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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 37 records · Page 2
All sourcesNASA NTRSDOE OSTI
NASA NTRS2018

Coalescence of DNA Double Strand Breaks Induced by Galactic Cosmic Radiation is Modulated by Genetics in 15 Inbred Strains of Mice

In this manuscript we address the challenges associated with the ability to predict radiation sensitivity associated with exposure to either cosmic radiation or X-rays in a population study, by monitoring DNA damage sensing protein 53BP1 forming small nuclear radiation-induced foci (RIF) as a surrogate biomarker of DNA double strand breaks (DSB). 76 primary skin fibroblasts were isolated from 10 collaborative cross strains and five reference inbred mice (C57Bl/6, BALB/CByJ, B6C3, C3H and CBA/CaJ) and exposed to three different charged nuclei of increasing LET (350 MeV/n Si, 350 MeV/n Ar and 600 MeV/n Fe) and X-ray. Our data brings strong evidence against the classic "contact-first" model where DSBs are assumed to be immobile and repaired at the lesion site. In contrast, our model suggests nearby DSBs move into single repair unit characterized by large RIF before the repair machinery kicks in. Such model has the advantage of being much more efficient molecularly but is poorly suited to deal with cosmic radiation, where energy is concentrated along the particle trajectory, inducing a large density of DSBs along each particle track. In accordance with this model, RIF quantification after X-ray exposition showed a saturated dose response for early time points post-irradiation for all strains. Similarly, the high-LET response showed that RIF number matched the number of track per cell, not the number of expected DSB per cell (1). At the temporal level, we noted that the percentage of unrepaired high-LET tracks over a 48 hour time-course increased with LET, confirming that the DNA repair process becomes more difficult as more DSB coalesce into single RIF. There was also good agreement between persistent RIF levels measured in-vitro in the primary skin cultures and survival levels of T-cells and B-cells collected in blood samples from 10 CC strains 24 hours after 0.1 Gy whole-body dose of X-ray. This suggests that persistent RIF 24 hour post-IR is a good surrogate in-vitro biomarker for in-vivo radiation toxicity. Finally, at the genomic level, large differences in repair rates between strains for high-LET allowed us to identify suggestive genetic loci associated with radiation sensitivity. Interestingly, the two highest LETs provided the most strain variation with a common locus on Chromosome 10 highly enriched for DNA repair associated genes we discussed in detail.

Radiation-Induced Foci↗
NASA NTRS1985

Search for heavy antinuclei in the cosmic radiation

The existence of significant amounts of antimatter in the Universe is demonstrated through cosmic radiation. The data from the Danish-French Cosmic Ray Spectrometer on the HEAO-3 satellite offers an opportunity to search for heavy antinuclei, since all the relevant parameters (charge, velocity, arrival direction, and satellite position at the time of arrival) are measured for each recorded nucleus. Using the 22676 positive only events in the data seletion corresponding to L 1.5 as a measure of our exposure factor to heavy antinuclei and noting that no corresponding antinuclei were found, an upper limit (95% confidence) is given to the ratio of antinuclei to nuclei as 1.4 x .0001 for particles with Z 9. The upper limit resulting from this work is compared with previous results of searches for heavy antimatter in the cosmic radiation. It is seen that, if one regards only antiparticles heavier than fluorine, then the present result represents a reduced upper limit over previous data. When taken together, all the available experiment data now push the upper limit for the ratio of antiparticles to particles well below .0001.

Lund, N.↗
NASA NTRS1972

A search for antihelium in primary cosmic radiation.

A search for anti-alpha-particles in the primary cosmic radiation has been carried out, and a new upper limit for these particles in the range 0.2-4.3 GeV per nucleon has been obtained. At the 95 per cent confidence level the upper limit is found to be 0.14 per cent of the alpha-particle flux. The instrument used for this purpose is a magnetic spectrometer employing spark chambers for determining particle trajectories and time-of-flight measurement for the rejection of upward-moving particles. Implications of these results for various models of the sources of cosmic radiation are discussed.

Evenson, P.↗
NASA NTRS1984

The case for antiparticles in the extragalactic cosmic radiation

The presence of an excess of low energy antiprotons in the primary cosmic radiation has given rise to a number of possible explanations. The possibility that these are extragalactic in origin is considered and it is shown that there are interesting implications for the bulk of the cosmic radiation at higher energies. In particular, it may be possible to account for a previously puzzling feature, a bump in the cosmic ray energy spectrum in the energy range 10(14) to 10(15) eV, with this primary extragalactic origin hypothesis. A method for testing this hypothesis experimentally is also described.

Stecker, F. W.↗
NASA NTRS1984

The case for antiparticles in the extragalactic cosmic radiation

The presence of an excess of low-energy antiprotons in the primary cosmic radiation has given rise to several possible explanations, some of which involve exotic processes such as mini-black holes and extragalactic antiparticles. The latter possibility is considered, and it is shown that there are interesting implications for the cosmic radiation at higher energies. Indeed, it may be possible to account for a previously puzzling feature of the cosmic ray spectrum (a 'bump' in the range between 10 to the 14th and 10 to the 15th eV) by hypothesizing a primary extragalactic origin for the bulk of the observed cosmic ray antiprotons, although such an explanation is not unique. In this model, most of the cosmic rays above 10 to the 15th eV are extragalactic. A method of testing this hypothesis experimentally is described.

Stecker, F. W.↗
NASA NTRSDate not supplied

Effects Of Five-Ion Galactic Cosmic Radiation Simulation On Immune Function, Brain, And Behavior In Male And Female Mice

Exposure to galactic cosmic radiation is a principal consideration of spaceflight missions, and with upcoming missions to the Moon and Mars, it is increasingly imperative to elucidate the effects of space travel beyond the lower Earth orbit. Additionally, with the first female astronaut to soon travel to the Moon there is a strong need to understand the biological sex differences to adaptation to the deep space environment. While the effects of spaceflight on the nervous system are not fully known, studies in animal models have shown that exposure to ionizing radiation can cause neuronal damage and lead to downstream cognitive and behavioral deficits. To simulate the type of radiation exposure occurring during spaceflight, model organisms can be exposed to relevant doses via Five-Ion Galactic Cosmic Radiation Simulation at the NASA National Space Radiation Laboratory at Brookhaven National Laboratory. We have investigated the neurobehavioral responses to space environment-like radiation exposure. Male and female 23–24-week-old mice (age-matched to average astronaut age) were exposed to 5, 15 and 50 cGy. Following exposure, immune, brain and behavioral (sensorimotor, risk-taking and cognitive) measures were acquired at ‘Acute’ (IR+24hrs, IR+72hrs), ‘Intermediate’ (IR+14 days) and ‘Delayed’ (IR+28 to IR+124 days) to inform biological responses anticipated during a transit to Moon and Mars. There were pronounced sex differences observed in all outcome measurements, while very few radiation induced effects were observed. Those dose effects that were observed were primarily in cytokine expression and less so in behavioral measurements. Further studies will investigate if radiation, microgravity and social isolation combine synergistically to trigger an oxidative stress response that alters immune homeostasis, brain structure/function, and neurobehavioral/cognitive performance, ultimately to characterize risks and identify appropriate countermeasures in both women and men in anticipation of future deep space missions.

Stephanie Puukila↗
NASA NTRS1980

Control of the Earth's electric field intensity through solar wind modulation of galactic cosmic radiation: Support for a proposed atmospheric electrical sun-weather mechanism

The ionospheric potential and galactic cosmic radiation, found to be inversely correlated with the solar wind velocity are examined as being germane to weather modification. Since the ionospheric potential is proportional to the fair weather electric field intensity and cosmic radiation is the dominant source of atmospheric ionization, it is concluded that the Earth's overall electric field varies in phase with atmospheric ionization and that the latter is modulated by the solar wind. A proposed mechanism, in which solar control of ionizing radiation influences atmospheric electrification and thus possibly cloud physical processes is discussed. An experimental approach to critically test the proposed mechanism through comparison of the temporal variation of the Earth's electric field with conditions in the interplanetary medium is outlined.

Markson, R.↗