Search NASA⌕ Search

SEARCH · Search NASA

Results for “COVID”

Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 361 records · Page 20
All sourcesNASA NTRSDOE OSTI
DOE OSTI2023

Multi-omics of NET formation and correlations with CNDP1, PSPB, and L-cystine levels in severe and mild COVID-19 infections

We report that we performed a multi-omics analysis of an immunologically naïve SARS-CoV-2 clinical cohort to characterize overall changes in plasma among control (uninfected), mild, and severe infections. A comparison of healthy controls and patient samples showed activation of neutrophil degranulation pathways. Consistent with this observation, we characterized neutrophil extracellular trap (NET) complexes that were partially initiated in a subset of the mild infections (showing partially formed NETs) and fully-formed NETs in a subset of severe infections (containing multiple NET proteins in individual patient samples). As a potential mechanism to suppress NET formation, multiple redox enzymes were elevated in the mild and severe population. Analysis of metabolites from the same cohort showed a 24 and 60-fold elevation in plasma L-cystine, the oxidized form of cysteine and substrate of the powerful antioxidant glutathione in mild and severe patients, respectively. Unique to patients with mild infections, the carnosine dipeptidase modifying enzyme (CNDP1) was up-regulated. The strong protein and metabolite oxidation signatures suggest multiple compensatory pathways working to suppress both free radical and NET formation in SARS-CoV-2 infections.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2020

COVID-19 Infection Prevention through Natural Product Molecules

This project evaluates natural product molecules with the potential to prevent 2019- nCOV infection. The molecules theoretically work by blocking the ACE2 protein active site in human airways. Previous work focused on modeling candidate natural compounds, but this work examined baicalin, hesperetin, glycyrrhizin, and scutellarin in experimental in vitro studies, which included recombinant protein inhibition assays, cell culture virus inhibition assays, and cytotoxicity assays. The project delivered selectivity indices (ratio that measures the window between cytotoxicity and antiviral activity) of the four natural compounds that will help guide the direction of SARS-CoV-2 therapeutic development.

59 BASIC BIOLOGICAL SCIENCES↗
DOE OSTI2021

Diagnostic Testing for COVID-19 Bridging Study for QIAamp Viral RNA Extraction vs Beckman RNAdvance vs Thermofisher MagMAX

This report describes testing that was performed by LANL’s Biological Agent Testing Lab (BATL) to validate modifications to the CDC EUA 2019-Novel Coronavirus (2019- nCoV) Real-Time RT-PCR Diagnostic Panel (EUA-CDC-nCoV-IFU). BATL intends to implement the modifications to increase thoughput for daily testing . BATL validated the viral RNA extraction process, using the orignial component, QIAamp Viral RNA Mini Kit (Cat # 52906) and the new components, Beckman Coulter magnetic 96-well plate RNAdvance Viral kit (Cat # C63510), Thermofisher MagMAX Viral/Pathogen Nucleic Acid Isolation Kit (Cat # A48310). Equivalency was demonstrated between the original component and the Beckman Coulter magnetic 96-well plate RNAdvance Viral kit (Cat # C63510). Equivalency was also demonstrated between the original component and the Thermofisher MagMAX Viral/Pathogen Nucleic Acid Isolation Kit (Cat # A48310). Subsequently, substitution of the original component with either of these kits for viral RNA extraction increased BATL’s extraction capability from 100 samples per day to 279 samples per day.

59 BASIC BIOLOGICAL SCIENCES↗
NASA NTRSDate not supplied

The Reinvention of Aviation: The Effects of Covid-19 on the Aviation Industry, and Actions Needed to Ensure its Future Success

This research project sought to develop short-term and long-term projections on the outlook of air transportation and to produce relevant recommendations for the direction of NASA aviation research as it adapts to the disrupted industry. We developed a model to estimate airline recovery trajectories, and researched the unique effects of the pandemic on various sectors of aviation. We found that the pandemic highlighted past flaws in the aviation system, creating widespread effects across the industry. As the industry looks towards recovery, we believe that it cannot simply return to 2019 operations, but instead perform a full reinvention to support long-term demand and prepare for future catastrophes. We recommend that NASA seize this opportunity to accelerate innovation through an increased focus on passenger satisfaction, meaningful steps towards sustainability, and significant collaboration with a diverse range of groups.

high school intern project↗
NASA NTRS2020

The Reinvention of Aviation: The Effects of Covid-19 on the Aviation Industry, and Actions Needed to Ensure its Future Success

This research project sought to develop short-term and long-term projections on the outlook of air transportation and to produce relevant recommendations for the direction of NASA aviation research as it adapts to the disrupted industry. We developed a model to estimate airline recovery trajectories, and researched the unique effects of the pandemic on various sectors of aviation. We found that the pandemic highlighted past flaws in the aviation system, creating widespread effects across the industry. As the industry looks towards recovery, we believe that it cannot simply return to 2019 operations, but instead perform a full reinvention to support long-term demand and prepare for future catastrophes. We recommend that NASA seize this opportunity to accelerate innovation through an increased focus on passenger satisfaction, meaningful steps towards sustainability, and significant collaboration with a diverse range of groups.

high school intern project↗