Results for “system response latency” — Page 2

NASA NTRS2022

Dermatitis during Spaceflight Associated with HSV-1 Reactivation

Human alpha herpesviruses herpes simplex virus (HSV-1) and varicella zoster virus (VZV) establish latency in various cranial nerve ganglia and often reactivate in response to stress-associated immune system dysregulation. Reactivation of Epstein Barr virus (EBV), VZV, HSV-1, and cytomegalovirus (CMV) is typically asymptomatic during spaceflight, though live/infectious virus has been recovered and the shedding rate increases with mission duration. The risk of clinical disease, therefore, may increase for astronauts assigned to extended missions (>180 days). Here, we report, for the first time, a case of HSV-1 skin rash (dermatitis) occurring during long-duration spaceflight. The astronaut reported persistent dermatitis during flight, which was treated onboard with oral antihistamines and topical/oral steroids. No HSV-1 DNA was detected in 6-month pre-mission saliva samples, but on flight day 82, a saliva and rash swab both yielded 4.8 copies/ng DNA and 5.3 × 104 copies/ng DNA, respectively. Post-mission saliva samples continued to have a high infectious HSV-1 load (1.67 × 107 copies/ng DNA). HSV-1 from both rash and saliva samples had 99.9% genotype homology. Additional physiological monitoring, including stress biomarkers (cortisol, dehydroepiandrosterone (DHEA), and salivary amylase), immune markers (adaptive regulatory and inflammatory plasma cytokines), and biochemical profile markers, including vitamin/mineral status and bone metabolism, are also presented for this case. These data highlight an atypical presentation of HSV-1 during spaceflight and underscore the importance of viral screening during clinical evaluations of in-flight dermatitis to determine viral etiology and guide treatment.

Satish K. Mehta↗

NASA NTRSDate not supplied

Dermatitis During Spaceflight Associated With HSV-1 Reactivation- A Case Study

Human alpha herpesviruses herpes simplex virus (HSV-1 or -2) and varicella zoster virus (VZV) establish latency in various cranial nerve ganglia, and often reactivate in response to stress-associated immune system dysregulation. Reactivation of Epstein Barr Virus (EBV), VZV, HSV-1 and Cytomegalovirus (CMV) is typically asymptomatic during spaceflight, though live/infectious virus has been recovered and the shedding rate increases with mission duration. The risk of clinical disease, therefore, may increase for astronauts assigned to extended missions (>180 days). Here, we report for the first time, a case of HSV-1 skin rash (dermatitis) occurring during a long duration spaceflight. The astronaut reported persistent dermatitis during flight, which was treated onboard with oral antihistamines and topical/oral steroids. No HSV-1 DNA was detected in 6-month pre-mission saliva samples, but on flight day 82, a saliva and rash swab both yielded 4.8 copies/ng DNA and 5.3×104 copies/ng DNA, respectively. Post-mission saliva samples continued to have high infectious HSV-1 load (1.67×107 copies/ng DNA). HSV-1 from both rash and saliva samples had 99.4% genotype homology. Additional physiological monitoring, including stress biomarkers (cortisol, dehydroepiandrosterone (DHEA), and salivary amylase), immune markers (adaptive regulatory and inflammatory plasma cytokines) and biochemical profile markers including vitamin/mineral status and bone metabolism are also presented for this case. These data highlight an atypical presentation of HSV-1 during spaceflight and underscore the importance of viral screening during clinical evaluations of in-flight dermatitis, to determine viral etiology and guide treatment.

Herpes, Viral Reactivation, Spaceflight, Dermatiti↗

NASA NTRS2002

Vestibular control of sympathetic activity. An otolith-sympathetic reflex in humans

It has been proposed that a vestibular reflex originating in the otolith organs and other body graviceptors modulates sympathetic activity during changes in posture with regard to gravity. To test this hypothesis, we selectively stimulated otolith and body graviceptors sinusoidally along different head axes in the coronal plane with off-vertical axis rotation (OVAR) and recorded sympathetic efferent activity in the peroneal nerve (muscle sympathetic nerve activity, MSNA), blood pressure, heart rate, and respiratory rate. All parameters were entrained during OVAR at the frequency of rotation, with MSNA increasing in nose-up positions during forward linear acceleration and decreasing when nose-down. MSNA was correlated closely with blood pressure when subjects were within +/-90 degrees of nose-down positions with a delay of 1.4 s, the normal latency of baroreflex-driven changes in MSNA. Thus, in the nose-down position, MSNA was probably driven by baroreflex afferents. In contrast, when subjects were within +/-45 degrees of the nose-up position, i.e., when positive linear acceleration was maximal along the naso-ocipital axis, MSNA was closely related to gravitational acceleration at a latency of 0.4 s. This delay is too short for MSNA changes to be mediated by the baroreflex, but it is compatible with the delay of a response originating in the vestibular system. We postulate that a vestibulosympathetic reflex, probably originating mainly in the otolith organs, contributes to blood pressure maintenance during forward linear acceleration. Because of its short latency, this reflex may be one of the earliest mechanisms to sustain blood pressure upon standing.

NASA Discipline Neuroscience↗

DOE OSTI2025

Best Practices for Grid Communications

As the grid evolves, the communications architecture will need to evolve with it. That architecture affords a structured means by which the evolving complexities of the modern electric grid can be managed. This document provides best practices that can be implemented in the grid of today and evolve towards the grid and grid architecture of the future. The evolving grid and its control communications increasingly rely on commercial communications providers and a variety of technologies, from wireless (e.g., 5G, microwave, Wi-Fi) to wireline (fiber, copper) to radio communications (P25, other repeater-based systems), and all these communications systems rely on electric power. A reliable and resilient grid must account for this complex set of interdependencies in its planning activities, especially those involving restoration and recovery. The participation of all relevant parties in both planning and exercising of plans can prevent unexpected conditions that impede the reliable operation and recovery of the grid. Best practices for grid communications include using a Network Management System to document the operational state, define and monitor baselines, detect changes, and accelerate response to abnormalities. If transitioning from SONET to IP/packet-based systems, translating grid requirements into communications requirements for latency, bandwidth and throughput, IP packet delay variation, packet loss, and availability should inform and drive technology planning and selection as well as that communication system’s Quality of Service (QoS) policies and Service Level Agreements (SLAs). Secure and reliable timing is another key component of a reliable and resilient grid that can operate through adverse events. A trusted internal NTP configuration, an integrated and diverse timing delivery system, optimizing the timing architecture based on the transport technologies of the communications system, and using established standards can deliver the level of timing accuracy required by a range of time-sensitive power system applications.

24 POWER TRANSMISSION AND DISTRIBUTION↗

NASA NTRS2015

Measured Response for UAS Integration into the National Airspace System

The measured response (MR) is the response time of aircraft to Air Traffic Controller (ATCo) commands and clearances. The overall MR can be broken up into several components, including the pilot verbal latencies (MR1), the time between the end of an ATCo clearance and the beginning of the pilots read back, and the execution initiation latency (MR2), the time between the end of the ATCos clearance and when the pilot begins to execute a maneuver. The MR is a crucial concern for the integration of Unmanned Aircraft Systems (UAS) into the National Airspace System (NAS) due to potentially greater latencies stemming from remote pilot communication and command execution. As a result, it is important to quantify what latencies in verbal responding and command execution are acceptable for safe and efficient operations in the NAS. The present studies begin to address these issues in a series of four simulations supported by the UAS Integration into the NAS program.

UAS in the NAS↗

NASA NTRS2018

Hosting Hyrax in the Cloud While Preserving the User Experience

Cloud object stores enable data providers to reduce costs and provide uniform data servers across organizational divisions. This talk will address how new capabilities provided by cloud computing can be used with existing software so that users get the benefits provided by cloud technology (access to data at lower cost, e.g.) without disrupting their existing workflow(s). We will address ways to reduce response latency often associated with Cloud object stores and ways to simulate the hierarchy of a POSIX file system using a key-value object store. This work is based an on-going NASA EED2 project to enhance the Hyrax data server for operation in the Amazon Web Services Cloud.

Hyrax server↗

NASA NTRS1990

Fault injection experiments using FIAT

The results of several experiments conducted using the fault-injection-based automated testing (FIAT) system are presented. FIAT is capable of emulating a variety of distributed system architectures, and it provides the capabilities to monitor system behavior and inject faults for the purpose of experimental characterization and validation of a system's dependability. The experiments consist of exhaustively injecting three separate fault types into various locations, encompassing both the code and data portions of memory images, of two distinct applications executed with several different data values and sizes. Fault types are variations of memory bit faults. The results show that there are a limited number of system-level fault manifestations. These manifestations follow a normal distribution for each fault type. Error detection latencies are found to be normally distributed. The methodology can be used to predict the system-level fault responses during the system design stage.

Barton, James H.↗

NASA NTRS1995

The PRP Effect Following Callosotomy: Residual Interference Despite Uncoupling of Lateralized Response Codes

A callosotomy patient was tested in two dual-task experiments requiring successive speeded responses to lateralized stimuli. In accord with the recent findings of Pashler, O'Brien, Luck, Hillyard, Mangun, and Gazzaniga (in press), the patient showed a robust psychological refractory period effect (PRP) responses on Task 2 were inversely related to the stimulus-onset asynchrony (SOA). However, three aspects of our data indicated that the processing limitations for the patient were different than those observed with control subjects. First, the split-brain patient did not show an increase in reaction time when the two tasks required responses from a common output system (i.e., both manual responses) in comparison to when different output systems were used (i.e., manual-vocal). Second, inconsistent stimulus-response mappings for the two tasks greatly inflated response latencies for the control subjects, but had minimal effect on the performance of the split-brain patient. Third, the consistency manipulation was underadditive with SOA for only the patient, suggesting a later bottleneck in processing following callosotomy than was observed for the control subjects. It is proposed that sectioning the corpus callosum eliminates interference resulting from competing stimulus response codes. Nonetheless, dual-task interference persists for the split-brain subject because a subcortical gate constrains when selected responses can be implemented.

Ivry, Richard B.↗

NASA NTRS2016

Automated Commanding of the SMAP Spacecraft Enables Efficient, Reliable, and Responsive Operations

The Soil Moisture Active Passive (SMAP) mission developed and deployed a system to autonomously handle most routine commanding of the observatory. This system of ground software is able to build commands, validate them, and radiate the commands to the spacecraft, all without human interaction. In the case of an off -nominal scenario, the system will abort gracefully and notify the mission operations team of the problem. The system was phased into operations during the first three months of the SMAP mission and handles over 90% of the weekly commanding of the vehicle. The gradual introduction of the automation in flight, along with an extensive test campaign, was instrumental in the success of the software. The automation has enabled substantial efficiencies in operations team staffing and has improved reliability by removing the potential for human error. The system also allows the SMAP project to be more responsive which has shown significant benefits in areas of data latency and science accuracy.

automation↗

NASA NTRS1997

Postural perturbations: new insights for treatment of balance disorders

This article reviews the neural control of posture as understood through studies of automatic responses to mechanical perturbations. Recent studies of responses to postural perturbations have provided a new view of how postural stability is controlled, and this view has profound implications for physical therapy practice. We discuss the implications for rehabilitation of balance disorders and demonstrate how an understanding of the specific systems underlying postural control can help to focus and enrich our therapeutic approaches. By understanding the basic systems underlying control of balance, such as strategy selection, rapid latencies, coordinated temporal spatial patterns, force control, and context-specific adaptations, therapists can focus their treatment on each patient's specific impairments. Research on postural responses to surface translations has shown that balance is not based on a fixed set of equilibrium reflexes but on a flexible, functional motor skill that can adapt with training and experience. More research is needed to determine the extent to which quantification of automatic postural responses has practical implications for predicting falls in patients with constraints in their postural control system.

Review↗

NASA NTRS2022

Characterization of Response Times based on Voice Communication and Traffic Surveillance Data

A barrier to the integration of remotely piloted aircraft operations in the U.S. National Airspace System is the latency of voice communications between the air traffic controller and the remote pilot, and the latency of communication between the aircraft and the remote pilot. The latency can be substantial especially when satellite-based beyond-radio-line-of-sight communication and relay through the aircraft are employed. This study uses voice recordings of controller-pilot communications and aircraft track data to establish a baseline of pilot readback latencies and maneuver detection delays in the current piloted operations. A machine learning pipeline was developed to parse the contents of the air traffic control clearances including the callsigns using natural language processing. After manually validating the results obtained using the pipeline, the average pilot readback latency was found to be about 0.6 seconds. The average latency between the end of maneuver (inferred from track data), initiated by the pilot in response to the clearance, and the end of clearance was found to be about 176 seconds for altitude change commands, 69 seconds for heading change commands, and 182 seconds for speed change commands. The average latency between the beginning of maneuver and the end of clearance was found to be about 17 seconds for altitude change commands, 17seconds for heading change commands, and 25 seconds for speed change commands.

controller-pilot communication, communication late↗

NASA NTRS2022

Characterization of Response Times Based on Voice Communication and Traffic Surveillance Data

A barrier to the integration of remotely piloted aircraft operations in the U.S. National Airspace System is the latency of voice communications between the air traffic controller and the remote pilot, and the latency of communication between the aircraft and the remote pilot. The latency can be substantial especially when satellite-based beyond-radio-line-of-sight communication and relay through the aircraft are employed. This study uses voice recordings of controller-pilot communications and aircraft track data to establish a baseline of pilot readback latencies and maneuver detection delays in the current piloted operations. A machine learning pipeline was developed to parse the contents of the air traffic control clearances including the callsigns using natural language processing. After manually validating the results obtained using the pipeline, the average pilot readback latency was found to be about 0.6 seconds. The average latency between the end of maneuver (inferred from track data), initiated by the pilot in response to the clearance, and the end of clearance was found to be about 176 seconds for altitude change commands, 69 seconds for heading change commands, and 182 seconds for speed change commands. The average latency between the beginning of maneuver and the end of clearance was found to be about 17 seconds for altitude change commands, 17seconds for heading change commands, and 25 seconds for speed change commands.

controller-pilot communication↗

DOE OSTI2026

Real-Time GPU-Accelerated OFDR With an Integrated Auxiliary Interferometer

A GPU-accelerated optical frequency domain reflectometry (OFDR) system with an improved integrated auxiliary interferometer is proposed. Unlike conventional approaches that require separate auxiliary interferometers and multiple detection channels, the proposed OFDR system embeds this functionality directly into the signal via an intentional beat component. This enables self-calibration of laser nonlinearity while maintaining a cost-effective hardware configuration. Building on this simplified configuration, the system leverages GPU acceleration with an NVIDIA RTX 4070 Ti to achieve real-time performance, delivering high-throughput signal processing for continuous OFDR interrogation. The signal processing pipeline comprises signal capture, resampling for nonlinearity compensation, and frequency shift computation, all optimized for parallel execution. Hardware benchmarking demonstrates substantial acceleration over CPU implementations, achieving up to a 45× speedup for resampling and frequency shift computations and enabling processing latencies below 30 ms. Thermal response validation is conducted under two complementary scenarios: localized heating using a water bath and cryogenic-temperature conditions using liquid nitrogen. Under localized heating, the system achieves an accuracy of 0.249 °C with a thermal sensitivity of 5.971 GHz/°C, while cryogenic-temperature validation demonstrates a frequency shift response with a sensitivity of 2.383 GHz/°C and an accuracy of 2.04 °C. The high acceleration of the proposed GPU-accelerated OFDR system and its accuracy are achieved by exploiting CUDA-based stride indexing, enabling efficient parallel segmentation and processing of large datasets without additional memory copies. The benchmarking results confirm the robustness, accuracy, and deployability of the proposed OFDR system across a wide temperature range, establishing it as a practical platform for real-time distributed fiber sensing in structurally dynamic environments.

Harb, Salah [Lawrence Berkeley National Laboratory↗

NASA NTRS1984

Far-field brainstem responses evoked by vestibular and auditory stimuli exhibit increases in interpeak latency as brain temperature is decreased

The effect of decreasing of brain temperature on the brainstem auditory evoked response (BAER) in rats was investigated. Voltage pulses, applied to a piezoelectric crystal attached to the skull, were used to evoke stimuli in the auditory system by means of bone-conducted vibrations. The responses were recorded at 37 C and 34 C brain temperatures. The peaks of the BAER recorded at 34 C were delayed in comparison with the peaks from the 37 C wave, and the later peaks were more delayed than the earlier peaks. These results indicate that an increase in the interpeak latency occurs as the brain temperature is decreased. Preliminary experiments, in which responses to brief angular acceleration were used to measure the brainstem vestibular evoked response (BVER), have also indicated increases in the interpeak latency in response to the lowering of brain temperature.

Hoffman, L. F.↗

NASA NTRSDate not supplied

Open Data Integration (ODIN): A Concurrent, Distributed Message-Based Architecture and Framework for Disaster Response

The Runtime for Airspace Concept Evaluation (RACE) is an open-source software architecture and framework to build configurable, highly concurrent and distributed message-based systems that offer scalable, low-latency performance on commodity hardware. RACE was used in commercial aviation applications to rapidly build systems that span several machines (including synchronized displays), interface existing hardware simulators and other live data feeds, and incorporate sophisticated visualization components such as NASA WorldWind. These RACE applications validated elements of the FAA’s System Wide Information Management (SWIM) Program, handling up to 1000 messages/sec from diverse sources (SFDPS, TFM-DATA, TAIS, ASDE-X, ITWS and local ADS) for 4,500 simultaneous flights tracked in the next-generation air transportation system’s digital backbone. We have since generalized RACE to support Open Data Integration (ODIN) applications outside aviation. Systems built with RACE/ODIN can be deployed in the field, on commodity hardware, and operate with limited or intermittent connectivity to the outside world. Our primary use case is a web-server with local/persistent data storage that runs within and only serves the stakeholder network (e.g. an incident command post). We are tailoring the RACE/ODIN system to support wildland fire management for the upcoming NASA Wildland Fire Safety Demonstration Series. RACE-ODIN is under consideration for application in the Scalable Traffic Management for Emergency Response Operations project, or STEReO, which aims to create a system that can be deployed during emergencies, to coordinate multiple elements of disaster response. Such data sources predominantly come from existing services on the internet (e.g. weather and satellite data, imported from so called "edge servers") but can also include dynamic (real-time) data from computer simulations and within the stakeholder network (such as aircraft and personnel tracking information). We will present the architecture and ODIN system demonstration incorporating local data from instrumented power-line towers, interpolated weather data and geospatial data from space-based platforms.

Joseph C Coughlan↗

NASA NTRSDate not supplied

Open Data Integration (ODIN): A Concurrent, Distributed Message-Based Architecture and Framework for Disaster Response

The Runtime for Airspace Concept Evaluation (RACE) is an open-source software architecture and framework to build configurable, highly concurrent and distributed message-based systems that offer scalable, low-latency performance on commodity hardware. RACE was used in commercial aviation applications to rapidly build systems that span several machines (including synchronized displays), interface existing hardware simulators and other live data feeds, and incorporate sophisticated visualization components such as NASA WorldWind. These RACE applications validated elements of the FAA’s System Wide Information Management (SWIM) Program, handling up to 1000 messages/sec from diverse sources (SFDPS, TFM-DATA, TAIS, ASDE-X, ITWS and local ADS) for 4,500 simultaneous flights tracked in the next-generation air transportation system’s digital backbone. We have since generalized RACE to support Open Data Integration (ODIN) applications outside aviation. Systems built with RACE/ODIN can be deployed in the field, on commodity hardware, and operate with limited or intermittent connectivity to the outside world. Our primary use case is a web-server with local/persistent data storage that runs within and only serves the stakeholder network (e.g. an incident command post). We are tailoring the RACE/ODIN system to support wildland fire management for the upcoming NASA Wildland Fire Safety Demonstration Series. RACE-ODIN is under consideration for application in the Scalable Traffic Management for Emergency Response Operations project, or STEReO, which aims to create a system that can be deployed during emergencies, to coordinate multiple elements of disaster response. Such data sources predominantly come from existing services on the internet (e.g. weather and satellite data, imported from so called "edge servers") but can also include dynamic (real-time) data from computer simulations and within the stakeholder network (such as aircraft and personnel tracking information). We will present the architecture and ODIN system demonstration incorporating local data from instrumented power-line towers, interpolated weather data and geospatial data from space-based platforms.

Guillaume P Brat↗

DOE OSTI2023

Efficient multi-scale representation of visual objects using a biologically plausible spike-latency code and winner-take-all inhibition

Deep neural networks have surpassed human performance in key visual challenges such as object recognition, but require a large amount of energy, computation, and memory. In contrast, spiking neural networks (SNNs) have the potential to improve both the efficiency and biological plausibility of object recognition systems. Here we present a SNN model that uses spike-latency coding and winner-take-all inhibition (WTA-I) to efficiently represent visual stimuli using multi-scale parallel processing. Mimicking neuronal response properties in early visual cortex, images were preprocessed with three different spatial frequency (SF) channels, before they were fed to a layer of spiking neurons whose synaptic weights were updated using spike-timing-dependent-plasticity. We investigate how the quality of the represented objects changes under different SF bands and WTA-I schemes. We demonstrate that a network of 200 spiking neurons tuned to three SFs can efficiently represent objects with as little as 15 spikes per neuron. Furthermore, studying how core object recognition may be implemented using biologically plausible learning rules in SNNs may not only further our understanding of the brain, but also lead to novel and efficient artificial vision systems.

59 BASIC BIOLOGICAL SCIENCES↗

DOE OSTI2021

Design Space Exploration of Emerging Memory Technologies for Machine Learning Applications

Memory design space exploration methods study memory systems’ performances and limitations before implementation. The computer memory design space has grown exponentially because of the enormous growth of memory types, memory controllers, and application software. Computer simulators are commonly used for memory design space exploration. However, complex memory simulations take an enormous amount of time. Hence, in this paper, we proposed a machine learning-based design space exploration method for dynamic random-access memory and non-volatile memory systems. We applied our method to the CosmoGAN and LeNet applications to predict the following six memory response parameters: (i) bandwidth, (ii) power, (iii) average latency, (iv) average total latency, (v) memory reads, and (vi) memory writes. Our experimental results show that machine learning models can predict memory response parameter values faster than simulations. We used support vector machine, random forest, and gradient boosting machine learning models. We observed that the support vector machine provides better performance for bandwidth, average latency, and average total latency. The random forest model works better for memory reads and writes. The gradient boosting model provides superior prediction performance for power. We provide a detailed discussion on learning curve characteristics, error analysis, and memory type recommendation.

Hasan, S M Shamimul↗