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At least 343 records · Page 19

Estimating the Subsolar Magnetopause Position from Soft X-Ray Images Using a Low-Pass Image Filter

The Lunar Environment heliospheric X-ray Imager (LEXI) and Solar wind Magnetosphere Ionosphere Link Explorer (SMILE) missions will image the Earth’s dayside magnetopause and cusps in soft X-rays after their respective launches in the near future, to specify global magnetic reconnection modes for varying solar wind conditions. To support the success of these scientific missions, it is critical to develop techniques that extract the magnetopause locations from the observed soft X-ray images. In this research, we introduce a new geometric equation that calculates the subsolar magnetopause position ( R s ) from a satellite position, the look direction of the instrument, and the angle at which the X-ray emission is maximized. Two assumptions are used in this method: (1) The look direction where soft X-ray emissions are maximized lies tangent to the magnetopause, and (2) the magnetopause surface near the subsolar point is almost spherical and thus R s is nearly equal to the radius of the magnetopause curvature. We create synthetic soft X-ray images by using the Open Geospace General Circulation Model (OpenGGCM) global magnetohydrodynamic model, the galactic background, the instrument point spread function, and Poisson noise. We then apply the fast Fourier transform and Gaussian low-pass filters to the synthetic images to remove noise and obtain accurate look angles for the soft X-ray peaks. From the filtered images, we calculate R 2 and its accuracy for different LEXI locations, look directions, and solar wind densities by using the OpenGGCM subsolar magnetopause location as ground truth. Our method estimates R s with an accuracy of <0.3 R E when the solar wind density exceeds >10 cm -3 . The accuracy improves for greater solar wind densities and during southward interplanetary magnetic fields. The method captures the magnetopause motion during southward interplanetary magnetic field turnings. Consequently, the technique will enable quantitative analysis of the magnetopause motion and help reveal the dayside reconnection modes for dynamic solar wind conditions. This technique will support the LEXI and SMILE missions in achieving their scientific objectives.

Hyangpyo Kim↗

Additive Manufacturing of Oxide Dispersion Strengthened Multi Principle Element Alloys for Future Aerospace Applications

Oxide Dispersion Strengthened (ODS) materials have long been of interest for their high temperature applications, and additive manufacturing enables their manufacturing viability. The ODS multi-principle element alloy NiCoCr was prepared using powder metallurgy techniques, additively manufactured, and evaluated for its processingmicrostructure-property relationships. The high temperature foundations of nickel-base superalloys and ODS materials were combined with the manufacturing advantages of 3D printing and the chemical simplicity of NiCoCr to inspire this work, which was divided into powder and printed material assessments. The project was achieved through multiple iterative project loops to assess the processing parameters’ impact on the microstructure and mechanical properties of the feedstock powder and printed material. The powder investigations (Chapter 3) focused on understanding the oxide coating that formed on the metal powder following acoustic mixing. Time of Flight Secondary Ion Mass Spectrometry was used to semi-quantitatively assess the amount of yttrium on the surface of the mixed powders, and indicated that a combination of higher mixing condition energy and moderate mixing time resulted in the most oxide coating on the NiCoCr powder. The results were supported by a qualitative assessment of scanning electron images of coated powder particles. Following mixing, the ODS NiCoCr was consolidated by Laser Powder Bed Fusion. The evaluations of the printed material (Chapter 4) frst considered screening experiments including Archimedes’ density, porosity, and grain size and number metrics from electron backscatter diffraction data. After the ideal additive manufacturing parameters were identifed, both the oxide homogeneity and yield strength were discussed for the idealized printed material. Overall, the project suggests that the combined use of qualitative or semi-quantitative powder surface analysis with Archimedes’ density analyses can be a valid high-throughput technique which can lead to process optimization of Laser Powder Bed Fusion additively manufactured ODS material.

Laura G Wilson↗

Image Guider Subsystem Analysis for the GHAPS Project

The Gondola for High-Altitude Planetary Science (GHAPS) project is a balloon-borne astronomical observatory designed operate in the UV, Visible, and near-mid IR spectral region. The GHAPS Optical Telescope Assembly (OTA) is designed around a one meter aperture narrow field-of-view telescope with near-diffraction-limited performance. GHAPS will utilize Wallops Arc-Second Pointing System (WASP) for pointing the OTA with an accuracy of 1 arc second or better. WASP relies heavily on a self-contained star tracker assembly to determine the OTA line of sight. Preliminary structural analysis indicates that potential misalignments could be present between the OTA line of sight and the star tracker FOV center during the expected flight conditions that could compromise GHAPS pointing accuracy. In response the GHAPS project undertook a trade study to resolve the following issues: (1) estimate the worst case long-term (or bias) pointing misalignments for the GHAPS opto-mechanical configuration, (2) examine the need for additional hardware to correct pointing errors, and (3) determine the best hardware and software implementation to do so. Quantitative comparisons of performance and qualitative estimates of other factors such as mass, volume, power consumption, and cost are combined into an overall assessment of potential solutions. Results are discussed and a recommended implementation is given that is optimized to best achieve pointing performance goals, while minimizing impact to the design, cost, and resources of the GHAPS project.

Star Tracker↗

Surface temperature/heat transfer measurement using a quantitative phosphor thermography system

A relative-intensity phosphor thermography technique developed for surface heating studies in hypersonic wind tunnels is described. A direct relationship between relative emission intensity and phosphor temperature is used for quantitative surface temperature measurements in time. The technique provides global surface temperature-time histories using a 3-CCD (Charge Coupled Device) video camera and digital recording system. A current history of technique development at Langley is discussed. Latest developments include a phosphor mixture for a greater range of temperature sensitivity and use of castable ceramics for inexpensive test models. A method of calculating surface heat-transfer from thermal image data in blowdown wind tunnels is included in an appendix, with an analysis of material thermal heat-transfer properties. Results from tests in the Langley 31-Inch Mach 10 Tunnel are presented for a ceramic orbiter configuration and a four-inch diameter hemisphere model. Data include windward heating for bow-shock/wing-shock interactions on the orbiter wing surface, and a comparison with prediction for hemisphere heating distribution.

Buck, G. M.↗

A Method to Retrieve Rainfall Rate over Land from TRMM Observations

Tropical Rainfall Measuring Mission (TRMM) Precipitation Radar (PR) observations over mesoscale convective systems (MCSs) reveal that there are localized maxima in the rain rate with a scale of about 10 to 20 km that represent thunderstorms (Cbs). Some of these Cbs are developing or intense, while others are decaying or weak. These Cbs constitute only about 20 % of the rain area of a given MCS. Outside of Cbs, the average rain rate is much weaker than that within Cbs. From an analysis of the PR data, we find that the spatial distribution of rain and its character, convective or stratiform, is highly inhomogeneous. This complex nature of rain exists on a scale comparable to that of a Cb. The 85 GHz brightness temperature, T85, observations of the TRMM Microwave Imager (TMI) radiometer taken over an MCS reflect closely the PR rain rate pattern over land. Local maxima in rain rate shown by PR are observed as local minima in T85. Where there are no minima in T85, PR observations indicate there is light rain. However, the TMI brightness temperature measurements (Tbs) have poor ability to discriminate convective rain from stratiform rain. For this reason, a TMI rain retrieval procedure that depends primarily on the magnitude of Tbs performs poorly. In order to retrieve rain rate from TMI data on land one has to include the spatial distribution information deduced from the T85 data in the retrieval method. Then, quantitative estimation of rain rate can be accomplished. A TMI rain retrieval method developed along these lines can yield estimates of rain rate and its frequency distribution which agree closely with that given by PR. We find the current TRMM project TMI (Version 5) rain retrieval algorithm on land could be improved with the retrieval scheme developed here. To support the conceptual frame work of the rain retrieval method developed here, a theoretical analysis of the TMI brightness temperatures in convective and stratiform regions is presented.

Prabhakara, C.↗

Effects of energy release on near field flow structure of gas jets

The primary objective is to understand how buoyancy affects the structure of the shear layer, the development of fluid dynamic instabilities, and formation of the coherent structures in the near-nozzle regions of gas jets. The secondary objectives are to study the role of buoyancy in lifting and reattachment process of diffusion flames, to evaluate the scaling behavior of diffusion flames, and to aid development and/or validation of theoretical models by providing quantitative data in the absence of buoyancy. Fast reacting hydrogen or hydrogen-inert fuels are used to isolate the effects of buoyancy on fluid dynamics without masking the flame behavior by soot and radiative heat transfer. This choice of fuel also permits an evaluation of simulating low gravity in low pressure ground experiments because the similarity constraints are relaxed for the fast reacting, nonsooting diffusion flames. The diagnostics consists primarily of a color schlieren system coupled with computer generated rainbow filters, video recording, and image analysis. The project involves (1) drop tower experiments, (2) ground experiments, and (3) theoretical analysis.

Agrawal, Ajay K.↗

An Advanced Approach to Simultaneous Monitoring of Multiple Bacteria in Space

The utility of a novel microarray-based microbial analyzer was demonstrated by the rapid detection, imaging, and identification of a mixture of microorganisms found in a waste water sample from the Lunar-Mars Life Support Test Project through the synergistic combination of: (1) judicious RNA probe selection via algorithms developed by University of Houston scientists; (2) tuned surface chemistries developed by Baylor College of Medicine scientists to facilitate hybridization of rRNA targets to DNA probes under very low salt conditions, thereby minimizing secondary structure; and (3) integration of the microarray printing and detection/imaging instrumentation by Genometrix to complete the quantitative analysis of microorganism mixtures.

Eggers, M.↗

Biomolecular Analysis Capability for Cellular and Omics Research on the International Space Station

International Space Station (ISS) assembly complete ushered a new era focused on utilization of this state-of-the-art orbiting laboratory to advance science and technology research in a wide array of disciplines, with benefits to Earth and space exploration. ISS enabling capability for research in cellular and molecular biology includes equipment for in situ, on-orbit analysis of biomolecules. Applications of this growing capability range from biomedicine and biotechnology to the emerging field of Omics. For example, Biomolecule Sequencer is a space-based miniature DNA sequencer that provides nucleotide sequence data for entire samples, which may be used for purposes such as microorganism identification and astrobiology. It complements the use of WetLab-2 SmartCycler"TradeMark", which extracts RNA and provides real-time quantitative gene expression data analysis from biospecimens sampled or cultured onboard the ISS, for downlink to ground investigators, with applications ranging from clinical tissue evaluation to multigenerational assessment of organismal alterations. And the Genes in Space-1 investigation, aimed at examining epigenetic changes, employs polymerase chain reaction to detect immune system alterations. In addition, an increasing assortment of tools to visualize the subcellular distribution of tagged macromolecules is becoming available onboard the ISS. For instance, the NASA LMM (Light Microscopy Module) is a flexible light microscopy imaging facility that enables imaging of physical and biological microscopic phenomena in microgravity. Another light microscopy system modified for use in space to image life sciences payloads is initially used by the Heart Cells investigation ("Effects of Microgravity on Stem Cell-Derived Cardiomyocytes for Human Cardiovascular Disease Modeling and Drug Discovery"). Also, the JAXA Microscope system can perform remotely controllable light, phase-contrast, and fluorescent observations. And upcoming confocal microscopy capability will allow for optical sectioning of biological tissues to determine microanatomical localization of biomarkers. Furthermore, NASA's geneLAB effort addresses integration of genomic, epigenomic, transcriptomic, proteomic and metabolomic datasets, by applying an innovative open source science platform for multi-investigator high throughput utilization of the ISS. In sum, the expanding ISS capability for analysis of biomolecules is enabling innovative research in a broad spectrum of areas such as cellular and molecular biology, biotechnology, tissue engineering, biomedicine, and Omics, providing manifold benefits for humanity.

Guinart-Ramirez, Y.↗

High Altitude Measurements of Radiance at High Spectral and Spatial Resolution for SIMBIOS Sensor Calibration, Validation, and Intercomparisons

The successful combination of data from different ocean color sensors depends on the correct interpretation of signal from each of these sensors. Ideally, the sensor measured signals are calibrated to geophysical units of spectral radiance, and sensor artifacts are removed and corrected. The calibration process resamples the signal into a common radiometric data space so that subsequent ocean color algorithms that are applied to the data are based on physical processes and are inherently sensor independent. The objective of this project is to calibrate and validate the on-orbit radiometric characteristics of Sea-Viewing Wide Field-of-view Sensor (SeaWiFS) with underflights of NASA's calibrated Airborne Visible/Infrared Imaging Spectrometer (AVIRIS). This objective is feasible because AVIRIS measures the same spectral range as SeaWIFS at higher spectral resolution. In addition to satellite sensor underflights, the AVIRIS project has supported comparison and analysis of the radiometric calibration standards used for AVIRIS and SeaWIFS. To date, both the OCTS and SeaWIFS satellite sensors have been underflown by AVIRIS with matching spectral, spatial, geometric, radiometric, and temporal domains. The calibration and validation objective of this project is pursued for the following reasons: (1) Calibration is essential for the quantitative use of SeaWIFS and other SIMBIOS (Sensor Intercomparison and Merger for Biological and Interdisciplinary Oceanic Studies) sensor data; (2) Calibration in the laboratory of spaceborne sensors is challenging; (3) Satellite sensors are subjected aging on the ground and to trauma during launch; (4) The Earth orbit environment is significantly different than the laboratory calibration environment; (5) Through years of effort AVIRIS has been demonstrated to be well calibrated; and (6) AVIRIS can match the spectral and spatial observation characteristics near the top of the atmosphere at the time of SeaWIFS measurements.

Green, Robert O.↗

Wake Cycle Robustness of the Mars Science Laboratory Flight Software

The Mars Science Laboratory (MSL) is a spacecraft being developed by the Jet Propulsion Laboratory (JPL) for the purpose of in-situ exploration on the surface of Mars. The objective of MSL is to explore and quantitatively assess a local region on the Martian surface as a habitat for microbial life, past or present. This objective will be accomplished through the assessment of the biological potential of at least one target environment, the characterization of the geology and geochemistry of the landing region, an investigation of the planetary process relevant to past habitability, and a characterization of surface radiation. For this purpose, MSL incorporates a total of ten scientific instruments for which functions are to include, among others, atmospheric and descent imaging, chemical composition analysis, and radiation measurement. The Flight Software (FSW) system is responsible for all mission phases, including launch, cruise, entry-descent-landing, and surface operation of the rover. Because of the essential nature of flight software to project success, each of the software modules is undergoing extensive testing to identify and correct errors.

Whitehill, Robert↗

Comparison of Different Global Information Sources Used in Surface Radiative Flux Calculation: Radiative Properties of the Surface

Direct estimates of surface radiative fluxes that resolve regional and weather-scale variabilty over the whole globe with reasonable accuracy have only become possible with the advent of extensive global, mostly satellite, datasets within the past couple of decades. The accuracy of these fluxes, estimated to be about 10-15 W per square meter is largely limited by the accuracy of the input datasets. The leading uncertainties in the surface fluxes are no longer predominantly induced by clouds but are now as much associated with uncertainties in the surface and near-surface atmospheric properties. This study presents a fuller, more quantitative evaluation of the uncertainties for the surface albedo and emissivity and surface skin temperatures by comparing the main available global datasets from the Moderate-Resolution Imaging Spectroradiometer product, the NASA Global Energy and Water Cycle Experiment Surface Radiation Budget project, the European Centre for Medium-Range Weather Forecasts, the National Aeronautics and Space Administration, the National Centers for Environmental Prediction, the International Satellite Cloud Climatology Project (ISCCP), the Laboratoire de Meteorologie Dynamique, NOAA/NASA Pathfinder Advanced Very High Resolution Radiometer project, NOAA Optimum Interpolation Sea Surface Temperature Analysis and the Tropical Rainfall Measuring Mission (TRMM) Microwave Image project. The datasets are, in practice, treated as an ensemble of realizations of the actual climate such that their differences represent an estimate of the uncertainty in their measurements because we do not possess global truth datasets for these quantities. The results are globally representative and may be taken as a generalization of our previous ISCCP-based uncertainty estimates for the input datasets. Surface properties have the primary role in determining the surface upward shortwave (SW) and longwave (LW) flux. From this study, the following conclusions are obtained. Although land surface albedos in the near near-infrared remain poorly constrained (highly uncertain), they do not cause too much error in total surface SW fluxes; the more subtle regional and seasonal variations associated with vegetation and snow are still on doubt. The uncertainty of the broadband black-sky SW albedo for land surface from this study is about 7%, which can easily induce 5-10 W per square meter uncertainty in (upwelling) surface SW flux estimates. Even though available surface (broadband) LW emissivity datasets differ significantly (3%-5% uncertainty), this disagreement is confined to wavelengths greater than 20 micrometers so that there is little practical effect (1-3 W per square meters) on the surface upwelling LW fluxes. The surface skin temperature is one of two leading factors that cause problems with surface LW fluxes. Even though the differences among the various datasets are generally only 2-4 K, this can easily cause 10-15 W per square meter uncertainty in calculated surface (upwelling) LW fluxes. Significant improvements could be obtained for surface LW flux calculations by improving the retrievals of (in order of decreasing importance): (1) surface skin temperature, (2) surface air and near-surface-layer temperature, (3) column precipitable water amount and (4) broadband emissivity. And for surface SW fluxes, improvements could be obtained (excluding improved cloud treatment) by improving the retrievals of (1) aerosols (from our sensitivity studies but not discussed in this work), and (2) surface (black-sky) albedo, of which, NIR part of the spectrum has much larger uncertainty.

Zhang, Yuanchong↗

Experimental and Computational Analysis of a Rotating Detonation Combustor

Rotating detonation combustor (RDC) research has progressed along parallel experimental and computational paths with limited opportunities for validation. Validation is a crucial step to ensure RDC simulations provide an accurate representation of the physical phenomena, and thus, can be used with confidence for design optimization in different applications. In this study, data from a quasi-two-dimensional computational fluid dynamic simulation in an annular RDC are compared with experimental measurements including particle image velocimetry at 100 kHz. Results show good agreement between measured and simulated dynamic pressures, Chapman-Jouguet speeds, and static pressure distributions. Velocity measurements at the annulus exit show good temporal and quantitative agreement with simulations including spikes from the passing shock.

Detonation↗

Hyperspectral Remote Sensing and Ecological Modeling Research and Education at Mid America Remote Sensing Center (MARC): Field and Laboratory Enhancement

The purpose of this project was to establish a new hyperspectral remote sensing laboratory at the Mid-America Remote sensing Center (MARC), dedicated to in situ and laboratory measurements of environmental samples and to the manipulation, analysis, and storage of remotely sensed data for environmental monitoring and research in ecological modeling using hyperspectral remote sensing at MARC, one of three research facilities of the Center of Reservoir Research at Murray State University (MSU), a Kentucky Commonwealth Center of Excellence. The equipment purchased, a FieldSpec FR portable spectroradiometer and peripherals, and ENVI hyperspectral data processing software, allowed MARC to provide hands-on experience, education, and training for the students of the Department of Geosciences in quantitative remote sensing using hyperspectral data, Geographic Information System (GIS), digital image processing (DIP), computer, geological and geophysical mapping; to provide field support to the researchers and students collecting in situ and laboratory measurements of environmental data; to create a spectral library of the cover types and to establish a World Wide Web server to provide the spectral library to other academic, state and Federal institutions. Much of the research will soon be published in scientific journals. A World Wide Web page has been created at the web site of MARC. Results of this project are grouped in two categories, education and research accomplishments. The Principal Investigator (PI) modified remote sensing and DIP courses to introduce students to ii situ field spectra and laboratory remote sensing studies for environmental monitoring in the region by using the new equipment in the courses. The PI collected in situ measurements using the spectroradiometer for the ER-2 mission to Puerto Rico project for the Moderate Resolution Imaging Spectrometer (MODIS) Airborne Simulator (MAS). Currently MARC is mapping water quality in Kentucky Lake and vegetation in the Land-Between-the Lakes (LBL) using Landsat-TM data. A Landsat-TM scene of the same day was obtained to relate ground measurements to the satellite data. A spectral library has been created for overstory species in LBL. Some of the methods, such as NPDF and IDFD techniques for spectral unmixing and reduction of effects of shadows in classifications- comparison of hyperspectral classification techniques, and spectral nonlinear and linear unmixing techniques, are being tested using the laboratory.

Cetin, Haluk↗

Camera, Hand Lens, and Microscope Probe (CHAMP): An Instrument Proposed for the 2009 MSL Rover Mission

The Camera, Hand Lens, and Microscope Probe (CHAMP) will allow examination of martian surface features and materials (terrain, rocks, soils, samples) on spatial scales ranging from kilometers to micrometers, thus enabling both microscopy and context imaging with high operational flexibility. CHAMP is designed to allow the detailed and quantitative investigation of a wide range of geologic features and processes on Mars, leading to a better quantitative understanding of the evolution of the martian surface environment through time. In particular, CHAMP will provide key data that will help understand the local region explored by Mars Surface Laboratory (MSL) as a potential habitat for life. CHAMP will also support other anticipated MSL investigations, in particular by helping identify and select the highest priority targets for sample collection and analysis by the MSL's analytical suite.

hand lenses↗

Fluid Dynamic Verification Experiments on STS-70

Fluid dynamic experiments were flown on STS-70 as phase two of the engineering evaluation of the first bioreactor Engineering Development Unit (EDU#1). The phase one experiments were comparative cell cultures in identical units on earth and onboard STS-70. In phase two, two types of fluid dynamic experiments were performed. Qualitative comparisons of the basic flow patterns were evaluated with the use of 'dye' streaklines formed from alternate injections of either a mild acid or base solution into the external flow loop that was then perfused into the vessel. The presence of Bromothymol Blue in the fluid then caused color changes from yellow to blue or vice versa, indicating the basic fluid motions. This reversible change could be repeated as desired. In the absence of significant density differences in the fluid, the flow patterns in space should be the same as on earth. Video tape records of the flow patterns for a wide range of operating conditions were obtained. The second type of fluid dynamic experiment was the quantitative evaluation of the trajectories of solid beads of various densities and sizes. The beads were introduced into the vessel and the paths recorded on video tape, with the vessel operated at various rotation rates and flow perfusion rates. Because of space limitations, the video camera was placed as close as possible to the vessel, resulting in significant optical distortion. This report describes the analysis methods to obtain comparisons between the in-flight fluid dynamics and numerical models of the flow field. The methods include optical corrections to the video images and calculation of the bead trajectories for given operating conditions and initial bead locations.

Kleis, Stanley J.↗

Intrinsic Dimensionality as a Metric for the Impact of Mission Design Parameters

High-resolution space-based spectral imaging of the Earth's surface delivers critical information for monitoring changes in the Earth system as well as resource management and utilization. Orbiting spectrometers are built according to multiple design parameters, including ground sampling distance (GSD), spectral resolution, temporal resolution, and signal-to-noise ratio. Different applications drive divergent instrument designs, so optimization for wide-reaching missions is complex. The Surface Biology and Geology component of NASA's Earth System Observatory addresses science questions and meets applications needs across diverse fields, including terrestrial and aquatic ecosystems, natural disasters, and the cryosphere. The algorithms required to generate the geophysical variables from the observed spectral imagery each have their own inherent dependencies and sensitivities, and weighting these objectively is challenging. Here, we introduce intrinsic dimensionality (ID), a measure of information content, as an applications-agnostic, data-driven metric to quantify performance sensitivity to various design parameters. ID is computed through the analysis of the eigenvalues of the image covariance matrix, and can be thought of as the number of significant principal components. This metric is extremely powerful for quantifying the information content in high-dimensional data, such as spectrally resolved radiances and their changes over space and time. We find that the ID decreases for coarser GSD, decreased spectral resolution and range, less frequent acquisitions, and lower signal-to-noise levels. This decrease in information content has implications for all derived products. ID is simple to compute, providing a single quantitative standard to evaluate combinations of design parameters, irrespective of higher-level algorithms, products, applications, or disciplines.

Intrinsic dimensionality↗

Global Skin-Friction Measurements Using Particle Image Surface FLow Visualization and a Luminescent Oil-Film

A quantitative global skin-friction measurement technique is proposed. An oil-film is doped with a luminescent molecule and thereby made to fluoresce in order to resolve oil-film thickness, and Particle Image Surface Flow Visualization is used to resolve the velocity field of the surface of the oil-film. Skin-friction is then calculated at location x as (x )xh, where x is the displacement of the surface of the oil-film and is the dynamic viscosity of the oil. The data collection procedure and data analysis procedures are explained, and preliminary experimental skin-friction results for flow over the wing of the CRM are presented.

FISF↗

Diet and the role of lipoproteins, lipases, and thyroid hormones in coronary lesion growth

The relationships between the coronary lesion growth and the blood contents of lipoprotein fractions, thyroic hormones, and the lipoprotein lipase activity were investigated in male patients with severe coronary atherosclerosis, who participated in a lipid-lowering dietary intervention program. A quantitative computer-assisted image-processing technique was used to assess the severity of coronary obstructions at the beginning of the program and at its termination two years later. Based on absolute coronary scores, patients were divided into a no-lesion growth group (14 patients) and a progression group (21 paients). At the end of the trial, the very-low-density lipoprotein cholesterol and triglycerides were found to be significantly higher, while the high-density lipoprotein cholesterol and hepatic lipase (HL) were lower in the progression group. Multivariate regression analysis showed HL to be the most important determinant of changes in coronary atherosclerotic lesions.

Barth, Jacques D.↗