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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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All sourcesNASA NTRSDOE OSTI
NASA NTRS1988

Knowledge acquisition for case-based reasoning systems

Case-based reasoning (CBR) is a simple idea: solve new problems by adapting old solutions to similar problems. The CBR approach offers several potential advantages over rule-based reasoning: rules are not combined blindly in a search for solutions, solutions can be explained in terms of concrete examples, and performance can improve automatically as new problems are solved and added to the case library. Moving CBR for the university research environment to the real world requires smooth interfaces for getting knowledge from experts. Described are the basic elements of an interface for acquiring three basic bodies of knowledge that any case-based reasoner requires: the case library of problems and their solutions, the analysis rules that flesh out input problem specifications so that relevant cases can be retrieved, and the adaptation rules that adjust old solutions to fit new problems.

Riesbeck, Christopher K.↗
NASA NTRS1993

The use of multiple models in case-based diagnosis

The work described in this paper has as its goal the integration of a number of reasoning techniques into a unified intelligent information system that will aid flight crews with malfunction diagnosis and prognostication. One of these approaches involves using the extensive archive of information contained in aircraft accident reports along with various models of the aircraft as the basis for case-based reasoning about malfunctions. Case-based reasoning draws conclusions on the basis of similarities between the present situation and prior experience. We maintain that the ability of a CBR program to reason about physical systems is significantly enhanced by the addition to the CBR program of various models. This paper describes the diagnostic concepts implemented in a prototypical case based reasoner that operates in the domain of in-flight fault diagnosis, the various models used in conjunction with the reasoner's CBR component, and results from a preliminary evaluation.

Karamouzis, Stamos T.↗
NASA NTRS1992

deltaT/T limits from the UCSB South Pole degree-scale experiment and constraints on the large-scale deviations from the Hubble flow

The limits to the cosmic microwave background radiation (CBR) temperature anisotropy derived from the results of the University of California at Santa Barbara South Pole degree-scale experiment are translated into upper bounds on large-scale deviations from the Hubble flow. The lack of measurable CBR anisotropy in this experiment implies very low upper bounds upon the rms amplitude V(R) of the streaming motion within a Gaussian window of radius R: Vmax(R is greater than 4000 km/s) less than 200 km/s, and Vmax(R is greater than 7500 km/s) is less than 100 km/s. Thus, the smoothness of the CBR at about 1-2 deg and the apparent large-amplitude (about 500 km/s) deviations from pure Hubble flow at R greater than about 4000 km/s cannot be simultaneously explained in the framework of usual large-scale structure formation models based on the assumptions involved in this calculation.

Gorski, Krzysztof M.↗
NASA NTRS1993

Case-based approach to handling aircraft malfunctions

Reasoning about physical systems in operation is a difficult task, and any attempt to automate the process must overcome the problems of modeling normal behavior, diagnosing faults, and predicting future behavior. This paper describes a prototypical case-based reasoner (CBR) that operates in the domain of in-flight fault diagnosis and prognosis of aviation subsystems, particularly jet engines. The reasoner operates on the observation that the ability of a CBR program to reason about physical systems can be significantly enhanced by the addition to the CBR program of a model of the physical system to describe the system's structural, functional, and causal behavior.

Karamouzis, Stamos T.↗
NASA NTRS1993

Measurements of the anisotropy of the cosmic background radiation at 0.5 deg scale near the star Mu Pegasi

Results are presented from the third flight of the MAX experiment, an attitude-controlled balloon-borne millimeter-wave telescope with a 0.5 deg beam, a 1 deg chop, and a three-channel bolometric photometer. Several hours of high-quality data were obtained during a flight on 1991 June 5, including long integrations to search for CBR anisotropy, two separate measurements of dust in the Galactic plane, a brief scan of the Coma Cluster to search for the Sunyaev-Zel'dovich (SZ) effect, and a number of important systematic tests. Data from one of the long CBR integrations, carried out in a region of sky near the star Mu Pegasi, are presented. The primary structure in the data is shown to be emission from Galactic dust via its spectrum and correlation with the IRAS 100/micron map. Several approaches are used to fit this dust component and remove it from the data. An upper limit to CBR anisotropy of deltaT/T less than 2.5 x 10 exp -5 is obtained for a Gaussian autocorrelation function with coherence angle omega(c) = 25'. This limit is significantly higher than the measurement sensitivity of deltaT/T about 1 x 10 exp -5 due to the presence of residual structure in the data after removal of the dust component.

Meinhold, P.↗
NASA NTRS1998

Case-Based Capture and Reuse of Aerospace Design Rationale

The goal of this project is to apply artificial intelligence techniques to facilitate capture and reuse of aerospace design rationale. The project applies case-based reasoning (CBR) and concept mapping (CMAP) tools to the task of capturing, organizing, and interactively accessing experiences or "cases" encapsulating the methods and rationale underlying expert aerospace design. As stipulated in the award, Indiana University and Ames personnel are collaborating on performance of research and determining the direction of research, to assure that the project focuses on high-value tasks. In the first five months of the project, we have made two visits to Ames Research Center to consult with our NASA collaborators, to learn about the advanced aerospace design tools being developed there, and to identify specific needs for intelligent design support. These meetings identified a number of task areas for applying CBR and concept mapping technology. We jointly selected a first task area to focus on: Acquiring the convergence criteria that experts use to guide the selection of useful data from a set of numerical simulations of high-lift systems. During the first funding period, we developed two software systems. First, we have adapted a CBR system developed at Indiana University into a prototype case-based reasoning shell to capture and retrieve information about design experiences, with the sample task of capturing and reusing experts' intuitive criteria for determining convergence (work conducted at Indiana University). Second, we have also adapted and refined existing concept mapping tools that will be used to clarify and capture the rationale underlying those experiences, to facilitate understanding of the expert's reasoning and guide future reuse of captured information (work conducted at the University of West Florida). The tools we have developed are designed to be the basis for a general framework for facilitating tasks within systems developed by the Advanced Design Technologies Testbed (ADTT) project at ARC. The tenets of our framework are (1) that the systems developed should leverage a designer's knowledge, rather than attempting to replace it; (2) that learning and user feedback must play a central role, so that the system can adapt to how it is used, and (3) that the learning and feedback processes must be as natural and as unobtrusive as possible. In the second funding period we will extend our current work, applying the tools to capturing higher-level design rationale.

Leake, David B.↗
NASA NTRS1992

Problem-Solving Software

CBR Express software solves problems by adapting sorted solutions to new problems specified by a user. It is applicable to a wide range of situations. The technology was originally developed by Inference Corporation for Johnson Space Center's Advanced Software Development Workstation. The project focused on the reuse of software designs, and Inference used CBR as part of the ACCESS prototype software. The commercial CBR Express is used as a "help desk" for customer support, enabling reuse of existing information when necessary. It has been adopted by several companies, among them American Airlines, which uses it to solve reservation system software problems.

Source record↗
NASA NTRS1998

Cardiovascular function following reduced aerobic activity

PURPOSE: The aim of this study was to test the hypothesis that a sustained reduction of physical activity (deconditioning) would alter the cardiovascular regulatory function. METHODS: Nineteen young, healthy volunteers participated in physical deconditioning for a period of 8 wk. Before (pre) and following (post) physical deconditioning, the responses of heart rate (HR), mean arterial pressure (MAP, measured by Finapres), central venous pressure (CVP), stroke volume (SV, Doppler), and forearm blood flow (FBF, plethysmography) were determined during lower body negative pressure (LBNP). The carotid baroreflex (CBR) function was assessed using a train of pulsatile neck pressure (NP) and suction, and the aortic baroreflex control of HR was assessed during steady-state phenylephrine (PE) infusion superimposed by LBNP and NP to counteract the PE increased CVP and carotid sinus pressure, respectively. RESULTS: Active physical deconditioning significantly decreased maximal oxygen uptake (-7%) and LBNP tolerance (-13%) without a change in baseline hemodynamics. Plasma volume (-3% at P = 0.135), determined by Evans Blue dilution, and blood volume (-4% at P = 0.107) were not significantly altered. During LBNP -20 to -50 torr, there was a significantly greater drop of SV per unit decrease in CVP in the post- (14.7 +/- 1.6%/mm Hg) than predeconditioning (11.2 +/- 0.7%/mm Hg) test accompanied by a greater tachycardia. Deconditioning increased the aortic baroreflex sensitivity (pre vs post: -0.61 +/- 0.12 vs -0.84 +/- 0.14 bpm.mm-1 Hg, P = 0.009) and the slope of forearm vascular resistance (calculated from [MAP-CVP]/FBF) to CVP (-2.75 +/- 0.26 vs -4.94 +/- 0.97 PRU/mm Hg, P = 0.086). However, neither the CBR-HR (-0.28 +/- 0.03 VS -0.39 +/- 0.10 bpm.mm-1 Hg) nor the CBR-MAP (-0.37 +/- 0.16 vs -0.25 +/- 0.07 mm Hg/mm Hg) gains were statistically different between pre- and postdeconditioning. CONCLUSIONS: We concluded that the functional modification of the cardiac pressure-volume relationship resulted in the reduced LBNP tolerance, despite the accentuated aortic and cardiopulmonary baroreflex function following deconditioning.

Non-NASA Center↗
DOE OSTI2022

Biocatalytic system for comparatively assessing the functional association of monolignol cytochrome P450 monooxygenases with their redox partners

Lignin is a complex heterogenous polymer derived from oxidative radical polymerization of three monolignols, i.e., p-coumaryl alcohol, coniferyl alcohol and sinapyl alcohol. These lignin monomeric precursors structurally differ in their methoxy groups of the benzene rings. In phenylpropanoid-monolignol biosynthetic pathway, the endoplasmic reticulum (ER)-resident cytochrome P450 monooxygenases, cinnamate 4-hydroxylase, coumaroyl ester 3´-hydroxylase and ferulate 5-hydroxylase, establish the key structural characteristics of monolignols. The catalysis of cytochrome P450 monooxygenase requires reducing power, which is supplied by the ER electron transfer chains, composed of cytochrome P450 oxidoreductase (CPR), cytochrome b5 reductase (CBR) and/or cytochrome b5 protein (CB5), from cofactor NADPH or NADH. While NADPH-dependent CPR serves as the typical electron donor for most P450 enzymes, in some cases, the CBR-CB5 or CPR-CB5 electron transfer system also transfers electrons to the terminal P450 enzymes. There are tremendous studies focusing on the discovery and characterization of cytochrome P450 monooxygenases. However, very limited attention has been paid to the versatility and the roles of electron transfer components in the P450 catalytic system. Due to the membrane-residence property of both P450 enzymes and electron transfer components, it is challenging to establish an effective experimental system to evaluate the functional association of P450s with their redox partners. This chapter describes a yeast cell biocatalytic system and the related experimental procedures for comparatively assessing the functional relationship of monolignol biosynthetic P450 enzymes and different redox partners in their catalysis.

59 BASIC BIOLOGICAL SCIENCES↗
DOE OSTI2025

Bipartite chromatin recognition by Hop1 from two diverged Holozoa

In meiosis, ploidy reduction is driven by a complex series of DNA breakage and recombination events between homologous chromosomes, orchestrated by meiotic HORMA domain proteins (HORMADs). Meiotic HORMADs possess a central chromatin binding region (CBR) whose architecture varies across eukaryotic groups. Here, we determine high-resolution crystal structures of the meiotic HORMAD CBR from two diverged aquatic Holozoa,Schistosoma mansoniandPatiria miniata, which reveal tightly associated plant homeodomain (PHD) and winged helix-turn-helix (wHTH) domains. We show that PHD–wHTH CBRs bind duplex DNA through their wHTH domains, and identify key residues that disrupt this interaction. Combining experimental and predicted structures, we show that the CBRs’ PHDs likely interact with the tail of histone H3, and may discriminate between unmethylated and trimethylated H3 lysine 4. Finally, we show that Holozoa Hop1 CBRs bind nucleosomes in vitro in a bipartite manner involving both the PHD and wHTH domain. Our data reveal how meiotic HORMADs with PHD–wHTH CBRs can bind chromatin and potentially discriminate between chromatin states to drive meiotic recombination to specific chromosomal regions.

Life Sciences & Biomedicine - Other Topics↗
NASA NTRS1987

Minimal cosmic background fluctuations implied by streaming motions

The minimal cosmic background radiation (CBR) anisotropy implied by the presence of peculiar motions of a given amplitude on some specified scale is calculated using a new, power spectrum-independent approach. If the tentative evidence for deviations from the Hubble flow of magnitude delta V/V roughly 0.1 at V roughly 5000 km/s is confirmed, microwave background fluctuations with a coherence scale of about 2 deg and dispersion delta T/T greater than 10 to the -5th are predicted. It is found that the existing upper limits on delta T/T are not inconsistent with v(r) = 500 km/s at r = 50/h Mpc. A reduction of the observational limits on the CBR anisotropy below the authors' minimal predictions for delta T/T would challenge the current interpretation of measurements of deviations from the Hubble flow. Gravitational instability without reheating as a mechanism for generation of the large-scale structure of the universe would be in severe difficulty.

Juszkiewicz, Roman↗
NASA NTRS1990

Ponderable soliton stars and cosmic background radiation

A theory is developed to describe the possible perturbations of the cosmic background radiation (CBR) by radiation from ponderable soliton stars in the early universe. Since the temperature of such stars is in the range of 10 to the 6th K, thermalization of their emitted radiation is possible. Two models are considered: one in which thermalization is ignored and one in which decoupling from thermalization is considered as a sudden process. The expected perturbation of the CBR is probably less than 1 percent and is largely around the short-wavelength end, in the form of point radio sources. This result is consistent with the most recent COBE measurements.

Chiu, Hong-Yee↗
NASA NTRS1992

A degree-scale measurement of anisotropy of the cosmic background radiation

We report on the preliminary result of a search for anisotropy in the cosmic background radiation (CBR) with a beam size of about 1.5 deg FWHM over a wavelength range of 8-12 mm. The system operated successfully for 500 hr at the South Pole during the 1990-1991 austral summer. The data from one region, representing 25 hr after editing, are presented here. A strong signal is present in the lower frequency channels with a spectrum unlike CBR fluctuations, and is probably due to foreground emission. The highest frequency channel has the smallest contribution from this signal and has been used to set a 95-percent confidence level upper limit of not greater than 1.4 x 10 exp -5 for fluctuations with a Gaussian autocorrelation function at a coherence angle of 1.2 deg. This is significantly more sensitive than previous experiments at this angle scale.

Gaier, Todd↗
NASA NTRS1993

The advanced cosmic microwave explorer - A millimeter-wave telescope and stabilized platform

We have developed and flown a 1 m diameter Gregorian telescope system for measurements of anisotropy in the Cosmic Background Radiation (CBR). The telescope is incorporated in a balloon-borne stabilized platform with arcminute stabilization capability. To date, the system has flown four times and observed from the ground at the South Pole twice. The telescope has used both coherent and incoherent detectors. We describe the development of the telescope, pointing platform, and one of the receivers employed in making measurements of the CBR. Performance of the system during the first flight and operation on the ground at the South Pole are described, and the quality of the South Pole as a millimeter wave observing site is discussed.

Meinhold, P. R.↗
NASA NTRS1993

Testing for the Gaussian nature of cosmological density perturbations through the three-point temperature correlation function

One of the crucial aspects of density perturbations that are produced by the standard inflation scenario is that they are Gaussian where seeds produced by topological defects tend to be non-Gaussian. The three-point correlation function of the temperature anisotropy of the cosmic microwave background radiation (CBR) provides a sensitive test of this aspect of the primordial density field. In this paper, this function is calculated in the general context of various allowed non-Gaussian models. It is shown that the Cosmic Background Explorer and the forthcoming South Pole and balloon CBR anisotropy data may be able to provide a crucial test of the Gaussian nature of the perturbations.

Luo, Xiaochun↗
NASA NTRS1994

The Pacor 2 expert system: A case-based reasoning approach to troubleshooting

The Packet Processor 2 (Pacor 2) Data Capture Facility (DCF) acquires, captures, and performs level-zero processing of packet telemetry for spaceflight missions that adhere to communication services recommendations established by the Consultative Committee for Space Data Systems (CCSDS). A major goal of this project is to reduce life-cycle costs. One way to achieve this goal is to increase automation. Through automation, using expert systems, and other technologies, staffing requirements will remain static, which will enable the same number of analysts to support more missions. Analysts provide packet telemetry data evaluation and analysis services for all data received. Data that passes this evaluation is forwarded to the Data Distribution Facility (DDF) and released to scientists. Through troubleshooting, data that fails this evaluation is dumped and analyzed to determine if its quality can be improved before it is released. This paper describes a proof-of-concept prototype that troubleshoots data quality problems. The Pacor 2 expert system prototype uses the case-based reasoning (CBR) approach to development, an alternative to a rule-based approach. Because Pacor 2 is not operational, the prototype has been developed using cases that describe existing troubleshooting experience from currently operating missions. Through CBR, this experience will be available to analysts when Pacor 2 becomes operational. As Pacor 2 unique experience is gained, analysts will update the case base. In essence, analysts are training the system as they learn. Once the system has learned the cases most likely to recur, it can serve as an aide to inexperienced analysts, a refresher to experienced analysts for infrequently occurring problems, or a training tool for new analysts. The Expert System Development Methodology (ESDM) is being used to guide development.

Sary, Charisse↗
NASA NTRS1994

The phenomenological status of late time phase transition models after cosmic background radiation anisotropy measurements

Some relatively model-independent results for structure formation via late time phase transitions (LTPT) are discussed. In particular, generic LTPT power spectra are presented. The implication of the recent Cosmic Background Explorer (COBE) detection of the cosmic background radiation (CBR) anisotropy at large angular scales (greater than or approximately equal to 7 deg) and the tight upper limits from small angular scales (approximately 1 deg) to LTPT models are discussed. Special attention is focused on the observational constraints and possible non-Gaussian signatures of CBR temperature anisotropies from LTPT and other non-Gaussian models. It is shown that while LTPT have been seriously constrained by the recent data, viable models do remain which provide more power on the 100-200 Mpc scales than do more traditional primordial Gaussian density fluctuation models. Tests for such models are presented, including possible anisotropies on angular scales less than 8 min.

Luo, Xiaochun↗
NASA NTRS1998

Photodisintegration of Ultrahigh Energy Cosmic Rays: A New Determination

We present the results of a new calculation of the photodisintegration of ultrahigh energy cosmic-ray (UHCR) nuclei in intergalactic space. The critical interactions for energy loss and photodisintegration of UHCR nuclei occur with photons of the 2.73 K cosmic background radiation (CBR) and with photons of the infrared background radiation (IBR). We have reexamined this problem making use of a new determination of the IBR based on empirical data, primarily from IRAS galaxies, consistent with direct measurements and upper limits from TeV gamma-ray observations. We have also improved the calculation by including the specific threshold energies for the various photodisintegration interactions in our Monte Carlo calculation. With the new smaller IBR flux, the steepness of the Wien side of the now relatively more important CBR makes their inclusion essential for more accurate results. Our results indicate a significant increase in the propagation time of UHCR nuclei of a given energy over previous results. We discuss the possible significance of this for UHCR origin theory.

Stecker, F. W.↗