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DOE OSTI2022

Bioimaging Science Program: 2022 Principal Investigator Meetings Proceedings

The mission of the U.S. Department of Energy’s (DOE) Biological and Environmental Research (BER) program’s Bioimaging Science Program (BSP) is to understand the translation of genomic information into the mechanisms that power living cells, communities of cells, and whole organisms. The goal of BSP is to develop new imaging and measurement technologies to visualize the spatial and temporal relationships of key metabolic processes governing phenotypic expression in plants and microbes. The extended goal of dynamic imaging is to functionally connect cellular components and interdependent organisms. Information about the time and place of chemical reactions in situ can identify causal relationships between biological activators and downstream effectors. BSP held its annual PI meeting virtually February 28–March 1. Contributing investigators are convened to review progress and current state-of-the-art bioimaging research. Holding the 2022 BSP meeting as part of the broader Genomic Science Program (GSP) PI meeting allowed researchers to interact with the extended GSP community. This convergence provided a platform for networking and exchange of ideas with experts in other technologies and in target BSP application areas, helping to forge new multidisciplinary collaborations among investigators from the sister programmatic areas within BER’s Biological Systems Science Division. An important highlight of the BSP meeting was the keynote presentation by Nobel Laureate Dr. Joachim Frank on Time-Resolved Macromolecular Imaging using Cryo-EM. He discussed microfluidic mixing and fast freezing to capture nonequilibrium intermediate states during molecular binding and conformational changes. The action of molecular machines can be captured at nanometer resolution and millisecond discrimination. BSP PIs made presentations describing their research focus and progress in plenary sessions on bioimaging science and on quantum-enabled bioimaging science research projects. BSP research at universities and DOE laboratories is presented in this report. A final discussion of the BSP was organized by meeting plenary session chairs, who prepared the following Executive Summary of current BSP research, research challenges, future opportunities, and potential ideas for expanding the BSP’s impact and interactions.

59 BASIC BIOLOGICAL SCIENCES↗

NASA NTRS1972

Technical supporting studies plan, revision A. Task 1: Principal investigator services

Proposed supporting studies for the Apollo 17 UV spectrometer include analyses of existing data and theories to construct lunar atmosphere models; acquisition of information on UV albedo of moon; engineering performance data for prototype Apollo 17 UV spectrometer; UV absolute calibration; and data reduction program interface with lunar atmosphere analysis program.

Source record↗

NASA NTRS1979

A bibliography of planetary geology principal investigators and their associates, 1978 - 1979

Approximately 450 articles on planetary geology are reported.

Boyce, J. M.↗

NASA NTRS1982

A bibliography of planetary geology principal investigators and their associates, 1981 - 1982

Over 800 publications submitted by researchers supported through NASA's Planetary Geology Program are cited and an author/editor index is provided. Entries are listed under the following subjects: (1) general interest topics; (2) solar system, comets, asteroids, and small bodies; (3) geologic mapping, geomorphology, and stratigraphy; (4) structure, tectonics, geologic and geophysical evolution; (5) impact craters: morphology, density, and geologic studies; (6) volcanism; (7) fluvial, mass wasting, and periglacial processes; (8) Eolian studies; (9) regolith, volatile, atmosphere, and climate; (10) remote sensing, radar, and photometry; and (11) cartography, photogrammetry, geodesy, and altimetry.

Plescia, J. B.↗

NASA NTRS1981

Controlled Ecological Life Support System. First Principal Investigators Meeting

Control problems in autonomous life support systems, CELSS candidate species, maximum grain yield, plant growth, waste management, air pollution, and mineral separation are discussed.

Berrien Moore III↗

NASA NTRS1984

A bibliography of planetary geology and geophysics principal investigators and their associates, 1983 - 1984

A compilation is given of selected bibliographic data specifically relating to recent publications submitted by principle investigators and their associates, supported through NASA's Office of Space Science and Applications, Solar System Exploration Division, Planetary Geology and Geophysics Program. Topics include the solar system, asteroids, volcanoes, stratigraphy, remote sensing, and planetary craters.

Witbeck, N. E.↗

NASA NTRS1990

A bibliography of planetary geology and geophysics principal investigators and their associates, 1989-1990

This is a compilation of selected bibliographic data specifically relating to recent publications submitted by principle investigators and their associates, supported through the NASA Office of Space Science and Applications, Solar System Exploration Division, Planetary Geology and Geophysics Program.

Source record↗

NASA NTRS1993

Principal investigators data package for Project Initiation Conference (PIC): EUVS sounding rocket no. 36.117CL. Target: Venus

The region of the UV between 500 and 1200 A is a rich one for the study of planetary and astrophysical targets. EUV atmospheric spectroscopy opens up an important window on ion and neutral nitrogen, oxygen, and noble gas emissions. In this document we describe the specific scientific background and motivations for this Venus EUV rocket observation along with experiment design and mission parameters.

Stern, S. Alan↗

NASA NTRS1997

Requesting AVIRIS Data: A Guide for Principal Investigators

This guide serves as a brief overview of the AVIRIS instrument and its role in the field of imaging spectrometry. Mission planning and flight operations are discussed, and recommendations are given regarding the deployment of ground truth experiments.

VISIBLE SPECTRA↗

NASA NTRS1998

Principal Investigator Microgravity Services: USMP-3

Two accelerometers provided acceleration data during the STS-75 mission in support of the third United States Microgravity Payload (USMP-3) experiments. The Orbital Acceleration Research Experiment (OARE) and the Space Acceleration Measurement System (SAMS) provided a measure of the microgravity environment of the Space Shuttle Columbia. The OARE provided investigators with quasi-steady acceleration measurements after about a six hour time lag dictated by downlink constraints. SAMS data were downlinked in near-real-time and recorded on-board for post-mission analysis. These two accelerometer systems are briefly described. Using a combination of data analysis techniques, the microgravity environment related to several different Orbiter, crew, and experiment operations is presented and interpreted. The microgravity environment represented by SAMS and OARE data is comparable to the environments measured by these instruments on earlier microgravity science missions. Thruster activity on this mission seen in the SAMS data appear to be more frequent than on other microgravity missions with the combined firings of the F5L and F5R jets producing significant acceleration transients. Of the events studied, the crew activities performed in the middeck and flight deck, SPREE table rotations, a waste collection system compaction, and a fuel cell purge had negligible effects on the microgravity environment of the USMP-3 carriers. The Ku band antenna repositioning activity resulted in a brief interruption of the ubiquitous 17 Hz signal in the SAMS data. In addition, the auxiliary power unit operations during the Flight Control System checkout appeared to have a significant impact on the microgravity environment.

Rogers, Melissa J. B.↗

NASA NTRS1994

Principal Investigator in a Box Technical Description Document

This document provides a brief overview of the PI-in-a-Box system, which can be used for automatic real-time reaction to incoming data. We will therefore outline the current system's capabilities and limitations, and hint at how best to think about PI-in-a-Box as a tool for real-time analysis and reaction in section two, below. We also believe that the solution to many commercial real-time process problems requires data acquisition and analysis combined with rule-based reasoning and/or an intuitive user interface. We will develop the technology reuse potential in section three. Currently, the system runs only on Apple Computer's Macintosh series.

Groleau, Nick↗

NASA NTRS2017

Astromaterials Curation Online Resources for Principal Investigators

The Astromaterials Acquisition and Curation office at NASA Johnson Space Center curates all of NASA's extraterrestrial samples, the most extensive set of astromaterials samples available to the research community worldwide. The office allocates ~1500 individual samples to researchers and students each year and has served the planetary research community for 45+ years. The Astromaterials Curation office provides access to its sample data repository and digital resources to support the research needs of sample investigators and to aid in the selection and request of samples for scientific study. These resources can be found on the Astromaterials Acquisition and Curation website at https://curator.jsc.nasa.gov. To better serve our users, we have engaged in several activities to enhance the data available for astromaterials samples, to improve the accessibility and performance of the website, and to address user feedback. We havealso put plans in place for continuing improvements to our existing data products.

Todd, Nancy S.↗

DOE OSTI2024