Measurement of the proton dosage of the gemini astronauts with nuclear emulsions messungen der protonendosis der gemini-astronauten mit kernemulsionen.
Measurement of proton dosage of gemini astronauts with nuclear emulsions
GEMINI FLIGHTS↗
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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.
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Robustness of cement-based materials: From dosage variations to yield stress fluctuations
The idea behind the present work is to assess robustness of fresh cement-based materials (i.e. their ability to display the same properties when submitted to variations in the way they are produced) from a generic and analytical point of view. First, analytical models from literature relating components proportions and yield stress are combined into a multi-scale and physical approach and compared to our experimental yield stress measurements. In the second part, the derivation of these analytical relationships is used to assess robustness as a function of components proportions, which allows for the most sensitive variations to be mapped onto component dosage from a yield stress point of view. In the case of fluid concretes, this approach showcases the interest of working at slightly higher water content and slightly lower aggregates fraction along with benefits of viscosity modifying agents / plasticizers combination.
36 MATERIALS SCIENCE↗
Effects of fiber dosage, loading orientation and stress on frequency response of enhanced Carbon Nano-Fiber Aggregates
Nanomaterial additives have been broadly used in cement and concrete-based sensors to measure the stress and strain in the structure. Most of the studies focused on measuring the resistivity of sensors with Direct Current (DC) or relatively low-frequency. Here in this work, the impedance responses of enhanced Carbon Nano-Fiber Aggregates (CNFAs) at different frequencies are rigorously studied and utilized as a tool for real-time structural health monitoring (SHM). The CNFA impedance measurements at different measurement frequencies provide an extra dimension (frequency dimension) to allow the characterization of different phenomena and multimodal measurements simultaneously. First, a comprehensive physical model is established to understand the frequency responses of the CNFA impedance. Second, COMSOL Multiphysics is used to simulate the frequency responses of the CNFA impedance, which provides more insights into the electric field and current density distribution. The impedance of CNFAs decreased with the increased dosage of carbon nanofibers (CNFs). Third, experimental studies are reported in detail. The electrical impedance variation (EZV) of the CNFA in parallel orientation is 151% higher than that of perpendicular orientation at the frequency of 2612 Hz and uniaxial compression stress of 4.65 MPa. The strain-EZV curve obtained from the response spectrum is linear for frequencies ranging from 98 Hz to 463.9 kHz. The strain-EZV curve for 5625 Hz has a linear fit with the gauge factor of 147.78. At 1000 Hz, the CNFA exhibited a repeatable behavior up to 9.35 MPa and detection limit up to the stress of 18.62 MPa.
36 MATERIALS SCIENCE↗
A high-throughput skim-sequencing approach for genotyping, dosage estimation and identifying translocations
The development of next-generation sequencing (NGS) enabled a shift from array-based genotyping to directly sequencing genomic libraries for high-throughput genotyping. Even though whole-genome sequencing was initially too costly for routine analysis in large populations such as breeding or genetic studies, continued advancements in genome sequencing and bioinformatics have provided the opportunity to capitalize on whole-genome information. As new sequencing platforms can routinely provide high-quality sequencing data for sufficient genome coverage to genotype various breeding populations, a limitation comes in the time and cost of library construction when multiplexing a large number of samples. Here we describe a high-throughput whole-genome skim-sequencing (skim-seq) approach that can be utilized for a broad range of genotyping and genomic characterization. Using optimized low-volume Illumina Nextera chemistry, we developed a skim-seq method and combined up to 960 samples in one multiplex library using dual index barcoding. With the dual-index barcoding, the number of samples for multiplexing can be adjusted depending on the amount of data required, and could be extended to 3,072 samples or more. Panels of doubled haploid wheat lines ( Triticum aestivum , CDC Stanley x CDC Landmark), wheat-barley ( T . aestivum x Hordeum vulgare ) and wheat-wheatgrass ( Triticum durum x Thinopyrum intermedium ) introgression lines as well as known monosomic wheat stocks were genotyped using the skim-seq approach. Bioinformatics pipelines were developed for various applications where sequencing coverage ranged from 1 × down to 0.01 × per sample. Using reference genomes, we detected chromosome dosage, identified aneuploidy, and karyotyped introgression lines from the skim-seq data. Leveraging the recent advancements in genome sequencing, skim-seq provides an effective and low-cost tool for routine genotyping and genetic analysis, which can track and identify introgressions and genomic regions of interest in genetics research and applied breeding programs.
60 APPLIED LIFE SCIENCES↗
Dosage optimization for reducing tumor burden using a phenotype-structured population model with a drug-resistance continuum
Abstract Drug resistance is a significant obstacle to effective cancer treatment. To gain insights into how drug resistance develops, we adopted a concept called fitness landscape and employed a phenotype-structured population model by fitting to a set of experimental data on a drug used for ovarian cancer, olaparib. Our modeling approach allowed us to understand how a drug affects the fitness landscape and track the evolution of a population of cancer cells structured with a spectrum of drug resistance. We also incorporated pharmacokinetic (PK) modeling to identify the optimal dosages of the drug that could lead to long-term tumor reduction. We derived a formula that indicates that maximizing variation in plasma drug concentration over a dosing interval could be important in reducing drug resistance. Our findings suggest that it may be possible to achieve better treatment outcomes with a drug dose lower than the levels recommended by the drug label. Acknowledging the current limitations of our work, we believe that our approach, which combines modeling of both PK and drug resistance evolution, could contribute to a new direction for better designing drug treatment regimens to improve cancer treatment.
Life Sciences & Biomedicine - Other Topics↗
Tissue dosages from alpha particles and heavy nuclei in solar particle beams in space
Tissue dosages from alpha particles and heavy nuclei in solar particle beams in space
PARTICLE BEAM↗
The calibration of photographic and spectroscopic films: The response of 2aO film to small dosages of alpha particles from 3/10th's rad to 8 rads at energy levels 153 MeV, 79 MeV and 47 MeV
The 2aO film, pre-exposed to a series of neutral density filters which on development under standard conditions will produce the standard H-D curve for that film, were then exposed to Alpha paricles with a dose range of 3/10ths rads to 8 rads while varying the energy of the particles using 153 MeV, 70 MeV, and 47 MeV, respectively. An analysis of the film shows that the 3/10th rad dose produces the lowest optical density changes at 70 MeV and 47 MeV. While the optical density readings for the darker patterns seem to oscillate and decrease when exposed to radiation dosages of 3/10th rads to 8 rads.
Hammond, E. C., Jr.↗
Stability of Dosage Forms in the Pharmaceutical Payload Aboard Space Missions
Efficacious pharmaceuticals with adequate shelf lives are essential for successful space medical operations. Stability of pharmaceuticals, therefore, is of paramount importance for assuring the health and wellness of astronauts on future space exploration missions. Unique physical and environmental factors of space missions may contribute to the instability of pharmaceuticals, e.g., radiation, humidity and temperature variations. Degradation of pharmaceutical formulations can result in inadequate efficacy and/or untoward toxic effects, which could compromise astronaut safety and health. Methods: Four identical pharmaceutical payload kits containing 31 medications in different dosage forms (liquid, tablet, capsule, ointment and suppository) were transported to the International Space Station aboard the Space Shuttle (STS-121). One of the 4 kits was stored on the Shuttle and the other 3 were stored on the International Space Station (ISS) for return to Earth at 6-month interval aboard a pre-designated Shuttle flight for each kit. The kit stored on the Shuttle was returned to Earth aboard STS-121 and 2 kits from ISS were returned on STS 117 and STS-122. Results: Analysis of standard physical and chemical parameters of degradation was completed for pharmaceuticals returned by STS-121 after14 days, STS - 117 after11 months and STS 122 after 19 months storage aboard ISS. Analysis of all flight samples along with ground-based matching controls was completed and results were compiled. Conclusion: Evaluation of results from the shuttle (1) and ISS increments (2) indicate that the number of formulations degraded in space increased with duration of storage in space and was higher in space compared to their ground-based counterparts. Rate of degradation for some of the formulations tested was faster in space than on Earth. Additionally, some of the formulations included in the medical kits were unstable, more so in space than on the ground. These results indicate that the space flight environment may adversely affect the shelf life of pharmaceuticals aboard space missions.
Du, Brian J.↗
Solar Energetic Particle Radiation Dosage Near a Simple Lunar Crater
The Moon has a harsh radiation environment that poses significant challenges to future science and exploration activities. Exposure hazards from space radiation are primarily due to galactic cosmic rays (GCRs) and solar energetic particles (SEPs) that are incident at the lunar surface from all directions. The Lunar Reconnaissance Orbiter’s (LRO) Cosmic Ray Telescope for Effects of Radiation (CRaTER) instrument has been observing space radiation around the Moon since 2009 [1].The CRaTER observations show as teady GCR flux with intermittent SEP events that have much higher fluxes. During solar minimum GCR shave a higher flux, while SEP events are less common. On the other hand, during solar maximum the SEP events have a higher rate, but the GCR flux is lower. This is due to variations in solar activity. GCR shave characteristic energies spanning from1 MeV to 10s of GeV[2]. SEPs, however, have much lower energy ranges of 50 keV to 100sof MeV. The level of exposure at a given location on the Moon is dependent on the amount of space radiation incident from above the local horizon(Figure 1). This means that radiation dosage depends on the surrounding terrain for any location on the surface, so it can vary substantially from point to point. Here we consider the radiation exposure around simple lunar craters that are representative of the types of landforms that will be encountered by future landed missions(e.g., the Artemis program)[3]. Of particular concern will be radiation exposure to biological targets, such as astronauts, and to critical electronic systems
P H Phipps↗
Galactic Cosmic Ray Proton Radiation Dosage Near a Simple Lunar Crater
The Moon has a harsh radiation environment that poses significant challenges to future science and exploration activities. Exposure hazards from space radiation are primarily due to galactic cosmic rays (GCRs) and solar energetic particles (SEPs) that are incident at the lunar surface from all directions. The Lunar Reconnaissance Orbiter’s (LRO) Cosmic Ray Telescope for Effects of Radiation (CRaTER)instrument has been observing space radiation around the Moon since 2009 [1].The CRaTER observations show a steady rate of GCR flux with intermittent SEP events that have much higher fluxes. During solar minimum the GCR have a higher flux rate while the SEP events are less common. On the other hand, during solar maximum the SEP events have a higher rate but the GCR flux is lower. This is due to variations in solar activity. GCR shave characteristic energies spanning from 1 MeV to 10s of GeV[2]. SEPs, however, have much lower energy ranges of 50 keV to 10 GeV. The level of exposure at a given location on the Moon is dependent on the amount of space radiation incident from above the local horizon(Figure 1). This means that, radiation dosage depends on the surrounding terrain for any location on the surface, so it can vary substantially from point to point. Here we consider the radiation exposure around simple lunar craters that are representative of the types of landforms that will be encountered by future landed missions(e.g., the Artemis program)[3]. Of particular concern will be radiation exposure to biological targets, such as astronauts, and to critical electronic systems.
P H Phipps↗
Paternal Imprinting of Dosage-Effect Defective1 (Ded1) Contributes to Seed Weight Xenia in Maize
Historically, xenia effects were hypothesized to be unique genetic contributions of pollen to seed phenotype, but most examples represent standard complementation of Mendelian traits. We identified the imprinted dosage-effect defective1 (ded1) locus in maize (Zea mays) as a paternal regulator of seed size and development. Hypomorphic alleles show a 5-10% seed weight reduction when ded1 is transmitted through the male, while homozygous mutants are defective with a 70-90% seed weight reduction. Ded1 encodes an R2R3-MYB transcription factor expressed specifically during early endosperm development with paternal allele bias. DED1 directly activates early endosperm genes and endosperm adjacent to scutellum cell layer genes, while directly repressing late grain-fill genes. These results demonstrate xenia as originally defined: Imprinting of Ded1 causes the paternal allele to set the pace of endosperm development thereby influencing grain set and size.
Genomics↗
Paternal Imprinting of Dosage-Effect Defective1 Contributes to Seed Weight Xenia in Maize4
Historically, xenia effects were hypothesized to be unique genetic contributions of pollen to seed phenotype, but most examples represent standard complementation of Mendelian traits. We identified the imprinted dosage-effect defective1 (ded1) locus in maize (Zea mays) as a paternal regulator of seed size and development. Hypomorphic alleles show a 5-10% seed weight reduction when ded1 is transmitted through the male, while homozygous mutants are defective with a 70-90% seed weight reduction. Ded1 encodes an R2R3-MYB transcription factor expressed specifically during early endosperm development with paternal allele bias. DED1 directly activates early endosperm genes and endosperm adjacent to scutellum cell layer genes, while directly repressing late grain-fill genes. These results demonstrate xenia as originally defined: Imprinting of Ded1 causes the paternal allele to set the pace of endosperm development thereby influencing grain set and size.
Genomics↗
Dosage unit uniformity and dissolution testing of extended-release pharmaceutical products marketed in the U.S.
Not Available
60 APPLIED LIFE SCIENCES↗
Scaleup of immediate release oral solid dosage forms
No abstract available
NASA Discipline Regulatory Physiology↗
Enabling energy‐efficient manufacturing of pharmaceutical solid oral dosage forms via integrated techno‐economic analysis and advanced process modeling
Abstract The global pharmaceutical industry is a trillion‐dollar market. However, the pharmaceutical sector often lags in manufacturing innovation and automation which limits its potential to maximize energy efficiency. The integration of techno‐economic analysis (TEA) with advanced process models as part of an overarching smart manufacturing platform, can help industries create business models, which can be adapted for manufacturing to reduce energy consumption and operating costs while ensuring product quality which can further enable a more sustainable process operation. In this study, a rational design of experiment on three unit‐operations (wet granulation, drying, and milling) was performed on a batch (case 1) and continuous (case 2) pharmaceutical process to obtain experimental data. Process models for predicting product quality and energy efficiency of each of the three‐unit operations were developed. The experimental data were used to validate the models and good agreement was observed. The energy consumption of each unit operation was calculated using statistical models relating the power consumption and the process parameters. The developed process models and energy models were further integrated into a TEA framework, which quantified the energy and monetary cost of manufacturing for both batch and continuous manufacturing cases. With this integrated framework, energy costs savings of ~33% was obtained in the continuous manufacturing process (case 2) over the batch process (case 1).
Sampat, Chaitanya↗
Two Photon lithography additive manufacturing: Video dataset of parameter sweep of light dosages, photo-curable resins, and structures
Not Available
97 MATHEMATICS AND COMPUTING↗
Coadministration of a Clinically Relevant Dexamethasone Dosage With Ablative Radiation Therapy Reduces Peripheral Lymphocytes But Does Not Alter In Vivo Intratumoral Lymphocyte Phenotype or Inhibit Efficacy of Radiation Therapy in a Murine Colorectal Tumor Model
Dexamethasone is commonly given during radiation therapy (RT) to manage toxicities. Our study examines if dexamethasone coadministration with RT inhibits the RT-induced antitumor T cell response in mouse.
62 RADIOLOGY AND NUCLEAR MEDICINE↗