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Comparative morphometry of fibers and capillaries in soleus following weightlessness (SL-3) and suspension

This work is a continuation of efforts to assess responses of rat skeletal muscle to weightlessness (W) and earthside laboratory experiments with unloading of hind limbs. The soleus is a slow-twitch, load-bearing (antigravity) muscle. Both exposure to W and to the hypokinesia/hypodynamia of whole-body suspension (WBS) results in soleus atrophy. Cross-sectional areas of both slow- and fast-twitch fibers decrease during 7 days of W or 7 or 14 days of WBS. Density and area changes tended to reverse to control levels during 7 days of recovery (R) following WBS. Capillary density was increased with 7 days of W or 7 or 14 days of WBS. During 7 days of R the capillary density returned toward control levels. In summary, the reduction in fiber cross-sectional areas and the increase in fiber and capillary densities support the hypothesis that in both W and WBS there is a loss in soleus muscle cell mass and not in fiber numbers.

Musacchia, X. J.

Payload specialist station study. Volume 3: Program study cost estimates. Part 1: Work breakdown structure

The work breakdown structure (WBS) for the Payload Specialist Station (PSS) is presented. The WBS is divided into two elements--PSS contractor and mission unique requirements. In accordance with the study ground rules, it is assumed that a single contractor, hereafter referred to as PSS Contractor will perform the following: (1) provide C and D hardware (MFDS and elements of MMSE), except for GFE; (2) identify software requirements; (3) provide GSE and ground test software; and (4) perform systems engineering and integration in support of the Aft Flight Deck (AFD) C and D concept. The PSS Contractor WBS element encompasses a core or standardized PSS concept. Payload peculiar C and D requirements identified by users will originate as a part of the WBS element mission unique requirements; these requirements will be provided to the PSS Contractor for implementation.

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Physiological comparison of rat muscle in body suspension and weightlessness

Hind limb unloading is achieved with whole body suspension (WBS) and with tail suspension (TS). Comparable levels of muscle mass loss and decreases in protein levels result during one to three weeks of exposure to microgravity (microG), WBS, and TS. Losses are most apparent in soleus (S), intermediate in gastrocnemius (G) and least in extensor digigorum longus (EDL). Comparison of S and EDL type I and II fiber changes (numbers and area) after seven days of microG flight and WBS showed, in S, an increase in Type I and Type II fiber density and a decrease in area. Except for a decrease in Type I fiber density in EDL, all other parameters remained comparable. The general conclusions were that the S under microG and WBS responds in a similar manner. The EDL, for the most part, shows little change under both conditions.

Musacchia, X. J.

Orbital transfer vehicle concept definition and system analysis study, 1985. Volume 5: Work breakdown structure and dictionary

To establish consistency and visibility within the Orbital Transfer Vehicle (OTV) program, a preliminary work breakdown structure (WBS) and dictionary were developed. The dictionary contains definitions of terms to be used in conjunction with the WBS so that a clear understanding of the content of the hardware, function, and cost elements may be established. The OTV WBS matrix is a two-dimensional structure which shows the interrelationship of these dimensions: the hardware elements dimension and the phase and function dimension. The dimension of time cannot be shown graphically, but must be considered. Each cost entry varies with time so that it is necessary to know these cost values by year for budget planning and approval as well as for establishing cost streams for discounting purposes in the economic analysis. While a multiple dimensional approach may at first appear complex, it actually provides benefits which outweigh any concern. This structural interrelationship provides the capability to view and analyze the OTV costs from a number of different financial and management aspects. Cost may be summed by hardware groupings, phases, or functions. The WBS may be used in a number of dimensional or single listing format applications.

Nelson, James H.

Definition and preliminary design of the Laser Atmospheric Wind Sounder (LAWS) phase 1. Volume 3: Program cost estimates

Cost estimates for phase C/D of the laser atmospheric wind sounder (LAWS) program are presented. This information provides a framework for cost, budget, and program planning estimates for LAWS. Volume 3 is divided into three sections. Section 1 details the approach taken to produce the cost figures, including the assumptions regarding the schedule for phase C/D and the methodology and rationale for costing the various work breakdown structure (WBS) elements. Section 2 shows a breakdown of the cost by WBS element, with the cost divided in non-recurring and recurring expenditures. Note that throughout this volume the cost is given in 1990 dollars, with bottom line totals also expressed in 1988 dollars (1 dollar(88) = 0.93 1 dollar(90)). Section 3 shows a breakdown of the cost by year. The WBS and WBS dictionary are included as an attachment to this report.

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Skeletal muscle response to spaceflight, whole body suspension, and recovery in rats

The effects of a 7-day spaceflight (SF), 7- and 14-day-long whole body suspension (WBS), and 7-day-long recovery on the muscle weight and the morphology of the soleus and the extensor digitorum longus (EDL) of rats were investigated. It was found that the effect of 7-day-long SF and WBS were highly comparable for both the soleus and the EDL, although the soleus muscle from SF rats showed greater cross-sectional area reduction than that from WBS rats. With a longer duration of WBS, there was a continued reduction in cross-sectional fast-twitch fiber area. Muscle plasticity, in terms of fiber and capillary responses, showed differences in responses of the two types of muscles, indicating that antigravity posture muscles are highly susceptible to unloading.

Musacchia, X. J.

Propulsion Technology Lifecycle Operational Analysis

The paper presents the results of a focused effort performed by the members of the Space Propulsion Synergy Team (SPST) Functional Requirements Sub-team to develop propulsion data to support Advanced Technology Lifecycle Analysis System (ATLAS). This is a spreadsheet application to analyze the impact of technology decisions at a system-of-systems level. Results are summarized in an Excel workbook we call the Technology Tool Box (TTB). The TTB provides data for technology performance, operations, and programmatic parameters in the form of a library of technical information to support analysis tools and/or models. The lifecycle of technologies can be analyzed from this data and particularly useful for system operations involving long running missions. The propulsion technologies in this paper are listed against Chemical Rocket Engines in a Work Breakdown Structure (WBS) format. The overall effort involved establishing four elements: (1) A general purpose Functional System Breakdown Structure (FSBS). (2) Operational Requirements for Rocket Engines. (3) Technology Metric Values associated with Operating Systems (4) Work Breakdown Structure (WBS) of Chemical Rocket Engines The list of Chemical Rocket Engines identified in the WBS is by no means complete. It is planned to update the TTB with a more complete list of available Chemical Rocket Engines for United States (US) engines and add the Foreign rocket engines to the WBS which are available to NASA and the Aerospace Industry. The Operational Technology Metric Values were derived by the SPST Sub-team in the form of the TTB and establishes a database for users to help evaluate and establish the technology level of each Chemical Rocket Engine in the database. The Technology Metric Values will serve as a guide to help determine which rocket engine to invest technology money in for future development.

Robinson, John W.

Fox Trails

1. This software utilizes python pandas to pull data from P6 databases or XER files. The software transforms the datasets into multiple main tables by joining, filtering, iteratively flattening hierarchical structured data, and pivoting datasets to give simple flat output tables. The activity table includes all of the information related to an activity including activity codes, global, EPS, and project codes, UDFs, and WBS information as separate columns. This includes the code id, code value and sequence number for all levels in hierarchical codes. The resource table is similar to the activity table and includes all of the information related to resources on activities including UPFs and resource codes. The resource time phased table takes the resource information and time phases it for the budget, forecast, late, and actual dates/units/costs that closely matches P6's user interface's values as it implements the resource curve and calendars. The wbs table contains the WBS structure broken out by levels and includes UDFs, codes, and notebook topics. The final P6 data table is the relationships table which simply contains the relationships. 2. When a user updates the tool with data (via giving it P6 project names with database username/password information or XER files) the system creates the data in #1, then creates a networkx graph with the activity data imbedded in the node data and the relationships added as edges. Each edge also has it's float calculated (working time distance between the predecessor and successor) and attached to the edge. Activities are also tagged as a potential start of a path based on their constraints, constraint dates, remaining start date, and activity status. When a user enters an activity ID into the UI, it runs a shortest path calculation on the network graph between each node tagged as potential start to the entered activity id based on the float tagged on the edge. Each path returned by the algorithm contains all of the nodes on the path in order, as well as the total float of the edges that make the path. This data is then collected and returned to the user in the form of a gantt chart with groupings for each path that includes the total float for each group. 3. Similar to 2, if the user passes through a reference dataset each activity set in the path is checked to see if it had a path in the reference dataset, if that path was the primary path between the start and end activities, and what has changed regarding logic and durations. These changes are color coded and summarized before sent to the user to be displayed by the UI for simple discovery. 4. Utilizing the data from #1, the user can submit desired grouping code(s) and filters to the system. The system will then pull the activities, resources, and relationships and create a gantt chart based on the groupings sent and filtered based on the filters sent. 5. The system will produce a gantt chart in a similar method to #4, but allows interactivity with the data. As the user interacts with the gantt chart, the software captures the changes and stores it with the user making the change so that project controls and implement those changes in P6.

Fox, Ben

Evolutionary space platform concept study. Volume 3: Programmatics for manned space platform concepts

The programmatic data for the reference concept of the Manned Space Platform is presented. Details regarding work breakdown structure (WBS) and dictionary, the facilities and equipment required to produce the modules, the project schedule and logic diagram, a preliminary assessment of environmental impacts and details regarding the estimated costs for the reference concept are included. The proposed WBS which was developed to provide summary and system level segregation of the nonrecurring and recurring portions of the Manned Space Platform project is also included. The accompanying dictionary outlines the function and activities contained within each WBS element. The facility and equipment required to produce the various modules is discussed. Generally, required equipment is within the existing state of the art although the size of some of the items to be manufactured is a consideration. A preliminary manufacturing flow was also provided. The project schedules presented consist of the Master Project Summary Schedule, the Master Project Phasing Chart and the Logic Network.

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Space Station Furnace Facility. Volume 3: Program cost estimate

The approach used to estimate costs for the Space Station Furnace Facility (SSFF) is based on a computer program developed internally at Teledyne Brown Engineering (TBE). The program produces time-phased estimates of cost elements for each hardware component, based on experience with similar components. Engineering estimates of the degree of similarity or difference between the current project and the historical data is then used to adjust the computer-produced cost estimate and to fit it to the current project Work Breakdown Structure (WBS). The SSFF Concept as presented at the Requirements Definition Review (RDR) was used as the base configuration for the cost estimate. This program incorporates data on costs of previous projects and the allocation of those costs to the components of one of three, time-phased, generic WBS's. Input consists of a list of similar components for which cost data exist, number of interfaces with their type and complexity, identification of the extent to which previous designs are applicable, and programmatic data concerning schedules and miscellaneous data (travel, off-site assignments). Output is program cost in labor hours and material dollars, for each component, broken down by generic WBS task and program schedule phase.

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Space transfer vehicle concepts and requirements study. Volume 3, book 1: Program cost estimates

The Space Transfer Vehicle (STV) Concepts and Requirements Study cost estimate and program planning analysis is presented. The cost estimating technique used to support STV system, subsystem, and component cost analysis is a mixture of parametric cost estimating and selective cost analogy approaches. The parametric cost analysis is aimed at developing cost-effective aerobrake, crew module, tank module, and lander designs with the parametric cost estimates data. This is accomplished using cost as a design parameter in an iterative process with conceptual design input information. The parametric estimating approach segregates costs by major program life cycle phase (development, production, integration, and launch support). These phases are further broken out into major hardware subsystems, software functions, and tasks according to the STV preliminary program work breakdown structure (WBS). The WBS is defined to a low enough level of detail by the study team to highlight STV system cost drivers. This level of cost visibility provided the basis for cost sensitivity analysis against various design approaches aimed at achieving a cost-effective design. The cost approach, methodology, and rationale are described. A chronological record of the interim review material relating to cost analysis is included along with a brief summary of the study contract tasks accomplished during that period of review and the key conclusions or observations identified that relate to STV program cost estimates. The STV life cycle costs are estimated on the proprietary parametric cost model (PCM) with inputs organized by a project WBS. Preliminary life cycle schedules are also included.

Peffley, Al F.

Rat cardiovascular responses to whole body suspension - Head-down and non-head-down tilt

Two experiments aimed at examining the versatility of the whole body suspension (WBS) system as a ground-based model for cardiovascular effects of microgravity are described. The first experiment studied heart rate and arterial pressure responses in rats during a 7-day period of head-down tilt (HDT) or nonhead-down tilt (NHDT) and after removal from whole body suspension (WBS). Mean arterial (MAP), systolic, and diastolic pressures increased about 20 percent in HDT rats on the fist day, heart rates were elevated about 10 percent. During postsuspension most cardiovascular parameters returned to presuspension levels. The second experiment evaluated responses to rapid head-up tilt in HDT and NHDT rats. It was observed that, while pulse pressures remained unchanged, MAP, systolic and diastolic pressures, and HR were elevated in HDT and NHDT rats during head-up tilt after one day of suspension. The WBS rats are considered to be useful as a model to better understand responses of rats exposed to microgravity.

Musacchia, X. J.

Analysis and effects of the advanced solid rocket motor on the Space Shuttle elements

This interim final report summarizes the activities and major accomplishments under NASA/MSFC Contract NAS8-39235 for the initial two year contractual effort beginning October 1, 1991, and ending September 30, 1993. It is not intended as an exhaustive treatment or review of any particular technical issue which was addressed during this two-year period, but does provide an overview of the many induced environment studies and test support activities undertaken by REMTECH and its subcontractors during this two-year period. The initial scope of work has been pursued vigorously through this two-year period by separating the effort into five functional areas. The five functional areas are ascent plume radiation, ascent plume convection, ascent aerodynamic heating, launch stand environments, and reentry heating. A work breakdown structure (WBS) for each functional area was devised to permit nearly autonomous activities within each functional responsibility while maintaining commonality in reporting procedures and cost accounting. The contract was modified 11 times to provide incremental funding and to expand the scope of work. Additional work breakdown structure was incorporated to meet the expanded scope. A contract chronology is provided in Section 2. The initial scope of work, expanded scope, and corresponding WBS designation are described in Section 3. A summary review of major accomplishments is also provided in Section 4 to show the breadth of activities and extent of reporting. Reports, meetings, test activities, and other accomplishments within each functional area are also summarized by WBS heading in the appendices.

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Advanced transportation system study: Manned launch vehicle concepts for two way transportation system payloads to LEO. Work breakdown structure and work breakdown structure dictionary

The report describes the work breakdown structure (WBS) and its associated WBS dictionary for task area 1 of contract NAS8-39207, advanced transportation system studies (ATSS). This WBS format is consistent with the preliminary design level of detail employed by both task area 1 and task area 4 in the ATSS study and is intended to provide an estimating structure for parametric cost estimates.

Duffy, James B.

Hybrid SOFC-Turbogenerator for Aircraft (Final Scientific/Technical Report)

The following paragraphs provide a high-level summary of the work performed during Phases I and II of this contract. Note that the order deviates from the WBS in places to better reflect the actual sequence of activities and the connections between them. Corresponding task numbers in the WBS are provided in parentheses after the task titles. There are a total of thirteen (13) tasks.

32 ENERGY CONSERVATION, CONSUMPTION, AND UTILIZATI

Handbook for preparation of work breakdown structures

Guidelines are presented for development of work breakdown structures (WBS) for NASA programs, projects, and contracts. The WBS were developed by starting with the end objective required and successively subdividing it into manageable components in terms of size and complexity, such as program, project, system, subsystems, components, tasks, subtasks, and work elements.

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Space Tug Docking Study. Volume 5: Cost Analysis

The cost methodology, summary cost data, resulting cost estimates by Work Breakdown Structure (WBS), technical characteristics data, program funding schedules and the WBS for the costing are discussed. Cost estimates for two tasks of the study are reported. The first, developed cost estimates for design, development, test and evaluation (DDT&E) and theoretical first unit (TFU) at the component level (Level 7) for all items reported in the data base. Task B developed total subsystem DDT&E costs and funding schedules for the three candidate Rendezvous and Docking Systems: manual, autonomous, and hybrid.

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Phase B - final definition and preliminary design study for the initial Atmospheric Cloud Physics Laboratory (ACPL): A spacelab mission payload. Work breakdown structure for phase C/D DR-MA-06 (preliminary issue)

The Work Breakdown Structure (WBS) and Dictionary (DR-MA-06) for initial and subsequent flights of the Atmospheric Cloud Physics Laboratory (ACPL) is presented. An attempt is made to identify specific equipment and components in each of the eleven subsystems; they are listed under the appropriate subdivisions of the WBS. The reader is cautioned that some of these components are likely to change substantially during the course of the study, and the list provided should only be considered representative.

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