 1 Stress Intensity Factor as a Function of Material Orientation For BX-265 Foam Insulation Material

Foam; a cellular material, is found all around us. Bone and cork are examples of biological cell materials. Many forms of man-made foam have found practical applications as insulating materials. NASA uses the BX-265 foam insulation material on the external tank (ET) for the Space Shuttle. This is a type of Spray-on Foam Insulation (SOFI), similar to the material used to insulate attics in residential construction. This foam material is a good insulator and is very lightweight, making it suitable for space applications. Breakup of segments of this foam insulation on the shuttle ET impacting the shuttle thermal protection tiles during liftoff is believed to have caused the space shuttle Columbia failure during re-entry. NASA engineers are very interested in understanding the processes that govern the breakup/fracture of this complex material from the shuttle ET. The foam is anisotropic in nature and the required stress and fracture mechanics analysis must include the effects of the direction dependence on material properties. Material testing at NASA MSFC has indicated that the foam can be modeled as a transversely isotropic material. As a first step toward understanding the fracture mechanics of this material, we present a general theoretical and numerical framework for computing stress intensity factors (SIFs), under mixed-mode loading conditions, taking into account the material anisotropy. We present mode I SIFs for middle tension - M(T) - test specimens, using 3D finite element stress analysis (ANSYS) and FRANC3D fracture analysis software, developed by the Cornel1 Fracture Group. Mode I SIF values are presented for a range of foam material orientations. Also, NASA has recorded the failure load for various M(T) specimens. For a linear analysis, the mode I SIF will scale with the far-field load. This allows us to numerically estimate the mode I fracture toughness for this material. The results represent a quantitative basis for evaluating the strength and fracture properties of anisotropic foam insulation material.

Knudsen, Erik↗

Shuttle Debris Impact Tool Assessment Using the Modern Design of Experiments

Computational tools have been developed to estimate thermal and mechanical reentry loads experienced by the Space Shuttle Orbiter as the result of cavities in the Thermal Protection System (TPS). Such cavities can be caused by impact from ice or insulating foam debris shed from the External Tank (ET) on liftoff. The reentry loads depend on cavity geometry and certain Shuttle state variables, among other factors. Certain simplifying assumptions have been made in the tool development about the cavity geometry variables. For example, the cavities are all modeled as shoeboxes , with rectangular cross-sections and planar walls. So an actual cavity is typically approximated with an idealized cavity described in terms of its length, width, and depth, as well as its entry angle, exit angle, and side angles (assumed to be the same for both sides). As part of a comprehensive assessment of the uncertainty in reentry loads estimated by the debris impact assessment tools, an effort has been initiated to quantify the component of the uncertainty that is due to imperfect geometry specifications for the debris impact cavities. The approach is to compute predicted loads for a set of geometry factor combinations sufficient to develop polynomial approximations to the complex, nonparametric underlying computational models. Such polynomial models are continuous and feature estimable, continuous derivatives, conditions that facilitate the propagation of independent variable errors. As an additional benefit, once the polynomial models have been developed, they require fewer computational resources to execute than the underlying finite element and computational fluid dynamics codes, and can generate reentry loads estimates in significantly less time. This provides a practical screening capability, in which a large number of debris impact cavities can be quickly classified either as harmless, or subject to additional analysis with the more comprehensive underlying computational tools. The polynomial models also provide useful insights into the sensitivity of reentry loads to various cavity geometry variables, and reveal complex interactions among those variables that indicate how the sensitivity of one variable depends on the level of one or more other variables. For example, the effect of cavity length on certain reentry loads depends on the depth of the cavity. Such interactions are clearly displayed in the polynomial response models.

DeLoach, R.↗

Vibroacoustic analysis and experimental validation of the structural responses of NASA Mars Exploration Rover spacecraft due to acoustic launch load

Structural responses of a spacecraft during liftoff are dominated by the intense acoustic pressure field imping on the exterior of the launch vehicle. Statistical Energy Analysis model of the NASA Mars Exploration Rover spacecraft has been developed and the SEA model was analyzed to predict vibroacoustic responses of the spacecraft under the diffuse acoustic loading condition.

vibroacoustic statistical energy analysis SEA↗

(abstract) Vibration Damping of the Cassini Spacecraft Structure

Cassini will be protected during launch ascent through the atmosphere by a lightweight aluminum payload fairing (PLF). As a result of the extreme noise levels generated by the powerful Titan IV at liftoff, and the acoustic transparency of the PLF, Cassini is predicted to experience severe acoustic levels. Furthermore, the high acoustic levels, coupled with the size and configuration of the spacecraft, will induce intense random vibration on the structure and critical spacecraft components. Efforts to mitigate the vibroacoustic environment by modifying the spacecraft structure were pursued. Preliminary studies indicated that a structural damping treatment using viscoelastic materials (VEMs) represented a viable technique of reducing vibration with minimum impact on weight, cost, and redesign. Tuned Vibration Absorbers (TVAs) - compact, single degree-of-freedom mechanical oscillators in which a VEM serves as the spring and damping element - will be used also. The operating principles, design, and installation of the TVAs are described, the test program is outlined, and test results are presented which show that significant vibration attenuation was achieved.

vibroacoustic environment↗

Vibration damping of the Cassini spacecraft structure

Cassini is a large robotic spacecraft currently under development at the Jet Propulsion Laboratory (JPL) whose interplanetary scientific mission is to explore Saturn, its ring, and its moons. Cassini is scheduled to launch on a Titan IV rocket with a Centaur upper stage booster, and will be protected during ascent through the atmosphere by a lightweight aluminum payload fairing (PLF). As a result of the extreme noise levels generated by the powerful Titan IV at liftoff, and the acoustic transparency of the PLF, Cassini is predicted to experience sever acoustic levels. Furthermore, the high acoustic levels, coupled with the size and configuration of the spacecraft, will induce unacceptable random vibration levels on the structure and critical spacecraft components. Studies showed that the use of Tuned Vibration Absorbers (TVAs) would be effective in reducing vibration. A series of reverberant acoustic tests were performed on a partial development test model (DTM) of Cassini to evaluate the effectiveness of TVAs in reducing the structural vibration. The test results showed that significant vibration attenuation was achieved.

vibration damping↗

Vibroacoustic analysis and experimental validation of the structural responses of NASA Mars Exploration Rover spacecraft due to acoustic launch load

Structural responses of a spacecraft during liftoff are dominated by the intense acoustic pressure field imping on the exterior of the launch vehicle. Statistical Energy Analysis model of the NASA Mars Exploration Rover spacecraft has been developed and the SEA model was analyzed to predict vibroacoustic responses of the spacecraft under the diffuse acoustic loading condition.

vibroacoustic statistical energy analysis SEA↗

Common Cause Case Study: An Estimated Probability of Four Solid Rocket Booster Hold-Down Post Stud Hang-ups

Until Solid Rocket Motor ignition, the Space Shuttle is mated to the Mobil Launch Platform in part via eight (8) Solid Rocket Booster (SRB) hold-down bolts. The bolts are fractured using redundant pyrotechnics, and are designed to drop through a hold-down post on the Mobile Launch Platform before the Space Shuttle begins movement. The Space Shuttle program has experienced numerous failures where a bolt has hung up. That is, it did not clear the hold-down post before liftoff and was caught by the SRBs. This places an additional structural load on the vehicle that was not included in the original certification requirements. The Space Shuttle is currently being certified to withstand the loads induced by up to three (3) of eight (8) SRB hold-down experiencing a "hang-up". The results of loads analyses performed for (4) stud hang-ups indicate that the internal vehicle loads exceed current structural certification limits at several locations. To determine the risk to the vehicle from four (4) stud hang-ups, the likelihood of the scenario occurring must first be evaluated. Prior to the analysis discussed in this paper, the likelihood of occurrence had been estimated assuming that the stud hang-ups were completely independent events. That is, it was assumed that no common causes or factors existed between the individual stud hang-up events. A review of the data associated with the hang-up events, showed that a common factor (timing skew) was present. This paper summarizes a revised likelihood evaluation performed for the four (4) stud hang-ups case considering that there are common factors associated with the stud hang-ups. The results show that explicitly (i.e. not using standard common cause methodologies such as beta factor or Multiple Greek Letter modeling) taking into account the common factor of timing skew results in an increase in the estimated likelihood of four (4) stud hang-ups of an order of magnitude over the independent failure case.

Cross, Robert↗

Subclinical Reactivation and Shed of Infectious Varicella Zoster Virus in Saliva of Astronauts

We have previously detected VZV in healthy astronauts both during spaceflight and shortly after landing. Herein, we show that VZV shed in seropositive astronauts is infectious. A total of 40 saliva samples were obtained from each of the 3 astronauts. From each astronaut, 14 samples were taken 109 to 133 days before liftoff, 1 sample was taken every day during 12 days in space, and one sample was taken for 14 consecutive days beginning the second day after landing. Quantitative PCR was used to detect VZV DNA in saliva. None of 42 preflight saliva samples contained VZV DNA. VZV DNA was detected in saliva from 2 of 3 astronauts. In 1 astronaut, 6 of 12 samples obtained during space flight contained 120 to 2,500 copies of VZV DNA per ml; after landing, 1250 copies of VZV DNA were present on day 2, 45 copies on day 3, and 110 copies on day 5. All samples taken 6 to 15 days after touchdown were negative for VZV DNA. In the second astronaut, 5 of 12 samples obtained during space flight contained 18 to 650 copies of VZV DNA per ml; after landing, 560 copies of VZV DNA were present in saliva on day 2, 340 copies on day 4, 45 copies on day 5, and 23 copes on day 6. All samples taken 7 to 15 days after touchdown were negative for VZV DNA. Saliva taken 2 to 6 days after landing from all 3 astronauts was cultured on human fetal lung cells. After one subcultivation, a cytopathic effect developed in cultures inoculated with saliva from the two astronauts whose saliva contained VZV DNA. Both PCR and immunostaining identified the isolates to be VZV and not HSV-1. Importantly, the astronaut in whom no VZV was detected had a history of zoster 9 years earlier. It is possible that a boost in cell-mediated immunity to VZV which is known to develop after zoster protected him from subclinical reactivation. The genotype of the two VZV isolates was determined by VZV ORF22-based PCR/sequencing along with FRET-based PCR assays that target specific nucleotide polymorphisms. Both VZV isolates were found to be the European genotype which also contained a rare MspI restriction enodnuclease site in VZV ORF62 at position 107,252. These findings extend our previous demonstration of VZV DNA in saliva of astronauts by showing that infectious VZV is also present. Thus, like HSV-1 and HSV-2, VZV can reactivate and shed infectious virus in the absence of clinical disease.

Cohrs, Randall J.↗

A Match Made in Space

Just before the space shuttle reaches orbit, its three main engines shut down so that it can achieve separation from the massive external tank that provided the fuel required for liftoff and ascent. In jettisoning the external tank, which is completely devoid of fuel at this point in the flight, the space shuttle fires a series of thrusters, separate from its main engines, that gives the orbiter the maneuvering ability necessary to safely steer clear of the descending tank and maintain its intended flight path. These thrusters make up the space shuttle s Reaction Control System. While the space shuttle s main engines only provide thrust in one direction (albeit a very powerful thrust), the Reaction Control System engines allow the vehicle to maneuver in any desired direction (via small amounts of thrust). The resulting rotational maneuvers are known as pitch, roll, and yaw, and are very important in ensuring that the shuttle docks properly when it arrives at the International Space Station and safely reenters the Earth s atmosphere upon leaving. To prevent the highly complex Reaction Control System from malfunctioning during space shuttle flights, and to provide a diagnosis if such a mishap were to occur, NASA turned to a method of artificial intelligence that truly defied the traditional laws of computer science.

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