Targeting Ras-, Rho-, and Rab-family GTPases via a conserved cryptic pocket
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Morstein, Johannes↗
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Unmanned Aircraft Systems (UAS) Integration in the National Airspace System (NAS) Project: ACAS Xu HITL Overview
This presentation provides an overview of a recently completed human-in-the-loop simulation, conducted as part of the Unmanned Aircraft Systems (UAS) Integration in the National Airspace System (NAS) Project. This study examined how to present resolution advisories (RAs) issued by Airborne Collision Avoidance System (ACAS) Xu, which can be in the vertical dimension, the horizontal dimension, or both (i.e., "blended"). The study varied the location of the ACAS Xu traffic information - it was either presented within an 'integrated' display or a 'standalone' display, where the traffic information was separated from the vehicle control interfaces and navigational information. The presentation covers the test set-up, scenario design, and facilities utilized in this experiment. The primary dependent variables are listed, but no detailed results are included in this outbrief since data analysis is still underway. Goal: assess ACAS Xu Run 5 in a HITL setting to measure pilot & system performance – RWC alerting and guidance – RA alerting and guidance • Horizontal-only, vertical-only, and blended RAs • Strengthening RAs, reversals and added/removed RAs during blended maneuvers – Incorporate realistic sensor noise into the simulation environment – Compare pilot and DAA system performance back to NASA’s Phase 1 DAA MOPS V&V HITL • We leveraged the findings of an engineering analysis conducted in March to help inform how to implement the Xu logic – Part 1 focused on how to display horizontal-only, vertical-only and blended RAs – Part 2 focused on how to display automated RA responses Xu Engineering Analysis Results Part 1 objectives: – Characterize pilot responses to (canned) ACAS Xu RAs in a variety of display configurations • With vs. Without text accompaniment • Simple vs. ‘Advanced’ aural alerting • Results – Pilots struggled to meet 5 seconds initial response requirement • Particularly against horizontal and blended RAs – Pilots failed to respond more quickly to secondary RAs • Expected response time to subsequent RAs = 2.5 seconds No clear effect of the different alerting conditions on response times – Response times primarily driven by RA type • Pilots demonstrated high level of compliance with RAs and self-reported Xu alerting and guidance as being acceptable – 1/5 reported text as being necessary – 4/5 wanted the aural alert to retain the original RA sequence (i.e., issue a follow-on RA second rather than first) – 4/5 wanted to retain the “Maintain Heading/Vertical Speed” aural alert in the event that the pilot reached their target response at the time of secondary RA Based on these results, we decided on the following for the HITL experimental design: – Incorporated an ‘auto-fill’ feature in Vigilant Spirit that removes the need for pilots to manually enter a heading or altitude for RAs • Pilots only have to click ‘Send’ to upload the RA target heading/altitude – Did not include an RA ‘text box’ • The auto-fill feature largely replaces the purpose of the text box – Using a combination of the ‘Basic’ and ‘Advanced’ aural alerting • In case of blended maneuvers will issue “Maintain Heading/Vertical Rate” if pilot has reached 1st RA target at the time the 2nd RA is issued • Integration and testing with Xu Run 5 also resulted in us adding display logic to modify how horizontal RAs are presented – Target heading was shown to update at approx. 1 Hz making it difficult for pilots to implement – Display logic limited horizontal RA strengthening to once every 5 seconds • Did not impact timing of reversals, new RAs (i.e., blended), or CoC Engineering Analysis Results
human systems integration↗
Helicopter Pilot Assessments of the Airborne Collision Avoidance System XR With Automated Maneuvering
The Airborne Collision Avoidance System X (ACAS X) is a next-generation collision avoidance tool developed to support different aircraft types and operations. The rotorcraft variant – referred to as ACAS XR – is designed to accommodate existing helicopter platforms as well as in-development, electric vertical takeoff and landing concepts, which are critical to the emerging concept of operations referred to as Advanced Air Mobility. The fundamental role of ACAS XR is to provide Detect and Avoid (DAA) and/or Collision Avoidance (CA) protection against airborne traffic. DAA alerting and guidance in the context of ACAS XR is caution-level and “suggestive,” and is to be used by the pilot if, and when, they decide to maneuver against an identified threat to DAA “well clear.” The CA alerting, by contrast, is warning-level and “directive,” with the pilot required to comply with the associated guidance to prevent a predicted Near Midair Collision (NMAC). The CA alerts generated by ACAS XR are referred to as Resolution Advisories (RAs) consistent with previous CA systems. Unlike earlier CA systems, ACAS XR issues RAs in the horizontal and vertical dimensions as well as multi-axis RAs (referred to as “Blended” RAs). According to the Minimal Operational Performance Standards of DAA systems for Unmanned Aircraft Systems, maneuvers to comply with RAs may be automated, whereas maneuvers based on DAA alerting assume a manual response. The current study was a human-in-the-loop simulation that presented rotorcraft pilots with ACAS XR alerts and guidance in a fixed-base eVTOL simulator with varying levels of automation. Objective results showed that pilots complied with all RAs within the expected 5-second time window and responded to DAA alerts quicker than in earlier studies with ACAS XU. Pilots often made larger horizontal deviations during Manual RAs, but often favored vertical and blended maneuvers. No NMACs occurred, and losses of well clear were mainly attributed to the obligation of the pilots and system to maneuver only after the CA phase of the encounter had begun. Other losses were due to pilots’ noncompliance or disregard for ACAS XR’s alerting and guidance. Noncompliance with RAs most frequently occurred when pilots determined they were too close to the terrain to continue to follow Descend RAs, performing vertical maneuvers instead of following Horizontal RAs, or rejecting Horizontal RA updates because they felt that enough maneuvering had been performed. Subjectively, pilots found the DAA and RA alerting and guidance intuitive and useful for VFR helicopter operations. Slightly more pilots preferred the Automated RA condition to the Manual RA condition. Lastly, they also felt that ACAS led to occasional unsafe Descend RAs. Caveats and future implications are discussed.
eVTOL↗
Helicopter Pilot Assessments of the Airborne Collision Avoidance System XR With Automated Maneuvering
The Airborne Collision Avoidance System X (ACAS X) is a next-generation collision avoidance tool developed to support different aircraft types and operations. The rotorcraft variant – referred to as ACAS XR – is designed to accommodate existing helicopter platforms as well as in-development, electric vertical takeoff and landing concepts, which are critical to the emerging concept of operations referred to as Advanced Air Mobility. The fundamental role of ACAS XR is to provide Detect and Avoid (DAA) and/or Collision Avoidance (CA) protection against airborne traffic. DAA alerting and guidance in the context of ACAS XR is caution-level and “suggestive,” and is to be used by the pilot if, and when, they decide to maneuver against an identified threat to DAA “well clear.” The CA alerting, by contrast, is warning-level and “directive,” with the pilot required to comply with the associated guidance to prevent a predicted Near Midair Collision (NMAC). The CA alerts generated by ACAS XR are referred to as Resolution Advisories (RAs) consistent with previous CA systems. Unlike earlier CA systems, ACAS XR issues RAs in the horizontal and vertical dimensions as well as multi-axis RAs (referred to as “Blended” RAs). According to the Minimal Operational Performance Standards of DAA systems for Unmanned Aircraft Systems, maneuvers to comply with RAs may be automated, whereas maneuvers based on DAA alerting assume a manual response. The current study was a human-in-the-loop simulation that presented rotorcraft pilots with ACAS XR alerts and guidance in a fixed-base eVTOL simulator with varying levels of automation. Objective results showed that pilots complied with all RAs within the expected 5-second time window and responded to DAA alerts quicker than in earlier studies with ACAS XU. Pilots often made larger horizontal deviations during Manual RAs, but often favored vertical and blended maneuvers. No NMACs occurred, and losses of well clear were mainly attributed to the obligation of the pilots and system to maneuver only after the CA phase of the encounter had begun. Other losses were due to pilots’ noncompliance or disregard for ACAS XR’s alerting and guidance. Noncompliance with RAs most frequently occurred when pilots determined they were too close to the terrain to continue to follow Descend RAs, performing vertical maneuvers instead of following Horizontal RAs, or rejecting Horizontal RA updates because they felt that enough maneuvering had been performed. Subjectively, pilots found the DAA and RA alerting and guidance intuitive and useful for VFR helicopter operations. Slightly more pilots preferred the Automated RA condition to the Manual RA condition. Lastly, they also felt that ACAS led to occasional unsafe Descend RAs. Caveats and future implications are discussed.
eVTOL↗
Comparisons of Mixing Efficiency for the Strut Fuel Injector Obtained from Large-Eddy and Reynolds-Averaged Simulations, and Experiments
Mixing efficiency is obtained for a strut fuel injector at hypervelocity flow conditions by using large-eddy simulations (LES), Reynolds-averaged simulations (RAS), and experiments. The injector and flow conditions have been previously investigated by using RAS and experiments as a part of the Enhanced Injection and Mixing Project (EIMP) at the NASA Langley Research Center (LaRC). Because the fidelity of LES is a strong function of the grid, the mixing efficiency is obtained on two grids, the coarser of which is a factor of two coarser in each of the three dimensions with respect to the fine grid. The RAS uses the two-equation linear eddy viscosity and diffusivity modeling of Menter. In RAS, the species diffusivity model exhibits a strong dependence on the turbulent Schmidt number, which is often adjusted until some metric of engineering interest, such as the mixing efficiency, matches the experimental data. In the absence of experimental data, scale-resolving simulations, such as LES, have been proposed as surrogates for experiments that could provide the data needed to “calibrate” the turbulent Schmidt number in the RAS models. This approach is followed because LES requires significantly more computational resources (CPU, data storage, and time) than RAS, making it prohibitive for use in many engineering applications and specifically for parameter exploration or optimization. Here we examine the mixing efficiency obtained from several RAS with different values of the turbulent Schmidt number, and compare the results with those obtained from the LES and experiments. In addition, the least squares fitting approach was used to demonstrate how to obtain an estimate for the turbulent Schmidt number from LES analytically. These estimates were then used together with prior knowledge about RAS model sensitivity to select a turbulence model that was expected to best match the LES data.
LES↗
Comparisons of Mixing Efficiency for the Strut Fuel Injector Obtained from Large-Eddy and Reynolds-Averaged Simulations, and Experiments
Mixing efficiency is obtained for a strut fuel injector at hypervelocity flow conditions by using large-eddy simulations (LES), Reynolds-averaged simulations (RAS), and experiments. The injector and flow conditions have been previously investigated by using RAS and experiments as a part of the Enhanced Injection and Mixing Project (EIMP) at the NASA Langley Research Center (LaRC). Because the fidelity of LES is a strong function of the grid, the mixing efficiency is obtained on two grids, the coarser of which is a factor of two coarser in each of the three dimensions with respect to the fine grid. The RAS uses the two-equation linear eddy viscosity and diffusivity modeling of Menter. In RAS, the species diffusivity model exhibits a strong dependence on the turbulent Schmidt number, which is often adjusted until some metric of engineering interest, such as the mixing efficiency, matches the experimental data. In the absence of experimental data, scale-resolving simulations, such as LES, have been proposed as surrogates for experiments that could provide the data needed to “calibrate” the turbulent Schmidt number in the RAS models. This approach is followed because LES requires significantly more computational resources (CPU, data storage, and time) than RAS, making it prohibitive for use in many engineering applications and specifically for parameter exploration or optimization. Here we examine the mixing efficiency obtained from several RAS with different values of the turbulent Schmidt number, and compare the results with those obtained from the LES and experiments. In addition, the least squares fitting approach was used to demonstrate how to obtain an estimate for the turbulent Schmidt number from LES analytically. These estimates were then used together with prior knowledge about RAS model sensitivity to select a turbulence model that was expected to best match the LES data.
LES↗
Display and Automation Considerations for the Airborne Collision Avoidance System Xu
In this paper we examine several display and automation considerations of a collision avoidance system that is currently under development: the Airborne Collision Avoidance System (ACAS) Xu. This study builds on previous work conducted as part of NASA’s Unmanned Aircraft Systems (UAS) Integration into the National Airspace System (NAS) project. ACAS Xu represents the next-generation successor to the Traffic Alert and Collision Avoidance System (TCAS II), wherein the Xu variant is intended for UAS applications. Whereas TCAS II exclusively issues RAs in the vertical dimension, a major distinction between ACAS Xu and previous collision avoidance (CA) systems is the introduction of horizontal and “blended” RAs (i.e., RAs with both horizontal and vertical components). This present work was conducted as an engineering analysis involving two parts. In Part 1, a two-by-two, within-subjects study was performed that manipulated how RAs were presented to a pilot situated at a UAS ground control station. Five participants experienced four experimental trials in which text and aural alerting characteristics were manipulated. In Part 2, another five participants experienced four trials in which the levels of automation were manipulated with regard to the CA and return-to-course (RTC) tasks. The results for Part 1 found no effect of display or alerting configuration on pilot performance. However, it was discovered that pilot response time to RAs greatly depended on the RA type. In particular, pilots were quicker to respond to vertical RAs (M = 4.52 seconds) than horizontal (M = 7.42 seconds) and blended (M = 9.68 seconds) RAs in which both dimensions were issued simultaneously. For Part 2 of the study, pilots found both auto-CA and auto-RTC functions equally useful. Most pilots were comfortable with the automation, however responses were mixed. Three of five participants indicated high levels of comfort with the auto-CA function, while two rated their comfort as low. Pilots’ comfort for the auto-RTC functionality was slightly higher: four out of five pilots gave high ratings, while one pilot gave a low rating. Overall, pilots ordinally ranked their preference for automated functions as auto-CA together with auto-RTC (when an aural alert announces a change between CA and RTC states), auto-CA, and auto-CA and RTC (without the aural state-change announcement). Recommendations for improving the display of automation are also discussed.
collision avoidance↗
Display and Automation Considerations for the Airborne Collision Avoidance System Xu
In this presentation we examine several display and automation considerations of a collision avoidance system that is currently under development: the Airborne Collision Avoidance System (ACAS) Xu. This study builds on previous work conducted as part of NASA’s Unmanned Aircraft Systems (UAS) Integration into the National Airspace System (NAS) project. ACAS Xu represents the next-generation successor to the Traffic Alert and Collision Avoidance System (TCAS II), wherein the Xu variant is intended for UAS applications. Whereas TCAS II exclusively issues RAs in the vertical dimension, a major distinction between ACAS Xu and previous collision avoidance (CA) systems is the introduction of horizontal and “blended” RAs (i.e., RAs with both horizontal and vertical components). This present work was conducted as an engineering analysis involving two parts. In Part 1, a two-by-two, within-subjects study was performed that manipulated how RAs were presented to a pilot situated at a UAS ground control station. Five participants experienced four experimental trials in which text and aural alerting characteristics were manipulated. In Part 2, another five participants experienced four trials in which the levels of automation were manipulated with regard to the CA and return-to-course (RTC) tasks. The results for Part 1 found no effect of display or alerting configuration on pilot performance. However, it was discovered that pilot response time to RAs greatly depended on the RA type. In particular, pilots were quicker to respond to vertical RAs (M = 4.52 seconds) than horizontal (M = 7.42 seconds) and blended (M = 9.68 seconds) RAs in which both dimensions were issued simultaneously. For Part 2 of the study, pilots found both auto-CA and auto-RTC functions equally useful. Most pilots were comfortable with the automation, however responses were mixed. Three of five participants indicated high levels of comfort with the auto-CA function, while two rated their comfort as low. Pilots’ comfort for the auto-RTC functionality was slightly higher: four out of five pilots gave high ratings, while one pilot gave a low rating. Overall, pilots ordinally ranked their preference for automated functions as auto-CA together with auto-RTC (when an aural alert announces a change between CA and RTC states), auto-CA, and auto-CA and RTC (without the aural state-change announcement). Recommendations for improving the display of automation are also discussed.
collision avoidance↗
Hypertrophic response to hemodynamic overload: role of load vs. renin-angiotensin system activation
Myocardial hypertrophy is one of the basic mechanisms by which the heart compensates for hemodynamic overload. The mechanisms by which hemodynamic overload is transduced by the cardiac muscle cell and translated into cardiac hypertrophy are not completely understood. Candidates include activation of the renin-angiotensin system (RAS) and angiotensin II receptor (AT1) stimulation. In this study, we tested the hypothesis that load, independent of the RAS, is sufficient to stimulate cardiac growth. Four groups of cats were studied: 14 normal controls, 20 pulmonary artery-banded (PAB) cats, 7 PAB cats in whom the AT1 was concomitantly and continuously blocked with losartan, and 8 PAB cats in whom the angiotensin-converting enzyme (ACE) was concomitantly and continuously blocked with captopril. Losartan cats had at least a one-log order increase in the ED50 of the blood pressure response to angiotensin II infusion. Right ventricular (RV) hypertrophy was assessed using the RV mass-to-body weight ratio and ventricular cardiocyte size. RV hemodynamic overload was assessed by measuring RV systolic and diastolic pressures. Neither the extent of RV pressure overload nor RV hypertrophy that resulted from PAB was affected by AT1 blockade with losartan or ACE inhibition with captopril. RV systolic pressure was increased from 21 +/- 3 mmHg in normals to 68 +/- 4 mmHg in PAB, 65 +/- 5 mmHg in PAB plus losartan and 62 +/- 3 mmHg in PAB plus captopril. RV-to-body weight ratio increased from 0.52 +/- 0.04 g/kg in normals to 1.11 +/- 0.06 g/kg in PAB, 1.06 +/- 0.06 g/kg in PAB plus losartan and 1.06 +/- 0.06 g/kg in PAB plus captopril. Thus 1) pharmacological modulation of the RAS with losartan and captopril did not change the extent of the hemodynamic overload or the hypertrophic response induced by PAB; 2) neither RAS activation nor angiotensin II receptor stimulation is an obligatory and necessary component of the signaling pathway that acts as an intermediary coupling load to the hypertrophic response; and 3) load, independent of the RAS, is capable of stimulating cardiac growth.
Non-NASA Center↗
Advanced Air Mobility Operations & Automation Part II Technical Lecture
The Airborne Collision Avoidance System X (ACAS X) is a next-generation collision avoidance tool developed to support different aircraft types and operations. The rotorcraft variant – referred to as ACAS XR – is designed to accommodate existing helicopter platforms as well as in-development, electric vertical takeoff and landing concepts, which are critical to the emerging concept of operations referred to as Advanced Air Mobility. The fundamental role of ACAS XR is to provide Detect and Avoid (DAA) and/or Collision Avoidance (CA) protection against airborne traffic. DAA alerting and guidance in the context of ACAS XR is caution-level and “suggestive,” and is to be used by the pilot if, and when, they decide to maneuver against an identified threat to DAA “well clear.” The CA alerting, by contrast, is warning-level and “directive,” with the pilot required to comply with the associated guidance to prevent a predicted Near Midair Collision (NMAC). The CA alerts generated by ACAS XR are referred to as Resolution Advisories (RAs) consistent with previous CA systems. Unlike earlier CA systems, ACAS XR issues RAs in the horizontal and vertical dimensions as well as multi-axis RAs (referred to as “Blended” RAs). According to the Minimal Operational Performance Standards of DAA systems for Unmanned Aircraft Systems, maneuvers to comply with RAs may be automated, whereas maneuvers based on DAA alerting assume a manual response. The current presentation discusses two human-in-the-loop simulations that presented rotorcraft pilots with ACAS XR alerts and guidance in eVTOL simulators with varying levels of automation. It also presents overviews of these studies as well as how they assisted live flight tests, which will occur throughout 2023.
air taxis↗
Impact of Flight Enthalpy, Fuel Simulant, and Chemical Reactions on the Mixing Characteristics of Several Injectors at Hypervelocity Flow Conditions
The high total temperatures or total enthalpies required to duplicate the high-speed flight conditions in ground experiments often place stringent requirements on the material selection and cooling needs for the test articles and intrusive flow diagnostic equipment. Furthermore, for internal flows, these conditions often complicate the use of nonintrusive diagnostics that need optical access to the test section and interior portions of the flowpath. Because of the technical challenges and increased costs associated with experimentation at high values of total enthalpy, an attempt is often made to reduce it. This is the case for the Enhanced Injection and Mixing Project (EIMP) currently underway in the Arc-Heated Scramjet Test Facility at the NASA Langley Research Center. The EIMP aims to investigate supersonic combustion ramjet (scramjet) fuel injection and mixing physics, improve the understanding of underlying physical processes, and develop enhancement strategies and functional relationships between mixing performance and losses relevant to flight Mach numbers greater than 8. The experiments will consider a "direct-connect" approach and utilize a Mach 6 nozzle to simulate the combustor entrance flow of a scramjet engine. However, while the value of the Mach number is matched to that expected at the combustor entrance in flight, the maximum value of the total enthalpy for these experiments is limited by the thermal-structural limits of the uncooled experimental hardware. Furthermore, the fuel simulant is helium, not hydrogen. The use of "cold" flows and non-reacting mixtures of fuel simulants for mixing experiments is not new and has been extensively utilized as a screening technique for scramjet fuel injectors. In this study, Reynolds-averaged simulations are utilized (RAS) to systematically verify the implicit assumptions used by the EIMP. This is accomplished by first performing RAS of mixing for two injector configurations at planned nominal experimental conditions. The mixing parameters of interest, such as mixing efficiency and total pressure recovery, are then computed and compared to the values obtained from RAS under the true enthalpy conditions and using helium and hydrogen. Finally, the impact of combustion on mixing, often deemed small enough to neglect at hypervelocity conditions, is assessed by comparing the results obtained from the hydrogen-fueled reacting and non-reacting RAS. For reacting flows, in addition to mixing efficiency and total pressure recovery, the combustion efficiency and thrust potential are also considered. In all of the simulations, the incoming air Mach number and the fuel-to-air ratio are the same, while the total pressure, total enthalpy, and the fuel simulant vary depending on the case considered. It is found that under some conditions the "cold" flow experiments are a good approximation of the flight.
Drozda, Tomasz G.↗
Numerical Investigation and Optimization of a Flushwall Injector for Scramjet Applications at Hypervelocity Flow Conditions
An investigation utilizing Reynolds-averaged simulations (RAS) was performed in order to demonstrate the use of design and analysis of computer experiments (DACE) methods in Sandia’s DAKOTA software package for surrogate modeling and optimization. These methods were applied to a flow- path fueled with an interdigitated flushwall injector suitable for scramjet applications at hyper- velocity conditions and ascending along a constant dynamic pressure flight trajectory. The flight Mach number, duct height, spanwise width, and injection angle were the design variables selected to maximize two objective functions: the thrust potential and combustion efficiency. Because the RAS of this case are computationally expensive, surrogate models are used for optimization. To build a surrogate model a RAS database is created. The sequence of the design variables comprising the database were generated using a Latin hypercube sampling (LHS) method. A methodology was also developed to automatically build geometries and generate structured grids for each design point. The ensuing RAS analysis generated the simulation database from which the two objective functions were computed using a one-dimensionalization (1D) of the three-dimensional simulation data. The data were fitted using four surrogate models: an artificial neural network (ANN), a cubic polynomial, a quadratic polynomial, and a Kriging model. Variance-based decomposition showed that both objective functions were primarily driven by changes in the duct height. Multiobjective design optimization was performed for all four surrogate models via a genetic algorithm method. Optimal solutions were obtained at the upper and lower bounds of the flight Mach number range. The Kriging model predicted an optimal solution set that exhibited high values for both objective functions. Additionally, three challenge points were selected to assess the designs on the Pareto fronts. Further sampling among the designs of the Pareto fronts may be required to lower the surrogate model errors and perform more accurate surrogate-model-based optimization.
Shenoy, Rajiv R.↗
A Human-in-the-Loop Evaluation of ACAS Xu
As part of the Phase 2 UAS DAA MOPS, a Class 3 DAA system has been under development with the potential to resolve many of the limitations of Class 1 and 2 systems. A Class 3 system would combine the DAA and CA functions into a single, unified system, and would also extend the CA capabilities relative to TCAS II. Class 3 is enabled by the Airborne Collision Avoidance System (ACAS) XU, a next generation CA system developed specifically for UAS operations. Unlike Class 2 systems, ACAS XU provides CA protection against both cooperative and non-cooperative traffic. Class 3 systems also expand the CA logic to allow horizontal RAs in addition to vertical RAs. The purpose of the current study was to evaluate ACAS XU in a real-time, HITL simulation. The latest version of ACAS XU was implemented and pilots were tasked with responding to scripted traffic conflicts over the course of four experimental trials. Variables included the location of the ACAS XU guidance information (standalone vs. integrated) and traffic conflict type (DAA or CA threat). Sixteen active UAS pilots participated in the study, with ATC and ‘pseudo’ pilots acting as airspace confederates. Results showed that pilots were able to maintain DWC with ACAS XU at a rate comparable to previous research (~5%). Compliance rates to initial RAs were high (~90%) but dropped significantly when the target heading value issued during horizontal RAs were updated over the course of an encounter (30-70%). The implications of these findings on the display, alerting, and guidance requirements for Class 3 systems will be discussed.
unmanned aircraft systems↗
A Human-in-the-Loop Evaluation of ACAS Xu
As part of the Phase 2 UAS DAA MOPS, a Class 3 DAA system has been under development with the potential to resolve many of the limitations of Class 1 and 2 systems. A Class 3 system would combine the DAA and CA functions into a single, unified system, and would also extend the CA capabilities relative to TCAS II. Class 3 is enabled by the Airborne Collision Avoidance System (ACAS) XU, a next generation CA system developed specifically for UAS operations. Unlike Class 2 systems, ACAS XU provides CA protection against both cooperative and non-cooperative traffic. Class 3 systems also expand the CA logic to allow horizontal RAs in addition to vertical RAs. The purpose of the current study was to evaluate ACAS XU in a real-time, HITL simulation. The latest version of ACAS XU was implemented and pilots were tasked with responding to scripted traffic conflicts over the course of four experimental trials. Variables included the location of the ACAS XU guidance information (standalone vs. integrated) and traffic conflict type (DAA or CA threat). Sixteen active UAS pilots participated in the study, with ATC and ‘pseudo’ pilots acting as airspace confederates. Results showed that pilots were able to maintain DWC with ACAS XU at a rate comparable to previous research (~5%). Compliance rates to initial RAs were high (~90%) but dropped significantly when the target heading value issued during horizontal RAs were updated over the course of an encounter (30-70%). The implications of these findings on the display, alerting, and guidance requirements for Class 3 systems will be discussed.
unmanned aircraft systems↗
A Human-in-theLoop Evaluation of ACAS Xu
As part of the Phase 2 UAS DAA MOPS, a Class 3 DAA system has been under development with the potential to resolve many of the limitations of Class 1 and 2 systems. A Class 3 system would combine the DAA and CA functions into a single, unified system, and would also extend the CA capabilities relative to TCAS II. Class 3 is enabled by the Airborne Collision Avoidance System (ACAS) XU, a next generation CA system developed specifically for UAS operations. Unlike Class 2 systems, ACAS XU provides CA protection against both cooperative and non-cooperative traffic. Class 3 systems also expand the CA logic to allow horizontal RAs in addition to vertical RAs. The purpose of the current study was to evaluate ACAS XU in a real-time, HITL simulation. The latest version of ACAS XU was implemented and pilots were tasked with responding to scripted traffic conflicts over the course of four experimental trials. Variables included the location of the ACAS XU guidance information (standalone vs. integrated) and traffic conflict type (DAA or CA threat). Sixteen active UAS pilots participated in the study, with ATC and ‘pseudo’ pilots acting as airspace confederates. Results showed that pilots were able to maintain DWC with ACAS XU at a rate comparable to previous research (~5%). Compliance rates to initial RAs were high (~90%) but dropped significantly when the target heading value issued during horizontal RAs were updated over the course of an encounter (30-70%). The implications of these findings on the display, alerting, and guidance requirements for Class 3 systems will be discussed.
unmanned aircraft systems↗
Understanding the Role of CFD, Including RANS, DES, LES and DNS, in Hypersonic Propulsion Design and Analysis
Computational fluid dynamics (CFD) has matured to the point where it is becoming ubiquitous in the design and analysis of aerospace vehicles and their propulsion systems. The current state-of-the-art of CFD in hypersonic propulsion design and analysis as well as a historical perspective of its development over the last 50 years is presented. The current state-of-the-art for the design of finite rate chemically reacting turbulent hypersonic flow is shown to currently be Reynolds averaged simulations (RAS) where the Reynolds averaged Navier-Stokes (RAS) equations are solved to obtain steady state solutions. An overview of the physical modeling techniques employed by RAS for the simulation of hypersonic chemically reacting flow are presented. However, scale resolving simulation techniques, such as detached eddy simulation (DES), large eddy simulations (LES), hybrid RAS/LES and direct numerical simulations (DNS), are becoming becoming powerful tools for point design analysis. One example of such a scale resolving technique, hybrid RAS/LES, will be briefly described as well as how it can be used to help address model form uncertainties in RAS.
Hypersonic↗
Free Energy and Flexibility Analysis of Autoinhibited Human BRAF
The RAF serine/threonine protein kinases function as direct effectors of RAS in the intracellular transmission of extracellular growth signals, and they are key targets for drug discovery, given the high incidence of oncogenic mutations in RAF and other components of this signaling pathway. In its inactive state, RAF is held in an autoinhibited conformation in the cytosol through a combination of intramolecular interactions and binding to a regulatory 14−3−3 protein dimer. Activation of RAF is initiated by its interaction with membrane-localized GTP-bound RAS, which induces conformational changes that release RAF from its autoinhibited state. However, the molecular mechanisms governing RAF activation remain incomplete, largely due to the challenges in experimentally capturing the intermediate conformational states in this process. To address this gap, we developed a comprehensive all-atom model of BRAF based on existing cryo-EM structures. Using this model, we performed extensive molecular dynamics simulations to evaluate the stability and free energy landscape of autoinhibited BRAF in solution. Our analysis reveals conformational flexibility within the autoinhibited complex, suggesting that this dynamic behavior may play a role in facilitating BRAF activation upon engagement with the membrane-bound RAS.
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗
LANDSAT technology transfer to the private and public sectors through community colleges and other locally available institutions, phase 2 program
A program established by NASA with the Environmental Research Institute of Michigan (ERIM) applies a network where the major participants are NASA, universities or research institutes, community colleges, and local private and public organizations. Local users are given an opportunity to obtain "hands on" training in LANDSAT data analysis and Geographic Information System (GIS) techniques using a desk top, interactive remote analysis station (RAS). The RAS communicates with a central computing facility via telephone line, and provides for generation of land use and land suitability maps and other data products via remote command. During the period from 22 September 1980 - 6 March 1982, 15 workshops and other training activities were successfully conducted throughout Michigan providing hands on training on the RAS terminals for 250 or more people and user awareness activities such as exhibits and demonstrations for 2,000 or more participants.
Rogers, R. H.↗