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At least 37 records · Page 2

Opinion to address the personal protective equipment shortage in the global community during the COVID-19 outbreak

The current COVID-19 pandemic is stretching both the global supply for face masks and personal protective equipment (PPE). Production capacity is severely limited in many countries. This is a call for the R&D community, particularly to those in the polymer degradation and stability field. We have not only an opportunity but an obligation to engage and collaborate with virology and bio-medical experts. We require comparative R&D for extended, reuse and recyclability options. Additionally, there is urgent need for large scale institutional approaches and methods that can be quickly applied locally by non-experts with limited resources.

36 MATERIALS SCIENCE↗

Effect of specific non-pharmaceutical intervention policies on SARS-CoV-2 transmission in the counties of the United States

Non-pharmaceutical interventions (NPIs) remain the only widely available tool for controlling the ongoing SARS-CoV-2 pandemic. We estimated weekly values of the effective basic reproductive number (R eff ) using a mechanistic metapopulation model and associated these with county-level characteristics and NPIs in the United States (US). Interventions that included school and leisure activities closure and nursing home visiting bans were all associated with a median R eff below 1 when combined with either stay at home orders (median R eff 0.97, 95% confidence interval (CI) 0.58–1.39) or face masks (median R eff 0.97, 95% CI 0.58–1.39). While direct causal effects of interventions remain unclear, our results suggest that relaxation of some NPIs will need to be counterbalanced by continuation and/or implementation of others.

60 APPLIED LIFE SCIENCES↗

Control of airborne infectious disease in buildings: Evidence and research priorities

The evolution of SARS-CoV-2 virus has resulted in variants likely to be more readily transmitted through respiratory aerosols, underscoring the increased potential for indoor environmental controls to mitigate risk. Use of tight-fitting face masks to trap infectious aerosol in exhaled breath and reduce inhalation exposure to contaminated air is of critical importance for disease control. Administrative controls including the regulation of occupancy and interpersonal spacing are also important, while presenting social and economic challenges. Indoor engineering controls including ventilation, exhaust, air flow control, filtration, and disinfection by germicidal ultraviolet irradiation can reduce reliance on stringent occupancy restrictions. However, the effects of controls-individually and in combination-on reducing infectious aerosol transfer indoors remain to be clearly characterized to the extent needed to support widespread implementation by building operators. We review aerobiologic and epidemiologic evidence of indoor environmental controls against transmission and present a quantitative aerosol transfer scenario illustrating relative differences in exposure at close-interactive, room, and building scales. We identify an overarching need for investment to implement building controls and evaluate their effectiveness on infection in well-characterized and real-world settings, supported by specific, methodological advances. Finally, improved understanding of engineering control effectiveness guides implementation at scale while considering occupant comfort, operational challenges, and energy costs.

60 APPLIED LIFE SCIENCES↗

Personal Interventions for Reducing Exposure and Risk for Outdoor Air Pollution: An Official American Thoracic Society Workshop Report

Poor air quality affects the health and wellbeing of large populations around the globe. Although source controls are the most effective approaches for improving air quality and reducing health risks, individuals can also take actions to reduce their personal exposure by staying indoors, reducing physical activity, altering modes of transportation, filtering indoor air, and using respirators and other types of face masks. A synthesis of available evidence on the efficacy, effectiveness, and potential adverse effects or unintended consequences of personal interventions for air pollution is needed by clinicians to assist patients and the public in making informed decisions about use of these interventions. To address this need, the American Thoracic Society convened a workshop in May of 2018 to bring together a multidisciplinary group of international experts to review the current state of knowledge about personal interventions for air pollution and important considerations when helping patients and the general public to make decisions about how best to protect themselves. From these discussions, recommendations were made regarding when, where, how, and for whom to consider personal interventions. In addition to the efficacy and safety of the various interventions, the committee considered evidence regarding the identification of patients at greatest risk, the reliability of air quality indices, the communication challenges, and the ethical and equity considerations that arise when discussing personal interventions to reduce exposure and risk from outdoor air pollution.

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTAN↗

Practices Implemented by DOE Better Plants Program Partners to Mitigate COVID-19

Screening for symptoms, maintaining physical distance, sanitizing surfaces, wearing appropriate face masks, maintaining good personal hygiene, and reconfiguring HVAC air management are the major activities that the DOE BP partners have implemented to mitigate COVID-19. This article shares some specific practices that BP program partners have implemented for these activities. The energy impact of some practices has also been discussed and some rules of thumb have been provided to estimate energy penalties.

32 ENERGY CONSERVATION, CONSUMPTION, AND UTILIZATI↗

Compact scalable nanofiber mass production using electrospinning

A low power out put high voltage power supply unit for mass producing thicker nanofiber mat has been built in-house and earned a provisional patent last year. This nanofiber fabrication unit has unique features to produce stand alone thick ceramic nanofiber for specialized application such as isotop production and accelerator targets for high energy physics experiments. This is a versatile unit which can produce wide variety of polymer nanofibers on a semi industrial scale for application in air filtration, face mask, facial beauty pads, gas sensors and many more.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

Respiratory analysis system and method

A system is described for monitoring the respiratory process in which the gas flow rate and the frequency of respiration and expiration cycles can be determined on a real time basis. A face mask is provided with one-way inlet and outlet valves where the gas flow is through independent flowmeters and through a mass spectrometer. The opening and closing of a valve operates an electrical switch, and the combination of the two switches produces a low frequency electrical signal of the respiratory inhalation and exhalation cycles. During the time a switch is operated, the corresponsing flowmeter produces electric pulses representative of the flow rate; the electrical pulses being at a higher frequency than that of the breathing cycle and combined with the low frequency signal. The high frequency pulses are supplied to conventional analyzer computer which also receives temperature and pressure inputs and computes mass flow rate and totalized mass flow of gas. From the mass spectrometer, components of the gas are separately computed as to flow rate. The electrical switches cause operation of up-down inputs of a reversible counter. The respective up and down cycles can be individually monitored and combined for various respiratory measurements.

Liu, F. F.↗

Volume measuring system

Chamber is designed to be airtight; it includes face mask for person to breathe outside air so that he does not disturb chamber environment. Chamber includes piston to vary air volume inside. Also included are two microphone transducers which record pressure information inside chamber.

Oele, J. S.↗

Mobile automatic metabolic analyzer

Two flexible pipes, attached to face mask, are connected to spirometers in mobile cart. Inhaled air volume is measured as it is drawn from one spirometer, and exhaled air volume is measured as it is breathed into second spirometer. Sensor is used to monitor heartbeat rate.

Bynum, B. G.↗

Calibration of image dissector tubes

Technique employs computer-controlled light-emitting diode (LED), precision machined mask, and analog-to-digital coverter (ADC). Computer turns on LED which floods masked face of tube. Intensity pattern, generated as tube is electromagnetically swept, is fed to ADC which controls tube calibration.

Klingman, E. E., III↗

Application of cabin atmosphere monitors to rapid screening of breath samples for the early detection of disease states

Analysis of human breath is a nonintrusive method to monitor both endogenous and exogenous chemicals found in the body. Several technologies were investigated and developed which are applicable to monitoring some organic molecules important in both physiological and pathological states. Two methods were developed for enriching the organic molecules exhaled in the breath of humans. One device is based on a respiratory face mask fitted with a polyethylene foam wafer; while the other device is a cryogenic trap utilizing an organic solvent. Using laboratory workers as controls, two organic molecules which occurred in the enriched breath of all subjects were tentatively identified as lactic acid and contisol. Both of these substances occurred in breath in sufficient amounts that the conventional method of gas-liquid chromatography was adequate for detection and quantification. To detect and quantitate trace amounts of chemicals in breath, another type of technology was developed in which analysis was conducted using high pressure liquid chromatography and mass spectrometry.

Valentine, J. L.↗

Technology transfer from space to earth - The NASA Firefighter's Breathing System

Responding to the recent demand of fire services for a better equipment, NASA has prepared two improved versions of Firefighter's Breathing System (FBS) by taking advantage of the spacesuit design. In the new FBS, the conventional oxygen tube is replaced by a 40% lighter air tube with twice as much pressure. The load is attached to a wide waist belt and distributed on the hips instead of the shoulder, thus making it easier to carry. The two versions of the FBS are essentially the same, the only difference being the capacities of the air tubes. Also the face mask used is smaller, lighter and provides better vision and mobility. The FBS had a notable impact, with the fire departments reporting improved efficiency. Unlike other technology transfer cases, the FBS concept is commercially successful in finding diverse fields of application.

Mclaughlan, P. B.↗

Personnel emergency carrier vehicle

A personnel emergency carrier vehicle is disclosed which includes a vehicle frame supported on steerable front wheels and driven rear wheels. A supply of breathing air is connected to quick connect face mask coupling and umbilical cord couplings for supplying breathing air to an injured worker or attendant either with or without a self-contained atmospheric protection suit for protection against hazardous gases at an accident site. A non-sparking hydraulic motion is utilized to drive the vehicle and suitable direction and throttling controls are provided for controlling the delivery of a hydraulic driving fluid from a pressurized hydraulic fluid accumulator. A steering axis is steerable through a handle to steer the front wheels through a linkage assembly.

Owens, Lester J.↗

Space Technology for the Fire Department

A National Bureau of Standards/NASA project directed by Johnson resulted in a lightweight breathing system including face mask, frame, harness and air bottle marketed by Scott Aviation. Aluminum composite material was used; frame and harness were easier to put on and take off. Today every major manufacturer of breathing apparatus incorporates NASA technology in some form, and inhalation injuries have been reduced.

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Fireman's Air Tanks

Together with NASA's Johnson Space Center, A-T-O Inc.'s Scott Aviation has developed light-weight firefighter's air tanks. New backpack system weighs only 20 pounds for 30 minute air supply, 13 pounds less than conventional firefighting tanks. They are pressurized at 4,500 psi, (twice current tanks). Made of aluminum liner wrapped by resin-impregnated glass fibers, eliminating corrosion as well as lightening the load. Redesigned face mask permits better vision. Warning device to tell fireman he is running out of air is personalized so it can't be heard by others reducing confusion in an already hectic environment. Structural Composites Inc., The Boeing Co., and Martin- Marietta Corp. have developed uses for this technology.

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Obstructive apnea during sleep is associated with peripheral vasoconstriction

Obstructive apnea during sleep is associated with a substantial transient blood pressure elevation. The mechanism of this pressor response is unclear. In this study we measured muscle sympathetic nerve activity (MSNA), mean arterial pressure (Psa), and mean limb blood velocity as an index of blood flow (MBV, Doppler) and calculated changes in limb vascular resistance during and after apneas during both wakefulness and sleep in patients with the obstructive sleep apnea syndrome. Immediately postapnea during sleep Psa increased significantly compared with the earlier stages of apnea and this was preceded by a rise of MSNA (n = 5). In contrast to blood pressure, MBV remained unchanged. Because resistance = blood pressure/blood flow, limb vascular resistance increased by 29 +/- 8% from late apnea to postapnea (n = 7, p < 0.002). Voluntary breathhold maneuvers during room air exposure evoked similar responses (n = 10). Supplemental oxygen administered via nonrebreather face mask attenuated the MSNA and vasoconstrictor responses to obstructive (n = 2) and voluntary apneas (n = 10). Our data suggest that obstructive apneas in patients with the obstructive apnea syndrome are accompanied by transient limb vasoconstriction. This vasoconstrictor response appears to be, at least in part, mediated by the sympathetic nervous system and may be linked to hypoxia.

NASA Discipline Cardiopulmonary↗

Low-Pressure Generator Makes Cleanrooms Cleaner

Scientists at NASA's Kennedy Space Center work in cleanrooms: laboratories with high degrees of cleanliness provided by strict control of particles such as dust, lint, or human skin. They are contaminant-free facilities, where the air is repeatedly filtered, and surfaces are smooth to prevent particles from getting lodged. Technicians working in these environments wear specially designed cleanroom "bunny suits" and booties over their street clothes, as well as gloves and face masks to avoid any contamination that may be imparted from the outside world. Even normal paper is not allowed in cleanrooms, only cleanroom low-particulate paper. These are sensitive environments where precision work, like the production of silicon chips or hard disk drives, is performed. Often in cleanrooms, positive air pressure is used to force particles outside of the isolated area. The air pressure in the Kennedy cleanrooms is monitored using high-accuracy, low-differential pressure transducers that require periodic calibration. Calibration of the transducers is a tricky business. In prior years, the analysis was performed by sending the transducers to the Kennedy Standards Laboratory, where a very expensive cross-floated, labor- intensive, dead-weight test was conducted. In the early 1990s, scientists at Kennedy determined to develop a technique and find equipment to perform qualification testing on new low-differential pressure transducers in an accurate, cost-effective manner onsite, without requiring an environmentally controlled room. They decided to use the highly accurate, cost-effective Setra Model C264 as the test transducer. For qualification testing of the Setra, though, a portable, lower-cost calibrator was needed that could control the differential pressure to a high degree of resolution and transfer the accuracy of the Standards Laboratory testing to the qualification testing. The researchers decided that, to generate the low-differential pressure setpoints needed for qualification testing, very small gas volume changes could be made against the test article, and a corresponding pressure change would be detected by a pressure standard. This allowed the researchers to recreate cleanroom air pressure settings without the use of a cleanroom. Thus was born the low-differential pressure generator. In 1993, a prototype was developed using a pair of PVC tanks, a volume controller, and a 1-pound-per-square-inch pressure standard. By 1995, the prototype was perfected into the unit that is still used today.

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