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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 37 records · Page 2
All sourcesNASA NTRSDOE OSTI
NASA NTRS2001

Differential global gene expression in red and white skeletal muscle

The differences in gene expression among the fiber types of skeletal muscle have long fascinated scientists, but for the most part, previous experiments have only reported differences of one or two genes at a time. The evolving technology of global mRNA expression analysis was employed to determine the potential differential expression of approximately 3,000 mRNAs between the white quad (white muscle) and the red soleus muscle (mixed red muscle) of female ICR mice (30-35 g). Microarray analysis identified 49 mRNA sequences that were differentially expressed between white and mixed red skeletal muscle, including newly identified differential expressions between muscle types. For example, the current findings increase the number of known, differentially expressed mRNAs for transcription factors/coregulators by nine and signaling proteins by three. The expanding knowledge of the diversity of mRNA expression between white and mixed red muscle suggests that there could be quite a complex regulation of phenotype between muscles of different fiber types.

Non-NASA Center↗
NASA NTRS1999

Skeletal muscle myostatin mRNA expression is fiber-type specific and increases during hindlimb unloading

Transgenic mice lacking a functional myostatin (MSTN) gene demonstrate greater skeletal muscle mass resulting from muscle fiber hypertrophy and hyperplasia (McPherron, A. C., A. M. Lawler, and S. -J. Lee. Nature 387: 83-90, 1997). Therefore, we hypothesized that, in normal mice, MSTN may act as a negative regulator of muscle mass. Specifically, we hypothesized that the predominately slow (type I) soleus muscle, which demonstrates greater atrophy than the fast (type II) gastrocnemius-plantaris complex (Gast/PLT), would show more elevation in MSTN mRNA abundance during hindlimb unloading (HU). Surprisingly, MSTN mRNA was not detectable in weight-bearing or HU soleus muscle, which atrophied 42% by the 7th day of HU in female ICR mice. In contrast, MSTN mRNA was present in weight-bearing Gast/PLT muscle and was significantly elevated (67%) at 1 day but not at 3 or 7 days of HU. However, the Gast/PLT muscle had only atrophied 17% by the 7th day of HU. Because the soleus is composed only of type I and IIa fibers, whereas the Gast/PLT expresses type IId/x and IIb in addition to type I and IIa, it was necessary to perform a more careful analysis of the relationship between MSTN mRNA levels and myosin heavy-chain (MHC) isoform expression (as a marker of fiber type). A significant correlation (r = 0.725, P < 0. 0005) was noted between the percentage of MHC isoform IIb expression and MSTN mRNA abundance in several muscles of the mouse hindlimb. These results indicate that MSTN expression is not strongly associated with muscle atrophy induced by HU; however, it is strongly associated with MHC isoform IIb expression in normal muscle.

Non-NASA Center↗
NASA NTRS1999

Intracellular Ca2+ transients in mouse soleus muscle after hindlimb unloading and reloading

The objective of this study was to determine whether altered intracellular Ca(2+) handling contributes to the specific force loss in the soleus muscle after unloading and/or subsequent reloading of mouse hindlimbs. Three groups of female ICR mice were studied: 1) unloaded mice (n = 11) that were hindlimb suspended for 14 days, 2) reloaded mice (n = 10) that were returned to their cages for 1 day after 14 days of hindlimb suspension, and 3) control mice (n = 10) that had normal cage activity. Maximum isometric tetanic force (P(o)) was determined in the soleus muscle from the left hindlimb, and resting free cytosolic Ca(2+) concentration ([Ca(2+)](i)), tetanic [Ca(2+)](i), and 4-chloro-m-cresol-induced [Ca(2+)](i) were measured in the contralateral soleus muscle by confocal laser scanning microscopy. Unloading and reloading increased resting [Ca(2+)](i) above control by 36% and 24%, respectively. Although unloading reduced P(o) and specific force by 58% and 24%, respectively, compared with control mice, there was no difference in tetanic [Ca(2+)](i). P(o), specific force, and tetanic [Ca(2+)](i) were reduced by 58%, 23%, and 23%, respectively, in the reloaded animals compared with control mice; however, tetanic [Ca(2+)](i) was not different between unloaded and reloaded mice. These data indicate that although hindlimb suspension results in disturbed intracellular Ca(2+) homeostasis, changes in tetanic [Ca(2+)](i) do not contribute to force deficits. Compared with unloading, 24 h of physiological reloading in the mouse do not result in further changes in maximal strength or tetanic [Ca(2+)](i).

NASA Program Biomedical Research and Countermeasur↗
NASA NTRSDate not supplied

Extravehicular Activity on the Lunar Surface: Mapping Mitigation Risk Consequence for Crew Needing Assistance or Rescue

Extravehicular activity (EVA) on the lunar surface presents unique risks to crew with possibility for injury. Without appropriate assistance or rescue capability, inability to nominally ambulate and return to a lander, especially during early Artemis missions, could have catastrophic consequences. Mapping likelihood and consequence safety risk associated with identified injury scenarios establishes a baseline from which to assess potential mitigation solutions to ensure crew health and safety. Causes leading to the need for incapacitated crew rescue (ICR) during EVA on the lunar surface were previously identified and classified using an ICR/Acute Injury scenario spectrum. Severe scenarios are those when the affected astronaut requires either partial or full continuous assistance from the rescuer. Evaluation of these continual reliance conditions included calculating event probabilities (likelihoods) associated with an early Artemis mission and mapping them to established Exploration System Directorate (ESD) probability thresholds; safety consequences were analyzed and correlated to defined ESD personnel safety categories. These resulting likelihood and consequence values served as a baseline for assessing risk reduction of three mitigation capabilities: crew assistance (rescuer crew) only, walking assist devices, and a wheeled transport device. Of the twenty-five continual reliance conditions, ten were evaluated as “catastrophic” (Level 5, loss of life) during EVA on the lunar surface with probabilities ranging from moderate to very low during an early Artemis mission. Crew assistance only and walking assist devices showed similar potential for risk reduction, with four of the ten causes decreasing to Level 4. A wheeled transport device further increased risk reduction with six of the ten conditions decreasing to Level 4. Given the catastrophic consequence of several identified conditions, assessments should be performed to determine the feasibility of mitigation capabilities. It is currently unknown whether a rescuer astronaut could effectively provide continuous assistance to enable both crew to return safely to the lander from the standpoint of both suit geometry and human performance. Although resulting in an increase in resources, providing a wheeled transport provides the highest risk reduction potential, and walking assist devices may have prevention as well as mitigation benefits.

lunar surface↗
NASA NTRS1971

Alkyl substituent effects on gas-phase acidities - The influence of hybridization.

Exploration of the effect on acidity of alkyl groups bonded to trigonal and digonal carbon. Some results on the relative acidities of toluene and p-xylene, and acetylene and substitute acetylenes, as determined by ion cyclotron resonance (icr) spectroscopy, are described. Some limitations of the CNDO/2 calculation method are discussed.

Brauman, J. I.↗
NASA NTRS1977

Ion cyclotron resonance studies of some reactions of N/+/ ions

Product distributions and rate constants for the reactions of ground-state N(+) ions with CO, NO, CO2, and CH4 were measured. Rate constants were obtained using ion-cyclotron-resonance trapped-ion methods, and product distributions were obtained using a tandem (Dempster-ICR) mass spectrometer. Rapid nitrogen isotope exchange was also observed in N(+)-N2 collisions.

Anicich, V. G.↗
NASA NTRS1978

Reproducibility of toxicity test data as a function of mouse strain, animal lot, and operator

The toxicity screening test method developed at the University of San Francisco was evaluated for reproducibility. The variables addressed were strain of mouse, lot of animals, and operator. There was a significant difference in response between Swiss Webster mice and ICR mice, with the latter exhibiting greater resistance. These two strains of mice are not interchangeable in this procedure. Variation between individual animals was significant and unavoidable. In view of this variation, between-lot and between-operator variations appear to have no practical significance. The significant variation between individual animals stresses the need for average values based on at least four animals, and preferably values based on at least two experiments and eight animals. Efforts to compare materials should be based on the evaluation of relatively simple responses using substantial numbers of animals, rather than on elaborate evaluation of single animals

Hilado, C. J.↗
NASA NTRS1978

Reactions of OH/+/ and H2O/+/ ions with some diatomic and simple polyatomic molecules

The rate constants and product distributions of the reactions of OH(+) and H2O(+) with some diatomic and simple polyatomic molecules were studied by ion cyclotron resonance (ICR) mass spectrometric techniques. Reaction rates with CO, NO, O2, N2, CO2, H2S, N2O, H2CO, CH4 and CD4 were measured. Charge transfer and proton transfer were generally observed in cases for which the reaction channel is exothermic, but processes involving rearrangement were not found.

Karpas, Z.↗
NASA NTRS1992

The Use of Subcarriers in Future DSN Missions

The performance of deep space telemetry signals that employ a residual carrier modulation technique is compared in the presence and absence of a subcarrier. When the subcarrier is present, the performance for the resulting pulse-coded modulation/phase-shift keyed/phase-modulated (PCM/PSK/PM) scheme is evaluated for both sine wave and square wave subcarriers and non-return-to zero (NRZ) data. When the subcarrier is absent, the performance for the resulting PCM/PM technique is evaluated for both the NRZ and the bi-phase data format. The comparison is based on telemetry performance as well as bandwidth efficiency. The first criterion is characterized in terms of the symbol error rate (SER) as a function of symbol SNR, loop bandwidth-to-data rate ratio, and modulation index. The bandwidth efficiency is characterized by the occupancy factor. The results of both the analysis and measurements show that when the interference-to-carrier ratio (ICR) is less than -15 dB, the performance degradation in the absence of a subcarrier is negligible. Various combinations of loop bandwidth-to-data rate ratios and modulation indices that achieve this performance are derived and listed. Bandwidth occupancy comparison indicates that PCM/PM/NRZ is the most efficient in this regard. Therefore, by eliminating the subcarrier and using the PCM/PM/NRZ scheme, many advantages can be realized without any sacrifice in performance.

Shihabi, M. M.↗
NASA NTRS1994

A Comparison of Telemetry Signals in the Presence and Absence of a Subcarrier

The performance of deep-space telemetry signals that employ a residual carrier modulation technique is compared in the presence and absence of a subcarrier. When the subcarrier is present, the performance for the resulting pulse-coded modulation/phase-shift keyed/phase-modulated (PCM/PSK/PM) scheme is evaluated for both sine-wave and square-wave subcarriers and Non-Return-to Zero (NRZ) data. When the subcarrier is absent, the performance for the resulting PCM/PM technique is evaluated for both the NRZ and the bi-phase data format. The comparison is based on telemetry performance as well as bandwidth efficiency. The first criterion is characterized in terms of the Symbol Error Rate (SER) as a function of symbol SNR, loop bandwidth-to-data rate ratio, and modulation index. The bandwidth efficiency is characterized by the occupancy factor. The results of both the analysis and measurements show that when the Interference-to-Carrier Ratio (ICR) is less than -20 dB, the performance degradation in the absence of a subcarrier is negligible. Various combinations of loop bandwidth-to-data rate ratios and modulation indices that achieve this performance are derived and listed. Bandwidth occupancy comparison indicates that PCM/PM/NRZ is the most efficient in this regard. Therefore, by eliminating the subcarrier and using the PCM/PM/NRZ scheme, many advantages can be realized without any sacrifice in performance.

Shihabi, Mazen M.↗
NASA NTRS1998

Characterization of Plasma Discharges in a High-Field Magnetic Tandem Mirror

High density magnetized plasma discharges in open-ended geometries, like Tandem Mirrors, have a variety of space applications. Chief among them is the production of variable Specific Impulse (I(sub sp)) and variable thrust in a magnetic nozzle. Our research group is pursuing the experimental characterization of such discharges in our high-field facility located at the Advanced Space Propulsion Laboratory (ASPL). These studies focus on identifying plasma stability criteria as functions of density, temperature and magnetic field strength. Plasma heating is accomplished by both Electron and Ion Cyclotron Resonance (ECR and ICR) at frequencies of 2-3 Ghz and 1-30 Mhz respectively, for both Hydrogen and Helium. Electron density and temperature has measured by movable Langmuir probes. Macroscopic plasma stability is being investigated in ongoing research.

Chang-Diaz, Franklin R.↗
NASA NTRS2003

Potential Refinement of the ICRF

The analysis and data used for the ICRF represented the state of the art in global, extragalactic, X/S band microwave astrometry in 1995. The same general analysis method was used to extend the ICRF with subsequent VLBI data in a manner consistent with the original catalog. Since 1995 there have been considerable advances in the geodetic/astrometric VLBI data set and in the analysis that would significantly improve the systematic errors, stability, and density of the next realization of the ICRS when the decision is made to take this step. In particular, data acquired since 1990, including extensive use of the VLBA, are of higher quality and astrometric utility because of changes in instrumentation, schedule design, and networks as well as specifically astrometric intent. The IVS (International VLBI Service for Geodesy and Astrometry) continues to devote a portion of its observing capability to systematic extension of the astrometric data set. Sufficient data distribution exists to select a better set of defining sources. Improvements in troposphere modeling will minimize known systematic astrometric errors while accurate modeling and estimation of station effects from loading and nonlinear motions will permit the reintegration of the celestial reference frame, terrestrial reference frame and Earth orientation parameters though a single VLBI solution. The differences between the current ICRF and the potential next realization will be described.

Ma, Chopo↗
NASA NTRS2005

Intelligent Engine Systems Work Element 1.2: Malfunction and Operator Error Reduction

Jet engines, although highly reliable and safe, do experience malfunctions that cause flight delays, passenger stress, and in some cases, in conjunction with inappropriate crew response, contribute to airplane accidents. On rare occasions, the anomalous engine behavior is not recognized until it is too late for the pilots to do anything to prevent or mitigate the resulting engine malfunction causing in-flight shutdowns (IFSDs), aborted takeoffs (ATOs), or loss of thrust control (LOTC). In some cases, the crew response to a myriad of external stimuli and existing training procedures is the source of the problem mentioned above. The problem is the reduction of jet engine malfunctions (IFSDs, ATOs, and LOTC) and inappropriate crew response (PSM+ICR) through the use of evolving and advanced technologies. The solution is to develop the overall system health maintenance architecture, detection and accommodation technologies, processes, and enhanced crew interfaces that would enable a significant reduction in IFSDs, ATOs, and LOTC. This program defines requirements and proposes a preliminary design concept of an architecture that enables the realization of the solution.

Wiseman, Matthew↗
NASA NTRS1997

Using Non-Linear Statistical Methods with Laboratory Kinetic Data

This paper will demonstrate the usefulness of standard non-linear statistical analysis on ICR and SIFT kinetic data. The specific systems used in the demonstration are the isotopic and change transfer reactions in the system of H2O+/D2O, H30+/D2O, and other permutations.

non-linear analysis kinetic isotopic permutations ↗
NASA NTRS1996

Ion-Molecule Association in Acrylonitrile

The association reaction of the ions CH(sub 2)CHCN+ and CH(sub 2)CHCN have been examined using ion cyclotron resonance (ICR) and selected ion flow tube (SIFT) techniques at room temperature.

Ion- molecule acrylonitrile↗
NASA NTRS2000

Extending the ICRF into the Infrared: 2MASS - UCAC Astrometry

An external comparison between the infrared 2MASS and the optical UCAC positions was performed, both being on the same system, the ICRS. About 48 million sources in common were identified. Random errors of the 2MASS catalog positions are about 60 to 70 mas per coordinate for the Ks = 4 to 14 range, increasing to about 100 to 150 mas for saturated and very faint stars. Systematic position differences between the 2 catalogs are very small, about 5 to 10 mas as a function of magnitude and color, with somewhat larger errors as a function of right ascension and declination. The extension of the ICRF into the infrared has become a reality.

USNO CCD Astrograph Catalog (UCAC)↗