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NASA NTRS2017

Enabling Future Science and Human Exploration with NASA's Next Generation near Earth and Deep Space Communications and Navigation Architecture

The National Aeronautics and Space Administration (NASA) is studying alternatives for the United States space communications architecture through the 2040 timeframe. This architecture provides communication and navigation services to both human exploration and science missions throughout the solar system. Several of NASA's key space assets are approaching their end of design life and major systems are in need of replacement. The changes envisioned in the relay satellite architecture and capabilities around both Earth and Mars are significant undertakings and occur only once or twice each generation, and therefore is referred to as NASA's next generation space communications architecture. NASA's next generation architecture will benefit from technology and services developed over recent years. These innovations will provide missions with new operations concepts, increased performance, and new business and operating models. Advancements in optical communications will enable high-speed data channels and the use of new and more complex science instruments. Modern multiple beam/multiple access technologies such as those employed on commercial high throughput satellites will enable enhanced capabilities for on-demand service, and with new protocols will help provide Internet-like connectivity for cooperative spacecraft to improve data return and coordinate joint mission objectives. On-board processing with autonomous and cognitive networking will play larger roles to help manage system complexity. Spacecraft and ground systems will coordinate among themselves to establish communications, negotiate link connectivity, and learn to share spectrum to optimize resource allocation. Spacecraft will autonomously navigate, plan trajectories, and handle off-nominal events. NASA intends to leverage the ever-expanding capabilities of the satellite communications industry and foster its continued growth. NASA's technology development will complement and extend commercial capabilities to meet unique space environment requirements and to provide capabilities that are beyond the commercial marketplace. The progress of the communications industry, including the emerging global space internet segment and its planned constellations of 100's of satellites offer additional opportunities for new capability and mission concepts. The opportunities and challenges of a future space architecture require an optimal solution encompassing a global perspective. The concepts and technologies intentionally define an architecture that applies not only to NASA, but to other U.S. government agencies, international space and government agencies, and domestic and international industries to advance the openness, interoperability, and affordability of space communications. Cooperation among the worlds space agencies, their capabilities, standards, operations, and interoperability are key to advancing humankind's understand of the universe and extending human presence into the solar system.

Communications↗

NASA NTRS2017

Enabling Future Science and Human Exploration with NASA's Next Generation Near Earth and Deep Space Communications and Navigation Architecture

The National Aeronautics and Space Administration (NASA) is studying alternatives for the United States space communications architecture through the 2040 timeframe. This architecture provides communication and navigation services to both human exploration and science missions throughout the solar system. Several of NASA's key space assets are approaching their end of design life and major systems are in need of replacement. The changes envisioned in the relay satellite architecture and capabilities around both Earth and Mars are significant undertakings and occur only once or twice each generation, and therefore is referred to as NASA's next generation space communications architecture. NASA's next generation architecture will benefit from technology and services developed over recent years. These innovations will provide missions with new operations concepts, increased performance, and new business and operating models. Advancements in optical communications will enable high-speed data channels and the use of new and more complex science instruments. Modern multiple beam/multiple access technologies such as those employed on commercial high throughput satellites will enable enhanced capabilities for on-demand service, and with new protocols will help provide Internet-like connectivity for cooperative spacecraft to improve data return and coordinate joint mission objectives. On-board processing with autonomous and cognitive networking will play larger roles to help manage system complexity. Spacecraft and ground systems will coordinate among themselves to establish communications, negotiate link connectivity, and learn to share spectrum to optimize resource allocation. Spacecraft will autonomously navigate, plan trajectories, and handle off-nominal events. NASA intends to leverage the ever-expanding capabilities of the satellite communications industry and foster its continued growth. NASA's technology development will complement and extend commercial capabilities to meet unique space environment requirements and to provide capabilities that are beyond the commercial marketplace. The progress of the communications industry, including the emerging global space internet segment and its planned constellations of 100's of satellites offer additional opportunities for new capability and mission concepts. The opportunities and challenges of a future space architecture require an optimal solution encompassing a global perspective. The concepts and technologies intentionally define an architecture that applies not only to NASA, but to other U.S. government agencies, international space and government agencies, and domestic and international industries to advance the openness, interoperability, and affordability of space communications. Cooperation among the worlds space agencies, their capabilities, standards, operations, and interoperability are key to advancing humankinds understand of the universe and extending human presence into the solar system.

deep space↗

NASA NTRS2018

Enabling Technologies for Deep Space Motion Imagery

From the beginning of the Space Age, imagery, particularly motion imagery, has been a part of crewed and uncrewed missions. As technologies have evolved the imagery gets better, more compelling, and more useful for operations and monitoring of systems, crew, and spacecraft. Film, video and live television have engaged the public and sparked the imaginations of engineers, scientists, and artists alike. As we look forward now to crewed missions beyond low-Earth orbit, such as the Deep Space Gateway being considered as a pre-cursor to future crewed Mars missions, there are both opportunities and challenges in implementing a multi-faceted imaging system that advances mission capabilities and technology.This paper will present a vision for an imaging system that is relevant for operations of the ISS and future crewed missions in deep space, with a detailed look at some of the key innovative technologies required to enable such a system. In addition, impacts to Space Operations, video distribution to the public and to science investigators, and video system interoperability will be presented. Opportunities where standardization can enable interoperability are also identified for those imagery and communications functions planned for inclusion in the Consultative Committee for Space Data Systems (CCSDS) Blue Book.

Grubbs, Rodney↗

NASA NTRS2018

Space User Visibility Benefits of the Multi-GNSS Space Service Volume: An Internationally-Coordinated, Global and Mission-Specific Analysis

The number and scope of Global Navigation Satellite System (GNSS)-based space applications has grown significantly since the first GNSS space receiver was flown in the early 1980's. The vast majority of GNSS space users operate in Low-Earth Orbit (LEO), where the use of GNSS receivers has become routine. However, the use of GNSS has expanded to other orbit regimes like Geostationary Orbits (GEO) and High Eccentric Orbits (HEO) but has been very limited due to the challenges involved. The major challenges for such types of orbits including much weaker signals, reduced geometric diversity, and limited signal availability. In any case, considering the recent development of multiple GNSS constellations and ongoing upgrades to existing constellations, GNSS signal availability will improve significantly. As a result, this expanded multi-GNSS signal capability will enable improved on-orbit navigation performance and will also allow the development of new mission concepts. High altitude space users will especially benefit from this evolution, which will provide GNSS signals to challenging regimes well beyond Low Earth Orbit. These benefits will only be realised, however, if additional signals are designed to be interoperable, are clearly documented and supported. In order to enhance the overall GNSS performance for spacecraft's in regimes from LEO, GEO to HEO and beyond, all Satellite Navigation constellation providers and regional augmentation system providers are working together through the United Nations International Committee on GNSS (ICG) forum to establish an interoperable GNSS Space Service Volume (SSV) for the benefit of all GNSS space users. This paper provides an overview of the technical work and in particular the simulations, performance analysis and discussions of the outcomes and results obtained by the UN ICG Working Group-B in the context of the GNSS Space Service Volume activities, which were supported by all GNSS service providers.

systems↗

NASA NTRS2018

The Multi-GNSS Space Service Volume

Global Navigation Satellite Systems (GNSS), now routinely used for navigation by spacecraft in low Earth orbit, are being used increasingly by high-altitude users in geostationary orbit and high eccentric orbits as well, near to and above the GNSS constellations themselves. Available signals in these regimes are very limited for any single GNSS constellation due to the weak signal strength, the blockage of signals by the Earth, and the limited number of satellites. But with the recent development of multiple GNSS constellations and ongoing upgrades to existing constellations, multi-GNSS signal availability is set to improve significantly. This will only be achieved if these signals are designed to be interoperable and are clearly documented and supported.All satellite navigation constellation providers are working together through the United Nations International Committee on GNSS (ICG) to establish an interoperable multi-GNSS Space Service Volume (SSV) for the benefit of all GNSS space users. The multi-GNSS SSV represents a common set of baseline definitions and assumptions for high-altitude service in space, documents the service provided by each constellation, and provides a framework for continued support for space users. This paper provides an overview of the GNSS SSV concept, development, status, and achievements within the ICG. It describes the final adopted definition and performance characteristics of the GNSS SSV, as well as the numerous benefits and use cases enabled by this development, and summarizes extensive technical analysis that was performed to illustrate these benefits in terms of signal availability, both on a global scale, and for multiple distinct mission types.

navigation↗

NASA NTRS2018

FAIRness and Usability for Open-Access Omics Data Systems

Omics data sharing is especially crucial to the biological research community, and the last decade or two has seen a huge rise in collaborative analysis systems, databases, and knowledge bases for omics and other systems biology data. We assessed the "FAIRness" of NASA's GeneLab Data Systems (GLDS) along with four similar kinds of systems in the research omics data domain, using 14 FAIRness metrics. 14 metrics. The range of Pass ratings was 29-79% of the 14 metrics, Partial Pass 0-21%, and Fail 7-50%. The range of overall FAIRness scores was 5-12 (out of 14). The systems we evaluated performed the best in the areas of data findability and accessibility, and worst in the area of data interoperability. We propose two new principles that Big Data systems, in particular, should consider for increasing data accessibility. We relate our experiences implementing semantic integration of omics data from several systems for the federated querying and retrieval functions of the GLDS, given the shortcomings in data interoperability of these systems.

Berrios, Daniel C.↗

NASA NTRS2018

FAIRness and Usability for Open-access Omics Data Systems

Omics data sharing is crucial to the biological research community, and the last decade or two has seen a huge rise in collaborative analysis systems, databases, and knowledge bases for omics and other systems biology data. We assessed the "FAIRness" of NASA's GeneLab Data Systems (GLDS) along with four similar kinds of systems in the research omics data domain, using 14 FAIRness metrics. The range of overall FAIRness scores was 6-12 (out of 14), average 10.1, and standard deviation 2.4. The range of Pass ratings for the metrics was 29-79%, Partial Pass 0-21%, and Fail 7-50%. The systems we evaluated performed the best in the areas of data findability and accessibility, and worst in the area of data interoperability. Reusability of metadata, in particular, was frequently not well supported. We relate our experiences implementing semantic integration of omics data from some of the assessed systems for federated querying and retrieval functions, given their shortcomings in data interoperability. Finally, we propose two new principles that Big Data system developers, in particular, should consider for maximizing data accessibility.

Berrios, Daniel C.↗

NASA NTRS2019

Free Space Optics - Transportable Test Platform

The study examines potential approaches and benefits to government space agencies and industry regarding the development and testing of free space optics (FSO) satellite communication systems should government space agencies launch optical satellite payloads and/or develop a transportable test platform with which industry provided optical ground systems (OGSs) could interface. The study examines atmospheric and environmental effects on FSO networks, as well as the multitude of mitigation techniques available to compensate for those effects. Research suggests that there are a multitude of potential techniques that could be implemented to mitigate the adverse effects of atmospheric/environmental conditions, and to optimize the effectiveness of FSO networks. Testing and selection of this broad array of techniques is a prerequisite to making FSO space segment systems and OGSs interoperable. The study discusses testing that is required to define FSO standards. The establishment of interoperable standards is complicated by the existence of a multitude of potential schemes/specifications to address each mitigation/optimization challenge; very little is yet standardized. Standardization is further complicated by the fact that the selection of a design approach which benefits one consideration often disadvantages another consideration. Each mitigation techniques must be evaluated as an element of the complete system to gain an accurate understanding of its effects on system efficacy.

Haddad, George↗

NASA NTRS2018

FAIRness and Usability for Open-access Omics Data Systems

Omics data sharing is crucial to the biological research community, and the last decade or two has seen a huge rise in collaborative analysis systems, databases, and knowledge bases for omics and other systems biology data. We assessed the “FAIRness” of NASA’s GeneLab Data Systems (GLDS) along with four similar kinds of systems in the research omics data domain, using 14 FAIRness metrics. The range of overall FAIRness scores was 6-12 (out of 14), average 10.1, and standard deviation 2.4. The range of Pass ratings for the metrics was 29-79%, Partial Pass 0-21%, and Fail 7-50%. The systems we evaluated performed the best in the areas of data findability and accessibility, and worst in the area of data interoperability. Reusability of metadata, in particular, was frequently not well supported. We relate our experiences implementing semantic integration of omics data from some of the assessed systems for federated querying and retrieval functions, given their shortcomings in data interoperability. Finally, we propose two new principles that Big Data system developers, in particular, should consider for maximizing data accessibility.

Berrios, Daniel C.↗

NASA NTRS1995

(abstract) Satellite-Enhanced Personal Communications Experiments

As an initial step in exploring the opportunities afforded by the merger of satellite-based and land-based networks, Bellcore and JPL conducted several experiments utilizing NASA's Advanced Communications Technology Satellite (ACTS) and JPL's ACTS Mobile Terminal (AMT). Experimental goals fell into three categories: a) demonstrate personal communication applications, b) demonstrate interoperability among multiple wireless networks and the Public Switched Telecommunications Network (PSTN), and c) evaluate new protocol mechanisms for data communications using wireless links. We describe the performance of Point-of-Sale, e-mail, FAX, and call control applications, where the communication path passed through up to four networks: a wireless packet data network, the Satellite network, the PSTN, and a wireless cellular network. One important element of satellite-terrestrial interoperability is the efficiency of data communications protocols. Most protocols in use today (e.g., TCP/IP) have been optimized for wireline channels; their use over wireless networks presents significant new challenges. The characteristics of wireless channels -- increased error, longer packet delay, and limited bandwidth -- affect the design of the protocol. We describe experimental results for differing protocol mechanisms and parameters, such as acknowledgment schemes and packet sizes, that demonstrate the types of protocol needed for efficient use of wireless satellite-terrestrial networks.

personal↗

NASA NTRS2018

A Standard Reference Model for Data Archives

An implementable Data Archive Architecture is being developed for trusted digital repositories based on the Reference Model for an Open Archival Information System (OAIS) – ISO 14721. A set of interoperable protocols and interface specifications are planned that will offer capabilities for accessing, merging, and re-using data, both within and across the operational boundaries of trustworthy digital repositories. The model will also provide support for the fundamental scientific need to verify the reproducibility of results. This standards development task is being performed by the Data Archive Interoperability (DAI) working group within the Consultative Committee for Space Data Systems (CCSDS). The architecture integrates concepts from the OAIS Reference Model, the ISO/IEC 11179 Metadata Registry (MDR) standard, the CCSDS Reference Architecture for Space Information Management (RASIM), the proposed draft recommended practice document, Information Preparation to Enable Long Term Use (IPELTU), and three decades of digital repository development for science research.

Ambacher, Bruce↗

NASA NTRS2022

The Standardization of In-space and Surface Docking Systems

The International Docking System Standard (IDSS) was developed and establish to aid on-orbit crew rescue and joint operations between different spacecraft. For the International Space Station (ISS), the IDSS has successfully enabled Global interoperability for Commercial Crew and it is now being extended to the Artemis campaign. Similarly, as more companies, agencies, and nations announce their intentions to explore and occupy Low Earth Orbit (LEO) and Cis-Lunar space, including the Lunar surface, it is a natural supposition that new, vehicle interface standards will be required to support the build-up of infrastructure for campaign-based exploration or permanent occupation by national and multi-national Agencies, Industries, and Companies. A surface version of the IDSS, a.k.a. IDSS-Surface (IDSS-S), is under consideration at the NASA Johnson Space Center (JSC) by the docking discipline leads responsible for the leadership of technical development and negotiation of the original IDSS over a decade ago. The IDSS-S, like its predecessor, will ultimately detail the physical geometric mating interface and design load requirements to ensure physical interoperability and to support a broad set of design reference missions which, if accommodated, increases the probability of successful Lunar surface docking between different modules enabling the accessibility and inclusivity required for multi-national, sustainable Lunar exploration.

Docking↗

NASA NTRS2022

Developing High Performance Space Networking Capabilities for the International Space Station and Beyond

A performance optimized implementation of Delay Tolerant Networking (DTN) with the capacity of gigabit-per second rates is developed for the International Space Station (ISS) and missions demanding large amounts of communications bandwidth. An overview of the High-rate Delay Tolerant Networking (HDTN) architecture and support for different convergence layers is provided. This paper then presents an overview of the testing and integration efforts to evaluate interoperability and capability in relevant environments. The first was interoperability testing with DTN Marshall Enterprise (DTNME) which resulted in near-gigabit per second data rates. This was followed by ISS emulation testing with the Software Development and Integration Laboratory (SDIL) at the Lyndon B. Johnson Space Center (JSC) and local testing based on the ISS DTN network topology. The local tests resulted in the discovery of potential sources of performance loss in the network and demonstrated near-gigabit rates between HDTN and DTNME.

Daniel Raible↗

NASA NTRSDate not supplied

Biological Data for Deep Space Mission Support

Increased biomedical risks and challenges associated with deep space missions (cis-Lunar, Mars transit, Mars surface) require new knowledge discovery and development of novel ecosystem and biomedical support capabilities. This paradigm shift supporting distant and long-duration missions requires biological data to be findable, accessible, interoperable, reusable (FAIR), and maximally open-access (i.e., there is a data governance continuum from closed to mediated to embargoed to open). The NASA “Open Science Data Repositories” (OSDR) aims to meet scientific, technical, and operational spaceflight needs, and offers the ability to upload, download, search, share, analyze, and visualize data across physiological, behavioral, ‘omics, and environmental monitoring telemetry datasets. OSDR includes NASA GeneLab, NASA Ames Life Sciences Data Archive (ALSDA), and NASA Biological Institutional Scientific Collection (NBISC). In the past year, ALSDA has undergone a transformation in its data collection, curation, and architecture methods. Standardizing non-genomic (phenotypic) datasets was, and will continue to be, a challenge because of their diverse nature (e.g., molecular, cellular, tissue, whole organism behavior; micro-computed tomography, intraocular pressure, fluorescence microscopy, western blot, ultrasonography; tabular, images, video). This year ALSDA, alongside GeneLab, introduced the Biological Data Management Environment (BDME) with the purpose to accept submission of data from space relevant experiments including spaceflight, radiation, simulated gravity, gravitropism, isolation and confinement, hostile closed environments and/or distance from Earth. In addition to bringing together omics, phenotypic, physiological, bioimaging, and behavioral data into one repository. By integrating with GeneLab a multi-project submission portal aims to reduce the burden on PIs submitting data and enabling the discovery of both omics and phenotypic data. The purpose of ALSDA is to collect, curate, and make all non-human space-relevant biological data maximally findable, accessible, interoperable, and reusable (FAIR). These scope of ALSDA data collected and submitted by PIs include study design metadata, subject metadata, assay metadata (parameters), raw and processed assay data, assay imagery/video, and subject-experienced mission data telemetry (radiation, temperature, humidity, acoustics, vibrations, etc.). In 2021, a community of researchers rallied to form the ALSDA Analysis Working Group (AWG) and provided scientific consensus on dataset sample and assay metadata. The community and excitement around the ALSDA/OSDR system has already led to several data reuse studies, demonstrating value using machine learning (ML), knowledge graphs, and meta-analysis approaches.

space biology↗

NASA NTRSDate not supplied

Additional Metadata Guidelines to Improve the Structure and Usability of HDF and NetCDF Files

The Hierarchical Data Format (HDF) and Network Common Data Form (NetCDF) are data file formats created to aid users in the creation or use of scientific data. These file formats are useful for handling large data volumes and hosting extensive metadata as global attributes or variables and are popular with the modeling community. HDF and NetCDF files are largely used with remote sensing data and have been used to support measurements from numerous campaigns, from satellite to aircraft or ground and mobile based measurements. The files from airborne field studies, however, vary greatly in terms of the file structure and the amount and content of metadata. Information relevant to the file that can be useful to the user such as the data producer, location where data was taken, variable descriptions, or information about the instrument might not be included in the file. This metadata might be present in another file in the dataset containing the same data using the International Consortium for Atmospheric Research on Transport and Transformation (ICARTT) format. Recently, the Aerosols, Clouds, and their Interactions for Earth System Models (MACIE) group started a grassroots effort to develop a set of requirements for the HDF and NetCDF files for field studies, aiming to make the data products more interoperable and usable. Particularly, these requirements seek to make the files more compliant to Climate and Forecast (CF) metadata conventions and to standardize the file structure and the global and variable attributes. These requirements would help to ensure that HDF and NetCDF files contain adequate metadata to better support their use for research, e.g., the modeling community, and to enhance the usability and interoperability of data for research communities at large. To be presented are the details of the MACIE requirements as well as examples of the implementation of these requirements for merge files and lidar observation data files.

Sean Leavor↗

NASA NTRSDate not supplied

Biological Data for Deep Space Mission Support

Increased biomedical risks and challenges associated with deep space missions (cis-Lunar, Mars transit, Mars surface) require new knowledge discovery and development of novel ecosystem and biomedical support capabilities. This paradigm shift supporting distant and long-duration missions requires biological data to be findable, accessible, interoperable, reusable (FAIR), and maximally open-access (i.e., there is a data governance continuum from closed to mediated to embargoed to open). The NASA “Open Science Data Repositories” (OSDR) aims to meet scientific, technical, and operational spaceflight needs, and offers the ability to upload, download, search, share, analyze, and visualize data across physiological, behavioral, ‘omics, and environmental monitoring telemetry datasets. OSDR includes NASA GeneLab, NASA Ames Life Sciences Data Archive (ALSDA), and NASA Biological Institutional Scientific Collection (NBISC). In the past year, ALSDA has undergone a transformation in its data collection, curation, and architecture methods. Standardizing non-genomic (phenotypic) datasets was, and will continue to be, a challenge because of their diverse nature (e.g., molecular, cellular, tissue, whole organism, behavior; micro-computed tomography, intraocular pressure, fluorescence microscopy, western blot, ultrasonography; tabular, images, video). This year ALSDA, alongside GeneLab, introduced the Biological Data Management Environment (BDME) with the purpose to accept submission of data from space relevant experiments including spaceflight, radiation, simulated gravity, gravitropism, isolation and confinement, hostile closed environments and/or distance from Earth. In addition to bringing together omics, phenotypic, physiological, bioimaging, and behavioral data into one repository. By integrating with GeneLab a multi-project submission portal aims to reduce the burden on PIs submitting data and enabling the discovery of both omics and phenotypic data. The purpose of ALSDA is to collect, curate, and make all non-human space-relevant biological data maximally findable, accessible, interoperable, and reusable (FAIR). These scope of ALSDA data collected and submitted by PIs include study design metadata, subject metadata, assay metadata (parameters), raw and processed assay data, assay imagery/video, and subject-experienced mission data telemetry (radiation, temperature, humidity, acoustics, vibrations, etc.). In 2021, a community of researchers rallied to form the ALSDA Analysis Working Group (AWG) and provided scientific consensus on dataset sample and assay metadata. The community and excitement around the ALSDA/OSDR system has already led to several data reuse studies, demonstrating value using machine learning (ML), knowledge graphs, and meta-analysis approaches.

space biology↗

NASA NTRSDate not supplied

Artemis Navigation Architecture: Early Capabilities and Long Term Evolvability and Evolution

With the awarding of multiple contracts within the Artemis program and building on the success of Artemis I, NASA is investing in and demonstrating the vehicle capabilities necessary for a return to human crewed Lunar Missions. To support activities on the lunar surface, NASA is also assessing architecture options and approaches to enable high precision in-situ navigation within the lunar sphere of influence. These capabilities build on decades of research and advancements within the field, building and evolving the techniques used during Apollo. To support inter-operability and broad application within its elements, NASA conducted a trade on Orbital and Surface Lunar Architecture for PNT. Time-defined mission requirements were captured across elements to inform a phased approach and deployment of needed capability. The architecture must also address unique aspects of the South Pole lunar environments, specifically in terms of harsh lighting and hazardous terrain. To inform the study, documentation of primary users, operational concepts of operations, driving scenarios, and mission needs were used to define performance constraints and phasing. Multiple technologies were assessed in terms of maturity, applicability, and performance to meet the primary user needs forecast. The results of this study support the utilization of in-situ orbital infrastructure to provide a back-bone for navigation and emphasize the need for a common Lunar Reference System and Lunar Time Reference. This deployment can ensure compatibility and enable a high-accuracy in-situ capability. This provides further justification for the capabilities being invested in and deployed by NASA and other international agencies. In addition to including advancements in terrestrial surface navigation, NASA is also applying lessons learned and innovation in the contractual approach to the individual elements by means of a services-based contract mechanism. This impacts the navigation architecture heavily in terms of government and provider roles, in terms of levels of implementation, interoperability, and verification. These distinctions in roles provide constraints to the architecture approach in terms of implementation and integration and will be discussed. The development, use, and mandate of interoperability standards are being deployed to support cross-element compatibility. This paper will provide a summary of the NASA Lunar Navigation needs across its various elements and the proposed deployment of an integrated navigation architecture to support early mission needs with inherent extensibility towards the future.

Evan Anzalone↗

NASA NTRSDate not supplied

Enabling Model Organism and Commercial Astronaut Data Access Through the NASA Open Science Data Repository

NASA’s Open Science Data Repository (OSDR) brings together omics data from NASA’s GeneLab project and non-omics data, including physiological, phenotypic, imaging, and behavioral data from NASA’s Ames Life Sciences Data Archive (ALSDA) collected from decades of space biology research, providing open and FAIR (findable, accessible, interoperable, and reusable) access of these precious data to scientists world-wide. This rich source of meticulously curated metadata and data from spaceflight and analog studies has been mined by the scientific community resulting in dozens of high impact scientific publications that reveals a complex network of molecular and physiological effects of spaceflight across living systems, from microbes to plants, to mammals. Understanding how these effects translate to the human condition is critical as we move deeper into the era of commercial space travel. However, the integration of data, specifically omics data, from astronauts is particularly challenging due to their sensitive nature. OSDR has risen to this challenge by developing a mechanism to control access to identifiable levels of omics data, such as raw sequence data, while enabling public access to processed, unidentifiable, data and associated metadata that will allow the scientific community to interrogate human astronaut data alongside data from model organisms to begin answering these critical questions. The 2021 SpaceX Inspiration4 (I4) mission collected a comprehensive atlas of biological measurements from four civilian astronauts, providing a wealth of data to characterize the effects of spaceflight on the human body. These data include both non-omics and omics assays such as direct RNA sequencing (RNA-seq), single nuclei ATAC-seq and RNA-seq, metagenomics, proteomics, and comprehensive metabolic and cytokine panels, all of which have been integrated into the OSDR system across no less than 9 studies. Each study has been carefully curated using community-backed OSDR standards for sample and assay level metadata ensuring these data are findable and accessible. In addition to hosting both raw and processed data from the principal investigator team for each assay type, the GeneLab team plans to re-process the I4 omics data using GeneLab’s standard processing pipelines. The GeneLab processed data outputs will allow for comparisons across studies on OSDR and enable visualization of these data through the OSDR data visualization platform thereby enabling data reusability and interoperability. Here we describe the robust privacy and security protocols implemented by OSDR to safeguard sensitive health data from astronauts while facilitating metadata and processed data sharing for research purposes. We further provide a road map for navigating the vast amount of data provided for each I4 study on the OSDR, including experimental design, associated experiments, payloads, and missions, data generation and analysis protocols, and associated scientific articles. Additionally, we illustrate how to interrogate the standardized metadata provided in the sample and assay tables as well as various means to download and access the data including programmatically through the GeneLab Open API (GLOpenAPI). The open access of datasets in NASA’s OSDR provides a unique opportunity for the scientific community, as well as citizen scientists and students, to continue using OSDR resources to further unlock profound insights into the consequences of space travel on the human body. Through implementation of security measures to protect sensitive human data, the OSDR seeks to strengthen the science exchange between the Biological and Physical Sciences Program and the Human Research Program, per recommendation 4-1 of the 2023-2032 Decadal Survey, and encourage further sharing and dissemination of astronaut data to provide the scientific community with the resources needed to lay the groundwork for developing targeted mitigation strategies to help withstand the rigors of long-duration spaceflight.

Amanda Marie Saravia-butler↗