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NASA NTRSDate not supplied

Space Flown Rodent Liver RNA Sequencing Data for Machine Learning in Space Biology Research

High-throughput nucleic acid sequencing (DNA-seq, RNA-seq) has become widespread in biomedical research due to the growing availability and affordability of these assays. Data analysis has been accelerated in recent years by the adoption of artificial intelligence (AI) and machine learning (ML) techniques by biomedical researchers. In space biology research, RNAseq datasets from space-flown experimental samples are critical for characterizing the gene expression aberrations associated with exposure to spaceflight stressors. However, space biological experiments tend to be very low sample size, so identifying proper AI/ML algorithms for sequencing data analysis is an ongoing challenge since these algorithms typically require large sample size. The NASA Science Mission Directorate (SMD) has started the “Benchmark Initiative for AI/ML”, focused on creating datasets meant for three main applications: 1) scientific benchmarking, which finds the best algorithm for a specific problem; 2) application benchmarking, which measures algorithm performance against a set of parameters; and 3) system benchmarking, which evaluates performance of hardware and software architecture. These scientific benchmarks consist of an AI-ready dataset and a reference implementation on a specific scientific question. In this work, we focused on generating standardized datasets to allow the scientific community to benchmark AI/ML algorithms in the domain of space biology. We present here a standardized, AI-ready, publicly available benchmark dataset for space biology RNA-seq data as a collaboration between the NASA AI4LS (Artificial Intelligence for Life Sciences) working group. and NASA’s SMD. This dataset consists of space-flown and ground control mouse liver found in the NASA GeneLab omics database. However, to amplify the small sample number (n=112 samples) for ML purposes, we employ Gaussian noise and a generative adversarial network to extend this dataset to 6,000 synthetic samples, matching the original gene expression characteristics.

James Casaletto↗

NASA NTRS2023

Exploration Systems Development Mission Directorate (ESDMD) Moon-to-Mars Architecture Definition Document

There are many opportunities in executing the ambitious Moon-to-Mars efforts through an integrated architecture. NASA addresses this in its Moon-to-Mars Strategy and Objectives Development2 document (hereafter referred to as the M2M Strategy). Many of these opportunities involve establishing a system engineering framework that can support the breadth of necessary program and system contributions. By applying these needs to nearer-term lunar development, NASA will be instituting the process, procedures, and techniques needed to enable longer-term Mars goals and more. Some of the challenges being addressed in the M2M Strategy are associated with the architecture definition and include broad/changing goals, funding, and external pressures/influences. This document and the methodology outlined for architecture definition have been crafted to contend with these using an iterative and adaptable framework. The primary purpose of the Architecture Definition Document (ADD) is to capture the methodology, organization, and decomposition necessary to translate the broad objectives outlined in the M2M Strategy into functions and use cases that can be allocated to implementable programs and projects. Inherent in this process will be the need to communicate the long-term vision, maintain traceability to responsible parties, and iterate on the architectural implementation as innovations and solutions develop. This document will be updated and improved in conjunction with the Architecture Concept Review (ACR) which will be held annually to help unify the Agency and to get buy-in and input from across the Agency on the human exploration architecture. The annual nature of the process provides the opportunity to continually incorporate new developments in technologies and new partnerships, whether they be with industry, the U.S. Government, international entities, or academia.

Moon-to-Mars Strategy↗

DOE OSTI2025

Solid State Transformer Architecture and Control Compensation for Common Mode Currents

A high-altitude electromagnetic pulse (HEMP) or similar geomagnetic disturbance (GMD) has the potential to impact the operation of large-scale electric power grids. By introducing low-frequency common-mode (CM) currents, these events can degrade the performance of critical system components, such as large power transformers by introducing CM currents which can lead to magnetic saturation of the transformer core. In this work, a solid-state transformer (SST) is developed to replace susceptible equipment and improve grid resiliency by safely absorbing these CM disturbances. This device will be referred to as a common-mode solid-state transformer (CM-SST). An SST architecture based on a four-legged AC/DC converter is developed. This architecture enables active control of CM signals without disturbing the AC voltages or the real and reactive power delivery capabilities. A system-level model of this architecture is created, and time-domain simulations are performed to evaluate the SST’s performance in response to simulated CM disturbances. A control strategy for mitigating CM current is also investigated. Hamiltonian surface shaping and power flow control (HSSPFC) is used to design a nonlinear controller for the SST’s output inverter. The objectives of the controller are to suppress CM-induced AC current offsets and regulate AC currents to desired setpoints. Nonlinear system analysis is applied to design and validate the controller. Two cases are tested: (a) the proposed four-leg inverter and (b) a standard three-leg inverter. The results show that the proposed controller rapidly mitigates CM disturbances while maintaining high-quality AC current waveforms in the four-leg configuration. Finally, the hardware performance of an SST prototype is evaluated. In particular, the ability of the SST to safely redirect and absorb CM currents is demonstrated, showing how it can protect neighboring conventional transformers in the system. The study confirms that appropriate control laws allow the SST to protect both itself and adjacent transformers during a HEMP or GMD event.

24 POWER TRANSMISSION AND DISTRIBUTION↗

NASA NTRS2020

Goal-Oriented Architecture for Telescope Control Software

Modern telescope control systems control a multitude of sensors and actuators physically distributed across subsystems. Traditionally, control systems are specified to compute system outputs based on reference setpoints despite environmental or internal disturbances. The control strategies are typically tightly coupled and very prescriptive, defining how exactly the control is to be achieved. In a goal-oriented approach, the control system architecture emphasizes the operational aspect, specifying the behavior at a higher level in terms of operational goals, considering several aspects such as environmental conditions and required wavefront quality. The result is an architecture that can more autonomously handle different control strategies, taking into account systematically the physical states of the system which are relevant for control. This paper demonstrates the feasibility of a goal-oriented approach by analyzing four fundamental functions: pointing, tracking, offsetting, and dome vignetting. The resulting SysML analysis and design models are used to develop a software prototype for distributed telescope control. Typical operational scenarios are discussed and compared to the ESO Very Large Telescope control software architecture.

Karban, R.↗

DOE OSTI2024

Performance of a phonon-mediated kinetic inductance detector at the NEXUS cryogenic facility

Microcalorimeters that leverage microwave kinetic inductance detectors to read out phonon signals in the particle-absorbing target, referred to as kinetic inductance phonon-mediated (KIPM) detectors, offer an attractive detector architecture to probe dark matter (DM) down to the fermionic thermal relic mass limit. A prototype KIPM detector featuring a single aluminum resonator patterned onto a 1-gram silicon substrate was operated in the Northwestern EXerimental Underground Site (NEXUS) low-background facility at Fermilab for characterization and evaluation of this detector architecture’s efficacy for a DM search. An energy calibration was performed by exposing the bare substrate to a pulsed source of 470-nm photons, resulting in a baseline resolution on the energy absorbed by the phonon sensor of 2.1 ± 0.2 eV, a factor of two better than the current state of the art, enabled by quasiparticle lifetimes extending up to 6.5 ms. However, due to the subpercent phonon collection efficiency, the resolution on energy deposited in the substrate is limited to σ E = 318 ± 29 eV. We further model both the signal pulse shape as a function of device temperature to extract quasiparticle lifetimes, and the observed noise spectra.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

NASA NTRS1976

An investigation of potential applications of OP-SAPS: Operational sampled analog processors

The impact of charge-coupled device (CCD) processors on future instrumentation was investigated. The CCD devices studied process sampled analog data and are referred to as OP-SAPS - operational sampled analog processors. Preliminary studies into various architectural configurations for systems composed of OP-SAPS show that they have potential in such diverse applications as pattern recognition and automatic control. It appears probable that OP-SAPS may be used to construct computing structures which can serve as special peripherals to large-scale computer complexes used in real time flight simulation. The research was limited to the following benchmark programs: (1) face recognition, (2) voice command and control, (3) terrain classification, and (4) terrain identification. A small amount of effort was spent on examining a method by which OP-SAPS may be used to decrease the limiting ground sampling distance encountered in remote sensing from satellites.

Parrish, E. A.↗

NASA NTRS1981

Panel C report: Standards needed for the use of ISO Open Systems Interconnection - basic reference model

The use of an International Standards Organization (ISO) Open Systems Interconnection (OSI) Reference Model and its relevance to interconnecting an Applications Data Service (ADS) pilot program for data sharing is discussed. A top level mapping between the conjectured ADS requirements and identified layers within the OSI Reference Model was performed. It was concluded that the OSI model represents an orderly architecture for the ADS networking planning and that the protocols being developed by the National Bureau of Standards offer the best available implementation approach.

Source record↗

NASA NTRS1991

Space transfer vehicle concepts and requirements study. Volume 1: Executive summary

A description of the study in terms of background, objectives, and issues is provided. NASA is currently studying new initiatives of space exploration involving both piloted and unpiloted missions to destinations throughout the solar system. Many of these missions require substantial improvements in launch vehicle and upper stage capabilities. This study provides a focused examination of the Space Transfer Vehicles (STV) required to perform these missions using the emerging national launch vehicle definition, the Space Station Freedom (SSF) definition, and the latest mission scenario requirements. The study objectives are to define preferred STV concepts capable of accommodating future exploration missions in a cost-effective manner, determine the technology development (if any) required to perform these missions, and develop a decision database of various programmatic approaches for the development of the STV family of vehicles. Special emphasis was given to examining space basing (stationing reusable vehicles at a space station), examining the piloted lunar mission as a primary design mission, and restricting trade studies to the high-performance, near-term cryogenics (LO2/LH2) as vehicle propellant. The study progressed through three distinct 6-month phases. The first phase concentrated on supporting a NASA 3 month definition of exploration requirements (the '90-day study') and during this phase developed and optimized the space-based point-of-departure (POD) 2.5-stage lunar vehicle. The second phase developed a broad decision database of 95 different vehicle options and transportation architectures. The final phase chose the three most cost-effective architectures and developed point designs to carry to the end of the study. These reference vehicle designs are mutually exclusive and correspond to different national choices about launch vehicles and in-space reusability. There is, however, potential for evolution between concepts.

Weber, Gary A.↗

NASA NTRS2006

Building the Core Architecture of a Multiagent System Product Line: With an example from a future NASA Mission

The field of Software Product Lines (SPL) emphasizes building a core architecture for a family of software products from which concrete products can be derived rapidly. This helps to reduce time-to-market, costs, etc., and can result in improved software quality and safety. Current AOSE methodologies are concerned with developing a single Multiagent System. We propose an initial approach to developing the core architecture of a Multiagent Systems Product Line (MAS-PL), exemplifying our approach with reference to a concept NASA mission based on multiagent technology.

Pena, Joaquin↗

NASA NTRS2010

Fission Surface Power System Initial Concept Definition

Under the NASA Exploration Technology Development Program (ETDP) and in partnership with the Department of Energy (DOE), NASA has embarked on a project to develop Fission Surface Power (FSP) technology. The primary goals of the project are to 1) develop FSP concepts that meet expected surface power requirements at reasonable cost with added benefits over other options, 2) establish a hardwarebased technical foundation for FSP design concepts and reduce overall development risk, 3) reduce the cost uncertainties for FSP and establish greater credibility for flight system cost estimates, and 4) generate the key products to allow NASA decision-makers to consider FSP as a preferred option for flight development. The FSP project was initiated in 2006 as the Prometheus Program and the Jupiter Icy Moons Orbiter (JIMO) mission were phased-out. As a first step, NASA Headquarters commissioned the Affordable Fission Surface Power System Study to evaluate the potential for an affordable FSP development approach. With a cost-effective FSP strategy identified, the FSP team evaluated design options and selected a Preliminary Reference Concept to guide technology development. Since then, the FSP Preliminary Reference Concept has served as a point-of-departure for several NASA mission architecture studies examining the use of nuclear power and has provided the foundation for a series of "Pathfinder" hardware tests. The long-term technology goal is a Technology Demonstration Unit (TDU) integrated system test using full-scale components and a non-nuclear reactor simulator. The FSP team consists of Glenn Research Center (GRC), Marshall Space Flight Center (MSFC) and the DOE National Laboratories at Los Alamos (LANL), Idaho (INL), Oak Ridge (ORNL), and Sandia (SNL). The project is organized into two main elements: Concept Definition and Risk Reduction. Under Concept Definition, the team performs trade studies, develops analytical tools, and formulates system concepts. Under Risk Reduction the team develops hardware prototypes and conducts laboratory-based testing.

Source record↗

NASA NTRS2011

Human Spaceflight Safety for the Next Generation on Orbital Space Systems

The National Aeronautics and Space Administration (NASA) Commercial Crew Program (CCP) has been chartered to facilitate the development of a United States (U.S.) commercial crew space transportation capability with the goal of achieving safe, reliable, and cost effective access to and from low Earth orbit (LEO) and the International Space Station (ISS) as soon as possible. Once the capability is matured and is available to the Government and other customers, NASA expects to purchase commercial services to meet its ISS crew rotation and emergency return objectives. The primary role of the CCP is to enable and ensure safe human spaceflight and processes for the next generation of earth orbital space systems. The architecture of the Program delineates the process for investment performance in safe orbital systems, Crew Transportation System (CTS) certification, and CTS Flight Readiness. A series of six technical documents build up the architecture to address the top-level CTS requirements and standards. They include Design Reference Missions, with the near term focus on ISS crew services, Certification and Service Requirements, Technical Management Processes, and Technical and Operations Standards Evaluation Processes.

Mango, Edward J.↗

NASA NTRS2022

Europa Clipper Mission: System Integration Review Report

Jupiter’s icy moon Europa is a prime target in our exploration of potentially habitable worlds beyond Earth. The combination of a subsurface liquid water layer in contact with a rocky seafloor may yield an ocean rich in the elements and energy needed for the emergence of life, and for potentially sustaining life through time. Europa may hold the clues to one of NASA’s long-standing quests – to determine whether or not we are alone in the universe. The Europa Clipper mission will characterize Europa’s habitability as the first step in the search for potential life at Europa by conducting approximately four dozen flybys. The project is preparing for a System Integration Review in November of 2021. This paper will summarize changes from the mission’s Preliminary Design Review (PDR) baseline, including science objectives, launch vehicle, interplanetary trajectory, science tour, flight system, payload and mission phases. Since PDR several of the Level 1 science requirements were descoped and the science requirement flow was realigned, in order to control cost growth. The realignment deemphasized science redundancy, which had resulted in an over-constrained science tour, in favor of a more targeted linkage to the primary responding instrument. Additionally, changes to the PDR flight system design baseline include changes to the sounding radar antenna design, the magnetometer architecture, and the heat redistribution system pumps. All changes have been incorporated into a reference science tour used to demonstrate that the requirements and design of the flight system and payload are mature enough to support flight builds.

Cook, Kendra↗

NASA NTRSDate not supplied

NASA’s Moon to Mars (M2M) Transit Habitat (TH) Refinement Point of Departure (PoD) Design

As NASA prepares for the next human footsteps on the lunar surface, the Agency is already looking ahead to systems that will enable a sustained human presence on the lunar surface and mission to Mars, including a lunar Surface Habitat and Mars Transit Habitat (TH). This paper describes the latest NASA government reference design for the TH and how it will support NASA's Moon to Mars human exploration architecture. First, it will serve as a test and demonstration platform in lunar orbit, demonstrating capabilities required for long-duration microgravity human spaceflight as part of the lunar-Mars analog missions. Then, the TH will also serve as a major Mars habitation exploration element to support the crew during their transit from the lunar orbit to Mars and returning them safely to lunar orbit. This paper will cover several considerations contributing to the latest habitat design refinement, including data on the TH's concept of operations, system functional definition, subsystem assumptions, notional interior layouts, a detailed mass and volume breakdown, and trade studies and analyses required to close identified technology/ development/architecture gaps. In addition to a technical description of the TH, this paper describes how the current TH government reference design will achieve many of the current lunar and Mars mission goals. Additionally, there are many assumed technological advances needed to support the prescribed mission phases leading up to the crewed mission to Mars in the late 2030s. The paper will describe many of the TH systems requiring further technology development and identify architectural solutions to achieve these mass, reliability, autonomy, and crew health targets. As a whole, the data in the paper shows that a TH meeting the 43 metric tons launch mass/trans-Mars injection burn limits specified by the Evolvable Mars Campaign is achievable near the desired timeframe with moderate strategic investments including maintainable life support systems, re-purposable structures and packaging, and lightweight exercise modalities. It also identifies operational and technological options to reduce this mass to less than 41 metric tons, including staging of launch structure/packaging and alternate structural materials. The resulting design detail and data contained in this paper are intended to help teams across NASA and potential commercial, academic, or international partners understand the current performance targets of the Transit Habitat and vehicle interface considerations imposed by the latest Moon to Mars mission scope.

Habitation Systems↗

NASA NTRS2011

Deep Space Habitat Team: HEFT Phase 2 Effects

HEFT was a NASA-wide team that performed analyses of architectures for human exploration beyond LEO, evaluating technical, programmatic, and budgetary issues to support decisions at the highest level of the agency in HSF planning. HEFT Phase I (April - September, 2010) and Phase II (September - December, 2010) examined a broad set of Human Exploration of Near Earth Objects (NEOs) Design Reference Missions (DRMs), evaluating such factors as elements, performance, technologies, schedule, and cost. At end of HEFT Phase 1, an architecture concept known as DRM 4a represented the best available option for a full capability NEO mission. Within DRM4a, the habitation system was provided by Deep Space Habitat (DSH), Multi-Mission Space Exploration Vehicle (MMSEV), and Crew Transfer Vehicle (CTV) pressurized elements. HEFT Phase 2 extended DRM4a, resulting in DRM4b. Scrubbed element-level functionality assumptions and mission Concepts of Operations. Habitation Team developed more detailed concepts of the DSH and the DSH/MMSEV/CTV Conops, including functionality and accommodations, mass & volume estimates, technology requirements, and DDT&E costs. DRM 5 represented an effort to reduce cost by scaling back on technologies and eliminating the need for the development of an MMSEV.

Toups, Larry D.↗

NASA NTRS2012

A Proposed Strategy for the U.S. to Develop and Maintain a Mainstream Capability Suite ("Warehouse") for Automated/Autonomous Rendezvous and Docking in Low Earth Orbit and Beyond

The ability of space assets to rendezvous and dock/capture/berth is a fundamental enabler for numerous classes of NASA fs missions, and is therefore an essential capability for the future of NASA. Mission classes include: ISS crew rotation, crewed exploration beyond low-Earth-orbit (LEO), on-orbit assembly, ISS cargo supply, crewed satellite servicing, robotic satellite servicing / debris mitigation, robotic sample return, and robotic small body (e.g. near-Earth object, NEO) proximity operations. For a variety of reasons to be described, NASA programs requiring Automated/Autonomous Rendezvous and Docking/Capture/Berthing (AR&D) capabilities are currently spending an order-of-magnitude more than necessary and taking twice as long as necessary to achieve their AR&D capability, "reinventing the wheel" for each program, and have fallen behind all of our foreign counterparts in AR&D technology (especially autonomy) in the process. To ensure future missions' reliability and crew safety (when applicable), to achieve the noted cost and schedule savings by eliminate costs of continually "reinventing the wheel ", the NASA AR&D Community of Practice (CoP) recommends NASA develop an AR&D Warehouse, detailed herein, which does not exist today. The term "warehouse" is used herein to refer to a toolbox or capability suite that has pre-integrated selectable supply-chain hardware and reusable software components that are considered ready-to-fly, low-risk, reliable, versatile, scalable, cost-effective, architecture and destination independent, that can be confidently utilized operationally on human spaceflight and robotic vehicles over a variety of mission classes and design reference missions, especially beyond LEO. The CoP also believes that it is imperative that NASA coordinate and integrate all current and proposed technology development activities into a cohesive cross-Agency strategy to produce and utilize this AR&D warehouse. An initial estimate indicates that if NASA strategically coordinates the development of a robust AR&D capability across the Agency, the cost of implementing AR&D on a spacecraft could be reduced from roughly $70M per mission to as low as $7M per mission, and the associated development time could be reduced from 4 years to 2 years, after the warehouse is completely developed. Table 1 shows the clear long-term benefits to the Agency in term of costs and schedules for various missions. (The methods used to arrive at the Table 1 numbers is presented in Appendices A and B.)

Krishnakumar, Kalmanje S.↗

NASA NTRSDate not supplied

SUbsonic Single Aft eNgine (SUSAN) Power/Propulsion System Hardware-in-the-Loop Test Results

Electrified Aircraft Propulsion (EAP) technology offers a promising path forward for reducing greenhouse gas emissions and other negative environmental effects from the commercial aviation sector. EAP systems can reduce fuel burn and improve performance over state-of the-art designs, however the increased complexity and highly coupled nature of these systems present challenges that require new control approaches. The SUbsonic Single Aft eNgine (SUSAN) Electrofan is a concept aircraft developed by NASA as a reference design for a commercial transport aircraft with a highly integrated hybrid-electric powertrain. This paper summarizes the results of a Hardware-in-the-Loop (HIL) test of a control architecture developed for the SUSAN power/propulsion system (PPS). The test was performed in the Hybrid Propulsion Emulation Rig (HyPER) facility at the NASA Glenn Research Center (GRC) and involved a real-time reference model of the SUSAN PPS and control system running with a sub-scale electro-mechanical system replacing one of the PPS subsystems. A side-by-side comparison of the simulated and real systems in the HIL test results shows that the control architecture functions well in both the simulation and the real-time HIL environment. In both cases the controller is able to simultaneously deliver the required thrust response and balance power levels between the electrical and turbomachinery subsystems.

Jonah J Sachs-Wetstone↗

NASA NTRSDate not supplied

SUbsonic Single Aft eNgine (SUSAN) Power/Propulsion System Hardware-in-the-Loop Test Results

EAP↗

DOE OSTI2025

Tuning 3-D Nanomaterial Architectures Using Atomic Layer Deposition to Direct Solution Synthesis

The ability to synthesize nanoarchitected materials with tunable geometries provides a means to control their functional properties, with applications in biological, environmental, and energy fields. To this end, various bottom-up and top-down synthesis processes have been developed. However, many of these processes require prepatterning or etching steps, making them challenging to scale-up to complex, nonplanar substrates. Furthermore, the ability to integrate nanomaterials into hierarchical arrays with precise control of feature spacing and orientation remains a challenge. One approach to overcome these patterning challenges is the use of surface modification layers to guide the resulting geometry of nanomaterial architectures grown from the substrate. A powerful strategy to accomplish this is what we will refer to as “surface-directed assembly,” where the resulting geometric parameters (feature size, shape, orientation) are predetermined by the initial surface layer. In particular, the use of Atomic Layer Deposition (ALD) to form a surface layer, followed by solution-based growth processes, has the ability to synthesize architected structures with tunable geometries on complex, nonplanar surfaces. Over the past decade, we have reported a series of studies where surface-directed assembly is used to synthesize ZnO nanowires (NWs) on top of a variety of substrates. In this case, a thin film of ZnO is deposited onto the substrate using ALD, which can guide the NW diameter, spacing, and angular orientation with respect to the substrate by controlling epitaxial relationships. Furthermore, we have shown that by depositing a submonolayer overcoat of a secondary material (e.g., amorphous TiO 2 ), nucleation sites are partially blocked, which can further tune the spacing between nanowires while minimizing changes to their other geometric properties. This approach can be used to generate multilevel hierarchical structures, such as hyperbranched NW arrays with tunable control of each level of hierarchy using ALD. Finally, we have demonstrated that the tunable control of geometric parameters can be scaled-up to curved, nonplanar substrates. This highlights the power of ALD to conformally and uniformly deposit the seed layers on complex substrates with subnanometer precision. To complement these seeded hydrothermal approaches, we expanded this strategy to include conversion chemistry of the initial ALD seed layers. For example, by replacing ZnO with Al 2 O 3 as the seed layer without changing the hydrothermal growth conditions, Al–Zn layered-double hydroxide nanosheets can be formed instead of nanowires. In another example of conversion chemistry, a solution anion-exchange process was used to incorporate sulfur into ALD metal oxide films. In both of these conversion processes, the properties of the initial ALD film enabled tuning of the resulting nanostructure geometry. In this Account, we describe the use of ALD to guide the growth of diverse nanomaterial systems, with tunable control over their geometry and composition. We further show how these approaches can be used to tune functional properties for a range of applications, including superomniphobic surfaces, antibiofouling coatings, and photocatalysis. In conclusion, we conclude with an outlook on how the combination of ALD and solution synthesis can enable future directions in scalable nanomanufacturing to overcome the limitations of traditional top-down and bottom-up approaches.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗