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At least 37 records · Page 2

Sleep and Respiration in Microgravity

Sleep is often reported to be of poor quality in microgravity, and studies on the ground have shown a strong relationship between sleep-disordered breathing and sleep disruption. During the 16-day Neurolab mission, we studied the influence of possible changes in respiratory function on sleep by performing comprehensive sleep recordings on the payload crew on four nights during the mission. In addition, we measured the changes in the ventilatory response to low oxygen and high carbon dioxide in the same subjects during the day, hypothesizing that changes in ventilatory control might affect respiration during sleep. Microgravity caused a large reduction in the ventilatory response to reduced oxygen. This is likely the result of an increase in blood pressure at the peripheral chemoreceptors in the neck that occurs when the normally present hydrostatic pressure gradient between the heart and upper body is abolished. This reduction was similar to that seen when the subjects were placed acutely in the supine position in one-G. In sharp contrast to low oxygen, the ventilatory response to elevated carbon dioxide was unaltered by microgravity or the supine position. Because of the similarities of the findings in microgravity and the supine position, it is unlikely that changes in ventilatory control alter respiration during sleep in microgravity. During sleep on the ground, there were a small number of apneas (cessation of breathing) and hypopneas (reduced breathing) in these normal subjects. During sleep in microgravity, there was a reduction in the number of apneas and hypopneas per hour compared to preflight. Obstructive apneas virtually disappeared in microgravity, suggesting that the removal of gravity prevents the collapse of upper airways during sleep. Arousals from sleep were reduced in microgravity compared to preflight, and virtually all of this reduction was as a result of a reduction in the number of arousals from apneas and hypopneas. We conclude that any sleep disruption in microgravity is not the result of respiratory factors.

West, John B.↗

Autogenic Feedback Training Exercise and pilot performance: enhanced functioning under search-and-rescue flying conditions

Studies have shown that autonomous mode behavior is one cause of aircraft fatalities due to pilot error. In such cases, the pilot is in a high state of psychological and physiological arousal and tends to focus on one problem, while ignoring more critical information. This study examined the effect of training in physiological self-recognition and regulation, as a means of improving crew cockpit performance. Seventeen pilots were assigned to the treatment and control groups matched for accumulated flight hours. The treatment group contained 4 pilots from HC-130 Hercules aircraft and 4 HH-65 Dolphin helicopter pilots; the control group contained 3 pilots of HC-130s and 6 helicopter pilots. During an initial flight, physiological data were recorded on each crewmember and an instructor pilot rated individual crew performance. Eight crewmembers were then taught to regulate their own physiological response levels using Autogenic-Feedback Training Exercise (AFTE). The remaining participants received no training. During a second flight, treatment participants showed significant improvement in performance (rated by the same instructor pilot as in pretests) while controls did not improve. The results indicate that AFTE management of high states of physiological arousal may improve pilot performance during emergency flying conditions.

NASA Discipline Neuroscience↗

Microgravity reduces sleep-disordered breathing in humans

To understand the factors that alter sleep quality in space, we studied the effect of spaceflight on sleep-disordered breathing. We analyzed 77 8-h, full polysomnographic recordings (PSGs) from five healthy subjects before spaceflight, on four occasions per subject during either a 16- or 9-d space shuttle mission and shortly after return to earth. Microgravity was associated with a 55% reduction in the apnea-hypopnea index (AHI), which decreased from a preflight value of 8.3 +/- 1.6 to 3.4 +/- 0.8 events/h inflight. This reduction in AHI was accompanied by a virtual elimination of snoring, which fell from 16.5 +/- 3.0% of total sleep time preflight to 0.7 +/- 0.5% inflight. Electroencephalogram (EEG) arousals also decreased in microgravity (by 19%), and this decrease was almost entirely a consequence of the reduction in respiratory-related arousals, which fell from 5.5 +/- 1.2 arousals/h preflight to 1.8 +/- 0.6 inflight. Postflight there was a return to near or slightly above preflight levels in these variables. We conclude that sleep quality during spaceflight is not degraded by sleep-disordered breathing. This is the first direct demonstration that gravity plays a dominant role in the generation of apneas, hypopneas, and snoring in healthy subjects.

short duration↗

Medial vestibular connections with the hypocretin (orexin) system

The mammalian medial vestibular nucleus (MVe) receives input from all vestibular endorgans and provides extensive projections to the central nervous system. Recent studies have demonstrated projections from the MVe to the circadian rhythm system. In addition, there are known projections from the MVe to regions considered to be involved in sleep and arousal. In this study, afferent and efferent subcortical connectivity of the medial vestibular nucleus of the golden hamster (Mesocricetus auratus) was evaluated using cholera toxin subunit-B (retrograde), Phaseolus vulgaris leucoagglutinin (anterograde), and pseudorabies virus (transneuronal retrograde) tract-tracing techniques. The results demonstrate MVe connections with regions mediating visuomotor and postural control, as previously observed in other mammals. The data also identify extensive projections from the MVe to regions mediating arousal and sleep-related functions, most of which receive immunohistochemically identified projections from the lateral hypothalamic hypocretin (orexin) neurons. These include the locus coeruleus, dorsal and pedunculopontine tegmental nuclei, dorsal raphe, and lateral preoptic area. The MVe itself receives a projection from hypocretin cells. CTB tracing demonstrated reciprocal connections between the MVe and most brain areas receiving MVe efferents. Virus tracing confirmed and extended the MVe afferent connections identified with CTB and additionally demonstrated transneuronal connectivity with the suprachiasmatic nucleus and the medial habenular nucleus. These anatomical data indicate that the vestibular system has access to a broad array of neural functions not typically associated with visuomotor, balance, or equilibrium, and that the MVe is likely to receive information from many of the same regions to which it projects.

Non-NASA Center↗

Aerospace manpower transfer to small business enterprises

The feasibility of a program to effect transfer of aerospace professional people from the ranks of the unemployed into gainful employment in the small business community was investigated. The effectiveness of accomplishing transfer of technology from the aerospace effort into the private sector through migration of people rather than products or hardware alone was also studied. Two basic methodologies were developed. One involves the matching of ex-aerospace professionals and small companies according to their mutual needs. A training and indoctrination program is aimed at familiarizing the professional with the small company environment, and a program of follow-up counseling is defined. The second methodology incorporates efforts to inform and arouse interest among the nonaerospace business community toward affirmative action programs that will serve mutual self-interests of the individuals, companies, and communities involved.

Green, M. K.↗

Electrophysiological studies of the nervous system

The electrophysiology of the nervous system is studied using cats and human subjects. Data cover effects of chlorolose on evoked potential, the evoked resistance shift that accompanies evoked potentials, and the relationship of eye movements to potentials aroused by visual stimulation.

Galambos, R.↗

A Multidisciplinary Survey for the Management of Alaskan Resources Utilizing ERTS Imagery

The application of ERTS-1 imagery for a multidisciplinary study of Alaskan resources is discussed. ERTS-1 data form a politically neutral base from which resource surveys can be made without arousing suspicions from groups which have mutually confliciting goals. The specific use of ERTS-1 imagery for monitoring migratory animals, pipeline locations, road construction, snow cover, and vegetation growth is reported. Maps, illustrations, and photographs are provided to support the data.

Miller, J. M.↗

Emotional state and efficiency

An investigation was made of the effect of emotional states-negative and positive- on work performance. Data cover intensity of emotional arousal, personality characteristics of person involved, typological features of person's nervous system, emotional stability of person, and past experience of person. Particular attention was given to emotional stress effects on efficiency, given modern working conditions.

Ovchinnikova, O. V.↗

Effects of aircraft noise on human sleep.

Under controlled conditions in two test rooms, studies were made of the response of sleeping subjects to the stimuli of simulated sonic booms and subsonic jet aircraft noise. Children were relatively nonresponsive to the stimuli. In general, the older the subject, the more likely is behavioral awakening. The response rates to the two types of stimuli were essentially the same. The stimulus intensity had little, if any, effect on frequency of arousal, although other degrees of response did increase.

Lukas, J. S.↗

A theory of microwave apparent temperature over the ocean

In the microwave region combined active (scatterometer) and passive (radiometer) remote sensors over the ocean show promise of providing surface wind speeds and weather information to the oceanographer and meteorologist. This has aroused great interest in the investigation of the scattering of waves from the sea surface. A composite surface scattering theory is investigated. The two-scale scattering theory proposed by Semyonov was specifically extended to compute the emmision and scattering characteristics of ocean surfaces. The effects of clouds and rain on the radiometer and scatterometer observations are also investigated using horizontally stratified model atmospheres with rough sea surfaces underneath. Various cloud and rain models proposed by meteorologist were employed to determine the rise in the microwave temperature when viewing downward through these model atmospheres. For heavy rain-fall rates the effects of scattering on the radiative transfer process are included.

Wu, S. T.↗

Habituation of vestibular responses: An overview

An historical survey of vestibular habituation experiments has been undertaken. Methodological problems are presented briefly, and the influence of arousal on vestibular responses is detailed. Data obtained from animals and from man are treated separately. At least for man, the term habituation may be better defined by a dynamic change in the form of vestibular responses than by a simple response reduction.

Collins, W. E.↗

Effects of noise upon human information processing

Studies of noise effects upon human information processing are described which investigated whether or not effects of noise upon performance are dependent upon specific characteristics of noise stimulation and their interaction with task conditions. The difficulty of predicting noise effects was emphasized. Arousal theory was considered to have explanatory value in interpreting the findings of all the studies. Performance under noise was found to involve a psychophysiological cost, measured by vasoconstriction response, with the degree of response cost being related to scores on a noise annoyance sensitivity scale. Noise sensitive subjects showed a greater autonomic response under noise stimulation.

Cohen, H. H.↗

Noise and sleep - A literature review and a proposed criterion for assessing effect

Results of a number of studies on the effects of various types of noise on the sleep of subjects of both sexes and a wide range of age groups are reviewed to develop a tentative criterion for assessing these effects. Available data suggest that reasonably accurate predictions of sleep disruption may be made if the interfering noise is specified in units (EPNdB or EdBA) which account for its spectral characteristics and duration. When EPNdB units are used as the measure of noise intensity, the correlation coefficient between intensity and the probability of no sleep disturbance is -0.86. Because of the paucity of data on the long-term results of frequent behavioral wakings or arousals, it is suggested that disturbance of sleep be defined as an electroencephalographic change of one or more sleep stages.

Lukas, J. S.↗

Coma recovery

Arousal from coma is defined as a function of the reticular activating system that is located between the spinal cord and the diencephalon core of the brain stem. This system receives information from all the sensory functions of the body for distribution to the various parts of the cortex in order to maintain normal activities. Multimodal, neurosensory stimulation techniques are outlined that are designed to help the patient recover from the comatose state.

Dimancescu, M. D.↗

The visual accommodation response during concurrent mental activity

The direction and magnitude of the human visual accommodation response during concurrent mental activity are investigated. Subject focusing responses to targets at distances of 0.0 D, 3.0 D and an indeterminate distance were monitored by means of an optometer during the performance of a backwards counting task and a visual imagery task (thinking near and thinking far). In both experiments a shift in accommodation towards the visual far point is observed particularly for the near target, which increases with the duration of the task. The results can be interpreted in terms of both the capacity model of Kahneman (1973) and the autonomic arousal model of Hess and Polt (1964), and are not inconsistent with the possibility of an intermediate resting position.

Malmstrom, F. V.↗