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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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All sourcesNASA NTRSDOE OSTI
DOE OSTI2020

Post Conference Activities for the NCSE 2019 Annual Conference: Sustainable Infrastructure & Resilience

The National Council for Science and the Environment (NCSE) held its 19th Annual Conference from January 7-10, 2019. The NCSE 2019 Annual Conference: Sustainable Infrastructure & Resilience explored how systems thinking that includes tools, data, and synthesis effectively supports the increasingly urgent need to advance a more resilient, sustainable society. Nearly 600 participants from a range of scientific disciplines and sectors including natural and social science, humanities, engineering, government, business, and civil society attended the conference. Post-conference activities planned through this project were planned to extend the impact of the Annual Conference and were made possible through support from the Department of Energy. These efforts included: 1) developing and producing a research pilot on Energy Systems and Resilient Infrastructure, which advances research focused on the better alignment of education and workforce needs with respect to energy resilience; 2) facilitating dialogue and in-person convenings with the Energy Education Community of Practice across the broader NCSE research community; and 3) designing and hosting a webinar series focused on the role of science in infrastructure and resilience. This report summarizes the outcomes of the proposed activities and additional work made possible by support from the Department of Energy.

54 ENVIRONMENTAL SCIENCES↗
DOE OSTI2024

Biomimicry in Clean Energy Futures: Workshop Report

On July 25, 2023, PNNL hosted a workshop to explore the potential for biomimicry – looking to nature and biology for solutions to human engineering challenges – to support clean energy futures and associated research. Participants represented a range of technical expertise ranging from ecological modeling to cyber-security. Workshop supporting material featured a literature review of biomimetic approaches in all renewable energy technologies and inspired from all kingdoms of life. Participants noted clear contrasts between natural design strategies and clean energy deployment and the electric grid. They also agreed that biomimicry offered a rich area of research potential but lacked definitive benefits or results in commercialization phases.

29 ENERGY PLANNING, POLICY, AND ECONOMY↗
DOE OSTI2025

Artificial Intelligence for (AI) Nuclear Security: Expert Perspectives on AI Priorities for the Office of International Nuclear Security

Artificial intelligence (AI) has the potential to transform nuclear security operations, offering opportunities to enhance effectiveness while simultaneously introducing new challenges. As AI technologies rapidly evolve, agencies across the United States Government (USG) are researching, implementing, and evaluating various AI models and systems. Given the broad capabilities and applications of these technologies, it is essential for each agency to identify and articulate those areas where it can make meaningful contributions aligned with its mission and expertise. To address this need for strategic focus, in late Fiscal Year 2025 (FY2025), the Office of International Nuclear Security (INS) established an AI Task Force (AITF) to gather input from subject matter experts (SMEs) regarding the most appropriate role INS could serve in researching, evaluating, or implementing AI for nuclear security. The AITF engaged 15 experts from national laboratories with backgrounds in cyber security, physical security, transport security, insider threat mitigation, nuclear engineering, human-systems engineering, and AI/ML development. This white paper summarizes the insights gathered from these SMEs and presents a potential roadmap for INS engagement with AI technologies. The recommendations outlined here are intended to inform INS leadership as they make strategic decisions about resource allocation and program direction in this rapidly evolving technological domain.

97 MATHEMATICS AND COMPUTING↗
DOE OSTI2023

Change Detection Applications in the Earth Sciences Using UAS-Based Sensing: A Review and Future Opportunities

Over the past decade, advancements in collection platforms such as unoccupied aerial systems (UAS), survey-grade GNSS, sensor packages, processing software, and spatial analytical tools have facilitated change detection analyses at an unprecedented resolution over broader spatial and temporal extents and in environments where such investigations present challenges. These technological improvements, coupled with the accessibility and versatility of UAS technology, have pushed the boundaries of spatial and temporal scales in geomorphic change detection. As a result, the cm-scale analysis of topographic signatures can detect and quantify surface anomalies during geomorphic evolution. This review focuses on the use of UAS photogrammetry for fine spatial (cm) and temporal (hours to days) scale geomorphic analyses, and it highlights analytical approaches to detect and quantify surface processes that were previously elusive. The review provides insight into topographic change characterization with precise spatial validations applied to landscape processes in various fields, such as the cryosphere and geosphere, as well as anthropogenic earth processes and national security applications. This work sheds light on previously unexplored aspects of both natural and human-engineered environments, demonstrating the potential of UAS observations in change detection. Our discussion examines the emerging horizons of UAS-based change detection, including machine learning and LIDAR systems. In addition, our meta-analysis of spatial and temporal UAS-based observations highlights the new fine-scale niche of UAS-photogrammetry. This scale advancement sets a new frontier in change detection, offering exciting possibilities for the future of land surface analysis and environmental monitoring in the field of Earth Science.

Andresen, Christian G.↗
DOE OSTI2020

Methods for delineating cellular regions and classifying regions of histopathology and microanatomy

Embodiments disclosed herein provide methods and systems for delineating cell nuclei and classifying regions of histopathology or microanatomy while remaining invariant to batch effects. These systems and methods can include providing a plurality of reference images of histology sections. A first set of basis functions can then be determined from the reference images. Then, the histopathology or microanatomy of the histology sections can be classified by reference to the first set of basis functions, or reference to human engineered features. A second set of basis functions can then be calculated for delineating cell nuclei from the reference images and delineating the nuclear regions of the histology sections based on the second set of basis functions.

59 BASIC BIOLOGICAL SCIENCES↗
DOE OSTI2024

Biomass Carbon Removal and Storage (BiCRS)

To achieve the ambitious net-zero emission goal by 2050, it is vital to explore practical approaches for removing carbon dioxide from the air. One promising method is Biomass Carbon Removal and Storage (BiCRS). BiCRS combines the natural ability of plants to convert carbon dioxide into biomass with human engineering to store the biomass, or derived products (char), belowground where it won't decompose. By securely storing these materials underground, we can trap the carbon dioxide absorbed by the plants during their growth, thus aiding in carbon removal from the atmosphere. BiCRS not only addresses carbon emissions but also has co-benefits such as wildfire risk reduction by utilizing forest residues. It is essential to establish best practices to ensure accurate measurements of net carbon dioxide removed by BiCRS for policymakers, businesses and communities. Presently, there is a lack of consistent methods for calculating these removals, considering variables like plant type, storage conditions, and conditions for converting the biomass to other products for storage like char. This project develops guidelines for monitoring and reporting BiCRS activities, offering a dependable framework for measuring carbon dioxide removal, enabling adoption of transparent BiCRS approaches for making significant contributions to reducing carbon dioxide levels in the atmosphere.

biomass carbon removal and storage↗
DOE OSTI2024

In vivo human T cell engineering with enveloped delivery vehicles

Viruses and virally derived particles have the intrinsic capacity to deliver molecules to cells, but the difficulty of readily altering cell-type selectivity has hindered their use for therapeutic delivery. Here, we show that cell surface marker recognition by antibody fragments displayed on membrane-derived particles encapsulating CRISPR–Cas9 protein and guide RNA can deliver genome editing tools to specific cells. Compared to conventional vectors like adeno-associated virus that rely on evolved capsid tropisms to deliver virally encoded cargo, these Cas9-packaging enveloped delivery vehicles (Cas9-EDVs) leverage predictable antibody–antigen interactions to transiently deliver genome editing machinery selectively to cells of interest. Antibody-targeted Cas9-EDVs preferentially confer genome editing in cognate target cells over bystander cells in mixed populations, both ex vivo and in vivo. By using multiplexed targeting molecules to direct delivery to human T cells, Cas9-EDVs enable the generation of genome-edited chimeric antigen receptor T cells in humanized mice, establishing a programmable delivery modality with the potential for widespread therapeutic utility.

42 ENGINEERING↗
DOE OSTI2025

Rancor-HUNTER: Using a Simulator Engine for Realistic Human Performance Modeling of Nuclear Power Operations

The Human Unimodel for Nuclear Technology to Enhance Reliability (HUNTER) is a software system to simulate human performance in support of human reliability analysis (HRA) in nuclear power plants. This paper summarizes recent work to integrate HUNTER with a plant simulator, namely the Rancor Microworld Simulator. Rancor is an offshoot of earlier work at Idaho National Laboratory (INL) to support plant modernization. The graphical software tools used to mimic digital human-system interface upgrades at INL’s Human Systems Simulation Laboratory were linked to the Rancor Microworld Simulator, an INL-developed simplified plant model. HUNTER becomes a “virtual operator” coupled to the Rancor simulator, thereby allowing a tight coupling between a digital human twin and a digital twin of the plant. Rancor-HUNTER may be run through Monte Carlo iterations across a dynamic range of performance shaping factors, thereby producing distributions of human performance in terms of procedure paths, errors instantiations, and task durations. This paper overviews the various unique features of Rancor-HUNTER and presents an example run of Rancor-HUNTER for a startup scenario.

99 - GENERAL AND MISCELLANEOUS↗
DOE OSTI2020

Human-System Interface Design Review Guidelines

The U.S. Nuclear Regulatory Commission (NRC) staff reviews the human factors engineering (HFE) aspects of nuclear power plants in accordance with the Standard Review Plan (NUREG-0800, Standard Review Plan for the Review of Safety Analysis Reports for Nuclear Power Plants: LWR Edition). The Human Factors Engineering Program Review Model (NUREG-0711, Revision 3, issued November 2012) contains detailed design review procedures. As part of the review process, the interfaces between plant personnel and the plant's systems and components are evaluated for conformance with HFE guidelines. This document, Human-System Interface Design Review Guidelines (NUREG-0700, Revision 3), provides the guidelines necessary to perform this evaluation. The review guidelines address the physical and functional characteristics of human-system interfaces (HSIs). Because these guidelines only address the HFE aspects of design and not other related considerations, such as instrumentation and control and structural design, they are referred to as HFE guidelines. In addition to the review of actual HSIs, the NRC staff can use the NUREG-0700 guidelines to evaluate a design-specific HFE guidelines document or style guide. The HFE guidelines are organized into four basic parts, which are divided into sections. Part I contains guidelines for the basic HSI elements: information displays, user-interface interaction and management, and analog displays and controls. These elements are used as building blocks to develop HSI systems to serve specific functions. Part II contains the guidelines for reviewing the following HSI systems: alarm system, safety parameter display system, group-view display system, soft control system, computer-based procedure system, automation system, and communication system. Part III provides guidelines for the review of workstations and workplaces. Part IV provides guidelines for the review of HSI support (i.e., maintainability of digital systems and degraded HSI and instrumentation and control conditions).

42 ENGINEERING↗
DOE OSTI2023

3D Modeling of Safety-Related Upgrade Pilot Project

Constellation Energy and the United States Department of Energy (DOE) have established a public/private partnership to implement a pilot digital upgrade to replace legacy analog, safety-related reactor protection and emergency safety feature actuation systems (RPS/ESFAS) with modern digital systems. This effort is occurring at Constellation’s Limerick Generating Station. This project is being performed in accordance with industry processes that have been adapted to better support digital upgrades. These processes include IP-ENG-001, Standard Design Process, NISP-EN-04, Standard Digital Engineering Process and Electric Power Research Institute Report 3002011816, Digital Engineering Guide. The Light Water Reactor Sustainability (LWRS) Program at the Idaho National Laboratory (INL) has been supporting this effort. Latest INL HFE efforts in support of this project have focused on definition and implementation of the Human Factors Engineering (HFE) Program in support of Constellation design and related licensing efforts. This paper will present the development of the HFE 3D modeling execution of the Main Control Room safety upgrades. New equipment and modifications are planned for upgrading the new safety systems. 3D modeling allows for visualization of the new equipment and modifications to be shared with engineering and design teams for evaluation and review. Anthropometric considerations such as sight lines and functional reach can be evaluated directly using the 3D model. This effort has helped to provide visualizations for additional review with operations personnel and project stakeholders.

3D Modeling↗
DOE OSTI2022

Demonstration and Evaluation of the Human-Technology Integration Function Allocation Methodology

There is an imminent need for the existing nuclear power plants to reduce their operating and maintenance (O&M) costs to remain economically viable. Digital technology, including automation, provides a significant opportunity for the existing nuclear power plant fleet to transform the way in which work is accomplished, reducing O&M costs, and allowing the fleet to remain economically competitive. One notable opportunity to significantly reduce O&M costs pertains to modifications to the plant equipment and main control room (MCR). Existing instrumentation and control (I&C) technologies in the MCR are highly analog, costly to operate and maintain, and demand a high cognitive and physical workload from plant staff (i.e., operators). Digitalizing the MCR has a range of broad economic benefits, including improved plant performance and reduced manual work. Further, digital I&C systems can fundamentally change the way in which plant staff operate the plant; this is the concept of operation. Human-technology integration is important to ensure that impacts to the concept of operation are done in a way that account for capabilities of people and technology. Human-technology integration employs human factors engineering (HFE) methods and principles to maximize the benefits of digital technology, reducing human error, improving overall decision-making and usability. The U.S. Department of Energy Light Water Reactor Sustainability Program is applying human-technology integration research to ensure digital technologies are safe, reliable, and efficient. This paper documents the demonstration of the human-technology guidance developed by the Light Water Reactor Sustainability Program from a first-of-a-kind digital I&C upgrade, specifically addressing function analysis and allocation for a new digital I&C system that included changes in automation levels. The program’s specific approach is included in this work, following lessons learned. This document serves as a resource for industry to follow in applying human-technology integration and HFE to digital modifications, specific to function analysis and allocation. The lessons learned should be considered in the planning and execution of HFE activities that support such digital modifications.

99 GENERAL AND MISCELLANEOUS↗
DOE OSTI2020

Data Collection and Analysis Challenges and Mitigation Strategies for Quantitative Human Factors Research Studies in Nuclear Power Plant Modernization

The United States (U.S.) Department of Energy (DOE) Light Water Reactor Sustainability (LWRS) program Plant Modernization Pathway is conducting targeted research and development (R&D) to address aging and reliability concerns with the legacy instrumentation and control and related information systems of the U.S. LWR fleet. In this effort, the application of human factors engineering (HFE) provides an important role in ensuring new digital plant technologies enable broad innovation and business improvement with continued operational safety. Evaluation is a key activity in HFE, which often occurs iteratively through the system design lifecycle. While qualitative methods are important in collecting information of how users perform tasks through observations, quantitative methods are equally important in assessing system design based on performance. In collecting and analyzing this quantitative data, there are notable challenges in the nuclear HFE domain that may threaten the validity and reliability of the inferences made in these studies. Notable challenges include small sample size and limited resources, large error variance and small effect size, an “adding test features to losing degrees of freedom” dilemma, non-normal distribution, and heterogeneity of variance. The results in control room usability studies are often statistically non-significant, which makes it hard to interpret. This work discusses these challenges across different scientific viewpoints and provides real-world examples of these challenges in practice. Collectively, the objective of this work is to position these challenges to the larger data science community as a means of identifying future opportunities to address these issues.

99 GENERAL AND MISCELLANEOUS↗
DOE OSTI2020

A Tool for Performing Link Analysis, Operational Sequence Analysis, and Workload Analysis to Support Nuclear Power Plant Control Room Modernization

Nuclear power continues to have an imperative role for the U.S.’s electricity generation. However, for these nuclear power plants (NPPs) to remain economically viable, new strategies for reducing operations and maintenance costs must be explored. The U.S. Department of Energy Light Water Reactor Sustainability Program is researching how to digitally transform existing analog and hybrid main control rooms into a fully integrated control room that addresses this challenge. The transformation will fundamentally change the conduct of operations for these U.S. NPPs. Human factors engineering has a vital role in this effort, where traditional task analysis methods are important in informing the design of advanced human-system interface displays. This work describes a preliminary tool to support task analysis for the development of these advanced displays. Details on the use of this tool, including the specific task analysis methods offered, are presented in this paper.

99 GENERAL AND MISCELLANEOUS↗
DOE OSTI2022

Demonstration and Evaluation of the Human-Technology Integration Guidance for Plant Modernization

The significance of nuclear power in its role producing carbon-free electricity to the U.S. cannot be overstated. However, with changes in the energy market coupled with changes in incentives given to certain resources like solar and wind, the operating and maintenance costs for these sources have seen a significant reduction, which has consequently negatively impacted the economic viability of the existing U.S. nuclear power plant fleet. Digital instrumentation and control (I&C) and control room modernization is a major critical work domain to reduce operating and maintenance costs. Existing nuclear power plants are commonly configured with mostly legacy analog I&C as well as isolated pockets of digital I&C (a plant process computer, digital recorders, etc.). One challenge with this analog I&C is that replacement parts are becoming prohibitively more expensive and difficult to obtain. Moreover, a significant challenge with the existing analog I&C is that the way in which plants are currently operated and maintained is no longer competitive with other electricity generating sources, like natural gas, where advanced digital I&C technologies are commonplace. This gap between the waynuclear power plants are operated compared to other electricity generating sources significantly challenges the economic viability of the nuclear industry. Indeed, digital I&C systems can fundamentally change the way the plant is operated (i.e., the concept of operation). The introduction of digital I&C technologies offers a wealth of benefits to the nuclear industry. However, it is important to emphasize that, to realize these benefits, a careful understanding of how to integrate technology in a collaborative way that leverages the capabilities of people and technologies is necessary. Human-technology integration applies human factors engineering methods and tools to ensure the safe and reliable use of these technologies while ensuring that the inherent features of the technologies that provide economic value are not missed. The scope of this work documents the demonstration of the recently developed human and technology integration methodology, as applied to developing a new vision and concept of operations for a major U.S. nuclear power plant fleet. This report focuses on the methodological aspects of developing a vision and concept of operations. This report shares the tools, activities, and lessons learned during a modernization currently underway for industry as a whole to consider when planning any significant digital modification and developing a new vision and concept of operations.

22 GENERAL STUDIES OF NUCLEAR REACTORS↗
DOE OSTI2021

Using Qualified On-Site Nuclear Power Plant Simulators in Human Factors Validations of Control Room Upgrades

Existing commercial nuclear power plants (NPPs) are valuable assets in the infrastructure portfolio of the United States (U.S.) because they safely and reliably generate about 1/5th of all the electricity used. The instrumentation and control (I&C) systems in commercial NPPs are the ‘eyes and ears' of the operator, allowing operators to maintain situation awareness, thereby allowing the plant to operate safely and efficiently for all phases of operation. Because the I&C systems in NPPs are still mostly based on analog technologies, which are reliable but not especially cost-effective, upgrading the existing I&C in com-mercial NPPs to new digital I&C is very important. Furthermore, simulators and simulation are critical human factors engineering tools for this I&C modernization work. NPP control room simulators are essential test beds to simulate normal, abnormal, and emergency operations that allow human factors researchers to safely and realistically evaluate early design phase prototypes of the upgraded digital I&C, and validate final as-built digital I&C systems that have been modernized deployed in NPPs. This paper describes research performed using qualified on-site NPP simulators to perform human factors validations of digital I&C control room upgrades.

99 GENERAL AND MISCELLANEOUS↗
DOE OSTI2020

Enzyme-mediated depletion of serum L -Met abrogates prostate cancer growth via multiple mechanisms without evidence of systemic toxicity

Extensive studies in prostate cancer and other malignancies have revealed that L -methionine ( L -Met) and its metabolites play a critical role in tumorigenesis. Preclinical and clinical studies have demonstrated that systemic restriction of serum L -Met, either via partial dietary restriction or with bacterial L -Met–degrading enzymes exerts potent antitumor effects. However, administration of bacterial L -Met–degrading enzymes has not proven practical for human therapy because of problems with immunogenicity. As the human genome does not encode L -Met–degrading enzymes, we engineered the human cystathionine-γ-lyase (hMGL-4.0) to catalyze the selective degradation of L -Met. At therapeutically relevant dosing, hMGL-4.0 reduces serum L -Met levels to >75% for >72 h and significantly inhibits the growth of multiple prostate cancer allografts/xenografts without weight loss or toxicity. We demonstrate that in vitro, hMGL-4.0 causes tumor cell death, associated with increased reactive oxygen species, S-adenosyl-methionine depletion, global hypomethylation, induction of autophagy, and robust poly(ADP-ribose) polymerase (PARP) cleavage indicative of DNA damage and apoptosis.

59 BASIC BIOLOGICAL SCIENCES↗
DOE OSTI2021

About the Complex Natural and Engineered Systems Pillar

Los Alamos National Laboratory is a world leader in applying multi-disciplinary science to complex systems within the Complex Natural and Engineered Systems (CNES) challenge areas. Our search for solutions requires science and technology innovation, as well as an integrated experiment, theory, and modeling and simulation approach. Our research and development spans from improving engineered systems such as nuclear weapons and the power grid, to understanding the interface of human and engineered systems from the subsurface to space, to studying how complex natural systems such as disease and climate impact humanity.

29 ENERGY PLANNING, POLICY, AND ECONOMY↗