Search NASA⌕ Search

SEARCH · Search NASA

Results for “AGE FACTOR”

Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 361 records · Page 20

Cellular and molecular mechanisms for the bone response to mechanical loading

To define the cellular and molecular mechanisms for the osteogenic response of bone to increased loading, several key steps must be defined: sensing of the mechanical signal by cells in bone, transduction of the mechanical signal to a biochemical one, and transmission of that biochemical signal to effector cells. Osteocytes are likely to serve as sensors of loading, probably via interstitial fluid flow produced during loading. Evidence is presented for the role of integrins, the cell's actin cytoskeleton, G proteins, and various intracellular signaling pathways in transducing that mechanical signal to a biochemical one. Nitric oxide, prostaglandins, and insulin-like growth factors all play important roles in these pathways. There is growing evidence for modulation of these mechanotransduction steps by endocrine factors, particularly parathyroid hormone and estrogen. The efficiency of this process is also impaired in the aged animal, yet what remains undefined is at what step mechanotransduction is affected.

Review↗

A Multi-Wavelength Search for a Counterpart of the Unidentified Gamma-ray source 3EG J2020+4017 (2CG078+2)

In search of the counterpart to the brightest unidentified gamma-ray source 3EG J2020+4017 (2CG078+2) we report on new X-ray and radio observations of the gamma-Cygni field with the Chandra X-ray Observatory and with the Green Bank Telescope (GBT). We also report on reanalysis of archival ROSAT data. With Chandra it became possible for the first time to measure the position of the putative gamma-ray counterpart RX J2020.2+4026 with sub-arcsec accuracy and to deduce its X-ray spectral characteristics. These observations demonstrate that RX J2020.2+4026 is associated with a K field star and therefore is unlikely to be the counterpart of the bright gamma-ray source 2CG078+2 in the SNR G78.2+2.1 as had been previously suggested. The Chandra observation detected 37 additional X-ray sources which were correlated with catalogs of optical and infrared data. Subsequent GBT radio observations covered the complete 99% EGRET likelihood contour of 3EG J2020+4017 with a sensitivity limit of L(sub 820) approx. 0.1 mJy kpc(exp 2) which is lower than most of the recent deep radio search limits. If there is a pulsar operating in 3EG J2020+4017, this sensitivity limit suggests that the pulsar either does not produce significant amounts of radio emission or that its geometry is such that the radio beam does not intersect with the line of sight. Finally, reanalysis of archival ROSAT data leads to a flux upper limit of f(sub x)(0.1-2.4 keV) < 1.8 x 10(exp -13) erg/s/sq cm for a putative point-like X-ray source located within the 68% confidence contour of 3EG J2020+4017. Adopting the SNR age of 5400 yrs and assuming a spin-down to X-ray energy conversion factor of 10(exp -3) this upper limit constraints the parameters of a putative neutron star as a counterpart for 3EG J2020+4017 to be P > or approx. 160/(d/1.5 kpc) ms, P > or approx. 5 x 10(exp -13)/(d/1.5kpc) s s1 and B > or approx. 9 x 10(exp 12)/(d/1.5 kpc) G.

Becker, Werner↗

A Multiwavelength Search for a Counterpart of the Brightest Unidentified Gamma-Ray Source 3EG J2020+4017 (2CG 078+2)

In search of the counterpart to the brightest unidentified gamma-ray source, 3EG J2020+4017 (2CG 078+2), we report on new X-ray and radio observations of the gamma Cygni field with the Chandra X-Ray Observatory and with the Green Bank Telescope (GBT). We also report on reanalysis of archival ROSAT data. With Chandra it became possible for the first time to measure the position of the putative gamma-ray counterpart, RX J2020.2+4026, with subarcsecond accuracy and to deduce its X-ray spectral characteristics. These observations demonstrate that RX J2020.2+4026 is associated with a K field star and therefore is unlikely to be the counterpart of the bright gamma-ray source 2CG 078+2 in the SNR G78.2+2.1 as had been previously suggested. The Chandra observation detected 37 additional X-ray sources, which were correlated with catalogs of optical and infrared data. Subsequent GBT radio observations covered the complete 99% EGRET likelihood contour of 3EG J2020+4017 with a sensitivity limit of L(sub 820) approximately 0.1 mJy kpc(exp 2), which is lower than most of the recent deep radio search limits. If there is a pulsar operating in 3EG J2020+40 17, this sensitivity limit suggests that either the pulsar does not produce significant amounts of radio emission or that its geometry is such that the radio beam does not intersect with the line of sight. Finally, reanalysis of archival ROSAT data leads to a flux upper limit of fx(0.1 - 2.4 keV) less than 1.8 x 10(exp -13) ergs s(exp -1) cm(exp -2) for a putative pointlike X-ray source located within the 68% confidence contour of 3EG J2020+4017. Adopting the supernova remnant age of 5400 yr and assuming a spin-down to X-ray energy conversion factor of 10(exp 14), this upper limit constrains the parameters of a putative neutron star as a counterpart for 3EG J2020+4017 to be P is approximately greater than 160 (d 1.5 kpc)(exp -1) ms, P is approximately greater than 5 x 10(exp -13) ((d 1.5 kpc)(exp -1)) s s(exp -1), and B (perpendicular) is approximately greater than 9 x 10(exp l2) )(d 1.5 kpc)(exp -1)) G.

Becker, Werner↗

Mapping Successional Stages in a Wet Tropical Forest Using Landsat ETM+ and Forest Inventory Data

In this study, we test whether an existing classification technique based on the integration of Landsat ETM+ and forest inventory data enables detailed characterization of successional stages in a wet tropical forest site. The specific objectives were: (1) to map forest age classes across the La Selva Biological Station in Costa Rica; and (2) to quantify uncertainties in the proposed approach in relation to field data and existing vegetation maps. Although significant relationships between vegetation height entropy (a surrogate for forest age) and ETM+ data were detected, the classification scheme tested in this study was not suitable for characterizing spatial variation in age at La Selva, as evidenced by the error matrix and the low Kappa coefficient (12.9%). Factors affecting the performance of the classification at this particular study site include the smooth transition in vegetation structure between intermediate and advanced successional stages, and the low sensitivity of NDVI to variations in vertical structure at high biomass levels.

forest structure↗

TOI-503: The First Known Brown-dwarf Am-star Binary from the TESS Mission

We report the discovery of an intermediate-mass transiting brown dwarf (BD), TOI-503b, from the TESS mission. TOI-503b is the first BD discovered by TESS, and it has circular orbit around a metallic-line A-type star with a period of P=3.6772±0.0001 days. The light curve from TESS indicates that TOI-503b transits its host star in a grazing manner, which limits the precision with which we measure the BD’s radius R(b) = 1.34(+0.26, -0.15)R(J). We obtained high resolution spectroscopic observations with the FIES, Ondrejov, PARAS, Tautenburg, and TRES spectrographs, and measured the mass of TOI-503b to be M(b)=53.7±1.2 M(J). The host star has a mass of M(*)=1.80±0.06M(ʘ), a radius of R(*)=1.70±0.05R(ʘ), an effective temperature of T(eff)=7650±160 K, and a relatively high metallicity of 0.61±0.07 dex. We used stellar isochrones to derive the age of the system to be ∼180 Myr, which places its age between that of RIK 72b (a ∼10 Myr old BD in the Upper Scorpius stellar association) and AD 3116b (a ∼600 Myr old BD in the Praesepe cluster). Given the difficulty in measuring the tidal interactions between BDs and their host stars, we cannot precisely say whether this BD formed in situ or has had its orbit circularized by its host star over the relatively short age of the system. Instead, we offer an examination of plausible values for the tidal quality factor for the star and BD. TOI-503b joins a growing number of known short-period, intermediate-mass BDs orbiting main sequence stars, and is the second such BD known to transit an A star, after HATS-70b. With the growth in the population in this regime, the driest region in the BD desert (35–55M(J) sin i) is reforesting.

Jan Subjak↗

Myogenic regulatory factors during regeneration of skeletal muscle in young, adult, and old rats

Myogenic factor mRNA expression was examined during muscle regeneration after bupivacaine injection in Fischer 344/Brown Norway F1 rats aged 3, 18, and 31 mo of age (young, adult, and old, respectively). Mass of the tibialis anterior muscle in the young rats had recovered to control values by 21 days postbupivacaine injection but in adult and old rats remained 40% less than that of contralateral controls at 21 and 28 days of recovery. During muscle regeneration, myogenin mRNA was significantly increased in muscles of young, adult, and old rats 5 days after bupivacaine injection. Subsequently, myogenin mRNA levels in young rat muscle decreased to postinjection control values by day 21 but did not return to control values in 28-day regenerating muscles of adult and old rats. The expression of MyoD mRNA was also increased in muscles at day 5 of regeneration in young, adult, and old rats, decreased to control levels by day 14 in young and adult rats, and remained elevated in the old rats for 28 days. In summary, either a diminished ability to downregulate myogenin and MyoD mRNAs in regenerating muscle occurs in old rat muscles, or the continuing myogenic effort includes elevated expression of these mRNAs.

Non-NASA Center↗

Atrial Arrhythmias in Astronauts. Summary of a NASA Summit

This slide presentation reviews the findings of a panel of heart experts brought together to study if atrial arrhythmias more prevalent in astronauts, and potential risk factors that may predispose astronauts to atrial arrhythmias. The objective of the panel was to solicit expert opinion on screening, diagnosis, and treatment options, identify gaps in knowledge, and propose relevant research initiatives. While Atrial Arrhythmias occur in approximately the same percents in astronauts as in the general population, they seem to occur at younger ages in astronauts. Several reasons for this predisposition were given: gender, hypertension, endurance training, and triggering events. Potential Space Flight-Related Risk factors that may play a role in precipitating lone atrial fibrillation were reviewed. There appears to be no evidence that any variable of the space flight environment increases the likelihood of developing atrial arrhythmias during space flight.

Barr, Yael↗

Factor analytic reduction of the carotid-cardiac baroreflex parameters

An accepted method for measuring the responsiveness of the carotid-cardiac baroreflex to arterial pressure changes is to artificially stimulate the baroreceptors in the neck. This is accomplished by using a pressurized neck cuff which constricts and distends the carotid artery and subsequently stimulates the baroreceptors. Nine physiological responses to this type of stimulation are quantified and used as indicators of the baroreflex. Thirty male humans between the ages 27 and 46 underwent the carotid-cardiac baroreflex test. The data for the nine response parameters were analyzed by principle component factor analysis. The results of this analysis indicated that 93 percent of the total variance across all nine parameters could be explained in four dimensions. Examination of the factor loadings following an orthogonal rotation of the principle components indicated four well defined dimensions. The first two dimensions reflected location points for R-R interval and carotid distending pressure respectively. The third dimension was composed of measures reflecting the gain of the reflex. The fourth dimension was the ratio of the resting R-R interval to R-R interval during simulated hypertension. The data suggests that the analysis of all nine baroreflex parameters is redundant.

Ludwig, David A.↗

Hygrothermal aging effects on polyimide and acrylate-based adhesive materials in high-performance flat-flex cable assemblies

Flat-flex assemblies are widely used across a diverse range of technologies, including consumer electronics, automotive systems, aerospace and defense applications, and medical devices, due to their compact form factor and flexibility. However, environmental stressors like temperature and humidity are known to degrade performance over time, though the main mechanisms for degradation remain unknown. Here, in this work, we examined the aging behavior of copper/polyimide/adhesive laminate systems under varying temperature and humidity conditions, focusing on material degradation and its effects on mechanical and dielectric properties. Results show that peel strength and breakdown voltage decrease with exposure time, temperature, and humidity; spectroscopic characterization revealed that the adhesive, and not the polyimide, is the weak link in the material stack-up. The adhesive, identified as a butyl acrylate-acrylonitrile (BA-AN) copolymer, exhibited age-related spectral changes that correlated with exposure severity and duration. Hydrolysis at BA ester and AN nitrile groups was identified as the primary degradation mechanism, producing amides, acids, and alcohols. We developed a mechanistic model that connects kinetic parameters for BA-AN spectral band decay to peel strength and breakdown voltage, and implicates hydrolysis at the AN moiety, not BA, in performance decrements. Modeling predictions at ambient conditions indicate faster decline in peel strength than dielectric strength at early times, followed by plateauing of both properties at longer times. These findings provide critical insights into laminate aging mechanisms and highlight the importance of addressing BA-AN degradation to improve the long-term reliability of these systems in high-humidity environments.

organic↗

Application of artificial intelligence methods in the international roughness index prediction of rigid and composite pavements: a systematic review

The International Roughness Index (IRI) is a widely adopted metric for quantifying pavement roughness, directly influencing vehicle safety, ride comfort, and overall roadway performance. In recent years, the use of Machine Learning (ML) models for IRI prediction has gained momentum, with the goal of improving the allocation of maintenance and rehabilitation resources by enabling accurate assessments of pavement conditions. Most prior reviews, however, have concentrated on flexible pavements, leaving a notable gap regarding rigid and composite pavements. To address this gap, the present study conducts a systematic review of Artificial Intelligence (AI) methods applied to IRI prediction for rigid and composite pavements. Literature published between 2004 and 2025 is synthesized to highlight prevailing trends, methodological contributions, and directions for future research. Particular attention is given to the types of models employed, the datasets used for training and validation, and the role of input variables and data-processing strategies. Across the included studies, ensemble learning methods (especially gradient boosting variants such as XGBoost), artificial neural networks, and hybrid architectures frequently achieved high predictive skill, with several models reporting test-set coefficients of determination approaching 0.9–0.96, indicating strong potential for capturing the influence of traffic, pavement structure, and climatic factors. Since these results are obtained from heterogeneous datasets and evaluation protocols, they are interpreted qualitatively rather than as strict cross-study rankings. Analysis of input variables revealed that pavement age and initial IRI were included in 91% (21 of 23) and 78% (18 of 23) of studies, respectively. Climatic variables such as the freezing index appeared in 57% (13 of 23), while traffic-related factors were considered in 65% (15 of 23). The findings underscore the importance of standardized, high-quality datasets, such as those from the Long-Term Pavement Performance (LTPP) program, along with data consistency, model interpretability, computational efficiency, and replicability in enhancing IRI prediction. Future research should focus on incorporating input variable selection techniques to identify the most influential predictors, thereby improving accuracy and robustness. Integrating these approaches with advanced non-linear data-driven models, coupled with robust hyperparameter optimization, holds considerable promise for strengthening the reliability of IRI prediction and supporting resilient pavement management strategies.

42 ENGINEERING↗

Virtual Inspection of Advanced Manufacturing via Process-Scale Digital Twins (Abbreviated Report)

Inspection and certification comprise the most significant bottlenecks in advanced manufacturing for NNSA applications, often requiring far more time and resources than the fabrication of the parts themselves. Traditional methods, such as manual review and X-ray computed tomography, are not only slow and costly, but also struggle to provide a clear connection between manufacturing instructions and the final performance of critical components. This gap limits both the agility and assurance needed to support the modernization and safety of the United States nuclear stockpile. In response, our Strategic Initiative established a digital twin framework that integrates realtime process monitoring, automated data analysis, and immersive virtual reality collaboration into a unified inspection pipeline. By leveraging data from sensors, machine instructions, and imaging, we created high-fidelity virtual models of manufactured parts that could be rapidly analyzed and certified. This approach was first demonstrated with Direct Ink Write, and then extended to other manufacturing settings, including conventional (or “subtractive”) manufacturing and to predict the end of life performance of parts per the aging and lifetimes programs. The result is a transformational capability: inspection times have been reduced by a factor of 120,000 without loss of accuracy and while simultaneously improving traceability and confidence in part quality. This framework not only streamlines certification for critical applications, but also positions the national security enterprise to respond more flexibly to emerging challenges, supporting agile manufacturing and digital engineering practices across a broad range of mission-relevant domains.

42 ENGINEERING↗

Kinematics of Saturn's spokes

Voyager 2 images of Saturn's rings have been analyzed for spoke activity. More than 80 and 40 different spokes have been measured at the morning and at the evening ansa, respectively. Higher rate of spoke formation has been found at 145 + or 15 deg SLS and at 305 + or - 15 deg SLS which persisted for at least 3 Saturn revolutions. Higher spoke activity (formation and growth in width) by more than a factor 3 has been observed over the nightside hemisphere of Saturn than over the dayside hemisphere. The age distribution (i.e., time from radial formation until observation, assuming Keplerian shear) of the leading (old) edges of spokes has its maximum at approximately 9,000 s and 6,000 s for spokes observed at the morning ansa and at the evening ansa, respectively. The highest spoke age observed is approximately 20,000 s.

Gruen, E.↗

Young thrust-fault scarps in the highlands - Evidence for an initially totally molten moon

Attention is given to thermoelastic stress calculations implying that if only the outer few hundreds of km of a moon with a cool interior were initially molten, the lunar highlands should not have young compressional tectonic features. Extrapolations from Apollo panoramic images showing young thrust faults in the highlands suggest that about 2000 thrust fault scarps exist on the highlands, generally occurring in series or complexes of four or five scarps that are on average 5 km long. The ages of the scarps range from 60 + or - 30 to 680 + or - 250 my, with a possible factor bias of +2 to -4. The scarps are the youngest endogenic features on the moon, and indicate that the moon was initially molten.

Binder, A. B.↗

X-ray sources in regions of star formation. III - Naked T Tauri stars associated with the Taurus-Auriga complex

Ground-based and IRAS optical and IR spectroscopic and photometric observations are reported for 90 stars in or near 59 Einstein Observatory X-ray error circles in the Tau-Aur region. The data are presented in extensive tables and sample spectra and characterized in detail, with particular attention to 28 newly discovered 'naked' T Tau stars, which are shown to be normal stars with no significant IR or UV excess and ages of 1-40 Myr. These stars are found to outnumber normal T Tau stars by a factor of 10 in an area near the Tau-Aur dark clouds, and it is argued that their evolution toward the ZAMS is typical for low-mass stars. The implications of this finding for the time scales of circumstellar-disk dissipation and planet formation are discussed.

Walter, Frederick M.↗

Space: The Final Frontier of Bone Density

It is a medical requirement at NASA to evaluate the skeletal integrity of "long-duration" astronauts by measuring bone mineral density [BMD] with DXA technology. A long-duration mission is a spaceflight that is greater than 30 days but is typically the continuous 120-180 day missions aboard the International Space Station [ISS]. Not only does NASA use the BMD index to monitor fracture risk in this astronaut population, but these measures are also used to describe the effects of spaceflight, to certify skeletal health readiness for flight, to monitor the recovery of lost bone mass after return to earth, and to evaluate the efficacy of countermeasures to bone loss. However, despite the fact that DXA-based BMD is a widely-applied surrogate for bone strength that is grounded in an abundance of population-based fracture data, its applicability to the long-duration astronaut is limited. The cohort of long-duration astronauts is not the typical group for evaluating osteoporosis or determining age-related fracture risk. The cohort is young (< 55 years), predominantly male and exposed to novel risk factors for bone loss besides the weightlessness of space. NASA is concerned about early onset osteoporosis in the astronaut exposed to long-duration spaceflight, especially since any detectable symptoms are likely to manifest after return to earth and perhaps years after space travel. This risk raises the question: is NASA doing enough now to mitigate a fracture event that may manifest later? This presentation will discuss the limitations and constraints to understanding skeletal changes due to prolonged spaceflight and the recommendations, by clinical experts in osteoporosis and BMD, to transition research technologies for clinical decision-making by NASA.

Sibonga, Jean D.↗

Youngstown and Warren Disasters: Mapping Flood Susceptibility, Vulnerability, and Risk and Tree Canopy Coverage in Northern Ohio to Inform Stormwater Management and Flood Mitigation Efforts

Both pluvial and fluvial flooding events pose direct challenges on urban infrastructure and communities across the United States. Heavy rainfall events oversaturate the ground, overflow waterbodies, and overwhelm stormwater infrastructure. Vulnerable areas receive heavy damage from flooding events due to physical factors like increased impervious surfaces, poor stormwater systems, and limited greenspaces. These vulnerable neighborhoods are comprised of aging populations, minority communities, and lower income levels. Lack of data in these communities have made it difficult to implement policymaking and flood mitigation strategies. Using the Urban Flood Risk Mitigation model (InVEST) and the PlanetScope satellite constellation, the team visualized historical flooding and tree canopy coverage as a measure of flood susceptibility. The team also used the Arc-Malstrom model to provide further insight into where flooding accumulates via surface elevation depressions in the study area. To validate these models, the team explored the spatial variation of rainfall events using NASA’s Integrated Multi-satellite Retrievals for Global Precipitation Measurement (GPM IMERG). The resulting maps highlight areas surrounding the cities of Youngstown and Warren as being the most flood susceptible and socially vulnerable, while the city centers contain the lowest tree canopy coverage. The DEVELOP team collaborated with the Environmental Collaborative of Ohio (ECO) to create products for end users within the City of Warren’s Water Pollution Control Department, the Eastgate Regional Council of Governments and the Healthy Community Partnership of Mahoning Valley. These products help identify target areas for preventative flood mitigation measures as well as areas ideal for green infrastructure intervention.

InVEST Urban Flood Risk Mitigation Model↗

Controlled Rest: Investigating the Use of an In-Flight Sleepiness Countermeasure

INTRODUCTION: Sleepiness is commonly reported amongst commercial airline pilots and is recognized as a safety risk due to its impact on performance. Controlled Rest (CR) refers to a short, voluntary nap opportunity taken by pilots on the flight deck as a countermeasure to unanticipated sleepiness in flight. This study explores the profile of CR use in a long-haul commercial airline. METHODS: Forty-four pilots filled in an application-based sleep/work diary and wore actiwatches for approximately 2 weeks. Complete data sets from 239 flights including sleep diaries, actigraphy, and schedules were merged and analyzed. Sleep diary entries were used to set CR intervals in the actigraphy software, which was then used to predict sleep within these intervals. All time-stamps of sleep periods and flight schedules were adjusted for home-base time of the pilots. Pearson Correlations were used to assess the influence of pilot demographics on CR use. A mixed-effects logistic regression was used to analyze the impact of schedule factors on CR. RESULTS: Pilots reported taking CR on 46% (n=110) of observed flights. Average CR attempt duration was 43.1 ± 11.0 minutes. Eighty-percent (n=106/133) of all CR attempts were estimated by actigraphy to have successfully achieved sleep with an average sleep duration during successful rest periods of 31.7 ± 12.2 minutes. Captains reported taking CR on 38% of flights (n=39/102), compared to First Officers reporting 52% (n=71/137) of flights with CR (p=0.131). Age, experience, BMI, and sleep need were not associated with the percentage of flights with CR (all p>0.244). The following schedule factors were associated with a higher frequency of CR: night (55%, n=76) vs. day flights (34%, n=34); <10h (63%, n=80) vs. >10h duration flights (27%, n=30); return (60%, n=71) vs. outbound flights (33%, n=39); and 2-pilot (69%, n=83) vs. >2-pilot flights (23%, n=27) (all p≤0.001). There was a trend for more CR on eastbound flights, but this was not significant (eastbound: 51%, n= 57; westbound: 40%, n= 44; p=0.059). Of note, 22% (n=26) of augmented flights (>2-pilots) contained both CR and Bunk Rest (in a designated rest facility). DISCUSSION: Data from this airline show that pilots commonly use CR to mitigate sleepiness in-flight, especially on flights <10h duration and during home-base nighttime flights. Future studies are required to determine generalizability of these results to other airlines.

sleepiness↗

Global isostatic geoid anomalies for plate and boundary layer models of the lithosphere

Commonly used one dimensional geoid models predict that the isostatic geoid anomaly over old ocean basins for the boundary layer thermal model of the lithosphere is a factor of two greater than that for the plate model. Calculations presented, using the spherical analogues of the plate and boundary layer thermal models, show that for the actual global distribution of plate ages, one dimensional models are not accurate and a spherical, fully three dimensional treatment is necessary. The maximum difference in geoid heights predicted for the two models is only about two meters. The thermal structure of old lithosphere is unlikely to be resolvable using global geoid anomalies. Stripping the effects of plate aging and a hypothetical uniform, 35 km, isostatically-compensated continental crust from the observed geoid emphasizes that the largest-amplitude geoid anomaly is the geoid low of almost 120 m over West Antarctica, a factor of two greater than the low of 60 m over Ceylon.

Hager, B. H.↗