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At least 37 records · Page 2

Spaceflight effects on biomechanical and biochemical properties of rat vertebrae

The biomechanical and biochemical responses of lumbar vertebral bodies during a 12.5-day spaceflight (Cosmos 1887 biosatellite) were determined for rapidly growing rats (90-day-old, Czechoslovakian-Wistar). By use of age-matched vivarium controls (normal cage environment) and synchronous controls (simulated flight conditions), as well as a basal control group (killed before lift-off on the 1st day of flight), the combined influences of growth and space-flight could be examined. Centra of the sixth lumbar vertebrae (L6) were compressed to 50% strain at a fast strain rate while immersed in physiological buffer (37 degrees C). The body masses of vivarium and synchronous controls were significantly heavier than either the flight or basal controls. The flight group had an L6 vertebral body compressional stiffness that was 39% less than the vivarium controls, 47% less than the synchronous control, and 16% less than the basal controls. In addition, the average initial maximum load of the flight L6 was 22% less than vivarium controls and 18% less than the synchronous controls, whereas the linear compressional load of the flight group averaged 34% less than the vivarium and 25% less than the synchronous groups. The structural properties of the vertebrae from the 12.5-day-younger basal group closely resembled the flight vertebrae. Calcium, phosphorous, and hydroxyproline concentrations were not significantly different among the groups. Nevertheless, the lack of strength and stiffness development in spaceflight, coupled with a smaller proportion of mature hydroxypyridinoline cross-links, suggested that the 12.5 days of spaceflight slowed the maturation of trabecular bone in the vertebral bodies of rapidly growing rats.

Non-NASA Center↗

Effects of spaceflight on rat humerus geometry, biomechanics, and biochemistry

The effects of a 12.5-day spaceflight (Cosmos 1887 biosatellite) on the geometric, biomechanical, and biochemical characteristics of humeri of male specific pathogen-free rats were examined. Humeri of age-matched basal control, synchronous control, and vivarium control rats were contrasted with the flight bones to examine the influence of growth and space environment on bone development. Lack of humerus longitudinal growth occurred during the 12.5 days in spaceflight. In addition, the normal mid-diaphysial periosteal appositional growth was affected; compared with their controls, the spaceflight humeri had less cortical cross-sectional area, smaller periosteal circumferences, smaller anterior-posterior periosteal diameters, and smaller second moments of area with respect to the bending and nonbending axes. The flexural rigidity of the flight humeri was comparable to that of the younger basal control rats and significantly less than that of the synchronous and vivarium controls; the elastic moduli of all four groups, nonetheless, were not significantly different. Generally, the matrix biochemistry of the mid-diaphysial cross sections showed no differences among groups. Thus, the spaceflight differences in humeral mechanical strength and flexural rigidity were probably a result of the differences in humeral geometry rather than material properties.

NASA Discipline Number 26-10↗

Probabilistic Modeling of Intracranial Pressure Effects on Optic Nerve Biomechanics

Altered intracranial pressure (ICP) is involved/implicated in several ocular conditions: papilledema, glaucoma and Visual Impairment and Intracranial Pressure (VIIP) syndrome. The biomechanical effects of altered ICP on optic nerve head (ONH) tissues in these conditions are uncertain but likely important. We have quantified ICP-induced deformations of ONH tissues, using finite element (FE) and probabilistic modeling (Latin Hypercube Simulations (LHS)) to consider a range of tissue properties and relevant pressures.

biomechanics↗

Integrated Model of the Eye/Optic Nerve Head Biomechanical Environment

Visual Impairment and Intracranial Pressure (VIIP) syndrome is a concern for long-duration space flight. Previously, it has been suggested that ocular changes observed in VIIP syndrome are related to the cephalad fluid shift that results in altered fluid pressures [1]. We are investigating the impact of changes in intracranial pressure (ICP) using a combination of numerical models, which simulate the effects of various environment conditions, including finite element (FE) models of the posterior eye. The specific interest is to understand how altered pressures due to gravitational changes affect the biomechanical environment of tissues of the posterior eye and optic nerve sheath. METHODS: Additional description of the numerical modeling is provided in the IWS abstract by Nelson et al. In brief, to simulate the effects of a cephalad fluid shift on the cardiovascular and ocular systems, we utilized a lumped-parameter compartment model of these systems. The outputs of this lumped-parameter model then inform boundary conditions (pressures) for a finite element model of the optic nerve head (Figure 1). As an example, we show here a simulation of postural change from supine to 15 degree head-down tilt (HDT), with primary outcomes being the predicted change in strains at the optic nerve head (ONH) region, specifically in the lamina cribrosa (LC), retrolaminar optic nerve, and prelaminar neural tissue (PLNT). The strain field can be decomposed into three orthogonal components, denoted as the first, second and third principal strains. We compare the peak tensile (first principal) and compressive (third principal) strains, since elevated strain alters cell phenotype and induces tissue remodeling. RESULTS AND CONCLUSIONS: Our lumped-parameter model predicted an IOP increase of c. 7 mmHg after 21 minutes of 15 degree HDT, which agreed with previous reports of IOP in HDT [1]. The corresponding FEM simulations predicted a relative increase in the magnitudes of the peak tensile and compressive strains in the lamina cribrosa of 42 and 43, respectively (Fig. 2). The corresponding changes in the optic nerve strains were 17 and 39, while in the PLNT they were 47 and 43. These magnitudes of relative elevations in peak strains may induce a phenotypic response in resident mechano-responsive resident cells [2]. This approach may be expanded to investigate other environmental changes (e.g. parabolic flight). Through our VIIP SCHOLAR project, we will validate and improve these integrated models by measuring patient-specific changes in optic nerve sheath geometry in patients with idiopathic intracranial hypertension before and after lumbar puncture and CSF removal.

biomechanics↗

Ergonomic Models of Anthropometry, Human Biomechanics and Operator-Equipment Interfaces

The Committee on Human Factors was established in October 1980 by the Commission on Behavioral and Social Sciences and Education of the National Research Council. The committee is sponsored by the Office of Naval Research, the Air Force Office of Scientific Research, the Army Research Institute for the Behavioral and Social Sciences, the National Aeronautics and Space Administration, and the National Science Foundation. The workshop discussed the following: anthropometric models; biomechanical models; human-machine interface models; and research recommendations. A 17-page bibliography is included.

Kroemer, Karl H. E.↗

Muscular activity and its relationship to biomechanics and human performance

The purpose of this manuscript is to address the issue of muscular activity, human motion, fitness, and exercise. Human activity is reviewed from the historical perspective as well as from the basics of muscular contraction, nervous system controls, mechanics, and biomechanical considerations. In addition, attention has been given to some of the principles involved in developing muscular adaptations through strength development. Brief descriptions and findings from a few studies are included. These experiments were conducted in order to investigate muscular adaptation to various exercise regimens. Different theories of strength development were studied and correlated to daily human movements. All measurement tools used represent state of the art exercise equipment and movement analysis. The information presented here is only a small attempt to understand the effects of exercise and conditioning on Earth with the objective of leading to greater knowledge concerning human responses during spaceflight. What makes life from nonliving objects is movement which is generated and controlled by biochemical substances. In mammals. the controlled activators are skeletal muscles and this muscular action is an integral process composed of mechanical, chemical, and neurological processes resulting in voluntary and involuntary motions. The scope of this discussion is limited to voluntary motion.

Ariel, Gideon↗

Biomechanical Analysis of T2 Exercise

Crewmembers regularly perform treadmill exercise on the ISS. With the implementation of T2 on ISS, there is now the capacity to obtain ground reaction force (GRF) data GRF data combined with video motion data allows biomechanical analyses to occur that generate joint torque estimates from exercise conditions. Knowledge of how speed and load influence joint torque will provide quantitative information on which exercise prescriptions can be based. The objective is to determine the joint kinematics, ground reaction forces, and joint kinetics associated with treadmill exercise on the ISS. This study will: 1) Determine if specific exercise speed and harness load combinations are superior to others in exercise benefit; and 2) Aid in the design of exercise prescriptions that will be most beneficial in maintaining crewmember health.

DeWitt, John K.↗

Metabolic Costs and Biomechanics of Inclined Ambulation and Exploration Tasks in a Planetary Suit

Observations from Apollo lunar surface extravehicular activities (EVAs) and a few studies conducted in partial-gravity simulation environments have helped us understand suited human performance in reduced-gravity environments. The Constellation Program EVA Systems Project Office initiated a series of tests aimed at increasing our understanding of human performance and suit kinematics under various simulated lunar EVA conditions, including matched unsuited controls, to identify the specific metabolic costs and biomechanics of the prototype Mark III Advanced Spacesuit Technology Demonstrator. A primary goal of the series is to provide evidence-based recommendations for suit mass, center of gravity, pressure, and suit kinematic constraints that optimize human performance in partial-gravity environments. Results will be combined with studies in other lunar analogs to evaluate the effectiveness and limitations of these environments. As our understanding of suited human performance matures, different combinations of variables can be evaluated to determine whether significant interactions exist between parameters. This report provides an overview of key findings of Integrated Suit Test (IST)-2. As future tests are completed, focusing on other suit factors, analog environments, or different suits, study results will be combined and reevaluated. The series of tests comprising IST-2 was conducted from June 13, 2007 through October 24, 2007.

Aerospace environments↗

Biomechanical Modeling of the Deadlift Exercise on the HULK Device to Improve the Efficacy of Resistive Exercise Microgravity Countermeasures

Extended spaceflight typically results in the loss of muscular strength and bone density due to exposure to microgravity. Resistive exercise countermeasures have been developed to maintain musculoskeletal health during spaceflight. The Advanced Resistive Exercise Device (ARED) is the "gold standard" of available devices; however, its footprint and volume are too large for use in space capsules employed in exploration missions. The Hybrid Ultimate Lifting Kit (HULK) device, with its smaller footprint, is a prototype exercise device for exploration missions. This work models the deadlift exercise being performed on the HULK device using biomechanical simulation, with the long-term goal to improve and optimize astronauts' exercise prescriptions, to maximize the benefit of exercise while minimizing time and effort invested.

Countermeasures↗

Earth-Based Analogs & Modeling for Exercise Biomechanics in Space

The biomechanics of exercise in space is difficult to study and there are unknowns surrounding exercise performance on future space exploration countermeasures systems. These issues are beginning to be addressed through enhanced modeling techniques fueled initially by human-in-the-loop data collections in ground-based environments. The presentation will focus on an effort completed at the University of South Florida to apply the Computer Assisted Rehabilitation Environment (CAREN) system to address a human spaceflight need. The research explored the interaction between a human and a moving platform while exercise was completed.

Kaitlin Lostroscio↗

Human Factors Applications of Biomechanical Modeling

Biomechanical data collection and modeling has applications to the field of human factors. Specifically, motion data can be used to determine the operational volume necessary for performing a task. The operational volume assessment can be performed in order to determine how much volume is needed to perform the task or if task performance can be contained and adequately performed within an allocated volume. Motion and external force data, along with computational modeling techniques, can be used to estimate the internal loading produced during performance of a task. Internal loading estimates can be used to determine if an adequate stimulus is generated for maintenance of musculoskeletal health and also for comparison to injury thresholds to determine injury risk during task performance.

Lewandowski, Beth↗

Anthropometric Measurement Procedures at the Anthropometry and Biomechanics Facility

The Anthropometry and Biomechanics Facility (ABF) at NASA Johnson Space Center (JSC) is the centralized source of anthropometry data at NASA for use in requirement development, engineering design, and verification of human-system integrations such as spacesuits and vehicles. To ensure the collection of consistent, accurate, and valid anthropometry data, ABF has defined anthropometric measurements and anatomical landmarks which are generally based on the Anthropometric Survey for US Army Personnel (ANSUR), but with additional measurements which have been uniquely designed for spacesuit and hardware accommodation purposes. Unlike ANSUR, NASA anthropometry measurements primarily rely on 3D body scanning, a method which allows for explicitly defining the process of collecting measurements and the quality control methods used to ensure measurement reliability. In addition to ABF’s anthropometry measurement definitions and procedures, this presentation will also compare specifics of different measurement techniques ABF uses, for example, laser scanning versus manual measurement methods (e.g., tape measure or anthropometer-based), and the benefits and considerations of each method. The evolution of ABF’s measurement process will also be addressed, as new spaceflight programs have been introduced which have required unique measurements and the need to capture body shape changes over time was identified to be critical for spacesuit fit in some instances.

Garima Gupta↗

Anthropometric Measurement Procedures at the Anthropometry and Biomechanics Facility

The Anthropometry and Biomechanics Facility (ABF) at NASA Johnson Space Center (JSC) is the centralized source of anthropometry data at NASA for use in requirement development, engineering design, and verification of human-system integrations such as spacesuits and vehicles. To ensure the collection of consistent, accurate, and valid anthropometry data, ABF has defined anthropometric measurements and anatomical landmarks which are generally based on the Anthropometric Survey for US Army Personnel (ANSUR), but with additional measurements which have been uniquely designed for spacesuit and hardware accommodation purposes. Unlike ANSUR, NASA anthropometry measurements primarily rely on 3D body scanning, a method which allows for explicitly defining the process of collecting measurements and the quality control methods used to ensure measurement reliability. In addition to ABF’s anthropometry measurement definitions and procedures, this presentation will also compare specifics of different measurement techniques ABF uses, for example, laser scanning versus manual measurement methods (e.g., tape measure or anthropometer-based), and the benefits and considerations of each method. The evolution of ABF’s measurement process will also be addressed, as new spaceflight programs have been introduced which have required unique measurements and the need to capture body shape changes over time was identified to be critical for spacesuit fit in some instances.

Garima Gupta↗

Next Generation Exercise Device (NGED): Advancing Exercise Capabilities for Future Space Missions Through Biomechanical Modeling

Background: As space exploration extends to long-duration missions on the Moon and Mars, maintaining astronaut health and fitness becomes increasingly critical. The Next Generation Exercise Device (NGED), developed and tested by the HumanWorks Lab at NASA Johnson Space Center (JSC), aims to address this challenge through innovative approaches. Objective: Development and evaluation of a NGED system, focusing on its adaptability to various Moon to Mars mission scenarios, including prospective use in a Lunar Pressurized Rover (LPR). To help inform vehicle and system requirements, an exercise volumetric assessment was performed via data collection and biomechanical modeling.

C Wang↗