Venomous Cargo: Diverse Toxin-Related Proteins Are Associated with Extracellular Vesicles in Parasitoid Wasp Venom
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Jennifer Chou↗
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Project LOCOST: Laser or Chemical Hybrid Orbital Space Transport
A potential mission in the late 1990s is the servicing of spacecraft assets located in GEO. The Geosynchronous Operations Support Center (GeoShack) will be supported by a space transfer vehicle based at the Space Station (SS). The vehicle will transport cargo between the SS and the GeoShack. A proposed unmanned, laser or chemical hybrid orbital space transfer vehicle (LOCOST) can be used to efficiently transfer cargo between the two orbits. A preliminary design shows that an unmanned, laser/chemical hybrid vehicle results in the fuel savings needed while still providing fast trip times. The LOCOST vehicle receives a 12 MW laser beam from one Earth orbiting, solar pumped, iodide Laser Power Station (LPS). Two Energy Relay Units (ERU) provide laser beam support during periods of line-of-sight blockage by the Earth. The baseline mission specifies a 13 day round trip transfer time. The ship's configuration consist of an optical train, one hydrogen laser engine, two chemical engines, a 18 m by 29 m box truss, a mission-flexible payload module, and propellant tanks. Overall vehicle dry mass is 8,000 kg. Outbound cargo mass is 20,000 kg, and inbound cargo mass is 6,000 kg. The baseline mission needs 93,000 kg of propellants to complete the scenario. Fully fueled, outbound mission mass is 121,000 kg. A regeneratively cooled, single plasma, laser engine design producing a maximum of 768 N of thrust is utilized along with two traditional chemical engines. The payload module is designed to hold 40,000 kg of cargo, though the baseline mission specifies less. A proposed design of a laser/chemical hybrid vehicle provides a trip time and propellant efficient means to transport cargo from the SS to a GeoShack. Its unique, hybrid propulsion system provides safety through redundancy, allows baseline missions to be efficiently executed, while still allowing for the possibility of larger cargo transfers.
Dixon, Alan↗
The Carrier's Liability for Damage Caused by Delay in International Air Transport
Delay in the air transport occurs when passengers, baggage or cargo do not arrive at their destination at the time indicated in the contract of carriage. The causes of delay in the carriage of passengers are booking errors or double booking, delayed departure of aircraft, incorrect information regarding the time of departure, failure to land at the scheduled destination and changes in flight schedule or addition of extra landing stops. Delay in the carriage of baggage or cargo may have different causes: no reservation, lack of space, failure to load the baggage or cargo at the right place, or to deliver the covering documents at the right place. The Montreal Convention of 1999 Article 19 provides that 'The carrier is liable for damage occasioned by delay in the carriage by air of passengers, baggage or cargo. Nevertheless, the carder shall not be liable for damage occasioned by delay if it proves that it and its servants and agents took all measures that could reasonably be required to avoid the damage or that it was impossible for it or them to take such measures'. The Montreal Convention Article 22 provides liability limits of the carrier in case of delay for passengers and their baggage and for cargo. In the carriage of persons, the liability of the carrier for each passenger is limited to 4,150 SDR. In the carriage of baggage, the liability of the carrier is limited to 1,000 SDR for each passenger unless a special declaration as to the value of the baggage has been made. In the carriage of cargo, the liability of the carrier is limited to 17 SDR per kilogram unless a special declaration as to the value of the cargo has been made. The Montreal Convention Article 19 has shortcomings: it is silent on the duration of the liability for carriage,andit does not make any distinction between persons and good. It does not give any indication concerning the circumstances to be taken into account in cases of delay, and about the length of delay. In conclusion, it is desirable to define the period of carriage with accuracy, and to insert the word 'unreasonable' in Article 19.
Lee, Kang Bin↗
An Evolvable Approach to Launch Vehicles for Exploration
This paper presents ideas that may be used individually or in combination to mitigate high costs for separate developments of new crew and heavy-lift cargo launch vehicles, while providing the foundation for a highly reliable and evolvable approach to exploration. Consideration is given to reclassification of cargo for launch purposes into high value versus low value categories, rather than the presently-defined crew versus cargo categories. Objectives for the reclassification are to reduce the gap between payload mass requirements for crew and cargo payloads to better allow closure on a single moderately-sized common core vehicle to reduce development cost, achieve an economical balance between launch frequency and payload mass, and to improve total mission reliability and safety, as compared a light-weight crew vehicle and heavy cargo lift approach. Concepts to reduce design and flight qualification costs for a common core vehicle with derivatives are presented. Appropriate types and mass of cargo for each class of vehicle are identified. Utilization of existing infrastructure and flight hardware is considered to reduce costs and build on proven capabilities. The approach enables low-risk incorporation of international and commercial launch of relatively low-cost, easily replaceable assets as a means to evolve toward longer-duration and more distant missions. Benefits are identified for ground idrastructure, personnel, training, logistics, spares, and system evolution. Technology needs are compared with needs for other aspects of exploration. Technology development phasing, demonstration, and reliability growth opportunities are considered. Flexibility to adapt to future technologies such as advanced in-space propulsion is contrasted with an approach of sizing the cargo launch vehicle based on today's in-space propellants.
Cheuvront, David L.↗
TPSAS-NF1676L-13680-DND
The International Space Station will require a continuous supply of replacement parts for ongoing maintenance and repair after the retirement of the Space Shuttle. These parts, existing line-replaceable items collectively called Orbital Replacement Units, include heavy and oversized items such as Control Moment Gyroscopes and stowed radiator arrays originally intended for delivery aboard the Space Shuttle. Current resupply spacecraft have limited to no capability to deliver these external logistics. In support of NASA?s Exploration Systems Architecture Study, a team at Langley Research Center designed an Unpressurized Cargo Delivery Vehicle to deliver bulk cargo to the Space Station. The Unpressurized Cargo Delivery Vehicle was required to deliver at least 13,200 lb of cargo mounted on at least 18 Flight Releasable Attachment Mechanisms. The baseline vehicle design developed here has a cargo capacity of 16,000 lbs mounted on up to 20 Flight Releasable Attachment Mechanisms. Major vehicle components are a 5.5m-diameter cargo module containing two detachable cargo pallets with the payload, a Service Module to provide propulsion and power, and an aerodynamic nose cone. To reduce cost and risk, the Service Module is identical to the one used for the Crew Exploration Vehicle design. The Crew Launch Vehicle design recommended in the Exploration Systems Architecture Study was used to launch one annual resupply flight to the International Space Station.
K Chauncey Wu↗
Subsonic Single Aft Engine Narrowbody (SUSAN) Freighter Concept and Market Analysis
The dedicated air cargo and freight market has the potential to be a critical early pathway for emerging technologies in low to zero emission propulsion. This study analyzes the cargo aviation market to understand current market trends and future market viability of a mid-sized all-electric or hybrid-electric concept aircraft. While cargo aviation’s overall emissions footprint is small relative to commercial passenger aviation, it remains an important and challenging transportation sector to decarbonize. Past research has focused on small, less than 19-seat electrified aircraft propulsion concepts that could serve both passenger and air cargo markets This study extends the electrified market space into larger aircraft classes, considering if a purpose-built large hybrid electric turboprop freighter can compete in the market currently served primarily by conversion narrowbody freighters. Specifically, this paper focuses on the mid-sized cargo market with payload ranges of 40,000-50,000lbs, and an all-electric range potential up to 750 miles. The concept aircraft is based on a 4-engine turboprop configuration, with mounted wing battery packs and an aft cargo door to allow for standardized palletization. The market analysis indicates broad market coverage with 73% of the existing mid-sized cargo network within the range of 750 miles. A breakeven analysis of operating and capital costs shows potential for market competition, however, additional energy and acquisition cost savings from the concept aircraft are needed. Evidence from the breakeven analysis also points to higher rates of aircraft utilization being a critical path to lowering costs and increasing cost effectiveness.
Jacob M. Wishart↗
Hybrid Electric Turboprop Commercial Freighter (HETCOF) Market Study
The dedicated air cargo and freight market has the potential to be a critical early pathway for emerging technologies in low to zero emission propulsion. This study analyzes the cargo aviation market to understand current market trends and future market viability of a mid-sized all-electric or hybrid-electric concept aircraft. While cargo aviation’s overall emissions footprint is small relative to commercial passenger aviation, it remains an important and challenging transportation sector to decarbonize. Past research has focused on small, less than 19-seat electrified aircraft propulsion concepts that could serve both passenger and air cargo markets. This study extends the electrified market space into larger aircraft classes, considering if a purpose-built large hybrid electric turboprop freighter can compete in the market currently served primarily by conversion narrowbody freighters. Specifically, this paper focuses on the mid-sized cargo market with payload ranges of 40,000-50,000lbs, and an all-electric range potential up to 750 miles. The concept aircraft is based on a 4-engine turboprop configuration, with wing mounted battery packs and an aft cargo door to allow for standardized palletization. The market analysis indicates broad market coverage with 73% of the existing mid-sized cargo network within the range of 750 miles. A breakeven analysis of operating and capital costs shows potential for market competition; however, this would require additional energy and acquisition cost savings from the concept aircraft. Evidence from the breakeven analysis also points to higher rates of aircraft utilization being a critical path to lowering costs and increasing cost effectiveness.
Hybrid Electric↗
U.S. launch systems evolution
Shuttle improvements and Shuttle-derived vehicles which could answer projected launch system demands for the 1990s are explored. Traffic volume is suggested to be at levels exceeding the STS ability to deliver, thereby necessitating use of unmanned launch vehicles. Some payload delivery increase is possible using an Aft Cargo Carrier attached to the bottom of the external tank. This configuration would handle cargo with a diameter larger than the 15 ft allowable in the Orbiter bay. Various configurations of solid rocket booster cargo rockets are described, together with use of a module containing the Shuttle main engines and avionics as a recoverable part of a system able to place cargo 30 ft in diam and 90-100 ft tall in orbit. Using liquid reusable boosters would permit an increase of cargo capacity by the Shuttle of 50%, while a side-mount cargo vehicle (unmanned) offers a payload capacity of 165-200 klb. It is predicted that launch vehicles in the beginning of the 21st century will be of a fully reusable design.
Marshall, W. R.↗
Project Exodus
A design for a manned Mars mission, PROJECT EXODUS is presented. PROJECT EXODUS incorporates the design of a hypersonic waverider, cargo ship and NIMF (nuclear rocket using indigenous Martian fuel) shuttle lander to safely carry out a three to five month mission on the surface of Mars. The cargo ship transports return fuel, return engine, surface life support, NIMF shuttle, and the Mars base to low Mars orbit (LMO). The cargo ship is powered by a nuclear electric propulsion (NEP) system which allows the cargo ship to execute a spiral trajectory to Mars. The waverider transports ten astronauts to Mars and back. It is launched from the Space Station with propulsion provided by a chemical engine and a delta velocity of 9 km/sec. The waverider performs an aero-gravity assist maneuver through the atmosphere of Venus to obtain a deflection angle and increase in delta velocity. Once the waverider and cargo ship have docked the astronauts will detach the landing cargo capsules and nuclear electric power plant and remotely pilot them to the surface. They will then descend to the surface aboard the NIMF shuttle. A dome base will be quickly constructed on the surface and the astronauts will conduct an exploratory mission for three to five months. They will return to Earth and dock with the Space Station using the waverider.
Bryant, Rodney↗
Lunar lander configuration study and parametric performance analysis
Future Lunar exploration plans will call for delivery of significant mounts or cargo to provide for crew habitation, surface tansportation, and scientific exploration activities. Minimization of costly surface based infrastructure is in large part directly related to the design of the cargo delivery/landing craft. This study focused on evaluating Lunar lander concepts from a logistics oriented perspective, and outlines the approach used in the development of a preferred configuration, sets forth the benefits derived from its utilization and describes the missions and system considered. Results indicate that only direct-to-surface downloading of payloads provides for unassisted cargo removal operations imperative to efficient and low risk site buildup, including the emplacement of Space Station derivative surface habitat modules, immediate cargo jettison for both descent abort and emergency surface ascent essential to piloted missions carrying cargo, and short habitat egress/ingress paths necessary to productive surface work tours for crew members carrying hand held experiments, tools and other bulky articles. Accommodating cargo in a position underneath the vehicles structural frame, landing craft described herein eliminate altogether the necessity for dedicated surface based off-loading vehicles, the operations and maintenance associated with their operation, and the precipitous ladder climbs to and from the surface that are inherent to traditional designs. Parametric evaluations illustrate performance and mass variation with respect to mission requirements.
Donahue, Benjamin B.↗
Airship Industry Study
There is an ongoing Government interest in the potential of airships for cargo transport; Conducting vertical or near-vertical airlift of heavy, outsized freight with little or no ground infrastructure is an attractive cargo transport option. USTRANSCOM wanted to understand the principal issues that are holding back commercial development of airship transports. NASA Ames Research Center was commissioned by USTRANSCOM to study the airship industry’s ability to design, develop, and operate cargo airships. Principal study objectives were to identify: (1) Current and near term state of the cargo airship industry; (2) Roadblocks hindering cargo airship development; (3) Steps needed to remove impediments to cargo airship deployment.
Hochstetler, Ron↗
Operational Integration Potential of Regional Uncrewed Aircraft Systems Into the Airspace System
As part of newly developing aviation markets, fixed-wing Uncrewed Aircraft Systems (UAS) are projected to impact airspace systems and conventional air traffic in the future. The initial introduction of fixed-wing cargo UAS for regional operations is anticipated to occur at smaller under-utilized airports. Therefore, this paper assesses the integration potential of regional fixed-wing cargo UAS into the airspace system. A baseline is established to identify potential airports for cargo UAS operations in different areas. Additionally, using 2022 data, regional aircraft eligible for future cargo UAS operations are investigated. Finally, the accessibility of these regional aircraft at the identified airports was analysed. Based on the availability of current certified landing systems needed for initial UAS operations, potential airports in the areas Germany, Texas, and California for UAS operations are compared. Additionally, based on the maximum takeoff weight allowances of airport runways, current air transport operations at airports, and airspace classes, individual airports with a high potential for the introduction of initial cargo UAS operations with and without the availability of landing systems needed for UAS are identified and compared among the investigated areas. Despite a total of 173 identified airports for potential UAS operations in Germany, 376 in Texas, and 231 in California, only eleven of these airports currently have the certified landing systems needed for initial UAS operations. However, other landing system technologies that are currently under development, such as vision-based landing systems, might support UAS accessibility at the identified airports for potential UAS operations in the future.
Uncrewed aircraft systems↗
Intracellular Biomacromolecule Delivery by Stimuli-Responsive Protein Vesicles Loaded by Hydrophobic Ion Pairing
Proteins can perform ideal therapeutic functions. However, their large size and significant surface hydrophilicity and charge prohibit them from reaching intracellular targets. These chemical features also render them poorly encapsulated by nanoparticles used for intracellular delivery. In this work, a novel combination of protein vesicles and hydrophobic ion pairing (HIP) was used to load protein cargo and achieve cytosolic delivery to overcome the limitations of previous protein vesicle properties. Protein vesicles are thermally self-assembling nanoparticles made from elastin-like polypeptide (ELP) fused to an arginine-rich leucine zipper and a globular protein fused to a glutamate-rich leucine zipper. To impart stimuli-responsive disassembly, physiological stability, and small size, the ELP sequence was modified to include histidine and tyrosine residues. HIP was used to load and release protein cargo requiring endosomal escape for cytosolic function. HIP vesicles enabled delivery of cytochrome c, a cytosolically active protein, and a significant reduction in viability in both a traditional two-dimensional (2D) human cancer cell line culture and a biomimetic three-dimensional (3D) organoid model of acute myeloid leukemia. By examining the uptake of positively and negatively charged fluorescent protein cargos loaded by HIP, this work revealed the necessity of HIP for cytosolic cargo delivery and how HIP loading influences protein vesicle self-assembly and disassembly using microscopy, small-angle X-ray scattering, and nanoparticle tracking analysis. HIP protein vesicles have the potential to broaden the use of intracellular proteins as therapeutics for various diseases and extend protein vesicles to deliver other biomacromolecules, as the strategy developed here resulted in the first cytosolic protein cargo delivery using protein vesicles.
59 BASIC BIOLOGICAL SCIENCES↗
Bacterial hemophilin homologs and their specific type eleven secretor proteins have conserved roles in heme capture and are diversifying as a family
Cellular life relies on enzymes that require metals, which must be acquired from extracellular sources. Bacteria utilize surface and secreted proteins to acquire such valuable nutrients from their environment. These include the cargo proteins of the type eleven secretion system (T11SS), which have been connected to host specificity, metal homeostasis, and nutritional immunity evasion. This Sec-dependent, Gram-negative secretion system is encoded by organisms throughout the phylum Proteobacteria, including human pathogens Neisseria meningitidis, Proteus mirabilis, Acinetobacter baumannii, and Haemophilus influenzae. Experimentally verified T11SS-dependent cargo include transferrin-binding protein B (TbpB), the hemophilin homologs heme receptor protein C (HrpC), hemophilin A (HphA), the immune evasion protein factor-H binding protein (fHbp), and the host symbiosis factor nematode intestinal localization protein C (NilC). Here, we examined the specificity of T11SS systems for their cognate cargo proteins using taxonomically distributed homolog pairs of T11SS and hemophilin cargo and explored the ligand binding ability of those hemophilin cargo homologs. In vivo expression in Escherichia coli of hemophilin homologs revealed that each is secreted in a specific manner by its cognate T11SS protein. Sequence analysis and structural modeling suggest that all hemophilin homologs share an N-terminal ligand-binding domain with the same topology as the ligand-binding domains of the Haemophilus haemolyticus heme binding protein (Hpl) and HphA. We term this signature feature of this group of proteins the hemophilin ligand-binding domain. Network analysis of hemophilin homologs revealed five subclusters and representatives from four of these showed variable heme-binding activities, which, combined with sequence-structure variation, suggests that hemophilins are diversifying in function.
59 BASIC BIOLOGICAL SCIENCES↗
Orbit to orbit transportation
Orbital transfer vehicle propulsion options for SPS include both chemical (COTV) and electrical (EOTV) options. The proposed EOTV construction method is similar to that of the SPS and, by the addition of a transmitting antenna, may serve as a demonstration or precursor satellite option. The results of the studies led to the selection of a single stage COTV for crew and priority cargo transfer. An EOTV concept is favored for cargo transfer because of the more favorable orbital burden factor over chemical systems. The gallium arsenide solar array is favored over the silicon array because of its self annealing characteristics of radiation damage encountered during multiple transitions through the Van Allen radiation belt. Transportation system operations are depicted. A heavy lift launch vehicle (HLLV) delivers cargo and propellants to LEO, which are transferred to a dedicated EOTV by means of an intraorbit transfer vehicle (IOTV) for subsequent transfer to GEO. The space shuttle is used for crew transfer from Earth to LEO. At the LEO base, the crew module is removed from the shuttle cargo bay and mated to a COTV for transfer to GEO. Upon arrival at GEO, the SPS construction cargo is transferred from the EOTV to the SPS construction base by IOTV. Crew consumables and resupply propellants are transported to GEO by the EOTV. Transportation requirements are dominated by the vast quantity of materials to be transported to LEO and GEO.
Bergeron, R. P.↗
Nuclear reactor power for an electrically powered orbital transfer vehicle
To help determine the systems requirements for a 300-kWe space nuclear reactor power system, a mission and spacecraft have been examined which utilize electric propulsion and this nuclear reactor power for multiple transfers of cargo between low earth orbit (LEO) and geosynchronous earth orbit (GEO). A propulsion system employing ion thrusters and xenon propellant was selected. Propellant and thrusters are replaced after each sortie to GEO. The mass of the Orbital Transfer Vehicle (OTV), empty and dry, is 11,000 kg; nominal propellant load is 5000 kg. The OTV operates between a circular orbit at 925 km altitude, 28.5 deg inclination, and GEO. Cargo is brought to the OTV by Shuttle and an Orbital Maneuvering Vehicle (OMV); the OTV then takes it to GEO. The OTV can also bring cargo back from GEO, for transfer by OMV to the Shuttle. OTV propellant is resupplied and the ion thrusters are replaced by the OMV before each trip to GEO. At the end of mission life, the OTV's electric propulsion is used to place it in a heliocentric orbit so that the reactor will not return to earth. The nominal cargo capability to GEO is 6000 kg with a transit time of 120 days; 1350 kg can be transferred in 90 days, and 14,300 kg in 240 days. These capabilities can be considerably increased by using separate Shuttle launches to bring up propellant and cargo, or by changing to mercury propellant.
Jaffe, L.↗
Nuclear-electric reusable orbital transfer vehicle
To help determine the systems requirements for a 300-kWe space nuclear reactor power system, a mission and spacecraft have been examined that utilize electric propulsion supported by the nuclear reactor's power for multiple transfers of cargo between low earth orbit (LEO) and geosynchronous earth orbit (GEO). A propulsion system employing ion thrusters and xenon propellant was selected. Propellant and thrusters are replaced after each sortie to GEO. The mass of the orbital transfer vehicle (OTV), empty and dry, is 11,000 kg; nominal propellant load is 5000 kg. The OTV operates between a circular orbit at 925-km altitude, 28.5-deg inclination, and GEO. Cargo is brought to the OTV by Shuttle and an orbital maneuvering vehicle (OMV); the OTV then takes it to GEO. The OTV can also bring cargo back from GEO for transfer by OMV to the Shuttle. OTV propellant is resupplied, and the ion thrusters are replaced, by the OMV before each sortie to GEO. At the end of mission life, the OTV's electric propulsion is used to place it in a heliocentric orbit so that the reactor will not return to earth. The nominal cargo capability to GEO is 6000 kg, with a transit time of 120 days; 1350 kg can be transferred in 90 days, and 14,300 kg in 240 days. These capabilities can be considerably increased by using separate Shuttle launches to bring up propellant and cargo or by changing to mercury propellant.
Jaffe, Leonard D.↗
Electric Propulsion for Manned Mars Exploration
Advanced high-power electric propulsion systems can significantly enhance piloted Mars missions. An increase in the science payload delivered to Mars and the reduction of the total Earth-departure mass are the major system-level benefits of electric propulsion. Other potential benefits are the return of the cargo vehicle to Earth orbit and the availability of high power in Mars orbit for high-power science and communications. Parametric analyses for sizing the cargo mission vehicle for Mars exploration missions are presented. The nuclear-electric propulsion system thruster size, power level, mass, propellant type and payload mass capability are considered in these system-level trade studies. Descriptions of the propulsion system selection issues for both ion and MPD thruster technologies are also discussed. On a manned Mars mission, the total launch mass for an unmanned cargo vehicle in low earth orbit (LEO) can be reduced by up to 50 percent over the baseline oxygen/hydrogen propulsion system. Because the cargo vehicle is sent to Mars prior to the manned mission, the trip time for the vehicle is not a critical factor. By taking advantage of the high specific impulse (I sub sp) of an ion or a Magneto-Plasma-Dynamic (MPD) thruster system, the total LEO mass is reduced from 590,000 kg for the oxygen/hydrogen propulsion system to 309,000 kg for the MPD system and 295,000 kg for the ion system. Many factors must be analyzed in the design of a electric propulsion Mars cargo vehicle. The propellant selection, the number of thrusters, the power level and the specific impulse are among the most important of the parameters. To fully address the electric propulsion system design, trade studies for the differing ion and MPD propulsion system configurations (thruster power levels, number of thrusters, propellants and power systems) must be conducted.
Palaszewski, Bryan↗