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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 343 records · Page 19

Ampk alpha2 T172 activation dictates exercise performance and energy transduction in skeletal muscle

Adenosine 5′-monophosphate–activated protein kinase (AMPK) is an energetic sensor for metabolic regulation and integration. Here, we used CRISPR-Cas9 to generate nonactivatable Ampkα knock-in (KI) mice with mutation of threonine-172 phosphorylation site to alanine (T172A), circumventing the limitations of previous genetic interventions that disrupt the protein stoichiometry. KI mice of Ampkα2, but not Ampkα1, demonstrated phenotypic changes with increased fat-to-lean mass, impaired endurance exercise capacity, and diminished mitochondrial maximal respiration and conductance in skeletal muscle. Integrated temporal multiomics analysis (proteomics/phosphoproteomics/metabolomics) in skeletal muscle at rest and during exercise establishes a pleiotropic yet imperative role of Ampkα2 T172 activation for glycolytic and oxidative metabolism, mitochondrial respiration, and contractile function. There is a substantial overlap of skeletal muscle proteomic changes in Ampkα2 T172A KI mice with that of patients with type 2 diabetes. Our findings suggest that Ampkα2 T172 activation is critical for exercise performance and energy transduction in skeletal muscle and may serve as a therapeutic target for type 2 diabetes.

Bioenergetics↗

MemFriend: Understanding Memory Performance with Spatial-Temporal Affinity

In HPC applications, memory access behavior is one of the main factors affecting performance. Improving an application’s memory access behavior involves optimizing data layout and/or restructuring code, and requires studying spatial-temporal data locality. Existing data locality analyses focus on single-location metrics and are restricted to evaluating temporal locality. We introduce spatial-temporal affinity metrics that quantify temporal access proximity, forward access correlation, and nearby access correlation between pairs of memory locations. We describe methods for distinguishing between potential vs. realized affinity and for reasoning about affinity at multiple resolutions (3D, 2D, 1D). Finally, we construct spatial-temporal affinity signatures that classify memory behavior and that be used to reason about changes in software (data relayout, code refactoring) or hardware (caching, prefetching). We describe methods for signature visualization, interpretation, and quantitative comparison of signatures. We evaluate our methodology using applications with variants that contrast data structures, data layouts and algorithms. We show that spatial-temporal affinity analysis provides novel insights and enables predictive reasoning about application performance when contrasted with reuse distance analysis.

Suriyakumar, Yasodhadevi↗

TFA Performance Improvement

The objective of this project was to increase the rate at which video data is processed using temporal frequency analysis. A common solution to increasing the speed of data processing is to increase the computing power of the system however size, weight and power (SWAP) constraints require computing power to be limited. This project focused on increasing the processing speed by reducing the expense of computing the Fourier Transform (FT).

97 MATHEMATICS AND COMPUTING↗

Localized Defect Detection from Spatially Mapped, In-Situ Process Data With Machine Learning

In powder bed fusion additive manufacturing, machines are often equipped with in-situ sensors to monitor the build environment as well as machine actuators and subsystems. The data from these sensors offer rich information about the consistency of the fabrication process within a build and across builds. This information may be used for process monitoring and defect detection; however, little has been done to leverage this data from the machines for more than just coarse-grained process monitoring. In this work we demonstrate how these inherently temporal data may be mapped spatially by leveraging scan path information. We then train a XGBoost machine learning model to predict localized defects—specifically soot–using only the mapped process data of builds from a laser powder bed fusion process as input features. The XGBoost model offers a feature importance metric that will help to elucidate possible relationships between the process data and observed defects. Finally, we analyze the model performance spatially and rationalize areas of greater and lesser performance.

3D printing↗

Anomalous type III bursts explained in terms of intermittent solar wind streams observed by Pioneer spacecraft.

Occasional solar radio bursts drift downward in frequency (like type III bursts), but the drift slows or ceases or it may even reverse. These anomalous forms are called L-bursts, U-bursts, etc., and are observed as low as 1 MHz by spacecraft. The conventional explanation involves guidance of relativistic exciting particles by solar magnetic fields that do not have the spiral shape expected in undisturbed conditions. A reasonable alternative explanation is possible and, indeed, it follows directly from the inferences which have been drawn from the Stanford dual-frequency experiment flown on four Pioneer spacecraft. Analysis of temporal variations in these data leads to the conclusion that narrow streams of enhanced concentration have lifetimes which are typically about one day and the streams seem to be intermittently ejected by long-enduring sources at the sun. Each enhancement is thought to lie along a spiral and to have a beginning and an end. It may happen that relativistic exciters encounter the tail of such a discrete streamer; the concentration encountered by such exciters would initially decline but, at the streamer tail, it would level off and perhaps increase. The plasma frequency versus time (the burst frequency) would then cease to drop in the typical type III profile and would level off or increase (as in a U-burst).

Croft, T. A.↗

Digital image processing for information extraction.

The modern digital computer has made practical image processing techniques for handling nonlinear operations in both the geometrical and the intensity domains, various types of nonuniform noise cleanup, and the numerical analysis of pictures. An initial requirement is that a number of anomalies caused by the camera (e.g., geometric distortion, MTF roll-off, vignetting, and nonuniform intensity response) must be taken into account or removed to avoid their interference with the information extraction process. Examples illustrating these operations are discussed along with computer techniques used to emphasize details, perform analyses, classify materials by multivariate analysis, detect temporal differences, and aid in human interpretation of photos.

Billingsley, F. C.↗

Slave finite elements: The temporal element approach to nonlinear analysis

A formulation method for finite elements in space and time incorporating nonlinear geometric and material behavior is presented. The method uses interpolation polynomials for approximating the behavior of various quantities over the element domain, and only explicit integration over space and time. While applications are general, the plate and shell elements that are currently being programmed are appropriate to model turbine blades, vanes, and combustor liners.

Gellin, S.↗

Balancing antagonistic time and resource utilization constraints in over-subscribed scheduling problems

In this paper, we report work aimed at applying concepts of constraint-based problem structuring and multi-perspective scheduling to an over-subscribed scheduling problem. Previous research has demonstrated the utility of these concepts as a means for effectively balancing conflicting objectives in constraint-relaxable scheduling problems, and our goal here is to provide evidence of their similar potential in the context of HST observation scheduling. To this end, we define and experimentally assess the performance of two time-bounded heuristic scheduling strategies in balancing the tradeoff between resource setup time minimization and satisfaction of absolute time constraints. The first strategy considered is motivated by dispatch-based manufacturing scheduling research, and employs a problem decomposition that concentrates local search on minimizing resource idle time due to setup activities. The second is motivated by research in opportunistic scheduling and advocates a problem decomposition that focuses attention on the goal activities that have the tightest temporal constraints. Analysis of experimental results gives evidence of differential superiority on the part of each strategy in different problem solving circumstances. A composite strategy based on recognition of characteristics of the current problem solving state is then defined and tested to illustrate the potential benefits of constraint-based problem structuring and multi-perspective scheduling in over-subscribe scheduling problems.

Smith, Stephen F.↗

Linear stability of compressible Taylor-Couette flow

A temporal stability analysis of compressible Taylor-Couette flow is presented. The viscous flow studied in this paper is contained between two concentric cylinders of infinite length, which are rotating with different angular velocities and are kept at different surface temperatures. The effects of differential rotation and temperature difference on the stability of Taylor-Couette flow are contrasted for a range of Mach numbers ranging from incompressible to Mach 3.0. The relative motion of the cylinders dramatically affects the characteristics of the Couette flow at the onset of instability. The flow is stabilized or destabilized depending upon the temperature ratio and speeds of the two cylinders. Independent of Mach number and temperature ratio, increasing Reynolds number generally promotes a destabilizing effect, indicating the inviscid nature of the Taylor-Couette flow.

Kao, Kai-Hsiung↗

Computational analysis of high resolution unsteady airloads for rotor aeroacoustics

The study of helicopter aerodynamic loading for acoustics applications requires the application of efficient yet accurate simulations of the velocity field induced by the rotor's vortex wake. This report summarizes work to date on the development of such an analysis, which builds on the Constant Vorticity Contour (CVC) free wake model, previously implemented for the study of vibratory loading in the RotorCRAFT computer code. The present effort has focused on implementation of an airload reconstruction approach that computes high resolution airload solutions of rotor/rotor-wake interactions required for acoustics computations. Supplementary efforts on the development of improved vortex core modeling, unsteady aerodynamic effects, higher spatial resolution of rotor loading, and fast vortex wake implementations have substantially enhanced the capabilities of the resulting software, denoted RotorCRAFT/AA (AeroAcoustics). Results of validation calculations using recently acquired model rotor data show that by employing airload reconstruction it is possible to apply the CVC wake analysis with temporal and spatial resolution suitable for acoustics applications while reducing the computation time required by one to two orders of magnitude relative to that required by direct calculations. Promising correlation with this body of airload and noise data has been obtained for a variety of rotor configurations and operating conditions.

Quackenbush, Todd R.↗

Computation of high resolution unsteady airloads using a constant vorticity contour free wake model

Recent work in the study of helicopter aerodynamic loading for acoustics applications has involved research on the development of an exceptionally efficient simulation of the velocity field induced by the rotor's vortex wake. This paper summarizes the work to date on the development of this analysis, which builds on the refined constant vorticity contour (CVC) free wake model recently developed for application to the study of vibratory loading. The particular focus of this paper is on demonstrations of a reconstruction approach that efficiently computes both the flow fields and airloads induced by CVC wakes on lifting rotor blades. Results of recent calculations on both main rotor and tail rotors are presented. These calculations show that by employing flow field reconstruction it is possible to apply the CVC wake analysis with temporal and spatial resolution suitable for acoustics applications while reducing the computation time required by one to two orders of magnitude relative to the direct calculations used in traditional methods.

Quackenbush, T. R.↗

A serach for moderate- and high-energy neturino emission correlated with gamma-ray bursts

A temporal correlation analysis between moderate- (60 Mev less than or equal to E(sub nu)greater than or equal to 2500 MeV) and high-energy (E(sub nu) greater than or equal to 2000 MeV) neutrino interactions consist of two types: the moderate-energy interactions that are contained within the volume of IMB-3 and the upward-going muons produced by high-energy nu(sub mu) interactions in the rock around the detector. No evidence is found for moderate- or high-energy neutrino emission from GRBs nor for any neutrino/neutrino correlation. The nonobservation of nu/GRB correlations allows upper limits to be placed on the neutrino flux associated with GRBs.

Becker-Szendy, R.↗

Demodulation System for Fiber Optic Bragg Grating Dynamic Pressure Sensing

Fiber optic Bragg gratings have been used for years to measure quasi-static phenomena. In aircraft engine applications there is a need to measure dynamic signals such as variable pressures. In order to monitor these pressures a detection system with broad dynamic range is needed. This paper describes an interferometric demodulator that was developed and optimized for this particular application. The signal to noise ratio was maximized through temporal coherence analysis. The demodulator was incorporated in a laboratory system that simulates conditions to be measured. Several pressure sensor configurations incorporating a fiber optic Bragg grating were also explored. The results of the experiments are reported in this paper.

Lekki, John D.↗

Characteristics of Impact Craters and Interior Deposits: Analysis of the Spatial and Temporal Distribution of Volatiles in the Highlands of Mars

The martian southern highlands contain impact craters that display pristine to degraded morphologies, and preserve a record of degradation that can be attributed to fluvial, eolian, mass wasting, volcanic and impact-related processes. However, the relative degree of modification by these processes and the amounts of material contributed to crater interiors are not well constrained. Impact craters (D>10 km) within Terra Cimmeria (0deg-60degS, 190deg-240degW), Terra Tyrrhena (0deg-30degS, 260deg-310degW) and Noachis Terra (20deg-50degS, 310deg-340degW) are being examined to better understand the degradational history and evolution of highland terrains. The following scientific objectives will be accomplished. 1) Determine the geologic processes that modified impact craters (and surrounding highland terrains). 2) Determine the sources (e.g. fluvial, lacustrine, eolian, mass wasting, volcanic, impact melt) and relative amounts of material composing crater interior deposits. 3) Document the relationships between impact crater degradation and highland fluvial systems. 4) Determine the spatial and temporal relationships between degradational processes on local and regional scales. And 5) develop models of impact crater (and highland) degradation that can be applied to these and other areas of the martian highlands. The results of this study will be used to constrain the geologic, hydrologic and climatic evolution of Mars and identify environments in which subsurface water might be present or evidence for biologic activity might be preserved.

Mest, S. C.↗

Effects of Tropospheric Spatio-Temporal Correlated Noise on the Analysis of Space Geodetic Data

The standard VLBI analysis models the distribution of measurement noise as Gaussian. Because the price of recording bits is steadily decreasing, thermal errors will soon no longer dominate. As a result, it is expected that troposphere and instrumentation/clock errors will increasingly become more dominant. Given that both of these errors have correlated spectra, properly modeling the error distributions will become increasingly relevant for optimal analysis. We discuss the advantages of modeling the correlations between tropospheric delays using a Kolmogorov spectrum and the frozen flow assumption pioneered by Treuhaft and Lanyi. We then apply these correlated noise spectra to the weighting of VLBI data analysis for two case studies: X/Ka-band global astrometry and Earth orientation. In both cases we see improved results when the analyses are weighted with correlated noise models vs. the standard uncorrelated models. The X/Ka astrometric scatter improved by approx.10% and the systematic Delta delta vs. delta slope decreased by approx. 50%. The TEMPO Earth orientation results improved by 17% in baseline transverse and 27% in baseline vertical.

instrumentation errors↗

Effects of Tropospheric Spatio-Temporal Correlated Noise on the Analysis of Space Geodetic Data

The standard VLBI analysis models measurement noise as purely thermal errors modeled according to uncorrelated Gaussian distributions. As the price of recording bits steadily decreases, thermal errors will soon no longer dominate. It is therefore expected that troposphere and instrumentation/clock errors will increasingly become more dominant. Given that both of these errors have correlated spectra, properly modeling the error distributions will become more relevant for optimal analysis. This paper will discuss the advantages of including the correlations between tropospheric delays using a Kolmogorov spectrum and the frozen ow model pioneered by Treuhaft and Lanyi. We will show examples of applying these correlated noise spectra to the weighting of VLBI data analysis.

thermal noise↗