A resume of sessions on motion sickness
Neurological elements in vomiting sequence and components of emetic reflex in motion sickness
Borison, H. L.↗
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The Local Stellar Velocity Field via Vector Spherical Harmonics
We analyze the local field of stellar tangential velocities for a sample of 42,339 nonbinary Hipparcos stars with accurate parallaxes, using a vector spherical harmonic formalism. We derive simple relations between the parameters of the classical linear model (Ogorodnikov-Milne) of the local systemic field and low-degree terms of the general vector harmonic decomposition. Taking advantage of these relationships, we determine the solar velocity with respect to the local stars of (V(sub X), V(sub Y), V(sub Z)) (10.5, 18.5, 7.3) +/- 0.1 km s(exp -1) not corrected for the asymmetric drift with respect to the local standard of rest. If only stars more distant than 100 pc are considered, the peculiar solar motion is (V(sub X), V(sub Y), V(sub Z)) (9.9, 15.6, 6.9) +/- 0.2 km s(exp -1). The adverse effects of harmonic leakage, which occurs between the reflex solar motion represented by the three electric vector harmonics in the velocity space and higher degree harmonics in the proper-motion space, are eliminated in our analysis by direct subtraction of the reflex solar velocity in its tangential components for each star. The Oort parameters determined by a straightforward least-squares adjustment in vector spherical harmonics are A=14.0 +/- 1.4, B=13.1 +/- 1.2, K=1.1 +/- 1.8, and C=2.9 +/- 1.4 km s(exp -1) kpc(exp -1). The physical meaning and the implications of these parameters are discussed in the framework of a general linear model of the velocity field. We find a few statistically significant higher degree harmonic terms that do not correspond to any parameters in the classical linear model. One of them, a third-degree electric harmonic, is tentatively explained as the response to a negative linear gradient of rotation velocity with distance from the Galactic plane, which we estimate at approximately -20 km s(exp -1) kpc(exp -1). A similar vertical gradient of rotation velocity has been detected for more distant stars representing the thick disk (z greater than 1 kpc), but here we surmise its existence in the thin disk at z less than 200 pc. The most unexpected and unexplained term within the Ogorodnikov-Milne model is the first-degree magnetic harmonic, representing a rigid rotation of the stellar field about the axis -Y pointing opposite to the direction of rotation. This harmonic comes out with a statistically robust coefficient of 6.2 +/- 0.9 km s(exp -1) kpc(exp -1) and is also present in the velocity field of more distant stars. The ensuing upward vertical motion of stars in the general direction of the Galactic center and the downward motion in the anticenter direction are opposite to the vector field expected from the stationary Galactic warp model.
Galaxy↗
The Local Stellar Velocity Field via Vector Spherical Harmonics
We analyze the local field of stellar tangential velocities for a sample of 42,339 nonbinary Hipparcos stars with accurate parallaxes, using a vector spherical harmonic formalism.We derive simple relations between the parameters of the classical linear model (Ogorodnikov-Milne) of the local systemic field and low-degree terms of the general vector harmonic decomposition. Taking advantage of these relationships, we determine the solar velocity with respect to the local stars of (V(sub X), V(sub Y), V(sub Z)) = (10.5, 18.5, 7.3) +/- 0.1 km s(exp -1) not for the asymmetric drift with respect to the local standard of rest. If only stars more distant than 100 pc are considered, the peculiar solar motion is (V(sub X), V(sub Y), V(sub Z)) = (9.9, 15.6, 6.9) +/- 0.2 km s(exp -1). The adverse effects of harmonic leakage, which occurs between the reflex solar motion represented by the three electric vector harmonics in the velocity space and higher degree harmonics in the proper-motion space, are eliminated in our analysis by direct subtraction of the reflex solar velocity in its tangential components for each star...
kinematics↗
The vestibulo-ocular reflex and its possible roles in space motion sickness
Prolonged exposure to an inappropriate vestibulo-ocular reflex (VOR) will usually lead to motion sickness, and it has been predicted on theoretical grounds that VOR gain may be decreased in weightlessness. While experiments during parabolic flight in aircraft tend to confirm this prediction, experiments during orbital spaceflight have led to apparently contradictory results. It is suggested that VOR gain is reduced initially, but that rapid compensatory mechanisms restore it to normal within minutes of reaching weightlessness. However, even though this process may lead to the rapid return of functionally normal gaze stability, it may not protect against the development of motion sickness.
Watt, Douglas G. D.↗
Space motion sickness and vestibular adaptation to weightlessness
Theories of space motion sickness are discussed together with near future vestibular experiments for three Spacelab missions. The sensory conflict theory is covered, as well as theories involving unequal otolith masses, semicircular canals, cardiovascular adaptation and fluid shift toward the head, and extra-labyrinthine effects. Experiments will test the hypothesis that the sensitivity of the otolith organ response is shifted during weightlessness and that this shift carries over to the post-flight experience. Visual-vestibular-tactile interaction, vestibulo-ocular reflexes, ocular counterrolling, awareness of body position, otolith-spinal reflexes, and motion sickness susceptibility are among the parameters to be studied. Preflight and postflight tests will emphasize evaluation of any residual effects of the seven day weightless exposure on vestibulo-spinal and vestibulo-ocular pathways.
Young, L. R.↗
Lightweight Helmet For Eye/Balance Studies
Lightweight helmet serves as mounting platform for stimulus and sensor modules in experiments on role of vestibulo-ocular reflex in motion sickness and space-adaptation syndrome. Fitted liner and five inflatable air bladders stabilize helmet with respect to subject's head. Personal bite board attached to chin-bar assembly makes hard palate in subject's mouth serve as final position reference for helmet.
Mcstravick, M. Catherine↗
Whole earth telescope observations of the white dwarf G29-38 - Phase variations of the 615 second period
An extensive set of high-speed photometric observations obtained with the Whole Earth Telescope network is used to show that the complex light curve of the ZZ Zeti (DAV) star G29-38 is dominated by a single, constant amplitude period of 615 s during the time span of these observations. The pulse arrival times for this period exhibit a systematic variation in phase readily explained by light-travel time effects produced by reflex orbital motion about an unseen companion. The best-fit model to the observations indicates a highly eccentric orbit, a period of 109 + or - 13 days and a minimum mass of 0.5 solar mass for the companion.
Winget, D. E.↗
Radial Velocity Detection of Extra-Solar Planetary Systems
The McDonald Observatory Planetary Search (MOPS) was designed to search for Jovian-mass planets in orbit around solar-type stars by making high-precision measurements of the Radial Velocity (RV) of a star, to attempt to detect the reflex orbital motion of the star around the star-planet barycenter. In our solar system, the velocity of the Sun around the Sun-Jupiter barycenter averages 12.3 m/ s. The MOPS survey started operation in September 1987, and searches 36 bright, nearby, solar-type dwarfs to 10 m/s precision. The survey was started using telluric O2 absorption lines as the velocity reference metric. Observations use the McDonald Observatory 2.7-m Harlan Smith Telescope coude spectrograph with the six-foot camera. This spectrograph configuration isolates a single order of the echelle grating on a Texas Instruments 800 x 800 CCD. The telluric line method gave us a routine radial velocity precision of about 15 m/s for stars down to about 5-th magnitude. However, the data obtained with this technique suffered from some source of long-term systematic errors, which was probably the intrinsic velocity variability of the terrestrial atmosphere, i.e. winds. In order to eliminate this systematic error and to improve our overall measurement precision, we installed a stabilized I2 gas absorption cell as the velocity metric for the MOPS in October 1990. In use at the telescope, the cell is placed directly in front of the spectrograph entrance slit, with starlight passing through the cell. The use of this sealed stabilized I2 cell removes potential problems with possible long-term drifts in the velocity metric. The survey now includes a sample of 36 nearby F, G, and K type stars of luminosity class V or IV-V.
Cochran, William D.↗
Primate translational vestibuloocular reflexes. II. Version and vergence responses to fore-aft motion
To maintain binocular fixation on near targets during fore-aft translational disturbances, largely disjunctive eye movements are elicited the amplitude and direction of which should be tuned to the horizontal and vertical eccentricities of the target. The eye movements generated during this task have been investigated here as trained rhesus monkeys fixated isovergence targets at different horizontal and vertical eccentricities during 10 Hz fore-aft oscillations. The elicited eye movements complied with the geometric requirements for binocular fixation, although not ideally. First, the corresponding vergence angle for which the movement of each eye would be compensatory was consistently less than that dictated by the actual fixation parameters. Second, the eye position with zero sensitivity to translation was not straight ahead, as geometrically required, but rather exhibited a systematic dependence on viewing distance and vergence angle. Third, responses were asymmetric, with gains being larger for abducting and downward compared with adducting and upward gaze directions, respectively. As frequency was varied between 4 and 12 Hz, responses exhibited high-pass filter properties with significant differences between abduction and adduction responses. As a result of these differences, vergence sensitivity increased as a function of frequency with a steeper slope than that of version. Despite largely undercompensatory version responses, vergence sensitivity was closer to ideal. Moreover, the observed dependence of vergence sensitivity on vergence angle, which was varied between 2.5 and 10 MA, was largely linear rather than quadratic (as geometrically predicted). We conclude that the spatial tuning of eye velocity sensitivity as a function of gaze and viewing distance follows the general geometric dependencies required for the maintenance of foveal visual acuity. However, systematic deviations from ideal behavior exist that might reflect asymmetric processing of abduction/adduction responses perhaps because of different functional dependencies of version and vergence eye movement components during translation.
NASA Program Biomedical Research and Countermeasur↗
Role of orientation reference selection in motion sickness
The overall objective of this proposal is to understand the relationship between human orientation control and motion sickness susceptibility. Three areas related to orientation control will be investigated. These three areas are (1) reflexes associated with the control of eye movements and posture, (2) the perception of body rotation and position with respect to gravity, and (3) the strategies used to resolve sensory conflict situations which arise when different sensory systems provide orientation cues which are not consistent with one another or with previous experience. Of particular interest is the possibility that a subject may be able to ignore an inaccurate sensory modality in favor of one or more other sensory modalities which do provide accurate orientation reference information. We refer to this process as sensory selection. This proposal will attempt to quantify subjects' sensory selection abilities and determine if this ability confers some immunity to the development of motion sickness symptoms. Measurements of reflexes, motion perception, sensory selection abilities, and motion sickness susceptibility will concentrate on pitch and roll motions since these seem most relevant to the space motion sickness problem. Vestibulo-ocular (VOR) and oculomotor reflexes will be measured using a unique two-axis rotation device developed in our laboratory over the last seven years. Posture control reflexes will be measured using a movable posture platform capable of independently altering proprioceptive and visual orientation cues. Motion perception will be quantified using closed loop feedback technique developed by Zacharias and Young (Exp Brain Res, 1981). This technique requires a subject to null out motions induced by the experimenter while being exposed to various confounding sensory orientation cues. A subject's sensory selection abilities will be measured by the magnitude and timing of his reactions to changes in sensory environments. Motion sickness susceptibility will be measured by the time required to induce characteristic changes in the pattern of electrogastrogram recordings while exposed to various sensory environments during posture and motion perception tests. The results of this work are relevant to NASA's interest in understanding the etiology of space motion sickness. If any of the reflex, perceptual, or sensory selection abilities of subjects are found to correlate with motion sickness susceptibility, this work may be an important step in suggesting a method of predicting motion sickness susceptibility. If sensory selection can provide a means to avoid sensory conflict, then further work may lead to training programs which could enhance a subject's sensory selection ability and therefore minimize motion sickness susceptibility.
Peterka, Robert J.↗
Variations in gravitoinertial force level affect the gain of the vestibulo-ocular reflex - Implications of the etiology of space motion sickness
Recordings of horizontal nystagmus were obtained on 16 male subjects exposed to repeated patterns of horizontal angular acceleration, constant velocity rotation, and sudden-stop deceleration in the laboratory and in the free-fall and high-force periods of parabolic flight. Nystagmus intensity was a clear function of gravitoinertial force level: slow phase velocity and beat frequency increased during exposure to high force levels and decreased in free-fall compared to values obtained at 1 G. These findings indicate that the gain of the vestibulo-ocular reflex decreases in free-fall. This fact likely accounts for the disorientation and dizziness sometimes experienced by astronauts when moving their heads in the early phases of orbital flight and again after splashdown. The implications of the present findings, both for the etiology and for the treatment of space motion sickness, are discussed.
Lackner, J. R.↗
Relationship of area postrema to three putative measures of motion sickness
Although the rat has an incomplete emetic reflex, several species-specific responses to motion were proposed as measures of 'motion sickness' in rats. The purpose was to determine the dependence of these responses on one of several neural structures known to be essential to motion-induced vomiting in species with a complete emetic reflex. The Area Postrema (AP) was shown to play an important role in the production of motion sickness in vomiting species. The effects of thermo-cautery ablations of the AP on three different responses supposedly reflecting motion sickness in the rat were compared: conditioned taste aversion (CTA); drinking suppression; and fecal boli. Efficacy of the ablations was determined by subjecting ablated, sham-operated, and unoperated control animals to a CTA test which is known to require a functional AP. Animals with AP ablations failed to form CTA when 0.15 M LiCl was paired with a 10 percent sucrose solution, while sham-operated control subjects conditioned as well as the unoperated control subjects. The extent of the ablations was evaluated histologically at the end of the experiment. To determine the effects of the ablations on the measures of motion sickness, all animals were subjected to rotation for 30 min or 90 min on a platform displaced 20 deg from earth horizontal. Results indicate that ablation of AP in the rat has no effect on the formation of CTA to a 4 percent solution of cider paired with motion, on the suppression of drinking immediately after exposure to motion, or on the frequency of fecal boli during exposure to motion. This failure of AP ablations to eliminate the effects of motion on any of these responses discourages their use as equivalents of motion-induced vomiting. The appropriateness of other suggested measures, e.g., pica, remains untested but the dependence of such measures on stimulation more severe than commonly used in motion sickness research and the absence of a demonstration of their dependence on neural structures essential to motion sickness in vomiting species, suggest caution in the use of such responses. Further, until more is known about the neural structures underlying these putative measures, the rat will remain a questionable subject in which to study motion sickness.
R Sutton↗
Driving a car with custom-designed fuzzy inferencing VLSI chips and boards
Vehicle control in a-priori unknown, unpredictable, and dynamic environments requires many calculational and reasoning schemes to operate on the basis of very imprecise, incomplete, or unreliable data. For such systems, in which all the uncertainties can not be engineered away, approximate reasoning may provide an alternative to the complexity and computational requirements of conventional uncertainty analysis and propagation techniques. Two types of computer boards including custom-designed VLSI chips were developed to add a fuzzy inferencing capability to real-time control systems. All inferencing rules on a chip are processed in parallel, allowing execution of the entire rule base in about 30 microseconds, and therefore, making control of 'reflex-type' of motions envisionable. The use of these boards and the approach using superposition of elemental sensor-based behaviors for the development of qualitative reasoning schemes emulating human-like navigation in a-priori unknown environments are first discussed. Then how the human-like navigation scheme implemented on one of the qualitative inferencing boards was installed on a test-bed platform to investigate two control modes for driving a car in a-priori unknown environments on the basis of sparse and imprecise sensor data is described. In the first mode, the car navigates fully autonomously, while in the second mode, the system acts as a driver's aid providing the driver with linguistic (fuzzy) commands to turn left or right and speed up or slow down depending on the obstacles perceived by the sensors. Experiments with both modes of control are described in which the system uses only three acoustic range (sonar) sensor channels to perceive the environment. Simulation results as well as indoors and outdoors experiments are presented and discussed to illustrate the feasibility and robustness of autonomous navigation and/or safety enhancing driver's aid using the new fuzzy inferencing hardware system and some human-like reasoning schemes which may include as little as six elemental behaviors embodied in fourteen qualitative rules.
Pin, Francois G.↗
The Central Nervous Connections Involved in the Vomiting Reflex
The vomiting reflex may be elicited by a number of different types or classes of stimuli involving many varieties of receptor structures and considerable diversity in afferent pathways and central connections. Central relay or mediating structures thus may vary widely according to the type of initial emetic stimulus. The emetic circuits which have been most completely delineated to date are probably those in which the Chemoreceptor Trigger Zone (CTZ) in the Area Postrema (AP) functions as a key mediating structure. Even in this system, however, there are large gaps in our knowledge of the nerve tracts and central nervous connections involved. Knowledge of most other emetic circuits subserving the emetic reflex resulting from many diverse types of stimuli such, for example, as emotional stress (e.g. psychogenic vomiting, Wruble et al. 1982), pain (e.g. testicular trauma), and chemical or mechanical irritation of the gastrointestinal tract or urinary tract is quite incomplete at this time, thus precluding any very adequate description of their central connections at present. One physiological system, however, which has received considerable attention recently in relation to the vomiting reflex elicited by motion stimuli is the vestibular system. Due to the paucity of data on central nervous connections of several or the non-vestibular types of emetic stimuli cited above, we will devote most of our attention in this brief review to the central connections of the vestibular system which seem likely to be involved in the vomiting response to motion stimuli. However, the latter part of the review will be concerned with the concept of the reticular vomiting centre in relation to the ParviCellular Reticular Formation (PCRF), and will thus probably pertain to all of the many classes of emetic stimuli since it will address the question of the final common emetic pathway.
Brizzee, K. R.↗
Straight Ahead in Microgravity
This joint ESA-NASA study will address adaptive changes in spatial orientation related to the subjective straight ahead, and the use of a vibrotactile sensory aid to reduce perceptual errors. The study will be conducted before and after long-duration expeditions to the International Space Station (ISS) to examine how spatial processing of target location is altered following exposure to microgravity. This project specifically addresses the sensorimotor research gap "What are the changes in sensorimotor function over the course of a mission?" Six ISS crewmembers will be requested to participate in three preflight sessions (between 120 and 60 days prior to launch) and then three postflight sessions on R+0/1 day, R+4 +/-2 days, and R+8 +/-2 days. The three specific aims include: (a) fixation of actual and imagined target locations at different distances; (b) directed eye and arm movements along different spatial reference frames; and (c) the vestibulo-ocular reflex during translation motion with fixation targets at different distances. These measures will be compared between upright and tilted conditions. Measures will then be compared with and without a vibrotactile sensory aid that indicates how far one has tilted relative to the straight-ahead direction. The flight study was been approved by the medical review boards and will be implemented in the upcoming Informed Crew Briefings to solicit flight subject participation. Preliminary data has been recorded on 6 subjects during parabolic flight to examine the spatial coding of eye movements during roll tilt relative to perceived orientations while free-floating during the microgravity phase of parabolic flight or during head tilt in normal gravity. Binocular videographic recordings obtained in darkness allowed us to quantify the mean deviations in gaze trajectories along both horizontal and vertical coordinates relative to the aircraft and head orientations. During some parabolas, a vibrotactile sensory aid provided feedback of body orientation relative to the plane coordinates. RESULTS Both variability and curvature of gaze trajectories increased during roll tilt compared to the upright position. The saccades were less accurate during parabolic flight compared to measurements obtained in normal gravity. Although subjects were instructed to look off in the distance while performing the eye movements, fixation distance varied with vertical gaze direction independent of whether the saccades were made along perceived aircraft or head orientations. The increased errors in gaze trajectories along both perceived orientations during microgravity can be attributed to the otolith's role in spatial coding of eye movements. A change in an individual's egocentric reference might have negative consequences on evaluating the direction of an approaching object or on the accuracy of reaching movements or locomotion. Consequently, investigating how microgravity affects the target location will have theoretical, operational and even clinical implications for future space exploration missions. The use of vibrotactile feedback as a sensorimotor countermeasure is applicable to balance therapy applications for vestibular loss patients and the elderly to mitigate risks due to loss of orientation.
Wood, S. J.↗
Primate translational vestibuloocular reflexes. I. High-frequency dynamics and three-dimensional properties during lateral motion
The dynamics and three-dimensional (3-D) properties of the primate translational vestibuloocular reflex (trVOR) for high-frequency (4-12 Hz, +/-0.3-0.4 g) lateral motion were investigated during near-target viewing at center and eccentric targets. Horizontal response gains increased with frequency and depended on target eccentricity. The larger the horizontal and vertical target eccentricity, the steeper the dependence of horizontal response gain on frequency. In addition to horizontal eye movements, robust torsional response components also were present at all frequencies. During center-target fixation, torsional response phase was opposite (anticompensatory) to that expected for an "apparent" tilt response. Instead torsional response components depended systematically on vertical-target eccentricity, increasing in amplitude when looking down and reversing phase when looking up. As a result the trVOR eye velocity vector systematically tilted away from a purely horizontal direction, through an angle that increased with vertical eccentricity with a slope of approximately 0.7. This systematic dependence of torsional eye velocity tilt on vertical eye position suggests that the trVOR might follow the 3-D kinematic requirements that have been shown to govern visually guided eye movements and near-target fixation.
NASA Discipline Neuroscience↗
Torsional vestibulo-ocular reflex measurements for identifying otolith asymmetries possibly related to space motion sickness susceptibility
Recent studies by Diamond and Markham have identified significant correlations between space motion sickness susceptibility and measures of disconjugate torsional eye movements recorded during parabolic flights. These results support an earlier proposal by von Baumgarten and Thumler which hypothesized that an asymmetry of otolith function between the two ears is the cause of space motion sickness. It may be possible to devise experiments that can be performed in the 1 g environment on earth that could identify and quantify the presence of asymmetric otolith function. This paper summarizes the known physiological and anatomical properties of the otolith organs and the properties of the torsional vestibulo-ocular reflex which are relevant to the design of a stimulus to identify otolith asymmetries. A specific stimulus which takes advantage of these properties is proposed.
Non-NASA Center↗
Advanced Techniques for Assessment of Postural and Locomotor Ataxia, Spatial Orientation, and Gaze Stability
In addition to adapting to microgravity, major neurovestibular problems of space flight include postflight difficulties with standing, walking, turning corners, and other activities that require stable upright posture and gaze stability. These difficulties inhibit astronauts' ability to stand or escape from their vehicle during emergencies. The long-ter7n goal of the NSBRI is the development of countermeasures to ameliorate the effects of long duration space flight. These countermeasures must be tested with valid and reliable tools. This project aims to develop quantitative, parametric approaches for assessing gaze stability and spatial orientation during normal gait and when gait is perturbed. Two of this year's most important findings concern head fixation distance and ideal trajectory analysis. During a normal cycle of walking the head moves up and down linearly. A simultaneous angular pitching motion of the head keeps it aligned toward an imaginary point in space at a distance of about one meter in front of a subject and along the line of march. This distance is called the head fixation distance. Head fixation distance provides the fundamental framework necessary for understanding the functional significance of the vestibular reflexes that couple head motion to eye motion. This framework facilitates the intelligent design of counter-measures for the effects of exposure to microgravity upon the vestibular ocular reflexes. Ideal trajectory analysis is a simple candidate countermeasure based upon quantifying body sway during repeated up and down stair stepping. It provides one number that estimates the body sway deviation from an ideal sinusoidal body sway trajectory normalized on the subject's height. This concept has been developed with NSBRI funding in less than one year. These findings are explained in more detail below. Compared to assessments of the vestibuo-ocular reflex, analysis of vestibular effects on locomotor function is relatively less well developed and quantified. We are improving this situation by applying methodologies such as nonlinear orbital stability to quantify responses and by using multivariate statistical approaches to link together the responses across separate tests. In this way we can exploit the information available and increase the ability to discriminate between normal and pathological responses. Measures of stability and orientation are compared to measures such as dynamic visual acuity and with balance function tests. The responses of normal human subjects and of patients having well documented pathophysiologies are being characterized. When these studies are completed, we should have a clearer idea about normal and abnormal patterns of eye, head, and body movements during locomotion and their stability in a wide range of environments. We plan eventually to use this information to validate the efficacy of candidate neurovestibular and neuromuscular rehabilitative techniques. Some representative studies made during this year are summarized.
Wall, Conrad., III↗