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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 37 records · Page 2
All sourcesNASA NTRSDOE OSTI
DOE OSTI2024

Bioactivity Profiling of Chemical Mixtures for Hazard Characterization

Abstract The assessment and regulation of chemical toxicity to protect human health and the environment are done one chemical at a time and seldom at environmentally relevant concentrations. However, chemicals are found in the environment as mixtures, and their toxicity is largely unknown. Understanding the hazard posed by chemicals within the mixture is critical to enforce protective measures. Here, we demonstrate the application of bioactivity profiling of environmental water samples using the sentinel and ecotoxicology model species Daphnia to reveal the biomolecular response induced by exposure to real-world mixtures. We exposed a Daphnia strain to 30 sampled waters of the Chaobai River and measured the gene expression response profiles. Using a multiblock correlation analysis, we establish correlations between chemical mixtures identified in 30 water samples with gene expression patterns induced by these chemical mixtures. We identified 80 metabolic pathways putatively activated by mixtures of inorganic ions, heavy metals, polycyclic aromatic hydrocarbons, industrial chemicals, and a set of biocides, pesticides, and pharmacologically active substances. Our data-driven approach discovered both known bioactivity signatures with previously described modes of action and new pathways linked to undiscovered potential hazards. This study demonstrates the feasibility of reducing the complexity of real-world mixture toxicity to characterize the biomolecular effects of a defined number of chemical components based on gene expression monitoring of the sentinel species Daphnia.

Engineering↗
NASA NTRS2009

Use of NASA Satellite Data in Aiding Mississippi Barrier Island Restoration Projects

This presentation discusses a NASA Stennis Space Center project in which NASA-supported satellite and aerial data is being used to aid state and federal agencies in restoring the Mississippi barrier islands. Led by the Applied Science and Technology Project Office (ASTPO), this project will produce geospatial information products from multiple NASA-supported data sources, including Landsat, ASTER, and MODIS satellite data as well as ATLAS multispectral, CAMS multispectral, AVIRIS hyperspectral, EAARL, and other aerial data. Project objectives include the development and testing of a regional sediment transport model and the monitoring of barrier island restoration efforts through remote sensing. Barrier islands provide invaluable benefits to the State of Mississippi, including buffering the mainland from storm surge impacts, providing habitats for valuable wildlife and fisheries habitat, offering accessible recreational opportunities, and preserving natural environments for educating the public about coastal ecosystems and cultural resources. Unfortunately, these highly valued natural areas are prone to damage from hurricanes. For example, Hurricane Camille in 1969 split Ship Island into East and West Ship Island. Hurricane Georges in 1998 caused additional land loss for the two Ship Islands. More recently, Hurricanes Ivan, Katrina, Rita, Gustav, and Ike impacted the Mississippi barrier islands. In particular, Hurricane Katrina caused major damage to island vegetation and landforms, killing island forest overstories, overwashing entire islands, and causing widespread erosion. In response, multiple state and federal agencies are working to restore damaged components of these barrier islands. Much of this work is being implemented through federally funded Coastal Impact Assessment and Mississippi Coastal Improvement programs. One restoration component involves the reestablishment of the island footprints to that in 1969. Our project will employ NASA remote sensing data and products to support these federally funded efforts on multiple fronts. Landsat and ASTER data is being analyzed to assess changes in barrier island land cover over the last 35 years. ASTER, SRTM, and EAARL terrain products and other NASA airborne imagery are being applied in assessing changes in barrier island geomorphology and geospatial extent. MODIS data is being examined as a tool for sediment transport modeling by supplying geospatial data that quantifies in-water sediment concentrations. MODIS satellite data is being assessed for monitoring changes in the spatial extent of individual barrier islands. Results thus far indicate that NASA data products are useful in assessing barrier island conditions and changes. This value is enhanced with additional historical geospatial data, commercial high resolution satellite data, other non-NASA aerial imagery, and field survey data. The project s products are relevant to the Gulf of Mexico Alliance priority issues, including coastal habitat conservation, restoration and coastal community resilience. Such products will be available to state and federal agencies involved with coastal restoration. Potential end-users of these products include the National Park Service, U.S. Geological Survey, U.S. Army Corps of Engineers, Environmental Protection Agency, Mississippi Department of Environmental Quality, and Mississippi Department of Marine Resources.

Giardino, Marco↗