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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 343 records · Page 19
All sourcesNASA NTRSDOE OSTI
DOE OSTI2023

Elucidating regulatory processes of intense physical activity by multi-omics analysis

Abstract Background Physiological and biochemical processes across tissues of the body are regulated in response to the high demands of intense physical activity in several occupations, such as firefighting, law enforcement, military, and sports. A better understanding of such processes can ultimately help improve human performance and prevent illnesses in the work environment. Methods To study regulatory processes in intense physical activity simulating real-life conditions, we performed a multi-omics analysis of three biofluids (blood plasma, urine, and saliva) collected from 11 wildland firefighters before and after a 45 min, intense exercise regimen. Omics profiles post- versus pre-exercise were compared by Student’s t -test followed by pathway analysis and comparison between the different omics modalities. Results Our multi-omics analysis identified and quantified 3835 proteins, 730 lipids and 182 metabolites combining the 3 different types of samples. The blood plasma analysis revealed signatures of tissue damage and acute repair response accompanied by enhanced carbon metabolism to meet energy demands. The urine analysis showed a strong, concomitant regulation of 6 out of 8 identified proteins from the renin-angiotensin system supporting increased excretion of catabolites, reabsorption of nutrients and maintenance of fluid balance. In saliva, we observed a decrease in 3 pro-inflammatory cytokines and an increase in 8 antimicrobial peptides. A systematic literature review identified 6 papers that support an altered susceptibility to respiratory infection. Conclusion This study shows simultaneous regulatory signatures in biofluids indicative of homeostatic maintenance during intense physical activity with possible effects on increased infection susceptibility, suggesting that caution against respiratory diseases could benefit workers on highly physical demanding jobs.

59 BASIC BIOLOGICAL SCIENCES↗
DOE OSTI2024

Site Occupancy Preference and Magnetic Properties in Nd 2 (Fe,Co) 14 B

Partial replacement of Fe by Co is an effective method to increase Curie temperature (T C ) , which improves the thermal stability of magnetic properties in Nd 2 Fe 14 B-based permanent magnets. The correlation between Fe substitution and magnetic properties has been studied in Nd 2 (Fe,Co) 14 B via a first-principles calculation. The calculated Fe substitution energies indicate that the Co atoms avoid the 8 j 2 site, which agrees with the experiments. The Co atoms are ferromagnetically coupled with Fe sublattice and show magnetic moments of about 1.2 to 1.7 μ B at different crystallographic sites, less than that of Fe (2.1–2.7 μ B ), resulting in the decrease in total magnetization at ground state (0 K) with increasing Co content. The effective exchange interaction parameter, derived from the energy difference between varied magnetic structures, increases from 7.8 meV to 17.0 meV with increasing Co content from x = 0 to x = 14 in Nd 2 Fe 14–x Co x B. This change in the effective exchange interaction parameter is responsible for the enhancement of T C in Nd 2 (Fe,Co) 14 B. The total magnetization at 300 K, derived from mean-field theory, shows a peak maximum value at x = 1 in Nd 2 Fe 14–x Co x B. The phenomenon results from the interplay between the reduction of the magnetic moment in the Fe(Co) sublattice and the enhancement of T C with increasing Co content.

36 MATERIALS SCIENCE↗
DOE OSTI2022

Sodium Dodecyl Sulfate–Mediated Graphene Sensor for Electrochemical Detection of the Antibiotic Drug: Ciprofloxacin

The present study involves detecting and determining CIP by a new electrochemical sensor based on graphene (Gr) in the presence of sodium dodecyl sulfate (SDS) employing voltammetric techniques. Surface morphology studies of the sensing material were analyzed using a scanning electron microscope (SEM) and atomic force microscope (AFM). In the electroanalysis of CIP at the developed electrode, an enhanced anodic peak response was recorded, suggesting the electro-oxidation of CIP at the electrode surface. Furthermore, we evaluated the impact of the electrolytic solution, scan rate, accumulation time, and concentration variation on the electrochemical behavior of CIP. The possible electrode mechanism was proposed based on the acquired experimental information. A concentration variation study was performed using differential pulse voltammetry (DPV) in the lower concentration range, and the fabricated electrode achieved a detection limit of 2.9 × 10 -8 M. The proposed sensor detected CIP in pharmaceutical and biological samples. The findings displayed good recovery, with 93.8% for tablet analysis and 93.3% to 98.7% for urine analysis. The stability of a developed electrode was tested by inter- and intraday analysis.

36 MATERIALS SCIENCE↗
DOE OSTI2020

Remodeling of the Histoplasma Capsulatum Membrane Induced by Monoclonal Antibodies

Antibodies play a central role in host immunity by directly inactivating or recognizing an invading pathogen to enhance different immune responses to combat the invader. However, the cellular responses of pathogens to the presence of antibodies are not well-characterized. Here, we used different mass spectrometry techniques to study the cellular responses of the pathogenic fungus Histoplasma capsulatum to monoclonal antibodies (mAb) against HSP60, the surface protein involved in infection. A proteomic analysis of H. capsulatum yeast cells revealed that mAb binding regulates a variety of metabolic and signaling pathways, including fatty acid metabolism, sterol metabolism, MAPK signaling and ubiquitin-mediated proteolysis. The regulation of the fatty acid metabolism was accompanied by increases in the level of polyunsaturated fatty acids, which further augmented the degree of unsaturated lipids in H. capsulatum’s membranes and energy storage lipids, such as triacylglycerols, phosphatidylcholines, phosphatidylethanolamines and phosphatidylinositols. MAb treatment also regulated sterol metabolism by increasing the levels of cholesterol and ergosterol in the cells. We also showed that global changes in the lipid profiles resulted in an increased susceptibility of H. capsulatum to the ergosterol-targeting drug amphotericin B. Overall, our data showed that mAb induction of global changes in the composition of H. capsulatum membranes can potentially impact antifungal treatment during histoplasmosis.

59 BASIC BIOLOGICAL SCIENCES↗
DOE OSTI2021

Multi-scale transport in the DIII-D ITER baseline scenario with direct electron heating and projection to ITER

Multi-scale fluctuations measured by turbulence diagnostics spanning long and short wavelength spatial scales impact energy confinement and the scale-lengths of plasma kinetic profiles in the DIII-D ITER baseline scenario with direct electron heating. Contrasting discharge phases with ECH + neutral beam injection (NBI) and NBI only at similar rotation reveal higher energy confinement and lower fluctuations when only NBI heating is used. Modeling of the core transport with TGYRO using the TGLF turbulent transport model and NEO neoclassical transport reproduces the experimental profile changes upon application of direct electron heating and indicates that multi-scale transport mechanisms are responsible for changes in the temperature and density profiles. Intermediate and high-k fluctuations appear responsible for the enhanced electron thermal flux, and intermediate-k electron modes produce an inward particle pinch that increases the inverse density scale length. Projection to ITER is performed with TGLF and indicates a density profile that has a finite scale length due to intermediate-k electron modes at low collisionality and increases the fusion gain. For a range of E×B shear, the dominant mechanism that increases fusion performance is suppression of outward low-k particle flux and increased density peaking.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗
NASA NTRS1973

Noise generation by ducted combustion systems

Analysis of the interaction between a zone of nonsteady combustion and its confining duct shows that resonant type oscillations occur with resulting noise intensities far greater than from corresponding unconfined flame zones. The blading action on the flow through the compressor and turbine of an engine generates discrete frequency noise which, it is found, is enhanced by the response of the combustion zone in between. Ducted combustor experiments verify the predicted resonant type noise, the amplitude and frequency of which are strongly influenced by the duct dimensions and end impedance. A convergent exit nozzle results in stronger internal resonant noise oscillations but also generates a higher jet velocity, with the attendant jet noise which exceeds noise from inside the duct at jet Mach numbers near unity.-

Chiu, H. H.↗
NASA NTRS1979

A mathematical and experimental simulation of the hematological response to weightlessness

A mathematical model of erythropoiesis control was used to simulate the effects of bedrest and zero-g on the circulating red cell mass. The model incorporates the best current understanding of the dynamics of red cell production and destruction and the associated feedback regulation. Specifically studied were the hemodynamic responses of a 28-day bedrest study devised to simulate Skylab experience. The results support the hypothesis that red cell loss during supine bedrest is a normal physiological feedback process in response to hemoconcentration enhanced tissue oxygenation and suppression of red cell production. Model simulation suggested the possibilities that this period was marked by some combination of increased oxygen-hemoglobin affinity, small reduction in mean red cell life span, ineffective erythropoiesis, or abnormal reticulocytosis.

Kimzey, S. L.↗
NASA NTRS1980

Energy-transfer mechanisms in the CH3F-SF6 optically pumped laser

The power of an optically pumped CH3F laser operating on the 496-micron line has been doubled with the addition of SF6 without any corresponding increase in pump absorption. It is suggested that a near-resonant energy transfer between CH3F and SF6 followed by SF6 deactivation is the mechanism responsible for the enhancement.

Lawandy, N. M.↗
NASA NTRS1982

Ion frictional heating at high latitudes and its possible use for an in situ determination of neutral thermospheric winds and temperatures

The Atmosphere Explorer C data base of ion temperature and ion drift velocities has been used to study the long recognized principle that large scale convection electric fields are responsible for substantial enhancements in the ion temperature at high latitudes. As had been indicated by various authors previously, the present study shows that there is a clear relationship between large ion velocities and ion temperature enhancements. Furthermore, with the help of a more quantitative study, it is found that, since ion heating is sensitive to the relative motion between the ion and neutral gases, the ion temperature and drift measurements can be used to extract neutral wind and neutral temperature information along the satellite track. From a study of several examples, it is concluded that the present approach can be used with varying degrees of accuracy for the diagnostic of thermospheric dynamical properties above 300 km when those properties are not measured directly. When neutral dynamical properties are measured, the approach could be used for a detailed study of the ion energy balance at high latitudes.

Saint-Maurice, J.-P.↗
NASA NTRS1982

Large beam observations of the galactic center at 150, 200, and 300 microns

Observations with 10 arcmin resolution of a 2 sq deg portion of the galactic plane around the galactic center at 150, 200, and 300 microns are presented, obtained as part of a galactic plane survey. In the galactic center region the mean dust temperature is about 30 K. Both the temperature and the dust-to-gas mass ratio in the galactic center region are typical of a large portion of the galactic plane. Three main emission peaks, Sgr A, B, and C, are detected; these peaks appear as dust column density enhancements rather than temperature enhancements. The dust responsible for the FIR emission may only be a fraction of the dust responsible for the visual extinction toward the galactic center.

Stier, M. T.↗
NASA NTRS1984

Measurement of convective heat transfer to solid cylinders inside ventilated shrouds

The influence of ventilated cylindrical shrouds on the convective heat transfer to circular cylinders has been studied experimentally. Geometries studied were similar to those used in commercially available platinum resistance thermometers. Experiments showed that thermal response (convection) was enhanced when the shroud ventilation factor was approximately 20 percent (80 percent solid), and that maximum enhancement occurred when the ventilation holes were located symmetrically on either side of the stagnation lines.

Daryabeigi, K.↗
NASA NTRS1987

Effects of exercise and conditioning on clotting and fibrinolytic activity in men

Blood clotting and fibrinolytic activity in three groups of nonsmoking, nonobese, healthy men ranging from 19 to 59 years are studied. The groups consisted of (1) marathoners (men running more than 50 miles/week); (2) joggers (men running 5-15 miles/week; and (3) sedentary subjects (men who did not exercise routinely). It is observed that the rate of blood clotting is accelerated by exercise; marathoners had greater increases in fibrinolytic activity than the other two groups; and fibrin degradation products increased with exercise. The data reveal that the changes in clotting assays with exercise do not correlate with changes in whole blood lactate, blood pyruvate, or rectal temperatures. It is noted that the level of acceleration for fibrinolytic activity is directly related to the maximum aerobic capacity and work load of the individual, and that conditioning enhances the fibrinolytic response to exercise.

Ferguson, Earl W.↗
NASA NTRS1988

Response Of A MOSFET To A Cosmic Ray

Theoretical paper discusses response of enhancement-mode metal oxide/semiconductor field-effect transistor to cosmic-ray ion that passes perpendicularly through gate-oxide layers. Even if ion causes no permanent damage, temporary increase of electrical conductivity along track of ion large enough and long enough to cause change in logic state in logic circuit containing MOSFET.

Benumof, Reuben↗
NASA NTRS1988

Far-ultraviolet and X-ray emission of the long period RS CVn star Sigma Geminorum

Observations of the RS CVn binary Sigma Gem were obtained in 1984 with the IUE and Exosat satellites. The longitudes of two starspot regions relative to the cental meridian are derived from the photometric data using an improved value of the orbital period. The observations support the theory that large active regions associated with starspots are responsible for the enhanced line emission commonly seen in RS CVn systems.

Engvold, O.↗
NASA NTRS1987

Incremental planning to control a blackboard-based problem solver

To control problem solving activity, a planner must resolve uncertainty about which specific long-term goals (solutions) to pursue and about which sequences of actions will best achieve those goals. A planner is described that abstracts the problem solving state to recognize possible competing and compatible solutions and to roughly predict the importance and expense of developing these solutions. With this information, the planner plans sequences of problem solving activities that most efficiently resolve its uncertainty about which of the possible solutions to work toward. The planner only details actions for the near future because the results of these actions will influence how (and whether) a plan should be pursued. As problem solving proceeds, the planner adds new details to the plan incrementally, and monitors and repairs the plan to insure it achieves its goals whenever possible. Through experiments, researchers illustrate how these new mechanisms significantly improve problem solving decisions and reduce overall computation. They briefly discuss current research directions, including how these mechanisms can improve a problem solver's real-time response and can enhance cooperation in a distributed problem solving network.

Durfee, E. H.↗
NASA NTRS1991

Nonlinear optical properties of organic materials: A theoretical study

Replacement of electronic switching circuits in computing and telecommunication systems with purely optical devices offers the potential for extremely high throughput and compact information processing systems. The potential application of organic materials containing molecules with large nonresonant nonlinear effects in this area have triggered intensive research during the last decade. Interest on this area was due to two facts: (1) that many organic materials show nonlinearities that are orders of magnitude larger than those of conventional inorganic materials such as lithium niobate and potassium dihydrogen phosphate; and (2) that organic materials show much flexibility in terms of molecular designs. Some of the desirable characteristics that these materials should have are that they be transparent to the frequency of the incident laser and its second or third harmonic, that they have a high damage threshold, and, in the case of second-order effects, that their crystal structure or molecular orientation be accentric. Since polymeric assemblages can enhance the nonlinear response of organic molecules severalfold, efforts have been directed toward the synthesis of thin films with interpenetrating lattices of electroactive molecules. The goal of this theoretical investigation is to predict the magnitude of the molecular polarizabilities of organic molecules that could be incorporated into films. These calculations are intended to become a powerful tool to assist material scientists in screening for the best candidates for optical applications. The procedure that was developed for the present calculations is based on the static-field approach, and is a modification to the method developed by Dewar and Stewart, 1984 for calculating molecular linear polarizabilities.

Cardelino, Beatriz H.↗
NASA NTRS1992

Response of a stably stratified atmosphere to low-level heating - An application to the heat island problem

Two-dimensional airflow characteristics past a heat island are investigated using both a linear analytic model and a nonlinear numerical model in the context of the response of a stably stratified atmosphere to specified low-level heating in a constant shear flow. Results from the steady-state, linear, analytic solutions exhibit typical flow response fields that gravity waves produce in response to the local heat source in the presence of environmental flow. The magnitude of the perturbation vertical velocity is shown to be much larger in the shear-flow case than in the uniform-flow case. Two distinct flow features are observed for larger heating amplitude (hence, larger nonlinearity factor): the gravity-wave-type response field on the upstream side of the heat island and the strong updraft circulation cell located on the downstream side. As the heating amplitude increases, the updraft circulation cell strengthens and shifts farther downwind. The strong updraft cell is believed to be partly responsible for precipitation enhancement observed on the downstream side of the heat island. It is found that the continuing downwind propagation of the updraft circulation cell is related to basic-state wind speed.

Baik, Jong-Jin↗