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Comparison of Multispectral Imaging and Traditional Fundoscopy in the Detection of Terrestrial Retinal and Optic Nerve Pathologies like those Encountered During and/or Immediately Following Long-Duration Spaceflight

INTRODUCTION: The purpose of this investigation was to evaluate if MultiColor Imaging (MCI) can replace color fundus photography (CFP) as a diagnostic screening tool during spaceflight. MCI significantly reduces crew time (approx. 115 minutes/session, 36 hours/year) by eliminating nominal on-orbit fundoscopy sessions, while also providing the option to capture a larger field of view (55 vs. 35). METHODS: A comprehensive PubMed literature search was conducted using the following key words: multicolor, multispectral, imaging, retina, choroid, optic nerve, optic disc, and papilledema. Publications were filtered based on optic nerve and chorioretinal pathologies matching those seen during or immediately after spaceflight: optic disc edema (ODE), cotton wool spots (CWS), retinal hemorrhage, pigment epithelial detachment (PED), and serous chorioretinopathy (SCR). In a separate effort, 44 multicolor images (30 abnormal) of terrestrial patients were graded and compared to corresponding color fundus images acquired at the Doheny Eye Centers and UCLA. RESULTS: The search identified 340 articles; 9 describing MCI in relevant pathologies, 6 comparing MCI to CFP. MCI is superior in detecting CWS (1 paper), PED (2 papers), retinal hemorrhages (2 papers), and choroidal folds (1 paper), and can better delineate extent or boundaries of subretinal fluid and identify areas of RPE damage in SCR (2 papers). On MCI, ODE was described as a hyperreflective ring with a green shift and indistinct disc margins, with equaldetectability as using CFP (3 papers). Grading at Doheny Eye Institute confirmed these findings. DISCUSSION: MCI can effectively detect all retinal and optic nerve findings detectable by CFP during and immediately post-spaceflight and represents a suitable replacement as an on-orbit diagnostic screening tool. Additionally, by eliminating the nominal on-orbit fundoscopy sessions, dozens of crew hours are spared per year by utilizing MCI.

Jorge Nagel↗

Vibrational spectra and structure of biphosphine and biphosphine-d4

Infrared and Raman spectra have been obtained for biphosphine and biphosphine-d4 in both solid and vapor phases. From the spectral data, it is concluded that only one conformer exists in both solid and fluid phases and that this is the gauche conformer. A normal-coordinate analysis has also been performed, in which the 24 vibrational frequencies of the two isotopes have been fitted by 10 force constants to an overall average error of 1.0%. The PED indicates that there is practically no mixing of the normal modes in the P2H4 molecule but the P-P stretch and the PD2 wagging modes are extensively mixed for the P2D4 molecule.

Odom, J. D.↗

Martian regolith geochemistry and sampling techniques

Laboratory study of samples of the intermediate and fine-grained regolith, including duricrust peds, is a fundamental prerequisite for understanding the types of physical and chemical weathering processes on Mars. The extraordinary importance of such samples is their relevance to understanding past changes in climate, availability (and possible physical state) of water, eolian forces, the thermal and chemical influences of volcanic and impact processes, and the inventory and fates of Martian volatiles. Fortunately, this regolith material appears to be ubiquitous over the Martian surface, and should be available at many different landing sites. Viking data has been interpreted to indicate a smectite-rich regolith material, implying extensive weathering involving aqueous activity and geochemical alteration. An all-igneous source of the Martian fines has also been proposed. The X-ray fluorescence measurement data set can now be fully explained in terms of a simple two-component model. The first component is silicate, having strong geochemical similarities with Shergottites, but not other SNC meteorites. The second component is salt. Variations in these components could produce silicate and salt-rich beds, the latter being of high potential importance for microenvironments in which liquid water (brines) could exist. It therefore would be desirable to scan the surface of the regolith for such prospects.

Clark, B. C.↗

Tracking performance with two breathing oxygen concentrations after high altitude rapid decompression

Current military aircraft Liquid Oxygen (LOX) systems supply 99.5 pct. gaseous Aviator's Breathing Oxygen (ABO) to aircrew. Newer Molecular Sieve Oxygen Generation Systems (MSOGS) supply breathing gas concentration of 93 to 95 pct. O2. The margin is compared of hypoxia protection afforded by ABO and MSOGS breathing gas after a 5 psi differential rapid decompression (RD) in a hypobaric research chamber. The barometric pressures equivalent to the altitudes of 46000, 52000, 56000, and 60000 ft were achieved from respective base altitudes in 1 to 1.5 s decompressions. During each exposure, subjects remained at the simulated peak altitude breathing either 100 or 94 pct. O2 with positive pressure for 60 s, followed by a rapid descent to 40000 ft. Subjects used the Tactical Life Support System (TLSS) for high altitude protection. Subcritical tracking task performance on the Performance Evaluation Device (PED) provided psychomotor test measures. Overall tracking task performance results showed no differences between the MSOGS breathing O2 concentration of 94 pct. and ABO. Significance RMS error differences were found between the ground level and base altitude trials compared to peak altitude trials. The high positive breathing pressures occurring at the peak altitudes explained the differences.

Nesthus, Thomas E.↗

Electronic collection system for spacelab mission timeline requirements

This paper describes the Functional Objective Requirements Collection System (FORCS) software tool that has been developed for use by Principal Investigators (PI's) and Payload Element Developers (PED's) on their own personal computers to develop on-orbit timelining requirements for their payloads. The FORCS tool can be used either in a totally stand-alone mode, storing the information in a local file on the user's personal computer hard disk or in a remote mode where the user's computer is linked to a host computer containing the integrated database of the timeline requirements for all of the payloads on a mission. There are a number of features incorporated in the FORCS software to assist the user. The user may move freely back and forth between the various forms for inputting the data. Several methods are used to input the information, depending on the type of the information. These methods range from filling in text boxes, using check boxes and radio buttons, to inputting information into a spreadsheet format. There are automated features provided to assist in developing the proper format for the data, ranging from limit checking on some of the parameters to automatic conversion of different formats of time data inputs to the one standard format used for the timeline scheduling software.

Lindberg, James P.↗

Investigation of Electromagnetic Field Threat to Fuel Tank Wiring of a Transport Aircraft

National Transportation Safety Board investigators have questioned whether an electrical discharge in the Fuel Quantity Indication System (FQIS) may have initiated the TWA-800 center wing tank explosion. Because the FQIS was designed to be incapable of producing such a discharge on its own, attention has been directed to mechanisms of outside electromagnetic influence. To support the investigation, the NASA Langley Research Center was tasked to study the potential for radiated electromagnetic fields from external radio frequency (RF) transmitters and passenger carried portable electronic devices (PEDs) to excite the FQIS enough to cause arcing, sparking or excessive heating within the fuel tank.

Ely, Jay J.↗

Ultrawideband Electromagnetic Interference to Aircraft Radios: Results of Limited Functional Testing With United Airlines and Eagles Wings Incorporated, in Victorville, California

On February 14, 2002, the FCC adopted a FIRST REPORT AND ORDER, released it on April 22, 2002, and on May 16, 2002 published in the Federal Register a Final Rule, permitting marketing and operation of new products incorporating UWB technology. Wireless product developers are working to rapidly bring this versatile, powerful and expectedly inexpensive technology into numerous consumer wireless devices. Past studies addressing the potential for passenger-carried portable electronic devices (PEDs) to interfere with aircraft electronic systems suggest that UWB transmitters may pose a significant threat to aircraft communication and navigation radio receivers. NASA, United Airlines and Eagles Wings Incorporated have performed preliminary testing that clearly shows the potential for handheld UWB transmitters to cause cockpit failure indications for the air traffic control radio beacon system (ATCRBS), blanking of aircraft on the traffic alert and collision avoidance system (TCAS) displays, and cause erratic motion and failure of instrument landing system (ILS) localizer and glideslope pointers on the pilot horizontal situation and attitude director displays. This report provides details of the preliminary testing and recommends further assessment of aircraft systems for susceptibility to UWB electromagnetic interference.

Ely, Jay J.↗

Ultrawideband Electromagnetic Interference to Aircraft Radios

A very recent FCC Final Rule now permits marketing and operation of new products that incorporate Ultrawideband (UWB) technology into handheld devices. Wireless product developers are working to rapidly bring this versatile, powerful and expectedly inexpensive technology into numerous consumer wireless devices. Past studies addressing the potential for passenger-carried portable electronic devices (PEDs) to interfere with aircraft electronic systems suggest that UWB transmitters may pose a significant threat to aircraft communication and navigation radio receivers. NASA, United Airlines and Eagles Wings Incorporated have performed preliminary testing that clearly shows the potential for handheld UWB transmitters to cause cockpit failure indications for the air traffic control radio beacon system (ATCRBS), blanking of aircraft on the traffic alert and collision avoidance system (TCAS) displays, and cause erratic motion and failure of instrument landing system (ILS) localizer and glideslope pointers on the pilot horizontal situation and attitude director displays. This paper provides details of the preliminary testing and recommends further assessment of aircraft systems for susceptibility to UWB electromagnetic interference.

Ely, Jay J.↗

Rotor Flapping Response to Active Control

Rotor active control using higher harmonic blade pitch has been proposed as a means to reduce both rotor radiated noise and airframe vibration and to enhance rotor performance. The higher harmonic input, however, can affect rotor thrust and cyclic flapping - the basic trim characteristics of the rotor. Some of the trim changes can negate the active control benefits. For example, wind tunnel test results of a full scale BO-105 rotor with individual-blade control indicate some rotor performance improvements, accompanied with changes in rotor trim, using two-per-rev blade pitch input. The observed performance benefits could therefore be a simple manifestation of the trim change rather than an efficient redistribution of the rotor airloads. More recently, the flight test of the BO-105 helicopter equip,ped with individual-blade-control actuators also reported trim changes whenever the two-per-rev blade pitch for noise reduction was activated. The pilot had to adjust the trim control to maintain the aircraft under a constant flight path. These two cases highlight the, importance of trim considerations in the application of active control to rotorcraft.

Nguyen, Khanh↗

An Investigation of EME as a Potential Cause of Fuel Tank Ignition

NASA researchers were tasked to study the potential for radio signals to excite an aircraft fuel quantity indication system (FQIS) enough to cause arcing, sparking or excessive heating within a fuel tank. Computational techniques were used to determine the threat from external high intensity radiated field (HIRF) transmitters nearby, like shipboard and airborne RADAR systems. Experimental methods were used to determine the threat from Portable Electronic Devices (PEDs) carried aboard by passengers. To support this work, unique electromagnetic coupling measurements were performed on a retired Boeing 747 aircraft, and new test and analysis methods were developed that may be applied to other FQIS designs as well as other aircraft electronic systems.

Ely, Jay J.↗

UWB EMI To Aircraft Radios: Field Evaluation on Operational Commercial Transport Airplanes

Ultrawideband (UWB) transmitters may soon be integrated into a wide variety of portable electronic devices (PEDs) that passengers routinely carry on board commercial airplanes. Airlines and the FAA will have difficulty controlling passenger use of UWB transmitters during flights with current airline policies and existing wireless product standards. The aeronautical community is concerned as to whether evolving FCC UWB rules are adequate to protect legacy and emerging aeronautical radio systems from electromagnetic interference (EMI) from emerging UWB products. To address these concerns, the NASA Office of Space Communications and Chief Spectrum Managers assembled a multidisciplinary team from NASA LaRC, NASA JPL, NASA ARC, FAA, United Airlines, Sky West Airlines, and Eagles Wings Inc. to carry out a comprehensive series of tests aimed at determining the nature and extent of any EMI to aeronautical communication and navigation systems from UWB devices meeting FCCapproved and proposed levels for unlicensed handheld transmitters.

Oria, A. J.↗

An Operational Safety and Certification Assessment of a TASAR EFB Application

This paper presents an overview of a Traffic Aware Strategic Aircrew Requests (TASAR) Electronic Flight Bag application intended to inform the pilot of trajectory improvement opportunities while en route that result in operational benefits. The results of safety analyses and a detailed review of Federal Aviation Administration (FAA) regulatory documents that establish certification and operational approval requirements are presented for TASAR. The safety analyses indicate that TASAR has a likely Failure Effects Classification of “No Effect,” and at most, is no worse than “Minor Effect.” Based on this safety assessment and the detailed review of FAA regulatory documents that determine certification and operational approval requirements, this study concludes that TASAR can be implemented in the flight deck as a Type B software application hosted on a Class 2 Portable Electronic Device (PED) Electronic Flight Bag (EFB). This implementation approach would provide a relatively low-cost path to certification and operational approval for both retrofit and forward fit implementation, while at the same time facilitating the business case for early ADS-B IN equipage. A preliminary review by FAA certification and operational approvers of the analyses presented here confirmed that the conclusions are appropriate and that TASAR will be considered a Type B application.

Koczo, Stefan↗

Caribbean Oceans: Utilizing NASA Earth Observations to Detect, Monitor, and Respond to Unprecedented Levels of Sargassum in the Caribbean Sea

In 2011 and 2015, the nations of the Caribbean Sea were overwhelmed by the unprecedented quantity of Sargassum that washed ashore. This issue prompted international discussion to better understand the origins, distribution, and movement of Sargassum, a free-floating brown macro alga with ecological, environmental, and commercial importance. In the open ocean, Sargassum mats serve a vital ecological function. However, when large quantities appear onshore without warning, Sargassum threatens local tourist industries and nearshore ecosystems within the Caribbean. As part of the international response, this project investigated the proliferation of this macro alga within the Caribbean Sea from 2003-2015, and used NASA Earth observations to detect and model Sargassum growth across the region. The Caribbean Oceans team calculated the Floating Algal Index (FAI) using Terra Moderate Resolution Imaging Spectroradiometer (MODIS) data, and compared the FAI to various oceanic variables to determine the ideal pelagic environment for Sargassum growth. The project also examined the annual spread of Sargassum throughout the region by using Earth Trends Modeler (ETM) in Clark Labs' TerrSet software. As part of the international effort to better understand the life cycle of Sargassum in the Caribbean, the results of this project will help local economies promote sustainable management practices in the region.

Ped, Jordan↗