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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 37 records · Page 2
All sourcesNASA NTRSDOE OSTI
DOE OSTI2022

Novel small molecule FGF 23 inhibitors increase serum phosphate and improve skeletal abnormalities in Hyp mice

We report that excess fibroblast growth factor 23 (FGF23) causes hereditary hypophosphatemic rickets, such as X-linked hypophosphatemia (XLH) and tumor induced osteomalacia (TIO). A small molecule that specifically binds to FGF23 to prevent activation of the FGFR/a-Klotho complex has potential advantages over the currently approved systemically administered FGF23 blocking antibody. Using structure-based drug design we previously identified ZINC13407541 (N-[[2-(2-phenylethenyl)cyclopenten-1-yl]methylidene]hydroxylamine) as a small molecule antagonist for FGF23. Additional structure-activity studies developed a series of ZINC13407541 analogues with enhanced drug-like properties. In this study, we tested in a pre-clinical Hyp mouse homologue of XLH a direct connect analogue (8n) [(E)-2-(4-(tert-butyl)phenyl)cyclopent-1-ene-1-carbaldehyde oxime] that exhibited the greatest stability in microsomal assays, and 13a [(E)-2-((E)-4-methylstyryl)benzaldehyde oxime] that exhibited increased in vitro potency. Using cryo-electron microscopy (Cryo-EM) structure and computational docking, we identified a key binding residue (Q156) of the FGF23 antagonists, ZINC13407541 and its analogues (8n and 13a) in the N-terminal domain of FGF23 protein. Site-directed mutagenesis and bimolecular fluorescence complementation (BiFC)-fluorescence resonance energy transfer (FRET) assay confirmed the binding site of these three antagonists. We found that pharmacological inhibition of FGF23 with either of these compounds blocked FGF23 signaling and increased serum phosphate and 1,25(OH)2D concentrations in Hyp mice. Long-term parenteral treatment with 8n or 13a also enhanced linear bone growth, increased mineralization of bone, and narrowed the growth plate in Hyp mice. The more potent 13a compound had greater therapeutic effects in Hyp mice. Further optimization of these FGF23 inhibitors may lead to versatile drugs to treat excess FGF23-mediated disorders.

60 APPLIED LIFE SCIENCES↗
NASA NTRS1972

State of the art in the detection of intelligent extraterrestrial signals.

Recent progress in ideas of how signals that might represent electromagnetic radiations of intelligent civilizations elsewhere in the galaxy is summarized. Project Cyclops, carried out at Ames Research Center under the auspices of NASA and the American Society for Engineering Education, determined that microwaves are superior to lasers for interstellar signalling. It is felt that the band lying between the resonances of the two dissociation products of water, the hydrogen line at 1420 MHz, and the first hydroxyl line at 1662 MHz, is the most suitable. Phased antenna arrays of perhaps 1000 to 10,000 dishes of 100 m diam would be required. It is considered that a list of likely stars should be compiled, and these should be searched one at a time. Procedures for combing the spectrum are outlined.

Oliver, B. M.↗
NASA NTRS1975

Measurement of dimensional stability

A technique was developed for measuring, with a precision of one part 10 to the 9th power, changes in physical dimensions delta L/L. Measurements have commenced on five materials: Heraeus-Schott Homosil (vitreous silica), Corning 7940 (vitreous silica), Corning ULE 7971 (titanium silicate), Schott Zero-Dur, and Owens-Illinois Cer-Vit C-101. The study was extended to include Universal Cyclops Invar LR-35 and Simonds-Saw Superinvar.

Jacobs, S. F.↗
NASA NTRS1975

A review of the theory of interstellar communication

The probability is analyzed that intelligent civilizations capable of interstellar communication exist in the galaxy. Drake's (1960) equation for the prevalence of communicative civilization is used in the calculations, and attempts are made to place limits on the search range that must be covered to contact other civilizations, the longevity of the communicative phase of such civilizations, and the possible number of two-way exchanges between civilizations in contact with each other. The minimum estimates indicate that some 100,000 civilizations probably coexist within several tens of astronomical units of each other and that some 1,000,000 probably coexist within 10 light years of each other. Attempts to detect coherent signals characteristic of intelligent life are briefly noted, including Projects Ozma and Cyclops as well as some Soviet attempts. Recently proposed American and Soviet programs for interstellar communication are outlined.

Billingham, J.↗
NASA NTRS1976

Ultraprecise thermal expansion measurements of seven low expansion materials

We summarize a large number of ultraprecise thermal expansion measurements made on seven different low expansivity materials. Expansion coefficients in the -150-300 C temperature range are shown for Owens-Illinois Cer-Vit C-101, Corning ULE 7971 (titanium silicate) and fused silica 7940, Heraeus-Schott Zerodur low-expansion material and Homosil fused silica, Universal Cyclops Invar LR-35, and Simonds Saw and Steel Super Invar.

Berthold, J. W., III↗
NASA NTRS1977

Antenna concepts for interstellar search systems

An evaluation is made of microwave receiving systems designed to search for signals from extraterrestrial intelligence. Specific design concepts are analyzed parametrically to determine whether the optimum antenna system location is on earth, in space, or on the moon. Parameters considered include the hypothesized number of transmitting civilizations, the number of stars that must be searched to give any desired probability of receiving a signal, the antenna collecting area, the search time, the search range, and the cost. This analysis suggests that (1) search systems based on the moon are not cost-competitive, (2) if the search is extended only a few hundred light years from the earth, a Cyclops-type array on earth may be the most cost-effective system, (3) for a search extending to 500 light years or more, a substantial cost and search-time advantage can be achieved with a large spherical reflector in space with multiple feeds, (4) radio frequency interference shields can be provided for space systems, and (5) cost can range from a few hundred million to tens of billions of dollars, depending on the parameter values assumed.

Basler, R. P.↗
NASA NTRS1976

OAST Space Theme Workshop. Volume 2: Theme summary. 3: Search for extraterrestrial intelligence (no. 9). A: Theme statement. B. 26 April 1976 presentation. C. Summary. D. Newer initiatives (form 4). E. Initiative actions (form 5)

Preliminary (1977-1983), intermediate (1982-1988), and long term (1989+) phases of the search for extraterrestrial intelligence (SETI) program are examined as well as the benefits to be derived in radioastronomy and the problems to be surmounted in radio frequency interference. The priorities, intrinsic value, criteria, and strategy for the search are discussed for both terrestrial and lunar-based CYCLOPS and for a space SETI system located at lunar liberation point L4. New initiatives related to antenna independent technology, multichannel analyzers, and radio frequency interference shielding are listed. Projected SETI program costs are included.

Source record↗
NASA NTRS1987

The windows of SETI - Frequency and time in the search for extraterrestrial intelligence

Since interstellar travel is not economically possible on the time scale of a human lifetime, communication with extraterrestrials can be achieved only by sending some form of energy or matter across space; photons (electromagnetic waves) are best. Of particular interest to SETI is the region from about 1,000-60,000 MHz known as the free-space microwave window. During the course of NASA's Cyclops program, it was pointed out that the hydrogen and hydroxyl lines bounded a band in which there were no other known lines. The threatened loss of the microwave window to earth-based services is discussed.

Oliver, Bernard M.↗
DOE OSTI2017

Cross-scale efficient tensor contractions for coupled cluster computations through multiple programming model backends

Coupled-cluster methods provide highly accurate models of molecular structure through explicit numerical calculation of tensors representing the correlation between electrons. These calculations are dominated by a sequence of tensor contractions, motivating the development of numerical libraries for such operations. While based on matrix–matrix multiplication, these libraries are specialized to exploit symmetries in the molecular structure and in electronic interactions, and thus reduce the size of the tensor representation and the complexity of contractions. The resulting algorithms are irregular and their parallelization has been previously achieved via the use of dynamic scheduling or specialized data decompositions. We introduce our efforts to extend the Libtensor framework to work in the distributed memory environment in a scalable and energy-efficient manner. We achieve up to 240× speedup compared with the optimized shared memory implementation of Libtensor. We attain scalability to hundreds of thousands of compute cores on three distributed-memory architectures (Cray XC30 and XC40, and IBM Blue Gene/Q), and on a heterogeneous GPU-CPU system (Cray XK7). As the bottlenecks shift from being compute-bound DGEMM's to communication-bound collectives as the size of the molecular system scales, we adopt two radically different parallelization approaches for handling load-imbalance, tasking and bulk synchronous models. Nevertheless, we preserve a unified interface to both programming models to maintain the productivity of computational quantum chemists.

97 MATHEMATICS AND COMPUTING↗