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Risk of Impaired Performance Due to Reduced Muscle Mass, Strength &, Endurance (Short Title: Muscle) and Risk of Reduced Physical Performance Capabilities Due to Reduced Aerobic Capacity (Short Title: Aerobic)

This report reviews the scientific literature regarding the human system risks to the microgravity environment of space flight in relation to human performance. The primary human performance-related risks involve deconditioning of the cardiovascular and skeletal muscles systems due to prolonged exposure to the reduced gravitational input. The chronological history of U.S. space flight is reviewed as a starting point to inform and understand the gaps in the knowledge to these risks. Maintenance of physical performance capabilities involves understanding the health of many organ systems (peripheral [vascular, heart, blood volume, skeletal muscle] and central [brain]) that ultimately contribute to the submaximal and maximal capacity of the aerobic (VO2peak), skeletal muscle (strength and endurance) systems. Maintaining astronaut VO2peak, muscle mass, strength, and endurance before, during, and after space flight is a significant priority to NASA for the current International Space Station (ISS) era, as well as for future exploration missions. A growing research database from both space flight and ground-based analog studies finds that the cardiorespiratory system is compromised and skeletal muscles (predominantly postural muscles of the lower limbs) undergo atrophy. These structural and metabolic responses to living in microgravity conditions contribute to physiological deconditioning during space flight that potentially increase the risks to astronauts returning to surface operations (i.e., Moon, Mars, or Earth). The time course changes from short to long-duration space flight and the relationships between in-flight performance deconditioning levels are not well characterized. Moreover, there are large interindividual variabilities that may be dependent on genetics, age, sex, preflight fitness levels, and individual exercise prescriptions that need further careful evaluations. Efforts should be made to understand the current status of preflight, in-flight, and postflight exercise performance capability and to define the operational goals and target areas for protection with the in-flight exercise program. There is a bi-directional relationship between exercise prescription and hardware countermeasures that need further understanding in-flight. For example, hardware with limited capabilities/modalities may be counterbalanced by changes in exercise prescription (i.e., frequency, time, intensity, volume) for providing effective responses to maintain fitness. Importantly, the minimal requirements for exercise prescription on ISS hardware may not translate to lower capability hardware on exploration missions. Due to limited volume on exploration vehicles, future Artemis missions to the Lunar surface will not have similar exercise hardware capabilities as ISS. This may alter the effectiveness of hardware to provide adequate physiological stress on bodily systems allowing for adaptations to maintain aerobic capacity, strength, and bone density. Thus, it will be important to understand the exercise responses of current ISS countermeasures to develop individualized exercise prescriptions that minimize aerobic and muscular risks, accounting for the large variability of responses among crewmembers. Newer exploration exercise hardware is currently being evaluated that is more compact (i.e., E4D and Orion Flywheel) and will require careful evaluation of the hardware on the stressor (i.e., metabolic rate, oxygen uptake, and heart rate work relationships, and force plate load profiles) needed the human body to protect and maintain crew health and performance. Moreover, exercise responses on the hardware need careful evaluation on the chronic adaptations. Lastly, in-flight evaluation of hardware exercise response may differ in 0-g or partial-g compared to 1-g. Therefore, it cannot be assumed that the stress on the body will be the same in each environment. Understanding this has a direct impact on exercise prescriptions. This document provides an overview of key scientific investigations that have been conducted before, during, and after human space flight missions, as well as from human ground-based analog studies that contribute to the evidence base on changes in aerobic capacity and muscle mass, strength, and endurance. Additional data from rodent and nonhuman primate experiments of skeletal muscle unloading completed during space flight or ground-based flight-simulations provide supportive information about this risk topic. Most importantly, a recent, large dataset from long-duration ISS crew has been added to give improved insight into the variability of exercise response of crew, demonstrating that a large portion of the crew population return to Earth with greater than 10-20% loss of aerobic capacity and muscle strength and endurance. Data from human space flight and ground-based studies are narrowing in on the required exercise paradigms but thus far still provide an incomplete answer to an effective approach for maintaining skeletal muscle function and aerobic fitness of all human space travelers. Finally, the relationship of this risk topic to various space flight operational scenarios is examined and discussed.

Eric Rivas

The Future of Integrated Performance Modeling in the Crew Health and Performance – Probabilistic Risk Assessment Project

The NASA engineering community utilizes event-driven and fault-tree probabilistic techniques to classify risks in the space environment by taking advantage of the inherent knowledge of complex spaceflight system design and testing to quantify failure risk. In harmonizing the risk of human space flight, answering the question of ‘How do we balance health, performance and resource risks with other engineering risks on long duration space missions?’ remains a deeply challenging and largely qualitative practice. The Human Research Program’s Medical Extensible Dynamic Probabilistic Risk Assessment Tool (MEDPRAT) was a significant step forward in efforts to robustly quantify the risk to crew health for exploration missions. However, there remains a significant gap in the ability to comprehensively assess and characterize risk across the disparate functionalities and capabilities which comprise the Crew Health and Performance (CHP) system. The Crew Health and Performance – Probabilistic Risk Assessment (CHP-PRA) project seeks to characterize CHP risks by expanding beyond the foundation established by its PRA predecessors like IMM and MEDPRAT, that simulate medical risk metrics like loss of crew life and evacuations. One of the new risk measures in the CHP-PRA system is embodied in our Performance Risk Model (PRisM). PRisM provides a novel way of assessing crew performance on mission tasks, using a generalized framework which relates back to NASA-STD-3001. This approach allows PRisM to capture and integrate data from a variety of different domains into a single, unified, reproducible representation of astronaut performance. In this presentation, we discuss the motivation for the CHP-PRA work and give a high level overview of the goals of the project, outline the forward work for PRisM, and discuss collaboration opportunities for the community who might explore if their domain knowledge and data could be represented, integrated, and quantified with these tools, whose outcomes are metrics useful for supporting operational mission planning and decision making.

Lauren McIntyre

Measurement-based performance evaluation technique for high-performance computers

A measurement-based performance evaluation technique has been used to characterize the OS performance of Cedar, a hierarchical shared-memory multiprocessor system. Thirteen OS performance meters were used to capture the operating system activities for compute-bound workloads. Three representative applications from the Perfect Benchmark Suite were used to measure the OS performance in a dedicated system and in multiprogrammed workloads. It was found that 13-23 percent of the total execution time on a dedicated system was spent in executing OS-related activities. Under multiprogramming, 12-14 percent of the total execution time was used by the OS. The impact of multiprogramming on the operating system performance meters was also measured.

Sharma, S.

Preliminary Results of Altitude-Wind-Tunnel Investigation of X24C-4B Turbojet Engine. II - Engine Performance: Engine Performance - II

An investigation was conducted in the NACA Cleveland altitude wind tunnel to evaluate the performance characteristics of the X24C-4B turbojet engine over a range of simulated altitudes from 5000 to 45,000 feet,simulated flight Mach numbers from 0 to 1.08, and engine speeds from 4000 to 12,500 rpm. Performance data are presented to show graphically the effects of altitude at a flight Mach number of 0.25 and of flight Mach number at an altitude of 25,000 feet. The performance data are generalized to show the applicability of methods used to determine performance at any altitude from data obtained at a given altitude. A complete tabulation of performance data, as well as lubrication- and fuel- system data, is presented.

Meyer, Carl L.

Effect of Various Blade Modifications in Performance of a 16-Stage Axial-flow Compressor. IV - Effect on Over-all Performance Characteristics of Decreasing Twelfth through Fifteenth Stage Stator-blade Angles 3 deg and Increasing Stator Angles in the Inlet Stages

The performance of a 16-stage axial-flow compressor, in which two modifications of unloaded inlet stages were combined with loaded exit stages, has been determined. In the first modification the exit stages were loaded by decreasing the twelfth through fifteenth stage stator angles 3 deg. as compared with the blade angles in the original compressor, and the inlet stages were unloaded by increasing the blade angles the following amounts: guide vanes and first-stage stator, 6 deg; second- and third-stage stators, 4 deg.; and fourth-stage stators, 3 deg. The over-all performance of this configuration was compared with that of the compressor with the original blade angles. The peak efficiency was increased at all speeds below design and the weight flow was higher at speeds below 80 percent of design, the same at 80 percent of design, and lower at speeds abovce 80 percent of design. The maximum reduction in weight flow occurred at design speed. The surge limit line was higher at speeds between 75 and 90 percent of design when presented on a pressure ratio against weight flow basis. The second configuration was the same as the first with the exception that the second-, third-, and fourth-stage stator blade angles were the same as in the compressor with the original blade angles. A comparison of the performance of this configuration with that of the compressor with the original blade angles showed the same general trends of changes in performance as the first configuration. Comparisons were made of compressor configurations to show the effects upon the performance of decreased loading in the inlet stages. Below 75 percent of design speed, decreased loading results in increased weight flow and peak efficiency; above 80 percent of design speed, decreased loading in the inlet stages results in decreased weight flow and small changes in peak efficiencies. Between 75 and 90 percent of design the changes in surge weight flow and pressure ratio were such that the surge limit line was raised with decreased loading in the inlet stages when presented as pressure ratio against weight flow.

Hatch, James E.

Effects on Task Performance and Psychophysiological Measures of Performance During Normobaric Hypoxia Exposure

Human-autonomous systems have the potential to mitigate pilot cognitive impairment and improve aviation safety. A research team at NASA Langley conducted an experiment to study the impact of mild normobaric hypoxia induction on aircraft pilot performance and psychophysiological state. A within-subjects design involved non-hypoxic and hypoxic exposures while performing three 10-minute tasks. Results indicated the effect of 15,000 feet simulated altitude did not induce significant performance decrement but did produce increase in perceived workload. Analyses of psychophysiological responses evince the potential of biomarkers for hypoxia onset. This study represents on-going work at NASA intending to add to the current knowledge of psychophysiologically-based input to automation to increase aviation safety. Analyses involving coupling across physiological systems and wavelet transforms of cortical activity revealed patterns that can discern between the simulated altitude conditions. Specifically, multivariate entropy of ECG/Respiration components were found to be significant predictors (p< 0.02) of hypoxia. Furthermore, in EEG, there was a significant decrease in mid-level beta (15.19-18.37Hz) during the hypoxic condition in thirteen of sixteen sites across the scalp. Task performance was not appreciably impacted by the effect of 15,000 feet simulated altitude. Analyses of psychophysiological responses evince the potential of biomarkers for mild hypoxia onset.The potential for identifying shifts in underlying cortical and physiological systems could serve as a means to identify the onset of deteriorated cognitive state. Enabling such assessment in future flightdecks could permit increasingly autonomous systems-supported operations. Augmenting human operator through assessment of cognitive impairment has the potential to further improve operator performance and mitigate human error in safety critical contexts. This study represents ongoing work at NASA intending to add to the current knowledge of psychophysiologically-based input to automation to increase aviation safety.

Stephens, Chad

Mars 2020 Surface Mission Performance Modeling: Part 3. Mission Performance Modeling Approach and Results

We have developed a comprehensive model of the Mars 2020 rover surface mission used to identify and evaluate mission productivity and operability challenges and opportunities. The surface mission performance model combines many aspects of rover design, operations approach, system behaviors, and mission constraints into an integrated model of surface mission performance. The surface mission model applies monte-carlo methodologies in order to investigate the key sources of mission performance variability and their effects with respect to overall mission performance. Our modeling efforts aims to investigate and inform engineering design and development efforts, as well as the landing site selection process led by the Mars science community. We believe that an integrated mission performance model such as this is important to aligning engineering and science efforts across the project.

Ono, Masahiro

NASA HECC Geometry and Performance Review Part 2: Geometric Differences Between the As-Manufactured and Design-Intent Impeller Geometry and their Effects on the Vaneless Diffuser Configuration Performance

An investigation of the NASA High Efficiency Centrifugal Compressor (HECC) vaneless diffuser configuration was performed. This multipart investigation focused on validating the computational model against experimental data. The validated model was then used to explore the effects of observed geometric differences between the As-Manufactured and Design-Intent impellers. Lastly, the validated model was used for comparison against an experimental tip clearance study. Part II of the investigation of the NASA HECC vaneless diffuser configuration focused on understanding the differences in geometry and performance between the As-Manufactured impeller and the Design-Intent impeller. This was achieved through comparison of the As-Manufactured HECC vaneless computational model, developed from the solid model of the impeller and validated in Part I, against a new model developed from the Design-Intent blade sections published in NASA/CR-2014-218114/Rev1. The 1D performance values showed that the As-Manufactured impeller underperformed compared to the Design-Intent for all four speedlines that were simulated. Further investigation of profiles, loading and contours showed consistent underperformance of the As-Manufactured relative to the Design-Intent. An investigation into the source of the performance differences led to the discovery of several significant variations in the impeller geometries. The differences that were observed can be summarized into four categories: fillets, trailing-edge exit radii variation, dissimilarity in the splitter leading-edge geometry and main blade thickness differences. The investigation then shifted its effort to quantify the performance effects caused by geometric differences. The investigation showed that out of the four geometric differences that were explored, the differences in the splitter blade had the largest impact. These differences most notably changed flow physics near the splitter leading edge, especially near the tip of the impeller.

centrifugal compressor

Utilizing Gaps and Key Performance Parameters to Inform NASA Environmental Control and Life Support and Human Health and Performance Capability Technology Decisions

Human spaceflight is a complex endeavor requiring a multitude of capabilities for transportation, crew health, scientific goals, and safe return to Earth. The difference between spaceflight proven capabilities and those needed for a particular mission is defined as a capability gap. Capability gaps are not technology specific. Each capability gap is approachable with a wide array of technologies that have unique benefits and challenges. Determining what a capability’s relevant and distinguishing key performance parameters (KPPs) are for a mission is critical. Mass, power, and volume are always constrained and important, but defining these in a way normalized by performance is challenging. Additionally, KPP definition for reliability, dormancy, and integration needs are very important and still evolving. This paper provides the approach of the Environmental Control and Life Support – Crew Health and Performance (ECLSS-CHP) System Capability Leadership Team (SCLT) to defining gaps and KPPs in support of the NASA’s Capabilities Integration Team data call objectives. The nine ECLSS-CHP capability areas are decomposed to capabilities, gaps, and KPPs. Rather than defining very detailed gaps, ECLSS-CHP defines high-level gaps to be technology agnostic. Within a gap, detailed KPPs are defined to both compare technologies and measure progress within a technology over time. Ideally, KPPs are clearly defined, widely communicated both internally and externally, and provide a common nomenclature to describe the state of the art and the degree of improvement required for exploration missions. KPPs help define when the gap is closed and the core mission objectives can be accomplished. Further technology improvements to enhance the capability, as measured by improved KPPs, must then be weighed against investments in open capability gaps that prevent NASA from achieving its exploration missions. It is uncommon that a technology maturation to improve all the relevant KPPs simultaneously but using KPPs is a critical technology investment decision making component. In addition to traditional technology selections, KPPs are informing how investments in ground testing prior to and in parallel with ISS technology demonstrations are required to improve reliability KPPs. The collection of all major technology activities within a capability area are captured on technology roadmaps to communicate how diverse program activities are coordinated to close gaps and infuse into exploration mission needs. A selection of ECLSS-CHP gaps and KPPs and their formulation, current state, and how they inform capability roadmap planning are discussed. The paper will contain a summary of the approximately 60 gaps. Gaps are classified as to their type (architecture, knowledge, technology, developmental, or engineering) depending on the magnitude of the gap. The paper will provide brief overviews of a few major technology challenges and the technologies being considered, but will reference detailed papers for a more thorough treatment of the challenges and state of the art. Data analysis of the gaps is in work and results are not currently available for this abstract. It is anticipated the paper will include examples of select KPPs with descriptions as to why these are the relevant measures. Additionally some KPPs will be graphically presented over time to show progress to date and when performance targets need to be achieved to support exploration missions. Graphical summaries of how gaps closures with near term mission elements support follow-on mission elements will be provided.

Life Support

Physics-informed machine learning for building performance simulation-A review of a nascent field

Building performance simulation (BPS) is critical for understanding building dynamics and behavior, analyzing the performance of the built environment, optimizing energy efficiency, improving demand flexibility, and enhancing building resilience. However, conducting BPS is not trivial. Traditional BPS relies on accurate building energy models, which are primarily physics-based and heavily dependent on detailed building information, expert knowledge, and case-by-case model calibrations, significantly limiting their scalability. With the development of sensing technology and the increased availability of data, there is growing attention and interest in data-driven BPS. However, purely data-driven models often suffer from limited generalization ability and a lack of physical consistency, resulting in poor performance in real-world applications. To address these limitations, recent studies have begun integrating physics priors into data-driven models, a methodology known as physics-informed machine learning (PIML). PIML is an emerging field where its definitions, methodologies, evaluation criteria, application scenarios, and future directions remain open. To bridge those gaps, this study systematically reviews the state-of-the-art PIML for BPS, offering a comprehensive definition of PIML and comparing it to traditional BPS approaches regarding data requirements, modeling effort, performance, and computational cost. We also summarize the commonly used methodologies, validation approaches, application domains, available data sources, open-source packages, and testbeds. In addition, this study provides a general guideline for selecting appropriate PIML models based on BPS applications. Finally, this study identifies key challenges and outlines future research directions, providing a solid foundation and valuable insights to advance R&D of PIML in BPS.

Jiang, Zixin

Simulation verification techniques study. Task report 4: Simulation module performance parameters and performance standards

Shuttle simulation software modules in the environment, crew station, vehicle configuration and vehicle dynamics categories are discussed. For each software module covered, a description of the module functions and operational modes, its interfaces with other modules, its stored data, inputs, performance parameters and critical performance parameters is given. Reference data sources which provide standards of performance are identified for each module. Performance verification methods are also discussed briefly.

Source record

A Full Mission Simulator Study of Aircrew Performances: the Measurement of Crew Coordination and Decisionmaking Factors and Their Relationships to Flight Task Performances

Sixteen three man crews flew a full mission scenario in an airline flight simulator. A high level of verbal interaction during instances of critical decision making was located. Each crew flew the scenario only once, without prior knowledge of the scenario problem. Following a simulator run and in accord with formal instructions, each of the three crew members independently viewed and commented on a videotape of their performance. Two check pilot observers rated pilot performance across all crews and, following each run, also commented on the video tape of the crew's performance. A linguistic analysis of voice transcript is made to provide assessment of crew coordination and decision making qualities. Measures of crew coordination and decision making factors are correlated with flight task performance measures.

Murphy, M. R.

AVIRIS performance during the 1987 flight season: An AVIRIS project assessment and summary of the NASA-sponsored performance evaluation

Results are presented of the assessment of AVIRIS performance during the 1987 flight season by the AVIRIS project and the earth scientists who were chartered by NASA to conduct an independent data quality and sensor performance evaluation. The AVIRIS evaluation program began in late June 1987 with the sensor meeting most of its design requirements except for signal-to-noise ratio in the fourth spectrometer, which was about half of the required level. Several events related to parts failures and design flaws further reduced sensor performance over the flight season. Substantial agreement was found between the assessments by the project and the independent investigators of the effects of these various factors. A summary of the engineering work that is being done to raise AVIRIS performance to its required level is given. In spite of degrading data quality over the flight season, several exciting scientific results were obtained from the data. These include the mapping of the spatial variation of atmospheric precipitable water, detection of environmentally-induced shifts in the spectral red edge of stressed vegetation, detection of spectral features related to pigment, leaf water and ligno-cellulose absorptions in plants, and the identification of many diagnostic mineral absorption features in a variety of geological settings.

Vane, Gregg

Orbit-determination performance of Doppler data for interplanetary cruise trajectories. Part 2: 8.4-GHz performance and data-weighting strategies

A consider error covariance analysis was performed in order to investigate the orbit-determination performance attainable using two-way (coherent) 8.4-GHz (X-band) Doppler data for two segments of the planned Mars Observer trajectory. The analysis includes the effects of the current level of calibration errors in tropospheric delay, ionospheric delay, and station locations, with particular emphasis placed on assessing the performance of several candidate elevation-dependent data-weighting functions. One weighting function was found that yields good performance for a variety of tracking geometries. This weighting function is simple and robust; it reduces the danger of error that might exist if an analyst had to select one of several different weighting functions that are highly sensitive to the exact choice of parameters and to the tracking geometry. Orbit-determination accuracy improvements that may be obtained through the use of calibration data derived from Global Positioning System (GPS) satellites also were investigated, and can be as much as a factor of three in some components of the spacecraft state vector. Assuming that both station-location errors and troposphere calibration errors are reduced simultaneously, the recommended data-weighting function need not be changed when GPS calibrations are incorporated in the orbit-determination process.

Ulvestad, J. S.

Integrated Advanced Microwave Sounding Unit-A (AMSU-A). Performance Verification Report: Initial Comprehensive Performance Test Report, P/N 1331200-2-IT, S/N 105/A2

This is the Performance Verification Report, Initial Comprehensive Performance Test Report, P/N 1331200-2-IT, S/N 105/A2, for the Integrated Advanced Microwave Sounding Unit-A (AMSU-A). The specification establishes the requirements for the Comprehensive Performance Test (CPT) and Limited Performance Test (LPT) of the Advanced Microwave Sounding, Unit-A2 (AMSU-A2), referred to herein as the unit. The unit is defined on Drawing 1331200. 1.2 Test procedure sequence. The sequence in which the several phases of this test procedure shall take place is shown in Figure 1, but the sequence can be in any order.

Platt, R.

Preliminary Results of Altitude-Wind-Tunnel Investigation of X24C-4B Turbojet Engine. IV - Performance of Modified Compressor: Performance of Modified Compressor - Part 4

The performance of the 11-stage axial-flow compressor, modified to improve the compressor-outlet velocity, in a revised X24C-4B turbojet engine is presented and compared with the performance of the compressor in the original engine. Performance data were obtained from an investigation of the revised engine in the MACA Cleveland altitude wind tunnel. Compressor performance data were obtained for engine operation with four exhaust nozzles of different outlet area at simulated altitudes from 15,OOO to 45,000 feet, simulated flight Mach numbers from 0.24 to 1.07, and engine speeds from 4000 to 12,500 rpm. The data cover a range of corrected engine speeds from 4100 to 13,500 rpm, which correspond to compressor Mach numbers from 0.30 to 1.00.

Thorman, H. Carl

Preliminary Results of Altitude-Wind-Tunnel Investigation of X24C-4B Turbojet Engine. V - Performance of Modified Engine: Performance of Modified Engine - V

An investigation has been conducted in the NACA Cleveland altitude wind tunnel to evaluate the performance characteristics of a modified X24C-4B turbojet engine over a range of simulated altitudes from 5000 to 45,000 feet, simulated flight Mach numbers from 0.25 to 1.07, and engine speeds from 4000 to 12,500 rpm. The engine was modified by the manufacturer to improve the velocity and temperature profiles within the engine. Performance data are graphically presented to show the effect of altitude at a flight Mach number of 0.25 and the effect of flight Mach number at an altitude of 25,000 feet. Original and modified engine performances for several specific operating conditions are compared. A complete tabulation of average pressures and temperatures throughout the engine, performance data, and lubrication and fuel-system data is presented.

Prince, William R.