Final Technical Report - A Novel Radium-Selective Separation Technique to Improve the Production of 225 Ac for Cancer Immunotherapy
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Drera, Saleem↗
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Sample detection and analysis techniques for electrophoretic separation
Methods for detecting and analyzing biological agents suitable for space flight operations were studied primarily by literature searches which were conducted of cell separation techniques. Detection methods discussed include: photometrometric, electric, radiometric, micrometry, ultrasonic, microscopic, and photographic. A bibliography, and a directory of vendors are included along with an index of commercial hardware.
Falb, R. D.↗
A modal separation measurement technique for broadband noise propagating inside circular ducts
A measurement technique which separates broadband noise propagating inside circular ducts into the acoustic duct modes is developed. The technique is also applicable to discrete frequency noise. The acoustic modes are produced by weighted combinations of the instantaneous outputs of microphones spaced around the duct circumference. The technique is compared with the cross spectral density approach presently available and found to have certain advantages, and disadvantages. Considerable simplification of both the new technique and the cross spectral density approach occurs when no correlation exists between different circumferential mode orders. The properties leading to uncorrelated modes and experimental tests which verify this condition are discussed. The modal measurement technique is applied to the case of broadband noise generated by flow through a coaxial obstruction (nozzle or orifice) in a pipe. Different circumferential mode orders are shown to be uncorrelated for this type of noise source.
Kerschen, E. J.↗
Generation and Study of Am(IV) by Temperature-Controlled Electron Pulse Radiolysis
Used nuclear fuel (UNF) separation techniques that strive to separate radiotoxic americium (Am) from trivalent lanthanide fission products through oxidation state control have increased research efforts surrounding Am(V) and Am(VI). However, equivalent knowledge of the tetravalent state, Am(IV), has remained elusive, particularly in conditions more representative of UNF reprocessing, i.e., in concentrated nitric acid (HNO3). With this in mind, we have used electron pulse radiolysis to study the radiation-induced redox reaction of Am(III) with the oxidizing nitrate radical (NO3?) in 6 M HNO3: Am(III) + NO3? ? Am(IV) + NO3? . These experiments enabled us to observe the growth and decay of Am(IV) in a concentrated acidic solution for the first time. The transient Am(IV) species was found to have a lifetime of ~16 µs?sufficiently long-lived to play a critical mechanistic role in UNF reprocessing systems. Additionally, we performed the first-ever temperature-dependent kinetics study of an actinide element, elucidating unprecedented Arrhenius and Eyring activation parameters for the reaction of Am(III) with NO3?. This new knowledge provides much-needed molecular-level insights into the radiation-induced behavior of Am.
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEA↗
An Analytic Technique to Separate Cochannel FM Signals
A new technique is presented that can perfectly separate two cochannel FM signals in a noiseless environment.
cochannel FM signals trellis algorithm separation ↗
Modal content of noise generated by a coaxial jet in a pipe
Noise generated by air flow through a coaxial obstruction in a long, straight pipe was investigated with concentration on the modal characteristics of the noise field inside the pipe and downstream of the restriction. Two measurement techniques were developed for separation of the noise into the acoustic duct modes. The instantaneous mode separation technique uses four microphones, equally spaced in the circumferential direction, at the same axial location. The time-averaged mode separation technique uses three microphones mounted at the same axial location. A matrix operation on time-averaged data produces the modal pressure levels. This technique requires the restrictive assumption that the acoustic modes are uncorrelated with each other. The measured modal pressure spectra were converted to modal power spectra and integrated over the frequency range 200-6000 Hz. The acoustic efficiency levels (acoustic power normalized by jet kinetic energy flow), when plotted vs. jet Mach number, showed a strong dependence on the ratio of restriction diameter to pipe diameter. The acoustic energy flow analyses based on the thermodynamic energy equation and on the results of Mohring both resulted in orthogonality properties for the eigenfunctions of the radial mode shape equation. These orthogonality relationships involve the eigenvalues and derivatives of the radial mode shape functions.
Kerschen, E. J.↗
Measurement of the Pion Exclusive Electro-Production Cross-Section in the E12-19-006 Experiment in Hall-C at Jefferson Lab
One of the most effective methods for exploring the transition from hadronic degrees of freedom to quark-gluon degrees of freedom in Quantum Chromodynamics (QCD) is through the investigation of \exclusive" pion and kaon electro-production reactions at various Q2 and ?t values. The E12-19-006 experiment is conducted within the confi?nes of experimental Hall C at the Thomas Jefferson National Accelerator Facility, USA, for such studies. The primary aim of the experiment is to ?first enhance our comprehension of the pion electro-production cross-section and its form factor at Q2 = 0.38 and 0.42 GeV2. This is the fi?rst run period of the E12-19-006 experiment which ran in summer 2019. A more profound understanding of the pion electro-production reaction, 1H(e,e'?+)n, at low Q2 is deemed essential to employ this electro-production reaction (an indirect technique) for the high Q2 studies, thereby delving deeper into the realm of QCD. Consequently, this dissertation presents a thorough analysis of the experimental data acquired in the ?first run period of the E12-19-006 experiment. In pursuit of precision, a series of systematic studies (target boiling correction study, the elastic reaction cross-section measurements, study for determining vari- ous kinematics o?sets, etc.) are conducted to discern the accuracy of the analyzed data, a prerequisite for the use of Rosenbluth separation technique to separate the pion electro-production cross-section terms in t bins. The separated pion electro-production cross-section through the Rosenbluth separation technique is then used to extract the pion electromagnetic form factor. In this dissertation, the pion electro-production cross-section is carefully dissected into its four constituent components: longitudinal (?L), transverse (?T ), longitudinal-transverse (?LT ), and transverse-transverse (?TT ), using the full version of Rosenbluth separation technique for the Q2 = 0.38 GeV2. The technique is simultaneously fi?tted to the unseparated pion electro-production cross-sections at the three values of polarization of the virtual photon (?), i.e., ? = 0.286, 0.629 and 0.781. An iterative process is applied to re?ne the parameters of the model cross-sections until the yield ratio of experimental and Monte Carlo simulation converges. In this study, 21 iterations are conducted to re?ne the model cross-section parameters. The fi?nal pion electro-production cross-section terms are then determined for 7 t bins using the optimized parameters of the model cross-sections.
Kumar, Vijay↗
Thermomechanical Separation of Biogenic and Non-biogenic Carbon from Non-Recyclable MSW
The effective separation of biogenic and non-biogenic carbon from non-recyclable municipal solid waste (n-MSW) presents a significant challenge in the United States. Currently, there are no efficient methods available to address this issue, hindering the potential for maximizing waste utilization and reducing landfilling rates. This project aims to develop and implement a combine thermomechanical separation techniques to separate biogenic and non-biogenic carbon within n-MSW, ultimately facilitating greater resource recovery and enhancing the efficiency and environmental impact of waste management practices.
09 - BIOMASS FUELS↗
Hydrogen sensing and separation
Techniques for hydrogen sensing and mitigation are provided. As one example, a device includes a chamber and a membrane that is permeable to a first gas and is impermeable to a second gas. The membrane separates the chamber from a gas mixture that contains the first gas, such that the first gas in the gas mixture can only enter the chamber via the membrane. The device also includes a pressure sensor configured to measure a pressure within the chamber.
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗
Thermodynamic modeling of adsorption at the liquid-solid interface
Adsorptive separation techniques are significantly energy efficient in comparison to conventional thermal separation techniques such as distillation. Despite extensive research and development activities undertaken for mixed-gas adsorption, the use of adsorption techniques for the separation of multicomponent liquid mixtures is still limited. A major barrier is the lack of accurate adsorption thermodynamic models, which form the scientific foundation of process simulation of such systems, making the translation to industrial scale challenging. In this work, we have rigorously computed the surface excess of adsorption for six binary liquid mixtures on silica gel at 303 K using the frameworks of the generalized Langmuir isotherm (gL) and the adsorbed solution theory (AST). The six binary liquid mixtures were formed by the pair-wise combinations of four components: benzene, 1,2-dichloroethane, cyclohexane, and n-heptane. We have based our calculations by considering simultaneous equilibria of three phases: saturated vapor phase, bulk liquid phase, and adsorbed phase. Further, the composition of the corresponding saturated vapor phase was estimated by the Nonrandom Two-Liquid activity coefficient model and experimental vapor-liquid equilibria data. The activity coefficients of the adsorbed phase, the central issue of multicomponent adsorption thermodynamics, were calculated using the adsorption Nonrandom Two-Liquid activity coefficient model. Devoid of simplifying assumptions, gL and AST provide rigorous thermodynamic frameworks for adsorption equilibria of multicomponent liquid mixtures.
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗
Evaluation of SLAR and thematic mapper MSS data for forest cover mapping using computer-aided analysis techniques
Separate holograms of horizontally (HH) and vertically (HV) polarized responses obtained by the APQ-102 side-looking radar were processed through an optical correlator and the resulting image was recorded on positive film from which black and white negative and positive prints were made. Visual comparison of the HH and HV images reveals a distinct dark band in the imagery which covers about 30% of the radar strip. Preliminary evaluaton of the flight line 1 date indicates that various features on the HH and HV images seem to have different response levels. The amount of sidelap due to the look angle between flight lines 1 and 2 is negligible. NASA mission #425 to obtain flightlines of NS-001 MSS data and supporting aerial photography was successfully flown. Flight line 3 data are of very good quality and virtually cloud-free. Results of data analysis for selection of test fields and for evaluation of waveband combination and spatial resolution are presented.
Hoffer, R. M.↗
Instrumental and analytic techniques for separating protons from electrons in the cosmic ray flux
Techniques are being investigated to aid in distinguishing between electrons and the large background of interacting protons which simulate electron-induced electromagnetic cascades. For cosmic ray primaries, incident on the HECRE ionization spectrometer, statistical criteria are employed to test the cascade curves with the incident energy and starting point as free parameters. The physical significance of the distribution of apparent cascade starting points is being studied using Monte Carlo 100-GeV protons. The proposed use of a CsI detector module (totally-active and high Z) to further discriminate against protons is described.
Crannell, C. J.↗
Modeling of Convective-Stratiform Precipitation Processes: Sensitivity to Partitioning Methods
Six different convective-stratiform separation techniques, including a new technique that utilizes the ratio of vertical and terminal velocities, are compared and evaluated using two-dimensional numerical simulations of a tropical [Tropical Ocean Global Atmosphere Coupled Ocean Atmosphere Response Experiment (TOGA COARE)] and midlatitude continental [Preliminary Regional Experiment for STORM-Central (PRESTORM)] squall line. Comparisons are made in terms of rainfall, cloud coverage, mass fluxes, apparent heating and moistening, mean hydrometeor profiles, CFADs (Contoured Frequency with Altitude Diagrams), microphysics, and latent heating retrieval. Overall, it was found that the different separation techniques produced results that qualitatively agreed. However, the quantitative differences were significant. Observational comparisons were unable to conclusively evaluate the performance of the techniques. Latent heating retrieval was shown to be sensitive to the use of separation technique mainly due to the stratiform region for methods that found very little stratiform rain.
Lang, S. E.↗
Enhanced protein electrophoresis technique for separating human skeletal muscle myosin heavy chain isoforms
Talmadge and Roy (J. Appl. Physiol. 1993, 75, 2337-2340) previously established a sodium dodecyl sulfate - polyacrylamide gel electrophoresis (SDS-PAGE) protocol for separating all four rat skeletal muscle myosin heavy chain (MHC) isoforms (MHC I, IIa, IIx, IIb); however, when applied to human muscle, the type II MHC isoforms (Ila, IIx) are not clearly distinguished. In this brief paper we describe a modification of the SDS-PAGE protocol which yields distinct and consistent separation of all three adult human MHC isoforms (MHC I, IIa, IIx) in a minigel system. MHC specificity of each band was confirmed by Western blot using three monoclonal IgG antibodies (mAbs) immunoreactive against MHCI (mAb MHCs, Novacastra Laboratories), MHCI+IIa (mAb BF-35), and MHCIIa+IIx (mAb SC-71). Results provide a valuable SDS-PAGE minigel technique for separating MHC isoforms in human muscle without the difficult task of casting gradient gels.
NASA Center JSC↗
Modeling of Convective-Stratiform Precipitation Processes: Sensitivity to Partitioning Methods and Numerical Advection Schemes
Six different convective-stratiform separation techniques, including a new technique that utilizes the ratio of vertical and terminal velocities, are compared and evaluated using two-dimensional numerical simulations of a tropical [Tropical Ocean Global Atmosphere Coupled Ocean-Atmosphere Response Experiment (TOGA COARE)] and midlatitude continental [Preliminary Regional Experiment for STORM-Central (PRESTORM)] squall line. The simulations are made using two different numerical advection schemes: 4th order and positive definite advection. Comparisons are made in terms of rainfall, cloud coverage, mass fluxes, apparent heating and moistening, mean hydrometeor profiles, CFADs (Contoured Frequency with Altitude Diagrams), microphysics, and latent heating retrieval. Overall, it was found that the different separation techniques produced results that qualitatively agreed. However, the quantitative differences were significant. Observational comparisons were unable to conclusively evaluate the performance of the techniques. Latent heating retrieval was shown to be sensitive to the use of separation technique mainly due to the stratiform region for methods that found very little stratiform rain. The midlatitude PRESTORM simulation was found to be nearly invariant with respect to advection type for most quantities while for TOGA COARE fourth order advection produced numerous shallow convective cores and positive definite advection fewer cells that were both broader and deeper penetrating above the freezing level.
Lang, Steve↗
Development of a Technique for Separating Raman Scattering Signals from Background Emission with Single-Shot Measurement Potential
A novel technique for extracting Q-branch Raman signals scattered by a diatomic species from the emission spectrum resulting from the irradiation of combustion products using a broadband excimer laser has been developed. This technique is based on the polarization characteristics of vibrational Raman scattering and can be used for both single-shot Raman extraction and time-averaged data collection. The Q-branch Raman signal has a unique set of polarization characteristics which depend on the direction of the scattering while fluorescence signals are unpolarized. For the present work, a calcite crystal is used to separate the horizonal component of a collected signal from the vertical component. The two components are then sent through a UV spectrometer and imaged onto an intensified CCD camera separately. The vertical component contains both the Raman signal and the interfering fluorescence signal. The horizontal component contains the fluorescence signal and a very weak component of the Raman signal; hence, the Raman scatter can be extracted by taking the difference between the two signals. The separation of the Raman scatter from interfering fluorescence signals is critically important to the interpretation of the Raman for cases in which a broadband ultraviolet (UV) laser is used as an excitation source in a hydrogen-oxygen flame and in all hydrocarbon flames. The present work provides a demonstration of the separation of the Raman scatter from the fluorescence background in real time.
Hartfield, Roy J., Jr.↗
Binary Oscillatory Crossflow Electrophoresis
Electrophoresis has long been recognized as an effective analytic technique for the separation of proteins and other charged species, however attempts at scaling up to accommodate commercial volumes have met with limited success. In this report we describe a novel electrophoretic separation technique - Binary Oscillatory Crossflow Electrophoresis (BOCE). Numerical simulations indicate that the technique has the potential for preparative scale throughputs with high resolution, while simultaneously avoiding many problems common to conventional electrophoresis. The technique utilizes the interaction of an oscillatory electric field and a transverse oscillatory shear flow to create an active binary filter for the separation of charged protein species. An oscillatory electric field is applied across the narrow gap of a rectangular channel inducing a periodic motion of charged protein species. The amplitude of this motion depends on the dimensionless electrophoretic mobility, alpha = E(sub o)mu/(omega)d, where E(sub o) is the amplitude of the electric field oscillations, mu is the dimensional mobility, omega is the angular frequency of oscillation and d is the channel gap width. An oscillatory shear flow is induced along the length of the channel resulting in the separation of species with different mobilities. We present a model that predicts the oscillatory behavior of charged species and allows estimation of both the magnitude of the induced convective velocity and the effective diffusivity as a function of a in infinitely long channels. Numerical results indicate that in addition to the mobility dependence, the steady state behavior of solute species may be strongly affected by oscillating fluid into and out of the active electric field region at the ends of the cell. The effect is most pronounced using time dependent shear flows of the same frequency (cos((omega)t)) flow mode) as the electric field oscillations. Under such conditions, experiments indicate that solute is drawn into the cell from reservoirs at both ends of the cell leading to a large mass build up. As a consequence, any initially induced mass flux will vanish after short times. This effect was not captured by the infinite channel model and hence numerical and experimental results deviated significantly. The revised model including finite cell lengths and reservoir volumes allowed quantitative predictions of the time history of the concentration profile throughout the system. This latter model accurately describes the fluxes observed for both oscillatory flow modes in experiments using single protein species. Based on the results obtained from research funded under NASA grant NAG-8-1080.S, we conclude that binary separations are not possible using purely oscillatory flow modes because of end effects associated with the cos((omega)t) mode. Our research shows, however, that a combination of cos(2(omega)t) and steady flow should lead to efficient separation free of end effects. This possibility is currently under investigation.
Molloy, Richard F.↗
Ion-Exclusion Chromatography for Analyzing Organics in Water
A liquid-chromatography technique has been developed for use in the quantitative analysis of urea (and of other nonvolatile organic compounds typically found with urea) dissolved in water. The technique involves the use of a column that contains an ion-exclusion resin; heretofore, this column has been sold for use in analyzing monosaccharides and food softeners, but not for analyzing water supplies. The prior technique commonly used to analyze water for urea content has been one of high-performance liquid chromatography (HPLC), with reliance on hydrophobic interactions between analytes in a water sample and long-chain alkyl groups bonded to an HPLC column. The prior technique has proven inadequate because of a strong tendency toward co-elution of urea with other compounds. Co-elution often causes the urea and other compounds to be crowded into a narrow region of the chromatogram (see left part of figure), thereby giving rise to low chromatographic resolution and misidentification of compounds. It is possible to quantitate urea or another analyte via ultraviolet- and visible-light absorbance measurements, but in order to perform such measurements, it is necessary to dilute the sample, causing a significant loss of sensitivity. The ion-exclusion resin used in the improved technique is sulfonated polystyrene in the calcium form. Whereas the alkyl-chain column used in the prior technique separates compounds on the basis of polarity only, the ion-exclusion-resin column used in the improved technique separates compounds on the basis of both molecular size and electric charge. As a result, the degree of separation is increased: instead of being crowded together into a single chromatographic peak only about 1 to 2 minutes wide as in the prior technique, the chromatographic peaks of different compounds are now separated from each other and spread out over a range about 33 minutes wide (see right part of figure), and the urea peak can readily be distinguished from the other peaks. Although the analysis takes more time in the improved technique, this disadvantage is offset by two important advantages: Sensitivity is increased. The minimum concentration of urea that can be measured is reduced (to between 1/5 and 1/3 of that of the prior technique) because it is not necessary to dilute the sample. The separation of peaks facilitates the identification and quantitation of the various compounds. The resolution of the compounds other than urea makes it possible to identify those compounds by use of mass spectrometry.
Sauer, Richard↗