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All sourcesNASA NTRSDOE OSTI
NASA NTRS2010

Space Toxicology: Human Health during Space Operations

Space Toxicology is a unique and targeted discipline for spaceflight, space habitation and occupation of celestial bodies including planets, moons and asteroids. Astronaut explorers face distinctive health challenges and limited resources for rescue and medical care during space operation. A central goal of space toxicology is to protect the health of the astronaut by assessing potential chemical exposures during spaceflight and setting safe limits that will protect the astronaut against chemical exposures, in a physiologically altered state. In order to maintain sustained occupation in space on the International Space Station (ISS), toxicological risks must be assessed and managed within the context of isolation continuous exposures, reuse of air and water, limited rescue options, and the need to use highly toxic compounds for propulsion. As we begin to explore other celestial bodies in situ toxicological risks, such as inhalation of reactive mineral dusts, must also be managed.

Khan-Mayberry, Noreen↗
NASA NTRS2004

The International Space Station: A Pathway to the Future

Nearly six years after the launch of the first International Space Station element, and four years after its initial occupation, the United States and our 16 international partners have made great strides in operating this impressive Earth orbiting research facility. This past year we have done so in the face of the adversity of operating without the benefit of the Space Shuttle. In his January 14, 2004, speech announcing a new vision for America's space program, President Bush affirmed the United States' commitment to completing construction of the International Space Station by 2010. The President also stated that we would focus our future research aboard the Station on the longterm effects of space travel on human biology. This research will help enable human crews to venture through the vast voids of space for months at a time. In addition, ISS affords a unique opportunity to serve as an engineering test bed for hardware and operations critical to the exploration tasks. NASA looks forward to working with our partners on International Space Station research that will help open up new pathways for future exploration and discovery beyond low Earth orbit. This paper provides an overview of the International Space Station Program focusing on a review of the events of the past year, as well as plans for next year and the future.

Kitmacher, Gary H.↗
NASA NTRS1994

Development of microgravity, full body functional reach envelope using 3-D computer graphic models and virtual reality technology

In microgravity conditions mobility is greatly enhanced and body stability is difficult to achieve. Because of these difficulties, optimum placement and accessibility of objects and controls can be critical to required tasks on board shuttle flights or on the proposed space station. Anthropometric measurement of the maximum reach of occupants of a microgravity environment provide knowledge about maximum functional placement for tasking situations. Calculations for a full body, functional reach envelope for microgravity environments are imperative. To this end, three dimensional computer modeled human figures, providing a method of anthropometric measurement, were used to locate the data points that define the full body, functional reach envelope. Virtual reality technology was utilized to enable an occupant of the microgravity environment to experience movement within the reach envelope while immersed in a simulated microgravity environment.

Lindsey, Patricia F.↗
NASA NTRS2013

Carbon Dioxide: Surprising Effects on Decision Making and Neurocognitive Performance

The occupants of modern submarines and the International Space Station (ISS) have much in common as far as their air quality is concerned. Air is polluted by materials offgassing, use of utility compounds, leaks of systems chemicals, and anthropogenic sources. The primary anthropogenic compound of concern to submariners and astronauts has been carbon dioxide (CO2). NASA and the US Navy rely on the National Research Council Committee on Toxicology (NRC-COT) to help formulate exposure levels to CO2 that are thought to be safe for exposures of 3-6 months. NASA calls its limits Spacecraft Maximum Allowable Concentrations (SMACs). Years of experience aboard the ISS and a recent publication on deficits in decision making in ground-based subjects exposed briefly to 0.25% CO2 suggest that exposure levels that have been presumed acceptable to preserve health and performance need to be reevaluated. The current CO2 exposure limits for 3-6 months set by NASA and the UK Navy are 0.7%, and the limit for US submariners is 0.5%, although the NRC-COT recommended a 90-day level of 0.8% as safe a few years ago. NASA has set a 1000-day SMAC at 0.5% for exploration-class missions. Anecdotal experience with ISS operations approaching the current 180-day SMAC of 0.7% suggest that this limit is too high. Temporarily, NASA has limited exposures to 0.5% until further peer-reviewed data become available. In the meantime, a study published last year in the journal Environmental Health Perspectives (Satish U, et al. 2012) demonstrated that complexdecision- making performance is somewhat affected at 0.1% CO2 and becomes "dysfunctional" for at least half of the 9 indices of performance at concentrations approaching 0.25% CO2. The investigators used the Strategic Management Simulation (SMS) method of testing for decisionmaking ability, and the results were so surprising to the investigators that they declared that their findings need to be independently confirmed. NASA has responded to the findings on decision making by developing a study to either confirm or refute the published results. In addition, other neurocognitive tests that have been and will be used aboard the ISS will be part of the ground-based study. Further evaluations during the exposures will include ocular and cardiovascular effects of CO2 exposure. In addition, the 1- carbon genetics of the test subjects will be evaluated to determine if any individual subjects are unusually susceptible to CO2 exposure because of genetic factors. Our plan is to extend the published study from Satish by employing a wider series of CO2 exposures to include concentrations of 0.06, 0.12, 0.25, and 0.50%. We believe that our findings will be of keen interest to submariners and to those designing "tight" buildings.

James, John T.↗
NASA NTRS2010

Microbial Anomalies Encountered on the International Space Station

Microorganisms in our living environments are unavoidable. A community of microbes arrived in space with the delivery of the first element of the International Space Station (ISS), attached to hardware and on the bodies of the humans tasked with the initial assembly missions. The risk that microorganisms could cause adverse effects in the health of both the human occupants of the ISS as well as the physical integrity of the station environment and life support systems has been both a driver and a function of engineering and operational controls. Scientists and engineers at NASA have gone to extensive measures to control microbial growth at levels safe for the crewmembers and the spacecraft environment. Many of these measures were initiated with the design of the spacecraft and its systems. Materials used in the ISS were tested for resistance to fungi, such as mold and a paint with a fungus-killing chemical was also used. Controlling the humidity of the air in the Station is also an effective way of discouraging microbe growth. The breathing air is reconditioned by the Environmental Control Life Support System (ECLSS) prior to distribution, utilizing High Efficiency Particulate Air (HEPA) filtration. Requirements restricting the accumulation of water condensate in the air handlers and habitable volume of the ISS were other safeguards added. Water for drinking and food rehydration is disinfected or filtered. A robust in-flight housekeeping regimen for the ISS significantly reduces inappropriate growth of microorganisms and includes a regular cleaning of accessible surfaces with disinfectant wipes. Most of these requirements were suggested by microbiologists to mitigate and possibly prevent many microbiological risks. In addition to these controls, before flight monitoring and analyses of the cabin air, exposed surfaces, water and food, consumables, and crew members are conducted to mitigate microbial risk to the crew and spacecraft. Many microbial risks are much easier to identify and resolve before launch than during space flight. Although the focus has been on prevention of microbiologically related, not all problems can be anticipated. A number of microbial anomalies have occurred on ISS. This paper will discuss the occurrences, root-cause investigations, and mitigation steps taken to remediate the contamination.

Bruce, Rebekah J.↗
NASA NTRS2010

Imaging Modalities Relevant to Intracranial Pressure Assessment in Astronauts: A Case-Based Discussion

Introduction: Intracranial pressure (ICP) elevation has been inferred or documented in a number of space crewmembers. Recent advances in noninvasive imaging technology offer new possibilities for ICP assessment. Most International Space Station (ISS) partner agencies have adopted a battery of occupational health monitoring tests including magnetic resonance imaging (MRI) pre- and postflight, and high-resolution sonography of the orbital structures in all mission phases including during flight. We hypothesize that joint consideration of data from the two techniques has the potential to improve quality and continuity of crewmember monitoring and care. Methods: Specially designed MRI and sonographic protocols were used to image eyes and optic nerves (ON) including the meningeal sheaths. Specific crewmembers multi-modality imaging data were analyzed to identify points of mutual validation as well as unique features of complementary nature. Results and Conclusion: Magnetic resonance imaging (MRI) and high-resolution sonography are both tomographic methods, however images obtained by the two modalities are based on different physical phenomena and use different acquisition principles. Consideration of the images acquired by these two modalities allows cross-validating findings related to the volume and fluid content of the ON subarachnoid space, shape of the globe, and other anatomical features of the orbit. Each of the imaging modalities also has unique advantages, making them complementary techniques.

Sargsyan, Ashot E.↗
DOE OSTI2022

Lighting System Control Data to Improve Design and Operation: Tunable Lighting System Data from NICU Patient Rooms

The advancement of LED and controls technology, computing capacity, and software provides new opportunities for researchers and designers to work together to further optimize spaces for occupant benefit. Here, lighting system control data from five neonatal intensive care unit patient rooms was collected over a 25-week monitoring period and analyzed to better understand occupant response to a tunable lighting system with automatic transitions throughout the day. Lighting systems are very rarely refined after installation based on actual use. Objective data detailing how the lighting system is used by the actual occupants highlights the opportunities for optimization after installation and provides insight for improving the next design. As use of the data becomes more commonplace, it can be leveraged for design recommendations. The collection of the data required no additional cost beyond the time for examining the data. The analysis revealed several clear opportunities for improvement, including adjustments to the default control setting at night, re-labeling of the control stations, and adjustments to the nighttime fade rate. The patient room occupants were active users of the different zones, dimming options, and manual overrides made available by the lighting system.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2021

Cylinder Occupancy and Measurement Suite

This software automatically records data from the Unattended Cylinder Verification Station, determines the state of the instrument, captures images of uranium hexafluoride shipment cylinders, and determines their weight. The code has been developed primarily for the International Atomic Energy Agency, but this type of instrument could be of interest to any facility operator in the uranium supply chain that handles uranium hexafluoride shipment cylinders (e.g. the 30B and 48Y cylinder). Operators may be interested in having this instrument confirm shipper declared measurement values upon receipt of a cylinder. They may also use it to aid in process monitoring if the quantity of material in the cylinder changes due to a processing activity.

Stewart, Scott L↗
NASA NTRS1976

NASA philosophy concerning space stations as operations centers for construction and maintenance of large orbiting energy systems

Future United States plans for manned space-flight activities are summarized, emphasizing the long-term goals of achieving permanent occupancy and limited self-sufficiency in space. NASA-sponsored studies of earth-orbiting Space Station concepts are reviewed along with lessons learned from the Skylab missions. Descriptions are presented of the Space Transportation System, the Space Construction Base, and the concept of space industrialization (the processing and manufacturing of goods in space). Future plans for communications satellites, solar-power satellites, terrestrial observations from space stations, and manned orbital-transfer vehicles are discussed.

Freitag, R. F.↗
NASA NTRS1977

Developing space occupancy - Perspectives on NASA future space program planning

Potential future manned space flight missions for the time after the development of the space transportation system with the space shuttle are considered, taking into account a sequence of activities concerning a gradually increasing penetration of space by man. The activities are related to the permanent occupancy of near-earth space, the permanent occupancy of near-moon space, the full self-sufficiency of man in earth-moon space, and the permanent occupancy of heliocentric space. Attention is given to Mars orbiting stations, the exploration of the asteroids, comet exploration, planet engineering programs, heliocentric orbit installation, the evolution of the earth orbit space community, space industrialization technology, lunar base development, and evolutionary paths to far-future space endeavors.

Von Puttkamer, J.↗
NASA NTRS2004

Implementation of ALARA radiation protection on the ISS through polyethylene shielding augmentation of the Service Module Crew Quarters

With 5-7 month long duration missions at 51.6 degrees inclination in Low Earth Orbit, the ionizing radiation levels to which International Space Station (ISS) crewmembers are exposed will be the highest planned occupational exposures in the world. Even with the expectation that regulatory dose limits will not be exceeded during a single tour of duty aboard the ISS, the "as low as reasonably achievable" (ALARA) precept requires that radiological risks be minimized when possible through a dose optimization process. Judicious placement of efficient shielding materials in locations where crewmembers sleep, rest, or work is an important means for implementing ALARA for spaceflight. Polyethylene (CnHn) is a relatively inexpensive, stable, and, with a low atomic number, an effective shielding material that has been certified for use aboard the ISS. Several designs for placement of slabs or walls of polyethylene have been evaluated for radiation exposure reduction in the Crew Quarters (CQ) of the Zvezda (Star) Service Module. Optimization of shield designs relies on accurate characterization of the expected primary and secondary particle environment and modeling of the predicted radiobiological responses of critical organs and tissues. Results of the studies shown herein indicate that 20% or more reduction in equivalent dose to the CQ occupant is achievable. These results suggest that shielding design and risk analysis are necessary measures for reducing long-term radiological risks to ISS inhabitants and for meeting legal ALARA requirements. Verification of shield concepts requires results from specific designs to be compared with onboard dosimetry. c2004 COSPAR. Published by Elsevier Ltd. All rights reserved.

NASA Center JSC↗
NASA NTRS1992

Crew health

Crew health concerns for Space Station Freedom are numerous due to medical hazards from isolation and confinement, internal and external environments, zero gravity effects, occupational exposures, and possible endogenous medical events. The operational crew health program will evolve from existing programs and from life sciences investigations aboard Space Station Freedom to include medical monitoring and certification, medical intervention, health maintenance and countermeasures, psychosocial support, and environmental health monitoring. The knowledge and experience gained regarding crew health issues and needs aboard Space Station Freedom will be used not only to verify requirements and programs for long duration space flight, but also in planning and preparation for Lunar and Mars exploration and colonization.

Billica, Roger D.↗
NASA NTRS2006

International Space Station Acoustics

The International Space Station (ISS) presents a significant acoustics challenge considering all of the Modules and equipment that make it an on-orbit laboratory workshop and home with long-term crew occupation. This challenge is further complicated by the fact there are numerous and a wide variety suppliers of Station hardware, including International Partners. This paper addresses how ISS acoustics are managed to ensure a safe and habitable environment by establishing requirements, providing oversight and design support, sharing lessons learned and information, testing for hardware compliance, predicting future acoustic levels, and performing on-orbit measurement and monitoring of actual acoustic levels. ISS acoustic requirements are classified by the type of hardware involved, in three categories: Modules; payloads; and Government Furnished Equipment (GFE). Current status of overall ISS acoustics for each of these hardware categories will be discussed. In addition, the following items will be discussed: examples where NASA design support has been used to aid in obtaining compliance; difficulties encountered; and areas of concern.

Goodman, Jerry↗
NASA NTRS2015

NASA Astronaut Occupational Surveillance Program and Lifetime Surveillance of Astronaut Health, LSAH, Astronaut Exposures and Risk in the Terrestrial and Spaceflight Environment

United States Astronauts have a very unique occupational exposure profile. In order to understand these risks and properly address them, the National Aeronautics and Atmospheric Administration, NASA, originally created the Longitudinal Study of Astronaut Health, LSAH. The first LSAH was designed to address a variety of needs regarding astronaut health and included a 3 to 1 terrestrial control population in order to compare United States "earth normal" disease and aging to that of a microgravity exposed astronaut. Over the years that program has been modified, now termed Lifetime Surveillance of Astronaut Health, still LSAH. Astronaut spaceflight exposures have also changed, with the move from short duration shuttle flights to long duration stays on international space station and considerable terrestrial training activities. This new LSAH incorporates more of an occupational health and medicine model to the study of occupationally exposed astronauts. The presentation outlines the baseline exposures and monitoring of the astronaut population to exposures, both terrestrial, and in space.

Keprta, Sean R.↗
NASA NTRS2023

Anomalous DOC Signatures Reveal Iron Control on Export Dynamics in the Pacific Southern Ocean

Here we shed light on two mechanisms that stimulate deep particle export via upper-ocean iron fertilization in the Southern Ocean: deep frontal mixing and melting of sea ice. We present data collected a decade apart in the Pacific sector of the Southern Ocean when, serendipitously, seasonal Antarctic ice melt was anomalously low (2008) and anomalously high (2017). In 2008, the low ice melt year, we concluded that vertical mixing of iron into the euphotic zone via deep-mixing fronts was the primary stimulant of export that reached depths of ~1500 meters. This process was evidenced by localized enhancements of dissolved organic carbon (DOC) concentrations up to 4 μmol C kg-1 beneath seven branches of fronts embedded within the Antarctic Circumpolar Current (ACC). We used these enhanced DOC concentrations in the bathypelagic as primary indications of the depths and locations of recent export, as it is a logical residue of such. In 2017, the year in which sea ice melt was anomalously high, we concluded that the main driver of a widespread export event to the seafloor was the lateral influx of iron within the melt. Indications of this event included substantial enhancements of DOC concentrations (2 - 31 6 μmol C kg-1), elevated beam attenuation, and enhanced surface iron concentrations associated with a layer of low salinity water at a nearby station. Further, significant deficits of upper ocean silicic acid during the 2017 occupation indicated that deep export was likely stimulated by an iron-fueled diatom bloom. This analysis highlights the impact of iron supplied from frontal vertical mixing and sea ice melt on export and ultimately for long-term carbon sequestration in the Southern Ocean, as well as the utility of deep DOC enrichments as signatures of particle export. Understanding the impact that ice melt events have on carbon export is crucial given that anomalous events are occurring more often as our climate changes.

Dissolved Organic Carbon↗
DOE OSTI2020

Panel Session 4 and 15: Japan Fukushima Daiichi D and D Update and Technological Challenges at Japan Fukushima Daiichi D and D and Update on Nuclear Overview and Development in Japan - Nuclear Fuel Cycle

Sessions 4 and 15 represent a two-part panel series that discusses progress and challenges associated with cleanup at Fukushima. Severe limitations on availability of original panelists from Japan due to strict restrictions put in place to alleviate the spread of coronavirus necessitated changes to both panels. The result was a significantly modified panel for Session 04 (shown above) and the elimination of all panelists for Session 15. The 4 and 15 Panel Sessions provide an overview of activities related to both the progress and challenges of cleanup and decommissioning of the Fukushima Daiichi Nuclear Power Station (NPS) in Japan. Five panelists discussed perspectives of the cleanup following a Tokyo Electric Power Company (TEPCO) video showing the progress on site since the devastating Great East Earthquake and tsunami that caused the explosions at three of the six reactors on the site. Three of the five panelists discussed on-going work being performed for the effort, while the other two provided expert perspectives of on strategic efforts at the site. The panel was attended by over 80 technologists and policy makers spanning the globe and was opened by Dr. Monica Regalbuto of Idaho National Laboratory and a short video provided by TEPCO. The video described changes at the site that spanned the cleanup efforts from stabilizing water intrusion into the contaminated reactor buildings to construction of new administrative facilities. The video explained the processes underway to retrieve spent fuel rods and challenges in retrieval of the compromised fuel debris. The video highlighted working condition improvements that included establishment of rest housing and a small convenience store on the site, and the rollback of protective equipment around the site due to decreases contamination. Panelists with presentations: Revision of 'the Mid-and-Long-Term Road-map towards the Decommissioning of TEPCO's Fukushima Daiichi Nuclear Power Station' (Paul Dickman); Sharing UK experience at Fukushima Daiichi (Adrian Simper); SRNL Japan (Andrew Fellinger); ABLE's Initiative to Dismantle the Exhaust Stack (Daniel Walter); JAEA R and D in Fukushima (Tokio Fukahori); TEPCO - Overview and Update of the Fukushima Decommissioning Process (Monica Regalbuto); Toshiba's Involvement in the Decommissioning of the Fukushima Daiichi Nuclear Power Plant (Yasuhiro Yuguchi); Remote Dismantling of the Exhaust Stack At Fukushima Dai-ichi NPS (Takashi Okutsu)

12 MANAGEMENT OF RADIOACTIVE AND NON-RADIOACTIVE W↗
DOE OSTI2020

Use of Shared Automated Vehicles for First-Mile Last-Mile Service: Micro-Simulation of Rail-Transit Connections in Austin, Texas

Shared fleets of fully automated vehicles (SAVs) coupled with real-time ride-sharing to and from transit stations are of interest to cities and nations in delivering more sustainable transportation systems. By providing first-mile last-mile (FMLM) connections to key transit stations, SAVs can replace walk-to-transit, drive-to-transit, and drive-only trips. Using the SUMO (Simulation of Urban MObility) toolkit, this paper examines mode splits, wait times, and other system features by micro-simulating two fleets of SAVs providing an FMLM ride-sharing service to 10% of central Austin’s trip-makers near five light-rail transit stations. These trips either start or end within two geofenced areas (called automated mobility districts [AMDs]), and travel time and wait time feedbacks affect mode choices. With rail service headways of 15?min, and 15 SAVs serving FMLM connections to and from each AMD, simulations predict that 3.7% of the person-trip-making will shift from driving alone to transit use in a 3?mi?×?6?mi central Austin area. During a 3-h morning peak, 30 SAVs serve about 10 person-trips each (to or from the stations), with 3.4?min average wait time for SAVs, and an average vehicle occupancy of 0.74 persons (per SAV mile-traveled), as a result of empty SAV driving between riders. Sensitivity analysis of transit headways (from 5 to 20?min) and fleet sizes (from 5 to 20 vehicles in each AMD) shows an increase in FMLM mode share with more frequent transit service and larger fleet size, but total travel time served as the biggest determinant in trip-makers’ mode share.

47 OTHER INSTRUMENTATION↗
NASA NTRS1993

Illness/injury pattern complex 40 (Titan)

On July 31, 1991, EG&G Medical began providing medical support at the Titan Area Clinic (TAC). The hours of operation are 0700-2300, Monday through Friday, with Emergency Medical Services (EMS) provided 24-hours a day, seven days a week. The TAC consists of a 10 x 10 ft section of a trailer that also houses Bechtel Safety. Supplies consisted of an examining table, an eye wash chair, first aid equipment, over-the-counter medications, spine boards, a portable rescuscitator, etc. All of the nurses are Advanced Cardiac Life Support (ACLS) certified. Although the Titan Area Clinic is strictly a first-aid station with no ACLS facilities on-site, it is staffed with an Occupational Health Nurse with ACLS certification. If ACLS or additional help is needed, the nurse activates EMS by dialing 911. The nurse responds to any medical problems or emergencies on the complex, but activates EMS prior to leaving the TAC. A Bechtel Safety Representative accompanies the nurse to the site and assists as needed. Other aspects of the complex and its functions are presented.

Blasdell, Sharon↗